产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗SNF5抗体
目录 :
PA1934
规格 :
100 ug/vial
价格 :
200美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化-石蜡切片
产品信息
SKU号 :
PA1934
名称 :
抗SNF5抗体
价格 :
200美元
免疫原 :
A synthetic peptide corresponding to a sequence at the C-terminus of human SNF5(362-377aa EKKIRDQDRNTRRMRR), identical to the related rat and mouse sequences.
形式 :
冻干
宿主 :
contents :
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
纯化 :
免疫原亲和纯化
克隆性 :
多克隆
描述 :
Rabbit IgG polyclonal antibody for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1(SMARCB1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
规格 :
100 ug/vial
反应物种 :
人类;小鼠;大鼠
应用 :
免疫组化-P;免疫印迹
背景 :
SMARCB1(SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1), also known as SNF5, INI1 or MALIGNANT RHABDOID TUMOR SUPPRESSOR, is a protein that in humans is encoded by the SMARCB1 gene. The SMARCB1 gene encodes a subunit of the SWI/SNF ATP-dependent chromatin-remodeling complex. The SMARCB1 gene maps to chromosome 22q11.2(Versteege et al., 1998). Wu et al.(2002) noted that GADD34(PPP1R15A) and SNF5 can coexist in a trimeric complex with chimeric leukemic HRX(MLL) fusion proteins, leading to inhibition of GADD34-mediated apoptosis. By mutation analysis, they showed that the GADD34 region homologous to the HSV-1 ICP34.5 protein was necessary for interaction with SNF5. SNF5 could bind independently with the protein phosphatase-1(PP1) catalytic subunit(PPP1CA) and stimulate its activity in solution and in complex with GADD34. SNF5 and PP1 did not compete for GADD34 binding, but rather formed a stable trimeric complex with GADD34. Wu et al.(2002) proposed that GADD34 mediates growth suppression, at least in part, through its interaction with SNF5. They suggested that SNF5 may function as a regulatory subunit of PP1, either independently or together with GADD34.
浓度 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
交叉活性 :
No cross reactivity with other proteins
基因全称 :
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
基因名称 :
SMARCB1
前体活性 :
protein function :
Core component of the BAF (hSWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.
蛋白名 :
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
重组 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
研究种类 :
epigenetics and nuclear signaling chromatin remodeling swi / snf epigenetics and nuclear signaling transcription cancer susceptibility tumor suppressors cancer oncoproteins/suppressors mediator complex
sequence similarities :
Belongs to the SNF5 family.
储存 :
At -20ËšC for one year. After reconstitution, at 4ËšC for one month. It can also be aliquotted and stored frozen at -20ËšC for a longer time.Avoid repeated freezing and thawing.
subcellular localization :
Nucleus.
同义词 :
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;BRG1-associated factor 47;BAF47;Integrase interactor 1 protein;SNF5 homolog;hSNF5;SMARCB1;BAF47, INI1, SNF5L1;
UniProt数据库编号 :
Q12824
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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