产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗MCK10/DDR1抗体
目录 :
PA1878
规格 :
100 ug/vial
价格 :
240美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 大鼠
应用 :
免疫印迹
图像
图像 1 :
武汉博士德生物工程有限公司 PA1878 图像 1
Anti-MCK10 antibody, PA1878, Western blotting. Recombinant Protein Detection Source: E.coli derived -recombinant human DDR1, 45.8KD (162aa tag+F669-V913). Lane 1: Recombinant Human DDR1 Protein 10ng . Lane 2: Recombinant Human DDR1 Protein 5ng . Lane 3: Recombinant Human DDR1 Protein 2.5ng . Lane 4: Recombinant Human DDR1 Protein 1.25ng
图像 2 :
武汉博士德生物工程有限公司 PA1878 图像 2
Anti-MCK10 antibody, PA1878, Western blotting. Lane 1: A431 Cell Lysate. Lane 2: A549 Cell Lysate. Lane 3: HELA Cell Lysate.
产品信息
SKU号 :
PA1878
状态 :
Enabled
名称 :
抗MCK10/DDR1抗体
目录名称 :
一抗, 多克隆抗体
基因名称 :
DDR1
价格 :
240美元
price various sizes :
30ug sample size / $99 100ug / $240 100ug+Free HRP Secondary BA1054 / $240 100ug+Free Biotin Secondary BA1003 / $240
克隆性 :
多克隆
浓度 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
共轭标签 :
No
contents :
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
描述 :
Polyclonal antibody for MCK10/DDR1 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. MCK10/DDR1 information: Molecular Weight: 101128 MW; Subcellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein; Tissue Specificity: Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin.
short description :
Rabbit IgG polyclonal antibody for Epithelial discoidin domain-containing receptor 1(DDR1) detection. Tested with WB in Human;Rat.
规格 :
100 ug/vial
sample size available :
30ug for $99, contact us for details
UniProt数据库编号 :
Q08345
宿主 :
免疫原 :
A synthetic peptide corresponding to a sequence at the C-terminus of human MCK10(898-913aa FSQLHRFLAEDALNTV), different from the related rat sequence by one amino acid, and from the related mouse sequence by two amino acids.
形式 :
冻干
纯化 :
免疫原亲和纯化
储存 :
At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.
交叉活性 :
No cross reactivity with other proteins
重组 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
应用细节 :
免疫印迹, 0.1 0.5微克/毫升, 人类, 大鼠
应用 :
免疫印迹
反应物种 :
人类, 大鼠
前体活性 :
图像标记 :
Anti-MCK10 antibody, PA1878, Western blotting. Recombinant Protein Detection Source: E.coli derived -recombinant human DDR1, 45.8KD (162aa tag+F669-V913). Lane 1: Recombinant Human DDR1 Protein 10ng . Lane 2: Recombinant Human DDR1 Protein 5ng . Lane 3: Recombinant Human DDR1 Protein 2.5ng . Lane 4: Recombinant Human DDR1 Protein 1.25ng Anti-MCK10 antibody, PA1878, Western blotting. Lane 1: A431 Cell Lysate. Lane 2: A549 Cell Lysate. Lane 3: HELA Cell Lysate.
背景 :
DDR1(Discoidin domain receptor family, member 1) also known as NEP, EDDR1, NTRK4, TRKE, DDR, CAK or RTK6, is a human gene. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen.This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain.The DDR1 gene is mapped on 6p21.33. The fibrillar collagens and immobilized collagen activated DDR1 receptor phosphorylation after prolonged treatment. Bhatt et al.(2000) showed that Ddr1 was highly expressed in the cerebellum of developing and adult mouse brain, and that both Ddr1 and collagen IV were highly expressed in the pial layer of the cerebellar cortex. Cocultures of collagen I- and IV-expressing mouse pial cells with Ddr1-expressing granule cells resulted in granule cell neurite extension. Inhibition of collagen-Ddr1signaling reduced granule cell neurite elongation.
competitor equivalent skus :
sc 532 sc 7553 sc 8988 sc 374618 sc 21790 sc 390268 sc 532 G
研究种类 :
Cancer, Cardiogenesis, Cardiovascular, Neuroscience, Neurotransmission, Protein Phosphorylation, Receptor Tyrosine Kinases, Receptors / Channels, Signal Transduction, Tyrosine Kinases
同义词 :
Epithelial discoidin domain-containing receptor 1;Epithelial discoidin domain receptor 1;2.7.10.1;CD167 antigen-like family member A;Cell adhesion kinase;Discoidin receptor tyrosine kinase;HGK2;Mammary carcinoma kinase 10;MCK-10;Protein-tyrosine kinase 3A;Protein-tyrosine kinase RTK-6;TRK E;Tyrosine kinase DDR;Tyrosine-protein kinase CAK;CD167a;DDR1;CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE;
基因全称 :
Epithelial discoidin domain-containing receptor 1
分子量 :
101128分子量
protein function :
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
subcellular localization :
Isoform 1: Cell membrane; Single-pass type I membrane protein.
组织特异性 :
Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin.
蛋白名 :
Epithelial discoidin domain-containing receptor 1
recommended detection systems :
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
sequence similarities :
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
更新 :
1/28/19 19:39
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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