产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
Anti-KCNA5 Picoband Antibody
目录 :
PB9651
规格 :
100 ug/vial
价格 :
240美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类
应用 :
免疫印迹
图像
图像 1 :
武汉博士德生物工程有限公司 PB9651 图像 1
Anti- KCNA5 Picoband antibody, PB9651, Western blotting. All lanes: Anti KCNA5 (PB9651) at 0.5ug/ml. Lane 1: 293T Whole Cell Lysate at 40ug. Lane 2: A549 Whole Cell Lysate at 40ug. Lane 3: PANC Whole Cell Lysate at 40ug. Predicted bind size: 67KD. Observed bind size: 67KD
产品信息
SKU号 :
PB9651
状态 :
Enabled
名称 :
Anti-KCNA5 Picoband Antibody
目录名称 :
一抗, 多克隆抗体
基因名称 :
KCNA5
价格 :
240美元
price various sizes :
30ug sample size / $99 100ug / $240 100ug+Free HRP Secondary BA1054 / $240 100ug+Free Biotin Secondary BA1003 / $240
克隆性 :
多克隆
浓度 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
共轭标签 :
No
contents :
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
描述 :
Polyclonal antibody for KV1.5/KCNA5 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. KV1.5/KCNA5 information: Molecular Weight: 67228 MW; Subcellular Localization: Cell membrane ; Multi-pass membrane protein ; Tissue Specificity: Pancreatic islets and insulinoma.
short description :
Rabbit IgG polyclonal antibody for Potassium voltage-gated channel subfamily A member 5(KCNA5) detection. Tested with WB in Human.
规格 :
100 ug/vial
sample size available :
30ug for $99, contact us for details
UniProt数据库编号 :
P22460
宿主 :
免疫原 :
A synthetic peptide corresponding to a sequence at the C-terminus of human KCNA5 (583-613aa LEKCNVKAKSNVDLRRSLYALCLDTSRETDL), different from the related mouse and rat sequences by two amino acids.
形式 :
冻干
纯化 :
免疫原亲和纯化
储存 :
At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.
交叉活性 :
No cross reactivity with other proteins
重组 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
应用细节 :
免疫印迹, 0.1 0.5微克/毫升, 人类
应用 :
免疫印迹
反应物种 :
人类
前体活性 :
图像标记 :
Anti- KCNA5 Picoband antibody, PB9651, Western blotting. All lanes: Anti KCNA5 (PB9651) at 0.5ug/ml. Lane 1: 293T Whole Cell Lysate at 40ug. Lane 2: A549 Whole Cell Lysate at 40ug. Lane 3: PANC Whole Cell Lysate at 40ug. Predicted bind size: 67KD. Observed bind size: 67KD
背景 :
Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or Kv1.5, is a protein that in humans is encoded by the KCNA5 gene. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. KCNA5 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization, thereby contributing to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Mutations in this gene have been related to both atrial fibrillation and sudden cardiac death. KCNA5 are also key players in pulmonary vascular function, where they play a role in setting the resting membrane potential and its involvement during hypoxic pulmonary vasoconstriction.
competitor equivalent skus :
sc 134660 sc 162473 sc 376999 sc 134660 X sc 376999 X
研究种类 :
Cancer, Cancer Metabolism, Cardiovascular, Hypoxia, Metabolism, Metabolism Processes, Neuroscience, Neurotransmission, Pathways And Processes, Potassium Channels, Receptors / Channels, Response To Hypoxia, Vasculature
同义词 :
Potassium voltage-gated channel subfamily A member 5;HPCN1;Voltage-gated potassium channel HK2;Voltage-gated potassium channel subunit Kv1.5;KCNA5;
基因全称 :
Potassium voltage-gated channel subfamily A member 5
分子量 :
67228分子量
protein function :
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461).
subcellular localization :
Cell membrane ; Multi-pass membrane protein .
组织特异性 :
Pancreatic islets and insulinoma.
蛋白名 :
Potassium voltage-gated channel subfamily A member 5
recommended detection systems :
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
更新 :
1/28/19 19:39
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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