产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
Anti-SIRT7 Picoband Antibody
目录 :
PB9358
规格 :
100 ug/vial
价格 :
280美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化
图像
图像 1 :
武汉博士德生物工程有限公司 PB9358 图像 1
Anti- SIRT7 Picoband antibody, PB9358, Western blotting. All lanes: Anti SIRT7 (PB9358) at 0.5ug/ml. Lane 1: Rat Spleen Tissue Lysate at 50ug. Lane 2: Rat Brain Tissue Lysate at 50ug. Lane 3: Rat Intestine Tissue Lysate at 50ug. Lane 4: SMMC Whole Cell Lysate at 40ug. Lane 5: JURKAT Whole Cell Lysate at 40ug. Predicted bind size: 45KD. Observed bind size: 45KD
图像 2 :
武汉博士德生物工程有限公司 PB9358 图像 2
Anti- SIRT7 Picoband antibody, PB9358, IHC(P). IHC(P): Mouse Spleen Tissue
图像 3 :
武汉博士德生物工程有限公司 PB9358 图像 3
Anti- SIRT7 Picoband antibody, PB9358, IHC(P). IHC(P): Rat Spleen Tissue
产品信息
SKU号 :
PB9358
状态 :
Enabled
名称 :
Anti-SIRT7 Picoband Antibody
目录名称 :
一抗, 多克隆抗体, 免疫组化免疫细胞化学IF抗体
基因名称 :
SIRT7
价格 :
280美元
price various sizes :
Unconjugated / $280 APC / $330 APC-Cy7 / $330 FITC / $330 PE / $330 PE-Cy5 / $330 PE-Cy7 / $330 30ug sample size / $99 100ug / $280 100ug+Free HRP Secondary BA1054 / $280 100ug+Free Biotin Secondary BA1003 / $280
克隆性 :
多克隆
浓度 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
共轭标签 :
No
contents :
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
描述 :
Polyclonal antibody for SIRT7 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IHC-P. Reactive species: Human. SIRT7 information: Molecular Weight: 44898 MW; Subcellular Localization: Cytoplasm. Nucleus, nucleolus. Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.
short description :
Rabbit IgG polyclonal antibody for NAD-dependent protein deacetylase sirtuin-7(SIRT7) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
规格 :
100 ug/vial
sample size available :
30ug for $99, contact us for details
UniProt数据库编号 :
Q9NRC8
宿主 :
免疫原 :
E.coli-derived human SIRT7 recombinant protein (Position: R8-G350). Human SIRT7 shares 96% and 95% amino acid (aa) sequence identity with mouse and rat SIRT7, respectively.
形式 :
冻干
纯化 :
免疫原亲和纯化
储存 :
At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.
交叉活性 :
No cross reactivity with other proteins.
重组 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
应用细节 :
Immunohistochemistry(Paraffin-embedded Section), 0.5-1ug/ml, Mouse, Rat, Human, By Heat. Western blot, 0.1-0.5ug/ml, Human, Rat.
应用 :
免疫组化, 免疫印迹
反应物种 :
人类, 小鼠, 大鼠
图像标记 :
Anti- SIRT7 Picoband antibody, PB9358, Western blotting. All lanes: Anti SIRT7 (PB9358) at 0.5ug/ml. Lane 1: Rat Spleen Tissue Lysate at 50ug. Lane 2: Rat Brain Tissue Lysate at 50ug. Lane 3: Rat Intestine Tissue Lysate at 50ug. Lane 4: SMMC Whole Cell Lysate at 40ug. Lane 5: JURKAT Whole Cell Lysate at 40ug. Predicted bind size: 45KD. Observed bind size: 45KD Anti- SIRT7 Picoband antibody, PB9358, IHC(P). IHC(P): Mouse Spleen Tissue Anti- SIRT7 Picoband antibody, PB9358, IHC(P). IHC(P): Rat Spleen Tissue
背景 :
SIRT7 is also known as SIR2L7. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
competitor equivalent skus :
sc 66283 sc 135055 sc 66281 sc 365344
研究种类 :
Oncoproteins/Suppressors, Pathways And Processes, Polymerase Associated Factors, Transcription, Transcription Factors
同义词 :
NAD-dependent protein deacetylase sirtuin-7;3.5.1.-;Regulatory protein SIR2 homolog 7;SIR2-like protein 7;SIRT7;SIR2L7;
基因全称 :
NAD依赖的蛋白脱乙酰基酶沉默调节蛋白7
分子量 :
44898分子量
protein function :
NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.
subcellular localization :
Cytoplasm. Nucleus, nucleolus. Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.
蛋白名 :
NAD依赖的蛋白脱乙酰基酶沉默调节蛋白7
recommended detection systems :
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
sequence similarities :
Belongs to the sirtuin family. Class IV subfamily.
更新 :
1/28/19 19:39
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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