抗体

Anti-Patched/PTCH1 Picoband Antibody

PB9352

100 ug/vial

240美元

多克隆

兔

nonconjugated

人类, 小鼠, 大鼠

Enabled

Anti-Patched/PTCH1 Picoband Antibody

一抗, 多克隆抗体

PTCH1

240美元

30ug sample size / $99 100ug / $240 100ug+Free HRP Secondary BA1054 / $240 100ug+Free Biotin Secondary BA1003 / $240

多克隆

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

No

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Polyclonal antibody for PTCH/PTCH1 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. PTCH/PTCH1 information: Molecular Weight: 160545 MW; Subcellular Localization: Membrane; Multi-pass membrane protein; Tissue Specificity: In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin.

Rabbit IgG polyclonal antibody for Protein patched homolog 1(PTCH1) detection. Tested with WB in Human;Mouse;Rat.

100 ug/vial

30ug for $99, contact us for details

Q13635

兔

E.coli-derived human Patched recombinant protein (Position: D1219-N1447). Human Patched shares 91% amino acid (aa) sequence identity with mouse Patched.

冻干

免疫原亲和纯化

At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.

No cross reactivity with other proteins.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

免疫印迹, 0.1 0.5微克/毫升, 小鼠, 大鼠, 人类

免疫印迹

人类, 小鼠, 大鼠

Anti- Patched Picoband antibody, PB9352, Western blotting. All lanes: Anti Patched (PB9352) at 0.5ug/ml. Lane 1: Rat Brain Tissue Lysate at 50ug. Lane 2: Rat Liver Tissue Lysate at 50ug. Lane 3: Mouse Brain Tissue Lysate at 50ug. Lane 4: Mouse Liver Tissue Lysate at 50ug. Predicted bind size: 160KD. Observed bind size: 160KD

PTCH1 is also known as PTC, BCNS or HPE7. This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

sc 34122 sc 6147 sc 6149 sc 9016

Cancer, Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Neurogenesis, Neurology Process, Neuroscience, Oncoproteins/Suppressors, Signaling Pathways, Stem Cells, Surface Molecules, Tumor Suppressors

Protein patched homolog 1;PTC;PTC1;PTCH1;PTCH;

Protein patched homolog 1

160545分子量

Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.

Membrane; Multi-pass membrane protein.

In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin.

Protein patched homolog 1

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

Belongs to the patched family.

1/28/19 19:39