抗体

Anti-TrkA/NTRK1 Antibody

PA2149-2

100μg/vial

315美元

多克隆

domestic rabbit

未共轭

小鼠, 大鼠

Anti-TrkA/NTRK1 Antibody

315美元

100μg/vial

多克隆

兔

大鼠, 小鼠

免疫印迹

免疫印迹, 0.1 0.5µg/毫升, 小鼠, 大鼠

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Boster Bio Anti-TrkA/NTRK1 Antibody catalog # PA2149-2. Tested in WB applications. This antibody reacts with Mouse, Rat.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

NTRK1

Q3UFB7

A synthetic peptide corresponding to a sequence at the N-terminus of mouse TrkA (71-90aa LYVENQQHLQRLEFEDLQGL), different from the related rat sequence by two amino acids.

冻干

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

免疫原亲和纯化

No cross reactivity with other proteins

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

High affinity nerve growth factor receptor

High affinity nerve growth factor receptor; 2.7.10.1; Neurotrophic tyrosine kinase receptor type 1; Ntrk1;

High affinity nerve growth factor receptor

87738分子量

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras- PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.

Cell membrane ; Single-pass type I membrane protein. Early endosome membrane ; Single-pass type I membrane protein. Late endosome membrane ; Single-pass type I membrane protein. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes (By similarity). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport.

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Neurotrophic tyrosine kinase receptor type 1, also called Trk-A, is a protein that in humans is encoded by the NTRK1 gene. The NTKR1 gene encodes the neurotrophic tyrosine kinase-1 receptor and belongs to a family of nerve growth factor receptors whose ligands include neurotrophins. This gene is mapped to 1q23.1. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.

Cancer, Growth And Development, Neurology Process, Neuroscience, Oncoproteins, Oncoproteins/Suppressors