抗体

Anti-Angiotensin II Type 1 Receptor/AGTR1 Antibody Picoband™

PB9470

100μg/vial

315美元

多克隆

domestic rabbit

未共轭

人类, 小鼠

免疫印迹, 免疫组化-石蜡切片

Anti-Angiotensin II Type 1 Receptor/AGTR1 Antibody Picoband™

315美元

100μg/vial

多克隆

兔

Human, Monkey, Mouse, Rat

仓鼠

免疫组化-P, 免疫印迹

Immunohistochemistry (Paraffin-embedded Section), 0.5-1µg/ml, Human, By Heat. Western blot, 0.1-0.5µg/ml, Human, Monkey, Mouse, Rat.

Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Boster Bio Anti-Angiotensin II Type 1 Receptor/AGTR1 Antibody Picoband™ catalog # PB9470. Tested in IHC-P, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

AGTR1

P30556

A synthetic peptide corresponding to a sequence at the N-terminus of human AGTR1 (1-28aa MILNSSTEDGIKRIQDDCPKAGRHNYIF), different from the related mouse and rat sequences by one amino acid.

冻干

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

免疫原亲和纯化

No cross reactivity with other proteins

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

类型1血管紧张素Ⅱ受体

类型1血管紧张素Ⅱ受体;AT1AR;AT1BR;血管紧张素ii类型1受体;AT1;AGTR1;AGTR1A, AGTR1B, AT2R1, AT2R1B;

类型1血管紧张素Ⅱ受体

41061分子量

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.

Cell membrane; Multi-pass membrane protein.

Liver, lung, adrenal and adrenocortical adenomas.

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

Belongs to the G-protein coupled receptor 1 family.

AGTR1 is known as Angiotensin II Type 1 Receptor. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. And it acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. Moreover, this gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.

Angiogenesis, Cancer, Cancer Metabolism, Cardiovascular, Invasion/Microenvironment, Metabolism