抗体

抗透明质酸酶1 HYAL1抗体

PA2181-1

100μg/vial

315美元

多克隆

domestic rabbit

未共轭

免疫印迹, 免疫组化, 免疫细胞化学

抗透明质酸酶1 HYAL1抗体

315美元

100μg/vial

多克隆

兔

人类

免疫组化, 免疫细胞化学, 免疫印迹

Immunocytochemistry , 0.5-1µg/ml, HumanImmunohistochemistry (Frozen Section), 0.5-1µg/ml, HumanImmunohistochemistry (Paraffin-embedded Section), 0.5-1µg/ml, Human, By Heat. Western blot, 0.1-0.5µg/ml, Human.

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Boster Bio Anti-Hyaluronidase-1 HYAL1 Antibody catalog # PA2181-1. Tested in IHC, ICC, WB applications. This antibody reacts with Human.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

HYAL1

Q12794

A synthetic peptide corresponding to a sequence at the N-terminus of human HYAL1 (32-47aa FTTVWNANTQWCLERH).

冻干

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

免疫原亲和纯化

No cross reactivity with other proteins

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

透明质酸酶1

Hyaluronidase-1; Hyal-1; 3.2.1.35; Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1; HYAL1; LUCA1;

透明质酸酶1

48368分子量

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.

Secreted. Lysosome.

Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P), IHC(F) and ICC.

Belongs to the glycosyl hydrolase 56 family.

Hyaluronidase-1, also known as HYAL1 or LUCA1, is an enzyme that in humans is encoded by the HYAL1 gene. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is though to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.

Cancer, Cytoskeleton / Ecm, Ecm Enzymes, Ecm Proteins, Extracellular Matrix, Invasion/Microenvironment, Signal Transduction