产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
Anti-Src Antibody
目录 :
PA1415
规格 :
10微克样本
价格 :
99美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹
图像
图像 1 :
武汉博士德生物工程有限公司 PA1415 图像 1
Anti-Src antibody, PA1415, Western blotting. Lane 1: Rat Testis Tissue Lysate. Lane 2: Rat Brain Tissue Lysate.
产品信息
SKU号 :
PA1415
状态 :
1
名称 :
Anti-Src Antibody
url key :
anti-src-antibody-pa1415-boster
产品种类 :
一抗
基因名称 :
SRC
价格 :
315
规格1 :
10微克样本
price for size 1 :
99美元
规格2 :
Full size
price for size 2 :
315
规格3 :
Full size carrier free
price for size 3 :
365
克隆性 :
多克隆
浓度 :
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
contents :
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
描述 :
Boster Bio Anti-Src Antibody catalog # PA1415. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
short description :
Boster Bio Anti-Src Antibody catalog # PA1415. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
规格 :
100μg/vial
UniProt数据库编号 :
P12931
宿主 :
免疫原 :
A synthetic peptide corresponding to a sequence at the C-terminus of human Src (514-536aa YLQAFLEDYFTSTEPQYQPGENL), identical to the related rat and mouse sequences.
形式 :
冻干
纯化 :
免疫原亲和纯化
储存 :
Store at -20ÀöC for one year from date of receipt. After reconstitution, at 4ÀöC for one month. It can also be aliquotted and stored frozen at -20ÀöC for six months. Avoid repeated freeze-thaw cycles.
交叉活性 :
No cross reactivity with other proteins
重组 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
敏感性 :
>5000 cells
应用细节 :
免疫印迹, 0.1 0.5微克/毫升, 人类, 大鼠, 小鼠
应用 :
免疫印迹
反应物种 :
大鼠, 小鼠, 人类
前体活性 :
images :
/antibody/pa1415-1-WB-anti-src-antibody.jpg
图像标记 :
Anti-Src antibody PA1415 Western blotting. Lane 1: Rat Testis Tissue Lysate. Lane 2: Rat Brain Tissue Lysate.
custom options :
name=Size,required=1,price=-216.0000,type=radio,sku=,max_characters=0,file_extension=,image_size_x=0,image_size_y=0,price_type=fixed,option_title=10ug sample name=Size,required=1,price=0.0000,type=radio,sku=,max_characters=0,file_extension=,image_size_x=0,image_size_y=0,price_type=fixed,option_title=Full size name=Size,required=1,price=50.0000,type=radio,sku=,max_characters=0,file_extension=,image_size_x=0,image_size_y=0,price_type=fixed,option_title=Full size carrier free
created at :
7/6/14 15:18
updated at :
3/2/22 2:54
meta title :
Anti-Src Antibody PA1415
meta keyword :
Anti-Src Antibody
meta description :
Boster Bio Anti-Src Antibody catalog # PA1415. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. Supplied as 100ug/vial in Lyophilized form antibody.
应用注释 :
Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
rating value :
100
背景 :
Sarcoma (Scr) is a proto-oncogenic tyrosine kinase originally discovered by J. Michael Bishop and Harold E. Varmus. belongs to a family of non-receptor tyrosine kinases called Src family kinases. The human SRC protooncogene was assigned to chromosome 20. Its gene is mapped to 20q12-q13. The discovery of Src family proteins has been instrumental to the modern understanding of cancer as a disease where normally healthy cellular signalling has gone awry. This proto-oncogene may play a role in the regulation of embryonic development and cell growth.
competitor equivalent skus :
sc 101802 sc 101803 sc 12928 R sc 130069 sc 130074 sc 130124 sc 13066 X sc 135561 sc 135799 sc 135800 sc 136012 sc 136077 sc 166751 X sc 166859 sc 166860 sc 16844 sc 16844 R sc 16845 R sc 16846 sc 16846 R sc 168867 sc 168869 sc 18 sc 19 sc 22126 sc 22126 R sc 22154 R sc 25742 X sc 28832 sc 32789 sc 32789 X sc 398134 sc 398928 sc 5266 sc 530 sc 5305 X sc 6096 sc 6096 X sc 6098 sc 6098 X sc 7216 X sc 73057 sc 74483 sc 8056 sc 81521 sc 85917 sc 85918 sc 85919 sc 8995 sc 8995 X
研究种类 :
蛋白磷酸化, 信号转导, 酪氨酸激酶
同义词 :
Proto-oncogene tyrosine-protein kinase Src;2.7.10.2;Proto-oncogene c-Src;pp60c-src;p60-Src;SRC;SRC1;
基因全称 :
Proto-oncogene tyrosine-protein kinase Src
分子量 :
59835分子量
protein function :
Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin- 43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1. Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors. Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated calcium-activated chloride channel activation. Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr- 1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of ADRBK1, leading to beta- arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor. Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus. Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376'. Phosphorylates BCAR1 at 'Tyr- 128'. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity.
subcellular localization :
Cell membrane. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton. Localizes to focal adhesion sites following integrin engagement. Localization to focal adhesion sites requires myristoylation and the SH3 domain.
组织特异性 :
Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues.
蛋白名 :
Proto-oncogene tyrosine-protein kinase Src
recommended detection systems :
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
sequence similarities :
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
template :
抗体
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
Premium Provider of Antibodies and ELISA Kits