产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
Anti-SIRT6 Picoband Antibody
目录 :
PB9357
规格 :
100 ug/vial
价格 :
280美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化
图像
图像 1 :
武汉博士德生物工程有限公司 PB9357 图像 1
Anti- SIRT6Picoband antibody, PB9357, Western blotting. All lanes: Anti SIRT6 (PB9357) at 0.5ug/ml. Lane 1: HELA Whole Cell Lysate at 40ug. Lane 2: A549 Whole Cell Lysate at 40ug. Lane 3: Human Placenta Tissue Lysate at 50ug. Predicted bind size: 39KD. Observed bind size: 39KD
图像 2 :
武汉博士德生物工程有限公司 PB9357 图像 2
Anti- SIRT6Picoband antibody, PB9357, IHC(P). IHC(P): Mouse Cardiac Muscle Tissue
图像 3 :
武汉博士德生物工程有限公司 PB9357 图像 3
Anti- SIRT6Picoband antibody, PB9357, IHC(P). IHC(P): Human Mammary Cancer Tissue
产品信息
SKU号 :
PB9357
状态 :
Enabled
名称 :
Anti-SIRT6 Picoband Antibody
目录名称 :
一抗, 多克隆抗体, 免疫组化免疫细胞化学IF抗体
基因名称 :
SIRT6
价格 :
280美元
price various sizes :
Unconjugated / $280 APC / $330 APC-Cy7 / $330 FITC / $330 PE / $330 PE-Cy5 / $330 PE-Cy7 / $330 30ug sample size / $99 100ug / $280 100ug+Free HRP Secondary BA1054 / $280 100ug+Free Biotin Secondary BA1003 / $280
克隆性 :
多克隆
浓度 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
共轭标签 :
No
contents :
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
描述 :
Polyclonal antibody for SIRT6 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IHC-P. Reactive species: Human. SIRT6 information: Molecular Weight: 39119 MW; Subcellular Localization: Nucleus, nucleoplasm . Predominantly nuclear. Associated with telomeric heterochromatin regions.
short description :
Rabbit IgG polyclonal antibody for NAD-dependent protein deacetylase sirtuin-6(SIRT6) detection. Tested with WB, IHC-P in Human;Mouse.
规格 :
100 ug/vial
sample size available :
30ug for $99, contact us for details
UniProt数据库编号 :
Q8N6T7
宿主 :
免疫原 :
E.coli-derived human SIRT6 recombinant protein (Position: D14-E180). Human SIRT6 shares 95% amino acid (aa) sequence identity with mouse SIRT6.
形式 :
冻干
纯化 :
免疫原亲和纯化
储存 :
At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.
交叉活性 :
No cross reactivity with other proteins.
重组 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
应用细节 :
Immunohistochemistry(Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, By Heat. Western blot, 0.1-0.5ug/ml, Human.
应用 :
免疫组化, 免疫印迹
反应物种 :
人类, 小鼠
图像标记 :
Anti- SIRT6Picoband antibody, PB9357, Western blotting. All lanes: Anti SIRT6 (PB9357) at 0.5ug/ml. Lane 1: HELA Whole Cell Lysate at 40ug. Lane 2: A549 Whole Cell Lysate at 40ug. Lane 3: Human Placenta Tissue Lysate at 50ug. Predicted bind size: 39KD. Observed bind size: 39KD Anti- SIRT6Picoband antibody, PB9357, IHC(P). IHC(P): Mouse Cardiac Muscle Tissue Anti- SIRT6Picoband antibody, PB9357, IHC(P). IHC(P): Human Mammary Cancer Tissue
背景 :
SIRT6 is also known as SIR2L6. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
competitor equivalent skus :
sc 66277 R
研究种类 :
Acetylation, Apoptosis, Atherosclerosis, Cancer, Cardiovascular, Chip'Ing Antibodies, Chromatin Modifying Enzymes, Diabetes Associated, Epigenetics And Nuclear Signaling, Metabolism, Nfkb Pathway, Nuclear Signaling Pathways, Obesity, Signal Transduction
同义词 :
NAD-dependent protein deacetylase sirtuin-6;3.5.1.-;Regulatory protein SIR2 homolog 6;SIR2-like protein 6;SIRT6;SIR2L6;
基因全称 :
NAD依赖的蛋白脱乙酰基酶沉默调节蛋白6
分子量 :
39119分子量
protein function :
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
subcellular localization :
Nucleus, nucleoplasm . Predominantly nuclear. Associated with telomeric heterochromatin regions.
蛋白名 :
NAD依赖的蛋白脱乙酰基酶沉默调节蛋白6
recommended detection systems :
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
sequence similarities :
Belongs to the sirtuin family. Class IV subfamily.
更新 :
1/28/19 19:39
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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