抗体

抗Rb2 p130/RBL2抗体

PA1895

100 ug/vial

240美元

多克隆

兔

nonconjugated

人类, 小鼠, 大鼠

Enabled

抗Rb2 p130/RBL2抗体

一抗, 多克隆抗体

RBL2

240美元

30ug sample size / $99 100ug / $240 100ug+Free HRP Secondary BA1054 / $240 100ug+Free Biotin Secondary BA1003 / $240

多克隆

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

No

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Polyclonal antibody for RB2 P130/RBL2 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. RB2 P130/RBL2 information: Molecular Weight: 128367 MW; Subcellular Localization: Nucleus.

Rabbit IgG polyclonal antibody for Retinoblastoma-like protein 2(RBL2) detection. Tested with WB in Human;Mouse;Rat.

100 ug/vial

30ug for $99, contact us for details

Q08999

兔

A synthetic peptide corresponding to a sequence at the C-terminus of human Rb2 p130(1120-1139aa ENHSALLRRLQDVANDRGSH), identical to the related rat sequence and different from the related mouse sequence by one amino acid.

冻干

免疫原亲和纯化

At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.

No cross reactivity with other proteins

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

免疫印迹, 0.1 0.5微克/毫升, 人类, 小鼠, 大鼠

免疫印迹

人类, 小鼠, 大鼠

仓鼠

Anti-Rb2 p130 antibody, PA1895, Western blotting. Lane 1: Rat Testis Tissue Lysate. Lane 2: NIH313 Cell Lysate.

RBL2(Retinoblastoma-like protein 2) is a protein that in humans is encoded by the RBL2 gene. It is also known as Retionblastoma-related gene(RB2), P130. Yeung et al.(1993) mapped the RBL2 gene to human chromosome 16q12.2 and rat chromosome 19, using fluorescence in situ hybridization and somatic hybrid cell analysis, respectively. Based on known syntenic relationships among human, rat and mouse, the data suggested that the mouse homolog resides on chromosome 8. Deletions of chromosome 16q have been found in several human neoplasms, including breast, ovarian, hepatic, and prostate cancers, which supports the involvement of RB2 in human cancer as a tumor suppressor gene. Kong et al.(2006)found that RBL2 and RINT1 were essential for telomere length control in human fibroblasts, with loss of either protein leading to longer telomeres. Williams et al.(2006)found that mouse fibroblasts lacking Rb were less susceptible to an oncogenic HRAS allele than wildtype cells. In contrast, p107(RBL1;) -/- and p130 -/- fibroblasts were more susceptible to HRAS-mediated transformation than wildtype cells.

sc 16299 sc 16299 R sc 16300 sc 16300 R sc 16301 sc 16301 R sc 169028 sc 20678 sc 22157 sc 22157 R sc 31338 sc 31339 sc 317 sc 317 G sc 317 X sc 365163 sc 365163 X sc 374521 sc 53641 sc 56176 sc 9963

Tumor Suppressors

Retinoblastoma-like protein 2;130 kDa retinoblastoma-associated protein;p130;Retinoblastoma-related protein 2;RBR-2;pRb2;RBL2;RB2;

Retinoblastoma-like protein 2

128367分子量

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Nucleus.

Retinoblastoma-like protein 2

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

Belongs to the retinoblastoma protein (RB) family.

1/28/19 19:39