产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
Anti-Cullin 2/CUL2 Antibody
目录 :
PA1877
规格 :
100 ug/vial
价格 :
240美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹
图像
图像 1 :
武汉博士德生物工程有限公司 PA1877 图像 1
Anti-Cullin 2 antibody, PA1877, Western blotting. Recombinant Protein Detection Source: E.coli derived -recombinant human Cul2, 46.5KD (162aa tag+L150-Y394). Lane 1: Recombinant Human Cul2 Protein 10ng . Lane 2: Recombinant Human Cul2 Protein 5ng . Lane 3: Recombinant Human Cul2 Protein 2.5ng
图像 2 :
武汉博士德生物工程有限公司 PA1877 图像 2
Anti-Cullin 2 antibody, PA1877, Western blotting. WB: Rat Brain Tissue Lysate
图像 3 :
武汉博士德生物工程有限公司 PA1877 图像 3
Anti-Cullin 2 antibody, PA1877, Western blotting. Lane 1: A431 Cell Lysate. Lane 2: SMMC Cell Lysate. Lane 3: HELA Cell Lysate. Lane 4: COLO320 Cell Lysate.
产品信息
SKU号 :
PA1877
状态 :
Enabled
名称 :
Anti-Cullin 2/CUL2 Antibody
目录名称 :
一抗, 多克隆抗体
基因名称 :
CUL2
价格 :
240美元
price various sizes :
30ug sample size / $99 100ug / $240 100ug+Free HRP Secondary BA1054 / $240 100ug+Free Biotin Secondary BA1003 / $240
克隆性 :
多克隆
浓度 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
共轭标签 :
No
contents :
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
描述 :
Polyclonal antibody for CULLIN 2/CUL2 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. CULLIN 2/CUL2 information: Molecular Weight: 86983 MW; .
short description :
Rabbit IgG polyclonal antibody for Cullin-2(CUL2) detection. Tested with WB in Human;Mouse;Rat.
规格 :
100 ug/vial
sample size available :
30ug for $99, contact us for details
UniProt数据库编号 :
Q13617
宿主 :
免疫原 :
A synthetic peptide corresponding to a sequence in the middle region of human Cullin 2(264-280aa HECQQRMVADHLQFLHA), different from the related mouse and rat sequences by one amino acid.
形式 :
冻干
纯化 :
免疫原亲和纯化
储存 :
At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.
交叉活性 :
No cross reactivity with other proteins
重组 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
应用细节 :
免疫印迹, 0.1 0.5微克/毫升, 人类, 大鼠, 小鼠
应用 :
免疫印迹
反应物种 :
人类, 小鼠, 大鼠
前体活性 :
仓鼠
图像标记 :
Anti-Cullin 2 antibody, PA1877, Western blotting. Recombinant Protein Detection Source: E.coli derived -recombinant human Cul2, 46.5KD (162aa tag+L150-Y394). Lane 1: Recombinant Human Cul2 Protein 10ng . Lane 2: Recombinant Human Cul2 Protein 5ng . Lane 3: Recombinant Human Cul2 Protein 2.5ng Anti-Cullin 2 antibody, PA1877, Western blotting. WB: Rat Brain Tissue Lysate Anti-Cullin 2 antibody, PA1877, Western blotting. Lane 1: A431 Cell Lysate. Lane 2: SMMC Cell Lysate. Lane 3: HELA Cell Lysate. Lane 4: COLO320 Cell Lysate.
背景 :
Cullin 2(CUL2) is a protein that in humans is encoded by the CUL2 gene. Using immunofluorescence, they showed that CUL2 is a cytosolic protein that can be translocated to the nucleus by VHL. By fluorescence in situ hybridization, Clifford et al.(1999)mapped the CUL2 gene to 10p11.2-p11.1, a region reported to show loss of heterozygosity(LOH) in several forms of human cancer, including non-clear cell renal cell carcinoma. Pause et al.(1997)suggested that CUL2 is a candidate tumor suppressor gene, as has been proposed for CUL1(603134). Lonergan et al.(1998) demonstrated that formation of the VBC-CUL2 complexes is linked to the regulation of hypoxia-inducible mRNAs by VHL. Cul2 was one of several proteins required for degradation of a class of RNA-binding germline proteins in somatic cells of the early blastomere.
competitor equivalent skus :
sc 10781 sc 166506 sc 8554 sc 8555
同义词 :
Cullin-2;CUL-2;CUL2;
基因全称 :
Cullin-2
分子量 :
86983分子量
protein function :
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
蛋白名 :
Cullin-2
recommended detection systems :
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
更新 :
1/28/19 19:39
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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