抗体

抗HDAC2抗体

PA1350-2

100 ug/vial

280美元

多克隆

兔

nonconjugated

人类, 大鼠

免疫印迹, 免疫组化

Enabled

抗HDAC2抗体

一抗, 多克隆抗体, 免疫组化免疫细胞化学IF抗体

HDAC2

280美元

30ug sample size / $99 100ug / $280 100ug+Free HRP Secondary BA1054 / $280 100ug+Free Biotin Secondary BA1003 / $280

多克隆

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

No

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Polyclonal antibody for Histone Deacetylase 2/HDAC2 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IHC-P. Reactive species: Human. Histone Deacetylase 2/HDAC2 information: Molecular Weight: 55364 MW; Subcellular Localization: Nucleus . Cytoplasm ; Tissue Specificity: Widely expressed; lower levels in brain and lung.

Rabbit IgG polyclonal antibody for Histone deacetylase 2(HDAC2) detection. Tested with WB, IHC-P in Human;Rat.

100 ug/vial

30ug for $99, contact us for details

Q92769

兔

A synthetic peptide corresponding to a sequence at the C-terminus of human HDAC2(462-478aa KEEDKSKDNSGEKTDTK), identical to the related rat sequence, and different from the related mouse sequence by one amino acid.

冻干

免疫原亲和纯化

At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.

No cross reactivity with other proteins

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Immunohistochemistry(Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat. Western blot, 0.1-0.5ug/ml, Human, Mouse, Rat.

免疫组化, 免疫印迹

人类, 大鼠

鸡

Anti-HDAC2 antibody, PA1350-2, Western blotting. All lanes: Anti HDAC2 (PA1350-2) at 0.5ug/ml. Lane 1: U87 Whole Cell Lysate at 40ug. Lane 2: A549 Whole Cell Lysate at 40ug. Predicted bind size: 55KD. Observed bind size: 55KD. Anti-HDAC2 antibody, PA1350-2, IHC(P). IHC(P): Human Mammary Cancer Tissue

Histone deacetylase 2 is an enzyme that in humans is encoded by the HDAC2 gene. This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones(H2A, H2B, H3 and H4). This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Betz et al.(1998) performed PCR using HDAC2-specific primers to screen a somatic cell hybrid mapping panel. They mapped the HDAC2 gene to human chromosome 6q21, a region of the genome altered in some cancers, including retinoblastoma.

sc 56685 sc 7899 sc 55542 sc 9959 sc 6296 sc 55541 sc 81599 sc 6296 R sc 7899 X sc 6296 X

Acetylation, Cardiovascular, Chromatin Modifying Enzymes, Class I, Epigenetics And Nuclear Signaling, Hypertrophy, Signaling Pathways, Stem Cells

组蛋白去乙酰化酶 2;HD2;3.5。 1.98;HDAC2;

组蛋白去乙酰化酶 2

55364分子量

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

Nucleus . Cytoplasm .

Widely expressed; lower levels in brain and lung.

组蛋白去乙酰化酶 2(HD2)

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

Belongs to the histone deacetylase family. HD type 1 subfamily.

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