产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
Anti-ErbB 4/ERBB4 Antibody
目录 :
PA1881
规格 :
100 ug/vial
价格 :
240美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹
图像
图像 1 :
武汉博士德生物工程有限公司 PA1881 图像 1
Anti-ErbB 4 antibody, PA1881, Western blotting. Lane 1: A549 Cell Lysate. Lane 2: HELA Cell Lysate.
图像 2 :
武汉博士德生物工程有限公司 PA1881 图像 2
Anti-ErbB 4 antibody, PA1881, Western blotting. Recombinant Protein Detection Source: E.coli derived -recombinant human ERRB4, 40.6KD (162aa tag+M1-P200). Lane 1: Recombinant Human ERRB4 Protein 10ng . Lane 2: Recombinant Human ERRB4 Protein 5ng . Lane 3: Recombinant Human ERRB4 Protein 2.5ng . Lane 4: Recombinant Human ERRB4 Protein 1.25ng
图像 3 :
武汉博士德生物工程有限公司 PA1881 图像 3
Anti-ErbB 4 antibody, PA1881, Western blotting. Lane 1: HELA Cell Lysate. Lane 2: U87 Cell Lysate. Lane 3: NEURO Cell Lysate.
产品信息
SKU号 :
PA1881
状态 :
Enabled
名称 :
Anti-ErbB 4/ERBB4 Antibody
目录名称 :
一抗, 多克隆抗体
基因名称 :
ERBB4
价格 :
240美元
price various sizes :
30ug sample size / $99 100ug / $240 100ug+Free HRP Secondary BA1054 / $240 100ug+Free Biotin Secondary BA1003 / $240
克隆性 :
多克隆
浓度 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
共轭标签 :
No
contents :
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
描述 :
Polyclonal antibody for Her4/ERBB4 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. Her4/ERBB4 information: Molecular Weight: 146808 MW; Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . In response to NRG1 treatment, the activated receptor is internalized; Tissue Specificity: Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart.
short description :
Rabbit IgG polyclonal antibody for Receptor tyrosine-protein kinase erbB-4(ERBB4) detection. Tested with WB in Human;Mouse;Rat.
规格 :
100 ug/vial
sample size available :
30ug for $99, contact us for details
UniProt数据库编号 :
Q15303
宿主 :
免疫原 :
A synthetic peptide corresponding to a sequence at the N-terminus of human ErbB 4(35-51aa KLSSLSDLEQQYRALRK), identical to the related rat and mouse sequences.
形式 :
冻干
纯化 :
免疫原亲和纯化
储存 :
At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.
交叉活性 :
No cross reactivity with other proteins
重组 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
应用细节 :
免疫印迹, 0.1 0.5微克/毫升, 人类, 小鼠, 大鼠
应用 :
免疫印迹
反应物种 :
人类, 小鼠, 大鼠
前体活性 :
仓鼠
图像标记 :
Anti-ErbB 4 antibody, PA1881, Western blotting. Lane 1: A549 Cell Lysate. Lane 2: HELA Cell Lysate. Anti-ErbB 4 antibody, PA1881, Western blotting. Recombinant Protein Detection Source: E.coli derived -recombinant human ERRB4, 40.6KD (162aa tag+M1-P200). Lane 1: Recombinant Human ERRB4 Protein 10ng . Lane 2: Recombinant Human ERRB4 Protein 5ng . Lane 3: Recombinant Human ERRB4 Protein 2.5ng . Lane 4: Recombinant Human ERRB4 Protein 1.25ng Anti-ErbB 4 antibody, PA1881, Western blotting. Lane 1: HELA Cell Lysate. Lane 2: U87 Cell Lysate. Lane 3: NEURO Cell Lysate.
背景 :
ERBB4(V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) also known as ONCOGENE ERBB4 or HER4, is an enzyme that in humans is encoded by the ERBB4 gene. The HER4/ERBB4 gene is a member of the type I receptor tyrosine kinase subfamily that includes EGFR, ERBB2 and ERBB3. The ERBB4 gene is mapped on 2q34. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domainbinding motif. Huang et al.(2000) reported that ERBB4 is enriched in the postsynaptic density and associates with PSD95. ERBB4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding its ligand, heregulin, or activation of protein kinase C by TPA, the ERBB4 ectodomain is cleaved by a metalloprotease. Ni et al.(2001)concluded that gamma-secretase cleavage of ERBB4 may represent another mechanism for receptor tyrosine kinase-mediated signaling.
competitor equivalent skus :
sc 283 sc 283 G sc 284 sc 284 G sc 31149 sc 31150 sc 31151 sc 33040 sc 514327 sc 514462 sc 515142 sc 53280 sc 71070 sc 71071 sc 7301 sc 8050 sc 81456 sc 81491
研究种类 :
Cancer, Cell Type Markers, Growth Factors, Growth Factors/Hormones, Oncoproteins, Oncoproteins/Suppressors, Protein Phosphorylation, Receptor Tyrosine Kinases, Signal Transduction, Tumor Associated, Tumor Biomarkers, Tyrosine Kinases
同义词 :
Receptor tyrosine-protein kinase erbB-4;2.7.10.1;Proto-oncogene-like protein c-ErbB-4;Tyrosine kinase-type cell surface receptor HER4;p180erbB4;ERBB4 intracellular domain;4ICD;E4ICD;s80HER4;ERBB4;HER4;
基因全称 :
Receptor tyrosine-protein kinase erbB-4
分子量 :
146808分子量
protein function :
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis.
subcellular localization :
Cell membrane ; Single-pass type I membrane protein . In response to NRG1 treatment, the activated receptor is internalized.
组织特异性 :
Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart.
蛋白名 :
Receptor tyrosine-protein kinase erbB-4
recommended detection systems :
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
sequence similarities :
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
更新 :
1/28/19 19:39
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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