产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
LEF1(C12A5)兔单克隆抗体
目录 :
2230
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
C12A5
反应物种 :
人类, 小鼠, 大鼠, 斑马鱼
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, EMSA, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片
文章摘录数: 51
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 1:200; 图 3a
Kuo A, Checa A, Niaudet C, Jung B, Fu Z, Wheelock C, et al. Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis. elife. 2022;11: pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:100; 图 4g
Ibarra B, Machen C, ATIT R. Wnt-Dependent Activation of ERK Mediates Repression of Chondrocyte Fate during Calvarial Development. J Dev Biol. 2021;9: pubmed 出版商
  • 免疫组化; 小鼠; 1:400; 图 2a
Li H, Kurtzeborn K, Kupari J, Gui Y, Siefker E, Lu B, et al. Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF. Development. 2021;148: pubmed 出版商
  • 免疫印迹; 斑马鱼; 1:1000; 图 1g
Yi C, Spitters T, Al Far E, Wang S, Xiong T, Cai S, et al. A calcineurin-mediated scaling mechanism that controls a K+-leak channel to regulate morphogen and growth factor transcription. elife. 2021;10: pubmed 出版商
  • 免疫组化; 小鼠; 图 2s1a
Rattner A, Terrillion C, Jou C, Kleven T, Hu S, Williams J, et al. Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus. elife. 2020;9: pubmed 出版商
  • 免疫组化; 小鼠; 1:300; 图 1a
Matos I, Asare A, Levorse J, Ouspenskaia T, de la Cruz Racelis J, Schuhmacher L, et al. Progenitors oppositely polarize WNT activators and inhibitors to orchestrate tissue development. elife. 2020;9: pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:200; 图 7b
Engelbrecht E, Lévesque M, He L, Vanlandewijck M, Nitzsche A, Niazi H, et al. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Chen X, Xiong X, Cui D, Yang F, Wei D, Li H, et al. DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals. Oncogene. 2020;39:1557-1571 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:2000; 图 s4t
  • 免疫印迹; 小鼠; 1:1000; 图 4i
Pedone E, Postiglione L, Aulicino F, Rocca D, Montes Olivas S, Khazim M, et al. A tunable dual-input system for on-demand dynamic gene expression regulation. Nat Commun. 2019;10:4481 pubmed 出版商
  • 免疫印迹; 人类; 图 3d
Jiang S, Zhang M, Zhang Y, Zhou W, Zhu T, Ruan Q, et al. WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling. Cell Commun Signal. 2019;17:109 pubmed 出版商
  • 免疫印迹; 人类; 图 4h
Li Q, Lai Q, He C, Fang Y, Yan Q, Zhang Y, et al. RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer. J Exp Clin Cancer Res. 2019;38:334 pubmed 出版商
  • 免疫印迹; 人类; 图 ex8j
Parolia A, Cieslik M, Chu S, Xiao L, Ouchi T, Zhang Y, et al. Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer. Nature. 2019;: pubmed 出版商
  • 免疫组化; 小鼠; 图 1b
Wang Y, Sabbagh M, Gu X, Rattner A, Williams J, Nathans J. Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures. elife. 2019;8: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:100; 图 1b
Krimpenfort P, Snoek M, Lambooij J, Song J, van der Weide R, Bhaskaran R, et al. A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis. Nat Commun. 2019;10:1425 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1a
Xing S, Gai K, Li X, Shao P, Zeng Z, Zhao X, et al. Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells. J Exp Med. 2019;: pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 1:50; 图 6d
Sahara M, Santoro F, Sohlmér J, Zhou C, Witman N, Leung C, et al. Population and Single-Cell Analysis of Human Cardiogenesis Reveals Unique LGR5 Ventricular Progenitors in Embryonic Outflow Tract. Dev Cell. 2019;48:475-490.e7 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Zhou L, Jing J, Wang H, Wu X, Lu Z. Decorin promotes proliferation and migration of ORS keratinocytes and maintains hair anagen in mice. Exp Dermatol. 2018;27:1237-1244 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 7a
Hoefert J, Bjerke G, Wang D, Yi R. The microRNA-200 family coordinately regulates cell adhesion and proliferation in hair morphogenesis. J Cell Biol. 2018;217:2185-2204 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:200; 图 8a
Yu W, Li X, Eliason S, Romero Bustillos M, Ries R, Cao H, et al. Irx1 regulates dental outer enamel epithelial and lung alveolar type II epithelial differentiation. Dev Biol. 2017;429:44-55 pubmed 出版商
  • 免疫印迹; 人类; 图 6c
Subramaniam M, Cicek M, Pitel K, Bruinsma E, Nelson Holte M, Withers S, et al. TIEG1 modulates ?-catenin sub-cellular localization and enhances Wnt signaling in bone. Nucleic Acids Res. 2017;45:5170-5182 pubmed 出版商
  • 免疫组化; 人类; 图 6a
  • 免疫印迹; 人类; 图 6b
Barnes L, Saurat J, Kaya G. Senescent Atrophic Epidermis Retains Lrig1+ Stem Cells and Loses Wnt Signaling, a Phenotype Shared with CD44KO Mice. PLoS ONE. 2017;12:e0169452 pubmed 出版商
  • 免疫组化; 小鼠; 1:250; 表 1
Bassett E, Tokarew N, Allemano E, Mazerolle C, Morin K, Mears A, et al. Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation. elife. 2016;5: pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 s7d
Lian G, Dettenhofer M, Lu J, Downing M, Chenn A, Wong T, et al. Filamin A- and formin 2-dependent endocytosis regulates proliferation via the canonical Wnt pathway. Development. 2016;143:4509-4520 pubmed
  • EMSA; 人类; 图 2h
Guo Y, Wang L, Li B, Xu H, Yang J, Zheng L, et al. Wnt/?-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling. Oncotarget. 2016;7:42513-42526 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:400; 图 6e
Petit F, Deng C, Jamin S. Partial Müllerian Duct Retention in Smad4 Conditional Mutant Male Mice. Int J Biol Sci. 2016;12:667-76 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6a
Lu C, Thoeni C, Connor A, Kawabe H, Gallinger S, Rotin D. Intestinal knockout of Nedd4 enhances growth of Apcmin tumors. Oncogene. 2016;35:5839-5849 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Kim J, Lee H, Park K, Choi Y, Nam J, Hong I. CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatment. Oncotarget. 2016;7:20395-409 pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 4d
Franco C, Jones M, Bernabeu M, Vion A, Barbacena P, Fan J, et al. Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling. elife. 2016;5:e07727 pubmed 出版商
  • 免疫细胞化学; 小鼠
Yuri S, Nishikawa M, Yanagawa N, Jo O, Yanagawa N. Maintenance of Mouse Nephron Progenitor Cells in Aggregates with Gamma-Secretase Inhibitor. PLoS ONE. 2015;10:e0129242 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100; 图 s3d
Yang N, Li L, Eguether T, Sundberg J, Pazour G, Chen J. Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis. Development. 2015;142:2194-202 pubmed 出版商
  • 免疫印迹; 人类; 图 3b
Beltran M, Aparicio Prat E, Mazzolini R, Millanes Romero A, Massó P, Jenner R, et al. Splicing of a non-coding antisense transcript controls LEF1 gene expression. Nucleic Acids Res. 2015;43:5785-97 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:500; 图 6n-s
Gay M, Valenta T, Herr P, Paratore Hari L, Basler K, Sommer L. Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation. BMC Biol. 2015;13:24 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:300; 图 1
Cui C, Yin M, Sima J, Childress V, Michel M, Piao Y, et al. Involvement of Wnt, Eda and Shh at defined stages of sweat gland development. Development. 2014;141:3752-60 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Landin Malt A, Cesario J, Tang Z, Brown S, Jeong J. Identification of a face enhancer reveals direct regulation of LIM homeobox 8 (Lhx8) by wingless-int (WNT)/β-catenin signaling. J Biol Chem. 2014;289:30289-301 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, et al. YAP/TAZ incorporation in the ?-catenin destruction complex orchestrates the Wnt response. Cell. 2014;158:157-70 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Zhu Z, Liu Y, Li K, Liu J, Wang H, Sun B, et al. Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility. Carcinogenesis. 2014;35:1901-10 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Xu Y, Xu Y, Liao L, Zhou N, Theissen S, Liao X, et al. Inducible knockout of Twist1 in young and adult mice prolongs hair growth cycle and has mild effects on general health, supporting Twist1 as a preferential cancer target. Am J Pathol. 2013;183:1281-1292 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:75
Lewis A, Vasudevan H, O Neill A, Soriano P, Bush J. The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Dev Biol. 2013;379:229-34 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Wallmen B, Schrempp M, Hecht A. Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/?-catenin target gene expression. Nucleic Acids Res. 2012;40:9455-69 pubmed 出版商
Wu J, Tian Y, Han L, Liu C, Sun T, Li L, et al. FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling. BMC Biol. 2020;18:87 pubmed 出版商
Alldredge A, Fuhrmann S. Loss of Axin2 Causes Ocular Defects During Mouse Eye Development. Invest Ophthalmol Vis Sci. 2016;57:5253-5262 pubmed 出版商
Phua Y, Chu J, Marrone A, Bodnar A, Sims Lucas S, Ho J. Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival. Physiol Rep. 2015;3: pubmed 出版商
Raines A, Magella B, Adam M, Potter S. Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development. BMC Dev Biol. 2015;15:28 pubmed 出版商
Bankhead E, Colasanto M, Dyorich K, Jamrich M, Murtaugh L, Fuhrmann S. Multiple requirements of the focal dermal hypoplasia gene porcupine during ocular morphogenesis. Am J Pathol. 2015;185:197-213 pubmed 出版商
Shang D, Bi R, Han T, Wang D, Tian Y, Liu Y. Expression and proliferation-promoting role of lymphoid enhancer-binding factor 1 in human clear cell renal carcinoma. Cancer Invest. 2014;32:368-74 pubmed 出版商
Boras Granic K, Dann P, VanHouten J, Karaplis A, Wysolmerski J. Deletion of the nuclear localization sequences and C-terminus of PTHrP impairs embryonic mammary development but also inhibits PTHrP production. PLoS ONE. 2014;9:e90418 pubmed 出版商
Wang W, Yao Y, Jiang L, Hu T, Ma J, Ruan Z, et al. Increased LEF1 expression and decreased Notch2 expression are strong predictors of poor outcomes in colorectal cancer patients. Dis Markers. 2013;35:395-405 pubmed 出版商
Walther N, Ulrich A, Vockerodt M, von Bonin F, Klapper W, Meyer K, et al. Aberrant lymphocyte enhancer-binding factor 1 expression is characteristic for sporadic Burkitt's lymphoma. Am J Pathol. 2013;182:1092-8 pubmed 出版商
Zhang Z, Wlodarczyk B, Niederreither K, Venugopalan S, Florez S, Finnell R, et al. Fuz regulates craniofacial development through tissue specific responses to signaling factors. PLoS ONE. 2011;6:e24608 pubmed 出版商
Luderer H, Gori F, Demay M. Lymphoid enhancer-binding factor-1 (LEF1) interacts with the DNA-binding domain of the vitamin D receptor. J Biol Chem. 2011;286:18444-51 pubmed 出版商
Kriegl L, Horst D, Reiche J, Engel J, Kirchner T, Jung A. LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer. J Transl Med. 2010;8:123 pubmed 出版商
产品信息
SKU号 :
2230S
产品名称 :
LEF1(C12A5)兔单克隆抗体
规格 :
100微升
Price-(USD) :
235美元
物种x :
H, M, R
应用 :
流式细胞仪
产品种类 :
发育生物学
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
25-58 kDa
宿主 :
靶标 :
LEF1
最初蛋白 :
LEF-1
别名 :
DKFZp586H0919,FLJ46390,LEF-1,LEF1,Lymphoid enhancer-binding factor 1,T cell-specific transcription factor 1-alpha,TCF1-alpha,TCF1ALPHA
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。