抗体

抗CEBP甲/CEBPA抗体

PA1459

100 ug/vial

280美元

多克隆

兔

nonconjugated

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学

Enabled

抗CEBP甲/CEBPA抗体

一抗, 多克隆抗体, 免疫组化免疫细胞化学IF抗体

CEBPA

280美元

30ug sample size / $99 100ug / $280 100ug+Free HRP Secondary BA1054 / $280 100ug+Free Biotin Secondary BA1003 / $280

多克隆

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

No

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Polyclonal antibody for CEBP alpha/CEBPA detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IHC-P. Reactive species: Human. CEBP alpha/CEBPA information: Molecular Weight: 37561 MW; Subcellular Localization: Nucleus .

Rabbit IgG polyclonal antibody for CCAAT/enhancer-binding protein alpha(CEBPA) detection. Tested with WB, IHC-P, ICC in Human;Mouse;Rat.

100 ug/vial

30ug for $99, contact us for details

P49715

兔

A synthetic peptide corresponding to a sequence at the C-terminus of human CEBP Alpha(342-358aa FRQLPESSLVKAMGNCA), identical to the related mouse and rat sequences.

冻干

免疫原亲和纯化

At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.

No cross reactivity with other proteins

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Immunocytochemistry , 0.5-1ug/ml, Human, -. Immunohistochemistry(Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat. Western blot, 0.1-0.5ug/ml, Human, Rat, Mouse.

免疫组化, 免疫细胞化学, 免疫印迹

人类, 小鼠, 大鼠

仓鼠

Anti-CEBP Alpha antibody, PA1459, Western blotting. Lane 1: MM231 Cell Lysate. Lane 2: JURKAT Cell Lysate. Lane 3: RAJI Cell Lysate . Lane 4: HELA Cell Lysate Anti-CEBP Alpha antibody, PA1459, IHC(P). IHC(P): Human Mammary Cancer Tissue

CEBPA, CCAAT/enhancer-binding protein alpha is a protein that in humans is encoded by the CEBPA gene. The CEBPA gene is intronless. Using human/hamster somatic cell hybrids containing restricted fragments of human chromosome 19, the CEBPA gene is mapped to chromosome 19q13.1, between the GPI and TGFB1 genes. The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis.

sc 74254 sc 16956 sc 390066 sc 25594 sc 390172

Cancer, Cardiovascular, Epigenetics And Nuclear Signaling, Fatty Acid Oxidation, Fatty Acids, Lipids / Lipoproteins, Metabolism, Pathways And Processes, Redox Metabolism, Signal Transduction, Transcription, Transcription Factors

CCAAT/增强结合蛋白甲;C/EBP甲;CEBPA;CEBP;

CCAAT/增强结合蛋白甲

37561分子量

Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Downregulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity).

Nucleus .

CCAAT/增强结合蛋白甲(C/EBP甲)

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P) and ICC.

Belongs to the bZIP family. C/EBP subfamily.

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