抗SLC6A4抗体 | 武汉博士德生物工程有限公司 RP1068 产品信息

产品简要

公司名称 :

武汉博士德生物工程有限公司

产品类型 :

抗体

产品名称 :

抗SLC6A4抗体

RP1068

规格 :

100 ug/vial

价格 :

200美元

克隆性 :

多克隆

宿主 :

兔

共轭标签 :

nonconjugated

反应物种 :

人类, 小鼠

应用 :

免疫印迹

更多信息或购买 :

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产品信息

SKU号 :

RP1068

名称 :

抗SLC6A4抗体

价格 :

200美元

免疫原 :

A synthetic peptide corresponding to a sequence at the N-terminus of human SLC6A4 (57-85aa DDTRHSIPATTTTLVAELHQGERETWGKK), different from the related mouse and rat sequences by six amino acids.

形式 :

冻干

宿主 :

兔

contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

纯化 :

免疫原亲和纯化

克隆性 :

多克隆

描述 :

Rabbit IgG polyclonal antibody for Sodium-dependent serotonin transporter (SLC6A4) detection. Tested with WB in Human;Mouse.

规格 :

100 ug/vial

反应物种 :

人类;小鼠

应用 :

免疫印迹

背景 :

SLC6A4 (Solute carrier family 6, member 4), also known as SERT(serotonin transporter), is a monoamine transporter protein. The SLC6A4 gene spans 31 kb and contains 14 exons. This protein integral membrane protein transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is the target of many antidepressant medications, including those of the SSRI class. It is a member of the sodium: neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.

浓度 :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

交叉活性 :

No cross reactivity with other proteins

基因全称 :

Sodium-dependent serotonin transporter

基因名称 :

SLC6A4

protein function :

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

蛋白名 :

Sodium-dependent serotonin transporter

重组 :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

研究种类 :

SLC6A4

sequence similarities :

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.

储存 :

At -20ËšC for one year. After reconstitution, at 4ËšC for one month. It can also be aliquotted and stored frozen at -20ËšC for a longer time.Avoid repeated freezing and thawing.

subcellular localization :

Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin.

同义词 :

Sodium-dependent serotonin transporter;5HT transporter;5HTT;Solute carrier family 6 member 4;SLC6A4;HTT, SERT;

组织特异性 :

Expressed in platelets (at protein level).

UniProt数据库编号 :

P31645

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