抗体

Anti-RASA1 Antibody Picoband™

PB9796

100μg/vial

315美元

多克隆

domestic rabbit

未共轭

免疫印迹, 免疫细胞化学, 流式细胞仪

Anti-RASA1 Antibody Picoband™

315美元

100μg/vial

多克隆

兔

人类

仓鼠

流式细胞仪, IF, 免疫细胞化学, 免疫印迹

免疫印迹, 0.1 0.5µg/毫升, 人类。 免疫细胞化学/免疫荧光, 2µg/毫升, 人类。 流式细胞仪, 1-3μg/1x10^6细胞, 人类

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Boster Bio Anti-RASA1 Antibody Picoband™ catalog # PB9796. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

RASA1

P20936

A synthetic peptide corresponding to a sequence at the C-terminus of human RASA1 (1018-1047aa AQQHVLKKLLAITELLQQKQNQYTKTNDVR), different from the related rat sequence by one amino acid.

冻干

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

免疫原亲和纯化

No cross reactivity with other proteins.

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ras的GTP酶激活蛋白1

Ras GTPase-activating protein 1; GAP; GTPase-activating protein; RasGAP; Ras p21 protein activator; p120GAP; RASA1; GAP, RASA;

ras的GTP酶激活蛋白1

116403分子量

Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1.

细胞质

In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level).

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for ICC.

RASA1, also known as RAS p21 protein activator 1, is a 120-kDacytosolic human protein. The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.

Cancer, G Protein Signaling, Ras Family, Regulators, Signal Transduction, Signaling Pathway, Small G Proteins