抗体

抗p57 Kip2抗体

PA1876

100 ug/vial

200美元

多克隆

兔

nonconjugated

小鼠, 大鼠

抗p57 Kip2抗体

200美元

A synthetic peptide corresponding to a sequence at the N-terminus of mouse p57 Kip2(51-70aa RLAELNAEDQNRWDFNFQQD), identical to the related rat sequence, and different from the related human sequence by two amino acids.

冻干

兔

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

免疫原亲和纯化

多克隆

Rabbit IgG polyclonal antibody for Cyclin-dependent kinase inhibitor 1C(CDKN1C) detection. Tested with WB in Mouse;Rat.

100 ug/vial

小鼠;大鼠

免疫印迹

CDKN1C(Cyclin-dependent kinase inhibitor 1C) also called p57(KIP2) or KIP2, is a protein which in humans is encoded by the CDKN1C imprinted gene. The CDKN1C gene encodes p57(KIP2), a potent tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. The CDKN1C gene is paternally imprinted, with preferential expression of the maternal allele. Matsuoka et al.(1995) demonstrated that the CDKN1C gene is located on chromosome 11p15.5, a region implicated in both sporadic cancers and Beckwith-Wiedemann syndrome, a familial cancer syndrome, making it a tumor suppressor candidate. The CDKN1C gene contains 3 exons. Mutations of CDKN1C are implicated in sporadic cancers and Beckwith-Wiedemann syndromesuggesting that it is a tumor suppressor candidate. Diaz-Meyer et al.(2005) concluded that CDKN1C may be downregulated by multiple mechanisms including some that do not involve promoter methylation.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

No cross reactivity with other proteins

Cyclin-dependent kinase inhibitor 1C

CDKN1C;Cdkn1c

仓鼠

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.

Cyclin-dependent kinase inhibitor 1C

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

cell biology cell cycle cell cycle inhibitors cip / kip epigenetics and nuclear signaling cip/kip cancer

At -20ËšC for one year. After reconstitution, at 4ËšC for one month. It can also be aliquotted and stored frozen at -20ËšC for a longer time.Avoid repeated freezing and thawing.

Nucleus.

Cyclin-dependent kinase inhibitor 1C;Cyclin-dependent kinase inhibitor p57;p57Kip2;Cdkn1c;Kip2;

Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.

P49919