产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗FER抗体
目录 :
PA1882
规格 :
100 ug/vial
价格 :
280美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 大鼠
应用 :
免疫印迹, 免疫组化
图像
图像 1 :
武汉博士德生物工程有限公司 PA1882 图像 1
Anti-FER antibody, PA1882, Western blotting. All lanes: Anti FER (PA1882) at 0.5ug/ml. Lane 1: HELA Whole Cell Lysate at 40ug. Lane 2: Rat Testis Tissue Lysate at 50ug. Lane 3: Rat Ovary Tissue Lysate at 50ug. Predicted bind size: 95KD. Observed bind size: 95KD
图像 2 :
武汉博士德生物工程有限公司 PA1882 图像 2
Anti-FER antibody, PA1882, IHC(P). IHC(P): Human Intestinal Cancer Tissue
图像 3 :
武汉博士德生物工程有限公司 PA1882 图像 3
Anti-FER antibody, PA1882, IHC(P). IHC(P): Rat Intestine Tissue
产品信息
SKU号 :
PA1882
状态 :
Enabled
名称 :
抗FER抗体
目录名称 :
一抗, 多克隆抗体, 免疫组化免疫细胞化学IF抗体
基因名称 :
FER
价格 :
280美元
price various sizes :
30ug sample size / $99 100ug / $280 100ug+Free HRP Secondary BA1054 / $280 100ug+Free Biotin Secondary BA1003 / $280
克隆性 :
多克隆
浓度 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
共轭标签 :
No
contents :
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
描述 :
Polyclonal antibody for FER detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IHC-P. Reactive species: Human. FER information: Molecular Weight: 94638 MW; Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell- cell contacts; Tissue Specificity: Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed.
short description :
Rabbit IgG polyclonal antibody for Tyrosine-protein kinase Fer(FER) detection. Tested with WB, IHC-P in Human;Rat.
规格 :
100 ug/vial
sample size available :
30ug for $99, contact us for details
UniProt数据库编号 :
P16591
宿主 :
免疫原 :
A synthetic peptide corresponding to a sequence in the middle region of human FER(521-536aa FSNIPQLIDHHYTTKQ), different from the related rat and mouse sequences by two amino acids.
形式 :
冻干
纯化 :
免疫原亲和纯化
储存 :
At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.
交叉活性 :
No cross reactivity with other proteins
重组 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
应用细节 :
Immunohistochemistry(Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, By Heat. Western blot, 0.1-0.5ug/ml, Human, Rat.
应用 :
免疫组化, 免疫印迹
反应物种 :
人类, 大鼠
前体活性 :
图像标记 :
Anti-FER antibody, PA1882, Western blotting. All lanes: Anti FER (PA1882) at 0.5ug/ml. Lane 1: HELA Whole Cell Lysate at 40ug. Lane 2: Rat Testis Tissue Lysate at 50ug. Lane 3: Rat Ovary Tissue Lysate at 50ug. Predicted bind size: 95KD. Observed bind size: 95KD Anti-FER antibody, PA1882, IHC(P). IHC(P): Human Intestinal Cancer Tissue Anti-FER antibody, PA1882, IHC(P). IHC(P): Rat Intestine Tissue
背景 :
FER(FPS/FES-Related tyrosine kinase) also known as TYK3, is an enzyme that in humans is encoded by the FER gene. Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. By in situ hybridization, Morris et al.(1990) concluded that the FER gene is located at 5q21-q22. Treatment of cells with JMP resulted in the release of FER from the cadherin complex and its accumulation in the integrin complex. The accumulation of FER in the integrin complex and the inhibitory effects of JMP could be reversed with a peptide that mimics the first coiled-coil domain of FER. The results suggested that FER mediates crosstalk between CDH2 and ITGB1. In Fer mutant mice, leukocyte emigration was exaggerated in response to LPS without altering vascular permeability, suggesting that FER has a role in regulating innate immunity.
competitor equivalent skus :
sc 30706 sc 14310 sc 30707 sc 28771 sc 390484 sc 81461 sc 81708 sc 81272
研究种类 :
细胞生物学, 细胞周期, 激酶/磷酸酶, 蛋白磷酸化, 信号转导, 酪氨酸激酶
同义词 :
Tyrosine-protein kinase Fer;2.7.10.2;Feline encephalitis virus-related kinase FER;Fujinami poultry sarcoma/Feline sarcoma-related protein Fer;Proto-oncogene c-Fer;Tyrosine kinase 3;p94-Fer;FER;TYK3;
基因全称 :
Tyrosine-protein kinase Fer
分子量 :
94638分子量
protein function :
Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.
subcellular localization :
Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell- cell contacts.
组织特异性 :
Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed.
蛋白名 :
Tyrosine-protein kinase Fer
recommended detection systems :
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
sequence similarities :
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
更新 :
1/28/19 19:39
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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