抗体

Anti-IL1 beta/IL1B Antibody Picoband™

PB9606

100μg/vial

315美元

多克隆

domestic rabbit

未共轭

Anti-IL1 beta/IL1B Antibody Picoband™

315美元

100μg/vial

多克隆

兔

大鼠

酶联免疫吸附测定

酶联免疫吸附测定, 0.1 0.5µg/毫升, 大鼠

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Boster Bio Anti-IL1 beta/IL1B Antibody Picoband™ catalog # PB9606. Tested in ELISA applications. This antibody reacts with Rat.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Il1b

Q63264

A synthetic peptide corresponding to a sequence at the C-terminus of rat IL-1 beta (202-229aa DPKQYPKKKMEKRFVFNKIEVKTKVEFE), different from the related human sequence by five amino acids, and from the related mouse sequence by one amino acid.

冻干

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

免疫原亲和纯化

No cross reactivity with other proteins

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

白细胞介素1β

白细胞介素1β;IL-1乙;Il1b;

白细胞介素1β

30644分子量

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Boster provides a series of assays reacted with primary antibodies.

Interleukin-1β (IL-1β) is a potent stimulator of bone resorption whose gene is mapped to 2q14, and has been implicated in the pathogenesis of high bone turnover and osteoporosis. IL-1β, a prominent microglia-derived cytokine, caused oligodendrocyte death in coculture with astrocytes and microglia, but not in pure culture of oligodendrocytes alone. It also can cause nuclear export of a specific NCOR corepressor complex, resulting in derepression of a specific subset of nuclear factor-kappa-B (NFKB)-regulated genes. Furthermore, Microenvironmental IL-1β and, to a lesser extent, IL-1α are required for in vivo angiogenesis and invasiveness of different tumor cells. Additional, the cooperation of IL-1β and PDGFB induces contractile-to-synthetic phenotype modulation of human aortic smooth muscle cells in culture. Moreover, the association with disease may be explained by the biologic properties of IL-1β, which is an important proinflammatory cytokine and a powerful inhibitor of gastric acid secretion.

Atherosclerosis, Cardiovascular, Cytokines, Immunology, Innate Immunity, Interleukins, Metabolism, Obesity, Vascular Inflammation