产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
Anti-RANTES/CCL5 Picoband Antibody
目录 :
PB9573
规格 :
100 ug/vial
价格 :
240美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定
图像
图像 1 :
武汉博士德生物工程有限公司 PB9573 图像 1
Anti-RANTES Picoband antibody, PB9573, Western blotting. All lanes: Anti RANTES (PB9573) at 0.5ug/ml. WB: HUT Whole Cell Lysate at 40ug. Predicted bind size: 11KD. Observed bind size: 11KD
产品信息
SKU号 :
PB9573
状态 :
Enabled
名称 :
Anti-RANTES/CCL5 Picoband Antibody
目录名称 :
一抗, 多克隆抗体
基因名称 :
CCL5
价格 :
240美元
price various sizes :
30ug sample size / $99 100ug / $240 100ug+Free HRP Secondary BA1054 / $240 100ug+Free Biotin Secondary BA1003 / $240
克隆性 :
多克隆
浓度 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
共轭标签 :
No
contents :
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
描述 :
Polyclonal antibody for RANTES/CCL5 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: ELISA. Reactive species: Human. RANTES/CCL5 information: Molecular Weight: 9990 MW; Subcellular Localization: Secreted; Tissue Specificity: T-cell and macrophage specific.
short description :
Rabbit IgG polyclonal antibody for C-C motif chemokine 5(CCL5) detection. Tested with WB, ELISA in Human.
规格 :
100 ug/vial
sample size available :
30ug for $99, contact us for details
UniProt数据库编号 :
P13501
宿主 :
免疫原 :
E. coli-derived human RANTES recombinant protein (Position: Y26-S91). Human RANTES shares 83.3% amino acid (aa) sequence identity with both mouse and rat RANTES.
形式 :
冻干
纯化 :
免疫原亲和纯化
储存 :
At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.
交叉活性 :
No cross reactivity with other proteins
重组 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
应用细节 :
免疫印迹, 0.1 0.5微克/毫升, 人类, -。 酶联免疫吸附测定, 0.1 0.5微克/毫升, 人类
应用 :
酶联免疫吸附测定, 免疫印迹
反应物种 :
人类
图像标记 :
Anti-RANTES Picoband antibody, PB9573, Western blotting. All lanes: Anti RANTES (PB9573) at 0.5ug/ml. WB: HUT Whole Cell Lysate at 40ug. Predicted bind size: 11KD. Observed bind size: 11KD
背景 :
Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the CCL5 gene. It is also known as RANTES. This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms.
competitor equivalent skus :
sc 101501 sc 1410 sc 20731 sc 32246 sc 32250 sc 34840 sc 34842 sc 34843 sc 365826 sc 373983 sc 373984 sc 514019
研究种类 :
Antiviral Signaling, Atherosclerosis, Cardiovascular, Chemokines, Immune System Diseases, Immunology, Innate Immunity, Vascular Inflammation
同义词 :
C-C motif chemokine 5;EoCP;Eosinophil chemotactic cytokine;SIS-delta;Small-inducible cytokine A5;T cell-specific protein P228;TCP228;T-cell-specific protein RANTES;RANTES(3-68);RANTES(4-68);CCL5;D17S136E, SCYA5;
基因全称 :
C-C motif chemokine 5
分子量 :
9990分子量
protein function :
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1- infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1- 68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).
subcellular localization :
Secreted.
组织特异性 :
T-cell and macrophage specific.
蛋白名 :
C-C motif chemokine 5
recommended detection systems :
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
sequence similarities :
Belongs to the intercrine beta (chemokine CC) family.
更新 :
1/28/19 19:39
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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