抗体

抗NOXA1抗体

PA1930

100μg/vial

315美元

多克隆

domestic rabbit

未共轭

抗NOXA1抗体

315美元

100μg/vial

多克隆

兔

人类

免疫印迹

免疫印迹, 0.1 0.5µg/毫升, 人类

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Boster Bio Anti-NOXA1 Antibody catalog # PA1930. Tested in WB applications. This antibody reacts with Human.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

NOXA1

Q86UR1

A synthetic peptide corresponding to a sequence in the middle region of human NOXA1 (176-195aa RQVPRGEVFRPHRWHLKHLE).

冻干

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

免疫原亲和纯化

No cross reactivity with other proteins

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

NADPH oxidase activator 1

NADPH oxidase activator 1; NOX activator 1; Antigen NY-CO-31; NCF2-like protein; P67phox-like factor; p51-nox; NOXA1; P51NOX;

NADPH oxidase activator 1

50933分子量

Functions as an activator of NOX1, a superoxide- producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.

Cytoplasm. Cell membrane. Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.

Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

Belongs to the NCF2/NOXA1 family.

NOXA1 (NADPH oxidase activator 1), also called NOX ACTIVATOR 1 or p51-NOX, is an enzyme that in humans is encoded by the NOXA1 gene. Hartz (2007) mapped the NOXA1 gene to chromosome 9q34.3 based on an alignment of the NOXA1 sequence with the genomic sequence (build 36.1). Banfi et al. (2003) mapped the mouse Noxa1 gene to chromosome 2. Using yeast 2-hybrid assays, Takeya et al. (2003) showed that human p51-NOX interacted with constitutively active forms of RAC1 and RAC2. In vitro binding assays revealed that p51-NOX bound GTP-bound RAC1, but not GDP-bound RAC1. p51-NOX also bound p47-PHOX (NCF1) and p41-NOX (NOXO1), and trp436 within the SH3 domain of p51-NOX was required for these interactions. Human cell lines or COS-7 cells cotransfected with p51-NOX and p41-NOX and either gp91-PHOX (CYBB) or NOX1 produced superoxide. Cells individually transfected with NOX1, p41-NOX, or p51-NOX and cells transfected with only p41-NOX and p51-NOX showed no superoxide production.

Associated Proteins, Cardiovascular, Cell Biology, Hypoxia, Metabolism, Organelle Proteins, Oxidative Stress, Pathways And Processes, Protein Trafficking, Redox Metabolism, Signal Transduction