抗体

Anti-BCRP/ABCG2 Picoband Antibody

PB9364

100 ug/vial

240美元

多克隆

兔

nonconjugated

人类, 小鼠, 大鼠

免疫印迹, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片

Anti-BCRP/ABCG2 Picoband Antibody

240美元

A synthetic peptide corresponding to a sequence at the N-terminus of human ABCG2(137-168aa RENLQFSAALRLATTMTNHEKNERINRVIQEL), different from the related mouse sequence by five amino acids, and from the related rat sequence by eight amino acids.

冻干

兔

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

免疫原亲和纯化

多克隆

Rabbit IgG polyclonal antibody for ATP-binding cassette sub-family G member 2(ABCG2) detection. Tested with WB, IHC-P, IHC-F, FCM in Human;Mouse;Rat.

100 ug/vial

人类;小鼠;大鼠

流式细胞仪;免疫组化-P;免疫组化-F;免疫印迹

ABCG2(Atp-binding cassette, subfamily g, member 2) also known as ABCP, BCRP or MRX, is a protein that in humans is encoded by the ABCG2 gene. The ABCG2 gene encodes a membrane transporter belonging to the ATP-binding cassette (ABC) superfamily of membrane transporters, which are involved in the trafficking of biologic molecules across cell membranes. The ABCG2 protein is also a high capacity transporter for uric acid excretion in the kidney, liver, and gut. The ABCG2 gene is mapped on 4q22.1. In vitro assays of isolated membrane preparations revealed a high-capacity, vanadate-sensitive ATPase activity associated with ABCG2 expression that was stimulated by compounds known to be transported by this protein. Ozvegy et al. (2001) concluded that ABCG2 is likely functioning as a homodimer or homooligomer in this expression system since it is unlikely that putative Sf9 transport partners would be overexpressed at similarly high levels.Abcg2 transports pheophorbide-a, which occurs in various plant-derived foods and food supplements and is highly efficient in limiting its uptake from ingested food. ABCG2 is a major factor in the concentrative transfer of drugs, carcinogens, and dietary toxins to the milk of mice, cows, and humans.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

No cross reactivity with other proteins.

ATP-binding cassette sub-family G member 2

SELP;ATP结合转运蛋白G超家族成员2

High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.

ATP-binding cassette sub-family G member 2

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

tags & cell markers cell type markers tumor associated signal transduction metabolism plasma membrane atpases stem cells neural stem cells surface molecules hematopoietic progenitors drug metabolism cancer drug resistance mrp-related proteins pathways and processes metabolic signaling pathways types of disease

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

At -20ËšC for one year. After reconstitution, at 4ËšC for one month. It can also be aliquotted and stored frozen at -20ËšC for a longer time.Avoid repeated freezing and thawing.

Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.

ATP-binding cassette sub-family G member 2;Breast cancer resistance protein;CDw338;Mitoxantrone resistance-associated protein;Placenta-specific ATP-binding cassette transporter;Urate exporter;CD338;ABCG2;ABCP, BCRP, BCRP1, MXR;

Highly expressed in placenta. Low expression in small intestine, liver and colon.

Q9UNQ0