抗体

抗胱氨酸-天冬氨酸蛋白酶3(P17)抗体

PA1961

100 ug/vial

200美元

多克隆

兔

nonconjugated

抗胱氨酸-天冬氨酸蛋白酶3(P17)抗体

200美元

A synthetic peptide corresponding to a sequence at the N-terminus of human Caspase-3(P17)(70-90aa DAANLRETFRNLKYEVRNKND).

冻干

兔

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

免疫原亲和纯化

多克隆

Rabbit IgG polyclonal antibody for Caspase-3(CASP3) detection. Tested with WB in Human.

100 ug/vial

人类

免疫印迹

CASP3(Caspase3 Apoptosis-Related Cysteine Protease), also known as YAMA, CPP32 or APOPAIN, is a caspase protein that interacts with caspase 8 and caspase 9. It is encoded by the CASP3 gene. The CASP3 protein is a member of the cysteine-aspartic acid protease(caspase) family. Tiso et al.(1996) used radiation hybrid mapping to localize the CPP32 gene to human chromosome 4q33-q35.1. Fernandes-Alnemri et al.(1994) found that overexpression of CPP32 in insect cells induced apoptosis. Coexpression of the 2 CPP32 subunits in insect cells also resulted in apoptosis. Tewari et al.(1995) showed that purified human ICE cleaved the Yama proenzyme into a proteolytically active form and that activated Yama cleaved PARP into the 85-kD apoptotic form.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

No cross reactivity with other proteins

胱氨酸-天冬氨酸蛋白酶3

CASP3

仓鼠

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

胱氨酸-天冬氨酸蛋白酶3

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

neuroscience neurology process neurodegenerative disease alzheimer's disease cell biology apoptosis intracellular caspases etc caspases neuroscience cancer invasion/microenvironment cell death apoptotic markers

Belongs to the peptidase C14A family.

At -20ËšC for one year. After reconstitution, at 4ËšC for one month. It can also be aliquotted and stored frozen at -20ËšC for a longer time.Avoid repeated freezing and thawing.

细胞质

Caspase-3;CASP-3;3.4.22.56;Apopain;Cysteine protease CPP32;CPP-32;Protein Yama;SREBP cleavage activity 1;SCA-1;Caspase-3 subunit p17;Caspase-3 subunit p12;CASP3;CPP32;

Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.

P42574