图像 1 :
Anti-IFN gamma antibody, PA1493, Western blotting. All lanes: Anti IFN gamma (PA1493) at 0.5ug/ml. Lane 1: Recombinant Human IFN gamma Protein 10ng. Lane 2: Recombinant Human IFN gamma Protein 5ng. Lane 3: Recombinant Human IFN gamma Protein 2.5ng. Lane 4: Recombinant Human IFN gamma Protein 1.25ng. Predicted bind size: 19KD. Observed bind size: 19KD
免疫印迹, 0.1 0.5µg/毫升, 人类
Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Boster Bio Anti-Interferon gamma/IFNG Antibody catalog # PA1493. Tested in WB applications. This antibody reacts with Human.
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
A synthetic peptide corresponding to a sequence at the C-terminus of human IFN gamma (151-166aa KRKRSQMLFRGRRASQ).
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
No cross reactivity with other proteins
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Interferon gamma; IFN-gamma; Immune interferon; IFNG;
Protein Function :
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Subcellular Localization :
Released primarily from activated T lymphocytes.
Recommended Detection Systems :
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
Sequence Similarities :
Belongs to the type II (or gamma) interferon family.
Interferon-gamma (IFN-gamma) is an inflammatory cytokine that has been implicated in the development of fibrosis in inflamed tissues. The production of IFN-gamma, which is under genetic control, can influence the development of fibrosis in lung allografts. IFN-gamma is also produced by natural killer (NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Interferon gamma is believed to be crucial for host defence against many infections. Genetically determined variability in IFN-gamma and expression might be important for the development of tuberculosis. IFN-gamma activates human macrophage oxidative metabolism and antimicrobial activity. In addition to having antiviral activity, IFN-gamma has important immunoregulatory functions. IFN-gamma plays an important role in the control of neointima proliferation.
Cancer, Cytokines, Immunology, Innate Immunity, Interferons, Signaling Pathways, Stem Cells, Tgf Beta, Tumor Immunology
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