产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
Anti-Optineurin/OPTN Picoband Antibody
目录 :
PB9343
规格 :
100 ug/vial
价格 :
280美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类
应用 :
免疫印迹, 免疫组化
图像
图像 1 :
武汉博士德生物工程有限公司 PB9343 图像 1
Anti- Optineurin Picoband antibody, PB9343, Western blotting. All lanes: Anti Optineurin (PB9343) at 0.5ug/ml. Lane 1: HELA Whole Cell Lysate at 40ug. Lane 2: U87 Whole Cell Lysate at 40ug. Lane 3: SMMC Whole Cell Lysate at 40ug. Lane 4: HT1080 Whole Cell Lysate at 40ug. Predicted bind size: 66KD. Observed bind size: 66KD
图像 2 :
武汉博士德生物工程有限公司 PB9343 图像 2
Anti- Optineurin Picoband antibody, PB9343, IHC(P). IHC(P): Human Placenta Tissue
产品信息
SKU号 :
PB9343
状态 :
Enabled
名称 :
Anti-Optineurin/OPTN Picoband Antibody
目录名称 :
一抗, 多克隆抗体, 免疫组化免疫细胞化学IF抗体
基因名称 :
OPTN
价格 :
280美元
price various sizes :
Unconjugated / $280 APC / $330 APC-Cy7 / $330 FITC / $330 PE / $330 PE-Cy5 / $330 PE-Cy7 / $330 30ug sample size / $99 100ug / $280 100ug+Free HRP Secondary BA1054 / $280 100ug+Free Biotin Secondary BA1003 / $280
克隆性 :
多克隆
浓度 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
共轭标签 :
No
contents :
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
描述 :
Polyclonal antibody for OPTINEURIN/OPTN detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IHC-P. Reactive species: Human. OPTINEURIN/OPTN information: Molecular Weight: 65921 MW; Subcellular Localization: Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy; Tissue Specificity: Present in aqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta.
short description :
Rabbit IgG polyclonal antibody for Optineurin(OPTN) detection. Tested with WB, IHC-P in Human.
规格 :
100 ug/vial
sample size available :
30ug for $99, contact us for details
UniProt数据库编号 :
Q96CV9
宿主 :
免疫原 :
E.coli-derived human Optineurin recombinant protein (Position: R241-I577). Human Optineurin shares 82% amino acid (aa) sequence identity with both mouse and rat Optineurin.
形式 :
冻干
纯化 :
免疫原亲和纯化
储存 :
At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.
交叉活性 :
No cross reactivity with other proteins
重组 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
应用细节 :
Immunohistochemistry(Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat. Western blot, 0.1-0.5ug/ml, Human.
应用 :
免疫组化, 免疫印迹
反应物种 :
人类
图像标记 :
Anti- Optineurin Picoband antibody, PB9343, Western blotting. All lanes: Anti Optineurin (PB9343) at 0.5ug/ml. Lane 1: HELA Whole Cell Lysate at 40ug. Lane 2: U87 Whole Cell Lysate at 40ug. Lane 3: SMMC Whole Cell Lysate at 40ug. Lane 4: HT1080 Whole Cell Lysate at 40ug. Predicted bind size: 66KD. Observed bind size: 66KD Anti- Optineurin Picoband antibody, PB9343, IHC(P). IHC(P): Human Placenta Tissue
背景 :
OPTN is also known as NRP, FIP2 or HYPL. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
competitor equivalent skus :
sc 100024 sc 100025 sc 136364 sc 166576 sc 166700 sc 271549 sc 368986 sc 48901 sc 48903 sc 8256 sc 8256 R sc 99214
研究种类 :
Adapters, Cytokines, Cytoplasmic, Immunology, Innate Immunity, Neuroscience, Sensory System, Signal Transduction, Tnf Superfamily, Visual System
同义词 :
Optineurin;E3-14.7K-interacting protein;FIP-2;Huntingtin yeast partner L;Huntingtin-interacting protein 7;HIP-7;Huntingtin-interacting protein L;NEMO-related protein;Optic neuropathy-inducing protein;Transcription factor IIIA-interacting protein;TFIIIA-IntP;OPTN;FIP2, GLC1E, HIP7, HYPL, NRP;
基因全称 :
Optineurin
分子量 :
65921分子量
protein function :
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.
subcellular localization :
Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy.
组织特异性 :
Present in aqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta.
蛋白名 :
Optineurin
recommended detection systems :
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
更新 :
1/28/19 19:39
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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