蛋白

重组人类SDF-1甲(CXCL12)蛋白

PROTP48061-5

Various Sizes

230美元

Enabled

重组人类SDF-1甲(CXCL12)蛋白

蛋白质, 重组蛋白

CXCL12

230美元

2微克/$125 10微克/$230 50微克/$374 100微克/$590 250微克/$995 500微克/$1670 1毫克/$2750

No

Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel.

SDF-1 and are stromal derived CXC chemokines, and signal through the CXCR4 receptor. SDF-1 and chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV suppressive activity in cells expressing the CXCR4 receptor. Recombinant human SDF-1 is an 8.0 kDa protein containing 68 amino acid residues.

SDF-1 and are stromal derived CXC chemokines, and signal through the CXCR4 receptor. SDF-1 and chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV suppressive activity in cells expressing the CXCR4 receptor. Recombinant human SDF-1 is an 8.0 kDa protein containing 68 amino acid residues.

Biological Activity And Protein Authenticity . Determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentation of 20-80 ng/ml.

Various Sizes

P48061

No

Solid; white powder or thin/invisible film

Store in -20 C for long term storage. After reconstitution, store in 4 C for short term usage within a few days. Avoid freeze-thaw cycles.

细胞培养

Recombinant protein fun image

Chemokines, Host Virus Interaction, Immunology, Innate Immunity, Interspecies Interaction, Microbiology

Stromal cell-derived factor 1;SDF-1;hSDF-1;C-X-C motif chemokine 12;Intercrine reduced in hepatomas;IRH;hIRH;Pre-B cell growth-stimulating factor;PBSF;SDF-1-beta(3-72);SDF-1-alpha(3-67);CXCL12;SDF1, SDF1A, SDF1B; Stromal-Cell Derived Factor-1, CXCL12, PBSF

Stromal cell-derived factor 1

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1- alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3- 67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T- cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

Secreted.

Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen.

大肠杆菌

2/15/19 23:59