产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
蛋白
产品名称 :
MCP-1 Monocyte Chemotactic Protein-1 Rat Recombinant Protein (CCL2)
目录 :
PROTP14844
规格 :
2微克, 10微克, 1毫克
价格 :
250美元
产品信息
SKU号 :
PROTP14844
产品名称 :
MCP-1 Monocyte Chemotactic Protein-1 Rat Recombinant Protein (CCL2)
产品网站地址 :
https://www.bosterbio.commcp-1-monocyte-chemotactic-protein-1-rat-recombinant-protein-ccl2-protp14844-boster.html
基因名称 :
Ccl2
价格 :
250美元
规格 :
2微克, 10微克, 1毫克
反应物种 :
小鼠
应用 :
细胞培养
Introduction :
Introduction: Chemokine (C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1). It is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor ?B (NF?B). CCL2 recruits immune cells, such as monocytes, to sites of tissue injury and infection. This chemokine is produced as a protein precursor containing signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a molecular weightof approximately 13kDa. As with many other CC chemokines, CCL2 is located on chromosome 17 in humans. The cell surface receptors that bind CCL2 are CCR2 and CCR5.
描述 :
Monocyte Chemotactic Protein-1 Rat Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 125 amino acids and having a molecular mass of 14.1 kDa. The MCP-1 is purified by proprietary chromatographic techniques.
来源 :
大肠杆菌
形式 :
Sterile Filtered White lyophilized (freeze-dried) powder.
Contents :
The protein was lyophilized from a concentrated (1mg/ml) sterile solution containing no additives.
氨基酸序列和/或生物活性 :
Amino Acid Sequence:QPDAVNAPLT CCYSFTGKMI PMSRLENYKR ITSSRCPKEA VVFVTKLKRE ICADPNKEWV QKYIRKLDQN QVRSETTVFY KIASTLRTSA PLNVNLTHKS EANASTLFST TTSSTSVEVT SMTEN. Biological Activity:ED50 =1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg. The biological activity was determined by measuring the dose dependent chemotaxis with human THP-1 cells. The optimal concentration should be determined for each specific application by an initial dose-response assay.
纯化 :
Greater than 98.0% as determined by SDS-PAGE.
储存 :
Lyophilized MCP-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
UniProt数据库编号 :
P14844
基因全称 :
C-C motif chemokine 2
同义词 :
C-C motif chemokine 2;Immediate-early serum-responsive protein JE;Monocyte chemoattractant protein 1;Monocyte chemotactic protein 1;MCP-1;Small-inducible cytokine A2;Ccl2;Je, Mcp1, Scya2;
Protein Function :
Chemotactic factor that attracts monocytes, but not neutrophils.
Subcellular Localization :
Secreted.
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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