抗体

Anti-Transcription factor MafA MAFA Antibody

RP1066

100μg/vial

315美元

多克隆

domestic rabbit

未共轭

人类, 大鼠

Anti-Transcription factor MafA MAFA Antibody

315美元

100μg/vial

多克隆

兔

人类, 大鼠

免疫印迹

免疫印迹, 0.1 0.5µg/毫升, 人类, 大鼠

WB: The detection limit for MAFA is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Boster Bio Anti-Transcription factor MafA MAFA Antibody catalog # RP1066. Tested in WB applications. This antibody reacts with Human, Rat.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

MAFA

Q8NHW3

A synthetic peptide corresponding to a sequence in the middle region of human MAFA (136-167aa EDAVEALIGSGHHGAHHGAHHPAAAAAYEAFR), identical to the related mouse sequence.

冻干

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

免疫原亲和纯化

No cross reactivity with other proteins

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Transcription factor MafA

Transcription factor MafA; Pancreatic beta-cell-specific transcriptional activator; Transcription factor RIPE3b1; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; MAFA;

Transcription factor MafA

36982分子量

Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.

Nucleus. Detected in nuclei of pancreas islet beta cells.

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

Belongs to the bZIP family. Maf subfamily.

MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene. MAFA plays a key role in coordinating and controlling the level of insulin gene expression in islet beta cells. It is located in 8q24.3. The intracellular domain of MAFA contains a single immunoreceptor tyrosine-based inhibitory motif (ITIM), which classifies MAFA as a member of an inhibitory receptor superfamily. The inhibitory capacity of MAFA is best defined in mast cells, where MAFA keeps in check the antigen-induced (i.e. Fc epsilon RI-induced) secretion ofinflammatory mediators.

Co-Factors, Epigenetics and Nuclear Signaling, Growth Factors/Hormones, Signal Transduction, Transcription