产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
蛋白
产品名称 :
PGR孕酮受体人类重组蛋白
目录 :
PROTP06401
规格 :
Sample: 2 ug
价格 :
250美元
产品信息
SKU号 :
PROTP06401
状态 :
1
名称 :
PGR孕酮受体人类重组蛋白
url key :
pgr-progesterone-receptor-human-recombinant-protein-protp06401-boster
产品种类 :
重组蛋白
基因名称 :
PGR
价格 :
250
规格1 :
Sample: 2 ug
price for size 1 :
250美元
规格2 :
Regular: 5ug
price for size 2 :
500
规格3 :
Bulk: 10ug
price for size 3 :
950
contents :
PGR in 50mM Tris-HCl, pH7.5, 10mM L-glutathione (reduced).
描述 :
Progesterone Receptor Human Recombinant (a.a. 412-562) expressed in E.coli, shows a 43 kDa SDS-PAGE (including GST tag). The PGR is purified by proprietary chromatographic techniques.
short description :
Progesterone Receptor Human Recombinant (a.a. 412-562) expressed in E.coli, shows a 43 kDa SDS-PAGE (including GST tag). The PGR is purified by proprietary chromatographic techniques.
规格 :
2微克, 5微克, 10微克
UniProt数据库编号 :
P06401
形式 :
Sterile Filtered clear solution.
储存 :
Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
应用 :
细胞培养
来源 :
大肠杆菌
反应物种 :
小鼠
images :
/r/e/recombinant-protein-thumbnail_1.png
图像标记 :
Recombinant protein fun image
custom options :
name=Size,required=1,price=0.0000,type=radio,sku=,max_characters=0,file_extension=,image_size_x=0,image_size_y=0,price_type=fixed,option_title=Sample: 2ug name=Size,required=1,price=250.0000,type=radio,sku=,max_characters=0,file_extension=,image_size_x=0,image_size_y=0,price_type=fixed,option_title=Regular: 5ug name=Size,required=1,price=700.0000,type=radio,sku=,max_characters=0,file_extension=,image_size_x=0,image_size_y=0,price_type=fixed,option_title=Bulk: 10ug
created at :
12/15/17 2:49
updated at :
3/15/22 17:51
custom listing information :
Available Sizes: 2ug, 5ug, 10ug Applications: ex vivo Cell Culture Source: E. Coli Purity: -
description before attributes :
Introduction . PGR belongs to the steroid receptor superfamily. PGR is located on chromosome 11q22. The progesterone receptor is an intracellular steroid receptor that specifically binds progesterone. The progesterone receptor (PgR) is an estrogen-regulated protein. PGR mediates the physiological effects of progesterone, which plays a fundamental role in reproductive events associated with establishing and maintaining pregnancy. PGR uses 2 distinct promotors and translation start sites in the first exon to produce 2 isoforms, A & B, which differ in their molecular weight (isoform A has 165 additional amino acids at the N-terminus). The progesterone receptor has an amino and a carboxyl terminal, the regulatory domain between them, a DNA binding domain, the hinge section, and the hormone binding domain. If no hormone is bound the carboxyl terminal inhibits transcription. Binding to a hormone stimulates a structural change which eliminates the inhibitory action. Following the progesterone binding to the receptor, restructuring with dimerization begins and the complex enters the nucleus where it binds to DNA. It has been proposed that expression of PgR determination indicates a responsive estrogen receptor (ER) pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PgR determination provides supplementary information to ER, both in predicting response to endocrine therapy and estimating survival. PgR has proved superior to ER as a prognostic indicator in some studies.
meta title :
人类PGR/孕酮受体重组蛋白
meta keyword :
PGR孕酮受体人类重组蛋白, 重组蛋白, 细胞培养, PROTP06401
meta description :
PGR Progesterone Receptor Human Recombinant Protein Progesterone Receptor Human Recombinant (a.a. 412-562) expressed in E.coli, shows a 43 kDa SDS-PAGE (including GST tag). The PGR is purified by proprietary chromatographic techniques. SKU: PROTP06401
rating value :
100
同义词 :
Progesterone receptor;PR;Nuclear receptor subfamily 3 group C member 3;PGR;NR3C3;
基因全称 :
孕激素受体
protein function :
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.
subcellular localization :
Nucleus. Cytoplasm. Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G (1) and G (2)/M phases.
custom attribute 6 :
Recombinant protein fun image
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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