产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗磷酸化ASK S83抗体
目录 :
P00929
规格 :
200微克
价格 :
329美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类
应用 :
免疫印迹
产品信息
SKU号 :
P00929
名称 :
抗磷酸化ASK S83抗体
价格 :
329美元
形式 :
Liquid
宿主 :
克隆性 :
多克隆
描述 :
Anti-ASK-1 phospho S83 Antibody validated for WB in Human.
规格 :
200微克
反应物种 :
人类
应用 :
免疫印迹
浓度 :
1.0 mg/mL by UV absorbance at 280 nm
基因全称 :
丝裂原活化蛋白激酶激酶激酶 5
基因名称 :
MAP3K5
protein function :
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
研究种类 :
cell biology apoptosis intracellular kinases cardiovascular heart hypertrophy
subcellular localization :
Cytoplasm. Endoplasmic reticulum. Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region.
同义词 :
丝裂原活化蛋白激酶激酶激酶 5;2.7。 11.25;凋亡信号调节激酶1;ASK-1;MAPK/ERK激酶激酶5;MEK激酶5;MEKK 5;MAP3K5;ASK1, mapkkk, MEKK5;
组织特异性 :
Abundantly expressed in heart and pancreas.
UniProt数据库编号 :
Q99683
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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