抗体

抗PD-L1/CD274抗体

PA1851

100 ug/vial

240美元

多克隆

兔

nonconjugated

人类, 小鼠, 大鼠

Enabled

抗PD-L1/CD274抗体

一抗, 多克隆抗体

CD274

240美元

30ug sample size / $99 100ug / $240 100ug+Free HRP Secondary BA1054 / $240 100ug+Free Biotin Secondary BA1003 / $240

多克隆

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

No

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Polyclonal antibody for PD L1/CD274 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. PD L1/CD274 information: Molecular Weight: 33275 MW; Subcellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein; Tissue Specificity: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

Rabbit IgG polyclonal antibody for Programmed cell death 1 ligand 1(CD274) detection. Tested with WB in Human;Mouse;Rat.

100 ug/vial

30ug for $99, contact us for details

Q9NZQ7

兔

A synthetic peptide corresponding to a sequence at the N-terminus of human CD274(100-114aa QITDVKLQDAGVYRC), different from the related rat and mouse sequences by one amino acid.

冻干

免疫原亲和纯化

At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.

No cross reactivity with other proteins

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

免疫印迹, 0.1 0.5微克/毫升, 人类, 大鼠, 小鼠

免疫印迹

人类, 小鼠, 大鼠

牛

Anti-CD274 antibody, PA1851, Western blotting. All lanes: Anti CD274 (PA1851) at 0.5ug/ml. Lane 1: Rat Heart Tissue Lysate at 50ug. Lane 2: Rat Liver Tissue Lysate at 50ug. Lane 3: A549 Whole Cell Lysate at 40ug. Lane 4: HELA Whole Cell Lysate at 40ug. Lane 5: RAJI Whole Cell Lysate at 40ug. Predicted bind size: 33KD. Observed bind size: 70KD

CD274(CD274 molecule), also known as PDCD1L1, PDL1, B7H1, CD274 molecule, cluster of differentiation(CD274) or B7 homolog 1(B7-H1), Programmed cell death 1 ligand 1, is a protein that in humans is encoded by the CD274 gene. Levels of B7H1 correlated with PTEN loss in glioblastoma specimens, and tumor-specific T cells lysed human glioma targets expressing wildtype PTEN more effectively than those expressing mutant PTEN. Sequence analysis predicted that it has 290-amino acid. immunoresistance in glioma is related to loss of the tumor suppressor PTEN and is mediated in part by B7H1.Programmed death ligand 1(PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. Using microarray analysis and flow cytometry, Barber et al.(2006) found that Pd1 was highly upregulated by functionally exhausted CD8 T cells from mice infected with a lymphocytic choriomeningitis virus(LCMV) strain causing chronic infection, but not by functional memory CD8 T cells from mice infected with an LCMV strain causing acute infection.Â

sc 161700 sc 161699

Autoimmune, Cancer, Cell Type Markers, Immune System Diseases, Immunology, Tumor Antigens, Tumor Biomarkers, Tumor Immunology, Tumor-Associated Antigens

Programmed cell death 1 ligand 1;PD-L1;PDCD1 ligand 1;Programmed death ligand 1;B7 homolog 1;B7-H1;CD274;CD274;B7H1, PDCD1L1, PDCD1LG1, PDL1;

Programmed cell death 1 ligand 1

33275分子量

Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

Programmed cell death 1 ligand 1(PD-L1/PDCD1 ligand 1/Programmed death ligand 1)

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

Belongs to the immunoglobulin superfamily. BTN/MOG family.

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