公司名称 :
产品类型 :
产品名称 :
Phospho-Akt (Thr308)
目录 :
克隆性 :
宿主 :
domestic rabbit
共轭标签 :
克隆名称 :
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片
文章摘录数: 111
  • 免疫印迹; 小鼠; 1:1000; 图 s4a
Cheung E, DeNicola G, Nixon C, Blyth K, Labuschagne C, Tuveson D, et al. Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer. Cancer Cell. 2020;37:168-182.e4 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5a
Xu C, Zhang M, Bian L, Li Y, Yao Y, Li D. N-glycosylated SGK196 suppresses the metastasis of basal-like breast cancer cells. Oncogenesis. 2020;9:4 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2b
  • 免疫印迹; 人类; 1:1000; 图 2a
VASAN N, Razavi P, Johnson J, Shao H, Shah H, Antoine A, et al. Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors. Science. 2019;366:714-723 pubmed 出版商
  • 免疫印迹; 人类; 图 5f
Chen Q, Yang C, Chen L, Zhang J, Ge W, Yuan H, et al. YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways. Br J Cancer. 2019;121:912-921 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5e, 5f, 5g
Helsley R, Varadharajan V, Brown A, Gromovsky A, Schugar R, Ramachandiran I, et al. Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3g
Jin Y, Li Y, Wang X, Yang Y. Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-κB and Akt pathways. Cancer Cell Int. 2019;19:220 pubmed 出版商
  • 免疫印迹; 人类; 图 s3e
Pan C, Jin L, Wang X, Li Y, Chun J, Boese A, et al. Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance. J Clin Invest. 2019;129:2431-2445 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4a
Yu Y, Shen Q, Lai Y, Park S, Ou X, Lin D, et al. Anti-inflammatory Effects of Curcumin in Microglial Cells. Front Pharmacol. 2018;9:386 pubmed 出版商
  • 免疫印迹; 人类; 图 7d
Xiao G, Chan L, Klemm L, Braas D, Chen Z, Geng H, et al. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018;173:470-484.e18 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1c
Rizzi C, Tiberi A, Giustizieri M, Marrone M, Gobbo F, Carucci N, et al. NGF steers microglia toward a neuroprotective phenotype. Glia. 2018;66:1395-1416 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2a
Urbanska M, Gozdz A, Macias M, Cymerman I, Liszewska E, Kondratiuk I, et al. GSK3β Controls mTOR and Prosurvival Signaling in Neurons. Mol Neurobiol. 2018;55:6050-6062 pubmed 出版商
  • 免疫印迹; 大鼠; 图 10b
Gasparotto J, Girardi C, Somensi N, Ribeiro C, Moreira J, Michels M, et al. Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment. J Biol Chem. 2018;293:226-244 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s2a
Mai W, Gosa L, Daniëls V, Ta L, Tsang J, Higgins B, et al. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nat Med. 2017;23:1342-1351 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4b
Zhang X, Spiegelman N, Nelson O, Jing H, Lin H. SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. elife. 2017;6: pubmed 出版商
  • 免疫印迹; 人类; 图 4c
  • 免疫印迹; 小鼠; 图 3b
CAROMILE L, Dortche K, Rahman M, Grant C, Stoddard C, Ferrer F, et al. PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer. Sci Signal. 2017;10: pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 4d
Cen M, Hu P, Cai Z, Fang T, Zhang J, Lu M. TIEG1 deficiency confers enhanced myocardial protection in the infarcted heart by mediating the Pten/Akt signalling pathway. Int J Mol Med. 2017;39:569-578 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Peng M, Yin N, Li M. SZT2 dictates GATOR control of mTORC1 signalling. Nature. 2017;543:433-437 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1b
Sugg K, Korn M, Sarver D, Markworth J, Mendias C. Inhibition of platelet-derived growth factor signaling prevents muscle fiber growth during skeletal muscle hypertrophy. FEBS Lett. 2017;591:801-809 pubmed 出版商
  • 免疫印迹; 人类; 图 5b
Ren H, Liu F, Huang G, Liu Y, Shen J, Zhou P, et al. Positive feedback loop of IL-1β/Akt/RARα/Akt signaling mediates oncogenic property of RARα in gastric carcinoma. Oncotarget. 2017;8:6718-6729 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s4a,s4b
Kim H, Kim M, Park Y, Park I, Kim T, Yang S, et al. Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice. Gastroenterology. 2017;152:616-630 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6a
Kunzler A, Zeidán Chuliá F, Gasparotto J, Girardi C, Klafke K, Petiz L, et al. Changes in Cell Cycle and Up-Regulation of Neuronal Markers During SH-SY5Y Neurodifferentiation by Retinoic Acid are Mediated by Reactive Species Production and Oxidative Stress. Mol Neurobiol. 2017;54:6903-6916 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:200; 图 s7d
  • 免疫印迹; 小鼠; 1:1000; 图 s6a
Karki R, Man S, Malireddi R, Kesavardhana S, Zhu Q, Burton A, et al. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 2016;540:583-587 pubmed 出版商
  • 免疫印迹; 人类; 图 s5a
Grabinski T, Kanaan N. Novel Non-phosphorylated Serine 9/21 GSK3?/? Antibodies: Expanding the Tools for Studying GSK3 Regulation. Front Mol Neurosci. 2016;9:123 pubmed
  • 免疫印迹; 人类; 1:1000; 表 1
Cardoso R, Burns A, Moeller J, Skinner D, Padmanabhan V. Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS. Endocrinology. 2016;157:4641-4653 pubmed
  • 免疫印迹; 人类; 图 7
  • 免疫细胞化学; 小鼠
  • 免疫印迹; 小鼠; 图 1
Cizmecioglu O, Ni J, Xie S, Zhao J, Roberts T. Rac1-mediated membrane raft localization of PI3K/p110? is required for its activation by GPCRs or PTEN loss. elife. 2016;5: pubmed 出版商
  • 免疫印迹; 人类; 图 6b
Cunningham C, Li S, Vizeacoumar F, Bhanumathy K, Lee J, Parameswaran S, et al. Therapeutic relevance of the protein phosphatase 2A in cancer. Oncotarget. 2016;7:61544-61561 pubmed 出版商
  • 流式细胞仪; 人类; 图 s18a
Kagoya Y, Nakatsugawa M, Yamashita Y, Ochi T, Guo T, Anczurowski M, et al. BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models. J Clin Invest. 2016;126:3479-94 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 1
Pan B, Huang X, Deng C. Chronic administration of aripiprazole activates GSK3β-dependent signalling pathways, and up-regulates GABAA receptor expression and CREB1 activity in rats. Sci Rep. 2016;6:30040 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Ma T, Fan B, Zhang C, Zhao H, Han C, Gao C, et al. Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway. Sci Rep. 2016;6:29926 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Chan W, Ismail H, Mayaki D, Sanchez V, Tiedemann K, Davis E, et al. Fibulin-5 Regulates Angiopoietin-1/Tie-2 Receptor Signaling in Endothelial Cells. PLoS ONE. 2016;11:e0156994 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
Wang N, Dong B, Quan Y, Chen Q, Chu M, Xu J, et al. Regulation of Prostate Development and Benign Prostatic Hyperplasia by Autocrine Cholinergic Signaling via Maintaining the Epithelial Progenitor Cells in Proliferating Status. Stem Cell Reports. 2016;6:668-678 pubmed 出版商
  • 免疫印迹; 人类; 图 6e
Vorvis C, Hatziapostolou M, Mahurkar Joshi S, Koutsioumpa M, Williams J, Donahue T, et al. Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer. Am J Physiol Gastrointest Liver Physiol. 2016;310:G1124-37 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6
  • 免疫印迹; 大鼠; 1:1000; 图 6
Yu Z, Zhao G, Li P, Li Y, Zhou G, Chen Y, et al. Temozolomide in combination with metformin act synergistically to inhibit proliferation and expansion of glioma stem-like cells. Oncol Lett. 2016;11:2792-2800 pubmed
  • 免疫印迹; 人类; 1:1000; 图 3
Maselli A, Capoccia S, Pugliese P, Raggi C, Cirulli F, Fabi A, et al. Autoantibodies specific to estrogen receptor alpha act as estrogen agonists and their levels correlate with breast cancer cell proliferation. Oncoimmunology. 2016;5:e1074375 pubmed
  • 免疫印迹; 大鼠; 1:1000; 图 2
Pan B, Huang X, Deng C. Aripiprazole and Haloperidol Activate GSK3?-Dependent Signalling Pathway Differentially in Various Brain Regions of Rats. Int J Mol Sci. 2016;17:459 pubmed 出版商
  • 免疫印迹; 人类; 图 6
An X, Zhao Z, Luo Y, Zhang R, Tang X, Hao D, et al. Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer. Oncotarget. 2016;7:24719-33 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7e
Lakshmipathi J, Alvarez Perez J, Rosselot C, Casinelli G, Stamateris R, Rausell Palamos F, et al. PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2. Diabetes. 2016;65:1283-96 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
Cherepkova M, Sineva G, Pospelov V. Leukemia inhibitory factor (LIF) withdrawal activates mTOR signaling pathway in mouse embryonic stem cells through the MEK/ERK/TSC2 pathway. Cell Death Dis. 2016;7:e2050 pubmed 出版商
  • 免疫印迹; 小鼠; 图 st1
Wang C, Che L, Hu J, Zhang S, Jiang L, Latte G, et al. Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade. Liver Int. 2016;36:1176-86 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5
Vajravelu B, Hong K, Al Maqtari T, Cao P, Keith M, Wysoczynski M, et al. C-Kit Promotes Growth and Migration of Human Cardiac Progenitor Cells via the PI3K-AKT and MEK-ERK Pathways. PLoS ONE. 2015;10:e0140798 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Lee I, Jung K, Kim I, Lee H, Kim M, Yun S, et al. Human neural stem cells alleviate Alzheimer-like pathology in a mouse model. Mol Neurodegener. 2015;10:38 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1c
Krishnan N, Krishnan K, Connors C, Choy M, Page R, Peti W, et al. PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J Clin Invest. 2015;125:3163-77 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Patergnani S, Giorgi C, Maniero S, Missiroli S, Maniscalco P, Bononi I, et al. The endoplasmic reticulum mitochondrial calcium cross talk is downregulated in malignant pleural mesothelioma cells and plays a critical role in apoptosis inhibition. Oncotarget. 2015;6:23427-44 pubmed
  • 免疫印迹; 人类; 图 3
Reis C, Chen P, Srinivasan S, Aguet F, Mettlen M, Schmid S. Crosstalk between Akt/GSK3β signaling and dynamin-1 regulates clathrin-mediated endocytosis. EMBO J. 2015;34:2132-46 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s9
Braccini L, Ciraolo E, Campa C, Perino A, Longo D, Tibolla G, et al. PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling. Nat Commun. 2015;6:7400 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Unni A, Lockwood W, Zejnullahu K, Lee Lin S, Varmus H. Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma. elife. 2015;4:e06907 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 2
Li X, Tao J, Cigliano A, Sini M, Calderaro J, Azoulay D, et al. Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver. Oncotarget. 2015;6:10102-15 pubmed
  • 免疫印迹; 人类; 1:1000; 图 1,2,3,4,5,6,7
Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, et al. Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy. EMBO J. 2015;34:1214-30 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5
Bitler B, Aird K, Garipov A, Li H, Amatangelo M, Kossenkov A, et al. Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. Nat Med. 2015;21:231-8 pubmed 出版商
  • 免疫印迹; 人类; 图 2b,3
Huang C, Sheng S, Li R, Sun X, Liu J, Huang G. Lactate promotes resistance to glucose starvation via upregulation of Bcl-2 mediated by mTOR activation. Oncol Rep. 2015;33:875-84 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s3
Banks A, McAllister F, Camporez J, Zushin P, Jurczak M, Laznik Bogoslavski D, et al. An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ. Nature. 2015;517:391-5 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 6c
Backer R, Helbig C, Gentek R, Kent A, Laidlaw B, Dominguez C, et al. A central role for Notch in effector CD8(+) T cell differentiation. Nat Immunol. 2014;15:1143-51 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Peng M, Yin N, Li M. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell. 2014;159:122-133 pubmed 出版商
Dodds S, Parihar M, Javors M, Nie J, Musi N, Dave Sharp Z, et al. Acarbose improved survival for Apc+/Min mice. Aging Cell. 2020;19:e13088 pubmed 出版商
Wang M, LAW M, Davis B, Yaaghubi E, Ghilardi A, Ferreira R, et al. Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway. Cell Death Discov. 2019;5:153 pubmed 出版商
Chopra S, Jenney A, Palmer A, Niepel M, Chung M, Mills C, et al. Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells. Cell Syst. 2019;: pubmed 出版商
Lee Y, Ho S, Graves J, Xiao Y, Huang S, Lin W. CGRRF1, a growth suppressor, regulates EGFR ubiquitination in breast cancer. Breast Cancer Res. 2019;21:134 pubmed 出版商
Srikantan S, Deng Y, Cheng Z, Luo A, Qin Y, Gao Q, et al. The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner. Nat Commun. 2019;10:4720 pubmed 出版商
Zheng X, Yang S, Zhang R, Wang S, Li G, Zhou S. Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes. Drug Des Devel Ther. 2019;13:3171-3180 pubmed 出版商
Jeyarajah M, Jaju Bhattad G, Kops B, Renaud S. Syndecan-4 regulates extravillous trophoblast migration by coordinating protein kinase C activation. Sci Rep. 2019;9:10175 pubmed 出版商
Chung C, Shin H, Berdan C, Ford B, Ward C, Olzmann J, et al. Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat Chem Biol. 2019;15:776-785 pubmed 出版商
Lionarons D, Hancock D, Rana S, East P, Moore C, Murillo M, et al. RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance. Cancer Cell. 2019;: pubmed 出版商
Ligorio M, Sil S, Malagon Lopez J, Nieman L, Misale S, Di Pilato M, et al. Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer. Cell. 2019;: pubmed 出版商
Pu Z, Wu L, Guo Y, Li G, Xiang M, Liu L, et al. LncRNA MEG3 contributes to adenosine-induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K-AKT-mTOR and beclin-1 signaling pathway. J Cell Biochem. 2019;: pubmed 出版商
Jia B, Wang Y, Yu G, Cheng Y, Yang C, Cao F, et al. Naringenin ameliorates insulin resistance by modulating endoplasmic reticulum stress in hepatitis C virus-infected liver. Biomed Pharmacother. 2019;115:108848 pubmed 出版商
Tan D, Li Y, Yang C, Li J, Tan S, Chin D, et al. PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells. Cell Rep. 2019;26:2316-2328.e6 pubmed 出版商
Wang M, Ferreira R, LAW M, Davis B, Yaaghubi E, Ghilardi A, et al. A novel proteotoxic combination therapy for EGFR+ and HER2+ cancers. Oncogene. 2019;38:4264-4282 pubmed 出版商
Kovalski J, Bhaduri A, Zehnder A, Neela P, Che Y, Wozniak G, et al. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. Mol Cell. 2019;73:830-844.e12 pubmed 出版商
Gu C, Stashko M, Puhl Rubio A, Chakraborty M, Chakraborty A, Frye S, et al. Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis. J Med Chem. 2019;62:1443-1454 pubmed 出版商
Zhang Z, Chen J, Huang W, Ning D, Liu Q, Wang C, et al. FAM134B induces tumorigenesis and epithelial-to-mesenchymal transition via Akt signaling in hepatocellular carcinoma. Mol Oncol. 2019;13:792-810 pubmed 出版商
Murillo M, Rana S, Spencer Dene B, Nye E, Stamp G, Downward J. Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer. Cell Rep. 2018;25:3545-3553.e2 pubmed 出版商
Zhang Z, Zhu J, Huang Y, Li W, Cheng H. MYO18B promotes hepatocellular carcinoma progression by activating PI3K/AKT/mTOR signaling pathway. Diagn Pathol. 2018;13:85 pubmed 出版商
Tolksdorf F, Mikulec J, Geers B, Endig J, Sprezyna P, Heukamp L, et al. The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production. Sci Rep. 2018;8:16123 pubmed 出版商
Zhang Y, Federation A, Kim S, O Keefe J, Lun M, Xiang D, et al. Targeting nuclear receptor NR4A1-dependent adipocyte progenitor quiescence promotes metabolic adaptation to obesity. J Clin Invest. 2018;128:4898-4911 pubmed 出版商
Shehata H, Khan S, Chen E, Fields P, Flavell R, Sanjabi S. Lack of Sprouty 1 and 2 enhances survival of effector CD8+ T cells and yields more protective memory cells. Proc Natl Acad Sci U S A. 2018;115:E8939-E8947 pubmed 出版商
Suzuki J, Yamada T, Inoue K, Nabe S, Kuwahara M, Takemori N, et al. The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation. Nat Commun. 2018;9:3296 pubmed 出版商
Zhao J, Jiao Y, Song Y, Liu J, Li X, Zhang H, et al. Stanniocalcin 2 Ameliorates Hepatosteatosis Through Activation of STAT3 Signaling. Front Physiol. 2018;9:873 pubmed 出版商
Li X, Zhong L, Wang Z, Chen H, Liao D, Zhang R, et al. Phosphorylation of IRS4 by CK1γ2 promotes its degradation by CHIP through the ubiquitin/lysosome pathway. Theranostics. 2018;8:3643-3653 pubmed 出版商
McCormick C, Waters H, Bezrukov L, Taginya R, Parikh V, Onyekaba G, et al. Subcutaneous adipose tissue imaging of human obesity reveals two types of adipocyte membranes: Insulin-responsive and -nonresponsive. J Biol Chem. 2018;293:14249-14259 pubmed 出版商
Park S, Burke R, Kareva T, Kholodilov N, Aimé P, Franke T, et al. Context-dependent expression of a conditionally-inducible form of active Akt. PLoS ONE. 2018;13:e0197899 pubmed 出版商
Lu S, Yao Y, Xu G, Zhou C, Zhang Y, Sun J, et al. CD24 regulates sorafenib resistance via activating autophagy in hepatocellular carcinoma. Cell Death Dis. 2018;9:646 pubmed 出版商
Nayak G, Odaka Y, Prasad V, Solano A, Yeo E, Vemaraju S, et al. Developmental vascular regression is regulated by a Wnt/β-catenin, MYC and CDKN1A pathway that controls cell proliferation and cell death. Development. 2018;145: pubmed 出版商
Igarashi A, Itoh K, Yamada T, Adachi Y, Kato T, Murata D, et al. Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility. J Biol Chem. 2018;293:9292-9300 pubmed 出版商
Wang X, Bi X, Zhang G, Deng Y, Luo X, Xu L, et al. Glucose-regulated protein 78 is essential for cardiac myocyte survival. Cell Death Differ. 2018;25:2181-2194 pubmed 出版商
Hong S, Song W, Zushin P, Liu B, Jedrychowski M, Mina A, et al. Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Mol Metab. 2018;12:25-38 pubmed 出版商
Zeng Z, Wu Y, Cao Y, Yuan Z, Zhang Y, Zhang D, et al. Slit2-Robo2 signaling modulates the fibrogenic activity and migration of hepatic stellate cells. Life Sci. 2018;203:39-47 pubmed 出版商
Liu C, Su C, Chen Y, Li G. MiR-144-3p promotes the tumor growth and metastasis of papillary thyroid carcinoma by targeting paired box gene 8. Cancer Cell Int. 2018;18:54 pubmed 出版商
Huang Y, Wang H, Lian Y, Wu X, Zhou L, Wang J, et al. Upregulation of kinesin family member 4A enhanced cell proliferation via activation of Akt signaling and predicted a poor prognosis in hepatocellular carcinoma. Cell Death Dis. 2018;9:141 pubmed 出版商
Zhang X, Cao J, Miller S, Jing H, Lin H. Comparative Nucleotide-Dependent Interactome Analysis Reveals Shared and Differential Properties of KRas4a and KRas4b. ACS Cent Sci. 2018;4:71-80 pubmed 出版商
Wilson K, Jagger A, Walker M, Seinkmane E, Fox J, Kröger R, et al. Glycans modify mesenchymal stem cell differentiation to impact on the function of resulting osteoblasts. J Cell Sci. 2018;131: pubmed 出版商
McKenzie M, Kirk R, Walker A. Glucose Uptake in the Human Pathogen Schistosoma mansoni Is Regulated Through Akt/Protein Kinase B Signaling. J Infect Dis. 2018;218:152-164 pubmed 出版商
Lv S, Ji L, Chen B, Liu S, Lei C, Liu X, et al. Histone methyltransferase KMT2D sustains prostate carcinogenesis and metastasis via epigenetically activating LIFR and KLF4. Oncogene. 2018;37:1354-1368 pubmed 出版商
Kaittanis C, Andreou C, Hieronymus H, Mao N, Foss C, Eiber M, et al. Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors. J Exp Med. 2018;215:159-175 pubmed 出版商
Li Z, Levine K, Bahreini A, Wang P, Chu D, Park B, et al. Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells. Endocrinology. 2018;159:285-296 pubmed 出版商
Chhabra Y, Wong H, Nikolajsen L, Steinocher H, Papadopulos A, Tunny K, et al. A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation. Oncogene. 2018;37:489-501 pubmed 出版商
Walton J, Farquharson M, Mason S, Port J, Kruspig B, Dowson S, et al. CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity. Sci Rep. 2017;7:16827 pubmed 出版商
Tripathi B, Grant T, Qian X, Zhou M, Mertins P, Wang D, et al. Receptor tyrosine kinase activation of RhoA is mediated by AKT phosphorylation of DLC1. J Cell Biol. 2017;216:4255-4270 pubmed 出版商
Palm W, Araki J, King B, Dematteo R, Thompson C. Critical role for PI3-kinase in regulating the use of proteins as an amino acid source. Proc Natl Acad Sci U S A. 2017;114:E8628-E8636 pubmed 出版商
Han X, Li B, Ye X, Mulatibieke T, Wu J, Dai J, et al. Dopamine D2 receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt/NF-?B signalling pathway. Br J Pharmacol. 2017;: pubmed 出版商
Kim K, Ryu D, Dongiovanni P, Ozcan L, Nayak S, Ueberheide B, et al. Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis. Gastroenterology. 2017;153:1568-1580.e10 pubmed 出版商
Shibutani S, Okazaki H, Iwata H. Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1). J Biol Chem. 2017;292:18052-18061 pubmed 出版商
Anderson G, Winter P, Lin K, Nussbaum D, Cakir M, Stein E, et al. A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution. Cell Rep. 2017;20:999-1015 pubmed 出版商
Hawse W, Boggess W, Morel P. TCR Signal Strength Regulates Akt Substrate Specificity To Induce Alternate Murine Th and T Regulatory Cell Differentiation Programs. J Immunol. 2017;199:589-597 pubmed 出版商
Zhang Z, Luo Z, Min W, Zhang L, Wu Y, Hu X. An anti-cancer WxxxE-containing azurin polypeptide inhibits Rac1-dependent STAT3 and ERK/GSK-3? signaling in breast cancer cells. Oncotarget. 2017;8:43091-43103 pubmed 出版商
Noguchi K, Dalton A, Howley B, McCall B, Yoshida A, Diehl J, et al. Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines. PLoS ONE. 2017;12:e0177830 pubmed 出版商
Hattori A, Tsunoda M, Konuma T, Kobayashi M, Nagy T, Glushka J, et al. Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia. Nature. 2017;545:500-504 pubmed 出版商
LeBlanc M, Wang W, Chen X, Caberoy N, Guo F, Shen C, et al. Secretogranin III as a disease-associated ligand for antiangiogenic therapy of diabetic retinopathy. J Exp Med. 2017;214:1029-1047 pubmed 出版商
Rose J, Huang P, Camp N, Ye J, Leidal A, Goreshnik I, et al. A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics. Nat Chem Biol. 2017;13:119-126 pubmed 出版商
Weidner P, Söhn M, Gutting T, Friedrich T, Gaiser T, Magdeburg J, et al. Myotubularin-related protein 7 inhibits insulin signaling in colorectal cancer. Oncotarget. 2016;7:50490-50506 pubmed 出版商
Ou B, Zhao J, Guan S, Feng H, Wangpu X, Zhu C, et al. CCR4 promotes metastasis via ERK/NF-κB/MMP13 pathway and acts downstream of TNF-α in colorectal cancer. Oncotarget. 2016;7:47637-47649 pubmed 出版商
Pan B, Chen J, Lian J, Huang X, Deng C. Unique Effects of Acute Aripiprazole Treatment on the Dopamine D2 Receptor Downstream cAMP-PKA and Akt-GSK3β Signalling Pathways in Rats. PLoS ONE. 2015;10:e0132722 pubmed 出版商
公司总部: 美国