出版应用/物种/样本/稀释 | 参考文献 |
---|
| Chen Q, Fan K, Chen X, Xie X, Huang L, Song G, et al. Ezrin regulates synovial angiogenesis in rheumatoid arthritis through YAP and Akt signalling. J Cell Mol Med. 2021;25:9378-9389 pubmed 出版商
|
| Kumar P, Zadjali F, Yao Y, Siroky B, Astrinidis A, Gross K, et al. Tsc Gene Locus Disruption and Differences in Renal Epithelial Extracellular Vesicles. Front Physiol. 2021;12:630933 pubmed 出版商
|
| Hamm M, Sohier P, Petit V, Raymond J, Delmas V, Le Coz M, et al. BRN2 is a non-canonical melanoma tumor-suppressor. Nat Commun. 2021;12:3707 pubmed 出版商
|
| Hao X, Qiu Y, Cao L, Yang X, Zhou D, Liu J, et al. Over-Expression of Centromere Protein U Participates in the Malignant Neoplastic Progression of Breast Cancer. Front Oncol. 2021;11:615427 pubmed 出版商
|
| Ganassi M, Badodi S, Wanders K, Zammit P, Hughes S. Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis. elife. 2020;9: pubmed 出版商
|
| Kumar A, Xie L, Ta C, Hinton A, Gunasekar S, Minerath R, et al. SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism. elife. 2020;9: pubmed 出版商
|
| Silva M, Nandi G, Tentarelli S, Gurrell I, Jamier T, Lucente D, et al. Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons. Nat Commun. 2020;11:3258 pubmed 出版商
|
| Koundouros N, Karali E, Tripp A, Valle A, Inglese P, Perry N, et al. Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids. Cell. 2020;181:1596-1611.e27 pubmed 出版商
|
| Feng Y, Mischler W, Gurung A, Kavanagh T, Androsov G, Sadow P, et al. Therapeutic Targeting of the Secreted Lysophospholipase D Autotaxin Suppresses Tuberous Sclerosis Complex-Associated Tumorigenesis. Cancer Res. 2020;80:2751-2763 pubmed 出版商
|
| Alajati A, D Ambrosio M, Troiani M, Mosole S, Pellegrini L, Chen J, et al. CDCP1 overexpression drives prostate cancer progression and can be targeted in vivo. J Clin Invest. 2020;130:2435-2450 pubmed 出版商
|
| Liu T, Han S, Dai Q, Zheng J, Liu C, Li S, et al. IL-17A-Mediated Excessive Autophagy Aggravated Neuronal Ischemic Injuries via Src-PP2B-mTOR Pathway. Front Immunol. 2019;10:2952 pubmed 出版商
|
| Wang C, Vegna S, Jin H, Benedict B, Lieftink C, Ramirez C, et al. Inducing and exploiting vulnerabilities for the treatment of liver cancer. Nature. 2019;: pubmed 出版商
|
| Wu R, Yun Q, Zhang J, Bao J. Downregulation of KLF13 through DNMT1-mediated hypermethylation promotes glioma cell proliferation and invasion. Onco Targets Ther. 2019;12:1509-1520 pubmed 出版商
|
| Teissier T, Quersin V, Gnemmi V, Daroux M, Howsam M, Delguste F, et al. Knockout of receptor for advanced glycation end-products attenuates age-related renal lesions. Aging Cell. 2019;18:e12850 pubmed 出版商
|
| Losier T, Akuma M, McKee Muir O, LeBlond N, Suk Y, Alsaadi R, et al. AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles. Cell Rep. 2019;26:2150-2165.e5 pubmed 出版商
|
| Guan H, Li N, Wang X, Shan X, Li Z, Lin Z. Role of Paip1 on angiogenesis and invasion in pancreatic cancer. Exp Cell Res. 2019;376:198-209 pubmed 出版商
|
| Urtishak K, Wang L, Culjkovic Kraljacic B, Davenport J, Porazzi P, Vincent T, et al. Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia. Oncogene. 2019;38:2241-2262 pubmed 出版商
|
| Hartleben G, Muller C, Kramer A, Schimmel H, Zidek L, Dornblut C, et al. Tuberous sclerosis complex is required for tumor maintenance in MYC-driven Burkitt's lymphoma. EMBO J. 2018;37: pubmed 出版商
|
| Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed 出版商
|
| Chennupati V, Veiga D, Maslowski K, Andina N, Tardivel A, Yu E, et al. Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation. J Clin Invest. 2018;128:1597-1614 pubmed 出版商
|
| Oldrini B, Hsieh W, Erdjument Bromage H, Codega P, Carro M, Curiel García A, et al. EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer. Nat Commun. 2017;8:2035 pubmed 出版商
|
| Urbanska M, Gozdz A, Macias M, Cymerman I, Liszewska E, Kondratiuk I, et al. GSK3β Controls mTOR and Prosurvival Signaling in Neurons. Mol Neurobiol. 2018;55:6050-6062 pubmed 出版商
|
| Pereira R, Tadinada S, Zasadny F, Oliveira K, Pires K, Olvera A, et al. OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance. EMBO J. 2017;36:2126-2145 pubmed 出版商
|
| Rozanska A, Richter Dennerlein R, Rorbach J, Gao F, Lewis R, Chrzanowska Lightowlers Z, et al. The human RNA-binding protein RBFA promotes the maturation of the mitochondrial ribosome. Biochem J. 2017;474:2145-2158 pubmed 出版商
|
| White M, Lin C, Rajapakshe K, Dong J, Shi Y, Tsouko E, et al. Glutamine Transporters Are Targets of Multiple Oncogenic Signaling Pathways in Prostate Cancer. Mol Cancer Res. 2017;15:1017-1028 pubmed 出版商
|
| Ip W, Hoshi N, Shouval D, Snapper S, Medzhitov R. Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science. 2017;356:513-519 pubmed 出版商
|
| Cai W, Sakaguchi M, Kleinridders A, Gonzalez Del Pino G, Dreyfuss J, O Neill B, et al. Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nat Commun. 2017;8:14892 pubmed 出版商
|
| Lee C, Hanna A, Wang H, Dagnino Acosta A, Joshi A, Knoblauch M, et al. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017;8:14659 pubmed 出版商
|
| Gupta A, Anjomani Virmouni S, Koundouros N, Dimitriadi M, Choo Wing R, Valle A, et al. PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Mol Cell. 2017;65:999-1013.e7 pubmed 出版商
|
| Samuel S, Ghosh S, Majeed Y, Arunachalam G, Emara M, Ding H, et al. Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death. Biochem Pharmacol. 2017;132:118-132 pubmed 出版商
|
| Ho T, Warr M, Adelman E, Lansinger O, Flach J, Verovskaya E, et al. Autophagy maintains the metabolism and function of young and old stem cells. Nature. 2017;543:205-210 pubmed 出版商
|
| Ercan E, Han J, Di Nardo A, Winden K, Han M, Hoyo L, et al. Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex. J Exp Med. 2017;214:681-697 pubmed 出版商
|
| Cooper H, Yang Y, Ylikallio E, Khairullin R, Woldegebriel R, Lin K, et al. ATPase-deficient mitochondrial inner membrane protein ATAD3A disturbs mitochondrial dynamics in dominant hereditary spastic paraplegia. Hum Mol Genet. 2017;26:1432-1443 pubmed 出版商
|
- 免疫组化-石蜡切片; 人类; 1:1000; 图 1b
- 免疫印迹; 小鼠; 1:1000; 图 1a
| Muranen T, Iwanicki M, Curry N, Hwang J, DuBois C, Coloff J, et al. Starved epithelial cells uptake extracellular matrix for survival. Nat Commun. 2017;8:13989 pubmed 出版商
|
| Fitter S, Matthews M, Martin S, Xie J, Ooi S, Walkley C, et al. mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation. Mol Cell Biol. 2017;37: pubmed 出版商
|
| Vakana E, Pratt S, Blosser W, Dowless M, Simpson N, Yuan X, et al. LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer. Oncotarget. 2017;8:9251-9266 pubmed 出版商
|
| Dou N, Yu S, Ye X, Yang D, Li Y, Gao Y. Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling. Oncotarget. 2016;7:86161-86173 pubmed 出版商
|
| Ayuso M, Martínez Alonso E, Regidor I, Alcazar A. Stress Granule Induction after Brain Ischemia Is Independent of Eukaryotic Translation Initiation Factor (eIF) 2? Phosphorylation and Is Correlated with a Decrease in eIF4B and eIF4E Proteins. J Biol Chem. 2016;291:27252-27264 pubmed 出版商
|
| Fröhlich D, Suchowerska A, Spencer Z, von Jonquieres G, Klugmann C, Bongers A, et al. In vivocharacterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL. Neurobiol Dis. 2017;97:24-35 pubmed 出版商
|
| Guillén Boixet J, Buzon V, Salvatella X, Mendez R. CPEB4 is regulated during cell cycle by ERK2/Cdk1-mediated phosphorylation and its assembly into liquid-like droplets. elife. 2016;5: pubmed 出版商
|
| Ren S, Luo Y, Chen H, Warburton D, Lam H, Wang L, et al. Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization. Am J Pathol. 2016;186:3261-3272 pubmed 出版商
|
| Catena V, Bruno T, De Nicola F, Goeman F, Pallocca M, Iezzi S, et al. Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells. Oncotarget. 2016;7:70546-70558 pubmed 出版商
|
| Carbonneau M, M Gagné L, Lalonde M, Germain M, Motorina A, Guiot M, et al. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat Commun. 2016;7:12700 pubmed 出版商
|
| Foltz S, Luan J, Call J, Patel A, Peissig K, Fortunato M, et al. Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy. Skelet Muscle. 2016;6:20 pubmed 出版商
|
| Ahmad M, Xue Y, Lee S, Martindale J, Shen W, Li W, et al. RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals. Nucleic Acids Res. 2016;44:6335-49 pubmed 出版商
|
| Walter C, Clemens L, Müller A, Fallier Becker P, Proikas Cezanne T, Riess O, et al. Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro. Neuropharmacology. 2016;108:24-38 pubmed 出版商
|
| Du R, Liu Z, Hou X, Fu G, An N, Wang L. Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells. Mol Med Rep. 2016;13:5045-52 pubmed 出版商
|
| Papke B, Murarka S, Vogel H, Martín Gago P, Kovacevic M, Truxius D, et al. Identification of pyrazolopyridazinones as PDE? inhibitors. Nat Commun. 2016;7:11360 pubmed 出版商
|
- 免疫印迹; 人类; 图 7f
- 免疫印迹; 小鼠; 图 6g
| Ro S, Xue X, Ramakrishnan S, Cho C, Namkoong S, Jang I, et al. Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis. elife. 2016;5:e12204 pubmed 出版商
|
| GarcÃa Prat L, MartÃnez Vicente M, Perdiguero E, Ortet L, RodrÃguez Ubreva J, Rebollo E, et al. Autophagy maintains stemness by preventing senescence. Nature. 2016;529:37-42 pubmed 出版商
|
| Lv H, Zhang Z, Wu X, Wang Y, Li C, Gong W, et al. Preclinical Evaluation of Liposomal C8 Ceramide as a Potent anti-Hepatocellular Carcinoma Agent. PLoS ONE. 2016;11:e0145195 pubmed 出版商
|
| Yamagishi M, Katano H, Hishima T, Shimoyama T, Ota Y, Nakano K, et al. Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma. Sci Rep. 2015;5:17868 pubmed 出版商
|
| Kim H, An S, Ro S, Teixeira F, Park G, Kim C, et al. Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains. Nat Commun. 2015;6:10025 pubmed 出版商
|
| Nikonova A, Deneka A, Eckman L, Kopp M, Hensley H, Egleston B, et al. Opposing Effects of Inhibitors of Aurora-A and EGFR in Autosomal-Dominant Polycystic Kidney Disease. Front Oncol. 2015;5:228 pubmed 出版商
|
| Antonucci L, Fagman J, Kim J, Todoric J, Gukovsky I, Mackey M, et al. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A. 2015;112:E6166-74 pubmed 出版商
|
| Knoll M, Macher Goeppinger S, Kopitz J, Duensing S, Pahernik S, Hohenfellner M, et al. The ribosomal protein S6 in renal cell carcinoma: functional relevance and potential as biomarker. Oncotarget. 2016;7:418-32 pubmed 出版商
|
| Barbáchano A, Fernández Barral A, Pereira F, Segura M, Ordóñez Morán P, Carrillo de Santa Pau E, et al. SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150. Oncogene. 2016;35:2991-3003 pubmed 出版商
|
| Thijssen R, Ter Burg J, van Bochove G, de Rooij M, Kuil A, Jansen M, et al. The pan phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor SAR245409 (voxtalisib/XL765) blocks survival, adhesion and proliferation of primary chronic lymphocytic leukemia cells. Leukemia. 2016;30:337-45 pubmed 出版商
|
| Conde Perez A, Gros G, Longvert C, Pedersen M, Petit V, Aktary Z, et al. A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity. Nat Commun. 2015;6:8093 pubmed 出版商
|
| Schipany K, Rosner M, Ionce L, Hengstschläger M, Kovacic B. eIF3 controls cell size independently of S6K1-activity. Oncotarget. 2015;6:24361-75 pubmed
|
| He L, Zang A, Du M, Ma D, Yuan C, Zhou C, et al. mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines. Virol Sin. 2015;30:174-89 pubmed 出版商
|
- 免疫印迹; 小鼠; 图 1c
- 免疫组化; 人类; 图 2c
| Zidek L, Ackermann T, Hartleben G, Eichwald S, Kortman G, Kiehntopf M, et al. Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice. EMBO Rep. 2015;16:1022-36 pubmed 出版商
|
| Kemmerer M, Finkernagel F, Cavalcante M, Abdalla D, Müller R, Brüne B, et al. AMP-Activated Protein Kinase Interacts with the Peroxisome Proliferator-Activated Receptor Delta to Induce Genes Affecting Fatty Acid Oxidation in Human Macrophages. PLoS ONE. 2015;10:e0130893 pubmed 出版商
|
| Zhao J, Zhao D, Poage G, Mazumdar A, Zhang Y, Hill J, et al. Death-associated protein kinase 1 promotes growth of p53-mutant cancers. J Clin Invest. 2015;125:2707-20 pubmed 出版商
|
| Mauro Lizcano M, Esteban MartÃnez L, Seco E, Serrano Puebla A, García Ledo L, Figueiredo Pereira C, et al. New method to assess mitophagy flux by flow cytometry. Autophagy. 2015;11:833-43 pubmed 出版商
|
| Roffé M, Lupinacci F, Soares L, Hajj G, Martins V. Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner. Cell Signal. 2015;27:1630-42 pubmed 出版商
|
| Chung J, Bauer D, Ghamari A, Nizzi C, Deck K, Kingsley P, et al. The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Sci Signal. 2015;8:ra34 pubmed 出版商
|
| Iervolino A, Trepiccione F, Petrillo F, Spagnuolo M, Scarfò M, Frezzetti D, et al. Selective dicer suppression in the kidney alters GSK3β/β-catenin pathways promoting a glomerulocystic disease. PLoS ONE. 2015;10:e0119142 pubmed 出版商
|
- 免疫印迹; 人类; 1:1000; 图 1,2,3,4,5,6,7
| Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, et al. Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy. EMBO J. 2015;34:1214-30 pubmed 出版商
|
| Ren H, Wang J, Yang F, Zhang X, Wang A, Sun L, et al. Cytoplasmic TRAF4 contributes to the activation of p70s6k signaling pathway in breast cancer. Oncotarget. 2015;6:4080-96 pubmed
|
| Stolze B, Reinhart S, Bulllinger L, Fröhling S, Scholl C. Comparative analysis of KRAS codon 12, 13, 18, 61, and 117 mutations using human MCF10A isogenic cell lines. Sci Rep. 2015;5:8535 pubmed 出版商
|
| Boj S, Hwang C, Baker L, Chio I, Engle D, Corbo V, et al. Organoid models of human and mouse ductal pancreatic cancer. Cell. 2015;160:324-38 pubmed 出版商
|
| Cebulla J, Huuse E, Pettersen K, van der Veen A, Kim E, Andersen S, et al. MRI reveals the in vivo cellular and vascular response to BEZ235 in ovarian cancer xenografts with different PI3-kinase pathway activity. Br J Cancer. 2015;112:504-13 pubmed 出版商
|
| Qin J, Rajaratnam R, Feng L, Salami J, Barber Rotenberg J, Domsic J, et al. Development of organometallic S6K1 inhibitors. J Med Chem. 2015;58:305-14 pubmed 出版商
|
| Alayev A, Berger S, Kramer M, Schwartz N, Holz M. The combination of rapamycin and resveratrol blocks autophagy and induces apoptosis in breast cancer cells. J Cell Biochem. 2015;116:450-7 pubmed 出版商
|
| Kocher B, White L, Piwnica Worms D. DAPK3 suppresses acini morphogenesis and is required for mouse development. Mol Cancer Res. 2015;13:358-67 pubmed 出版商
|
- 免疫沉淀; 人类; 图 3d
- 免疫印迹; 人类; 图 3a
- 免疫印迹; 小鼠; 图 3h
| Kazyken D, Kaz Y, Kiyan V, Zhylkibayev A, Chen C, Agarwal N, et al. The nuclear import of ribosomal proteins is regulated by mTOR. Oncotarget. 2014;5:9577-93 pubmed
|
| Rodriguez Martin T, Cuchillo Ibanez I, Noble W, Nyenya F, Anderton B, Hanger D. Tau phosphorylation affects its axonal transport and degradation. Neurobiol Aging. 2013;34:2146-57 pubmed 出版商
|
| Chang J, Zhang W, Yeh H, Park M, Yao C, Shi Y, et al. An integrative model for alternative polyadenylation, IntMAP, delineates mTOR-modulated endoplasmic reticulum stress response. Nucleic Acids Res. 2018;46:5996-6008 pubmed 出版商
|
| Wang Y, Wong C, Yan M, Li L, Liu T, Or P, et al. Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma. Cancer Lett. 2018;429:54-65 pubmed 出版商
|
| Romano G, Chen P, Song P, McQuade J, Liang R, Liu M, et al. A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling. Cancer Discov. 2018;8:556-567 pubmed 出版商
|
| Beadnell T, Nassar K, Rose M, Clark E, Danysh B, Hofmann M, et al. Src-mediated regulation of the PI3K pathway in advanced papillary and anaplastic thyroid cancer. Oncogenesis. 2018;7:23 pubmed 出版商
|
| Al Ali H, Ding Y, Slepak T, Wu W, Sun Y, Martinez Y, et al. The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury. J Neurosci. 2017;37:7079-7095 pubmed 出版商
|
| Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, et al. Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017;214:1471-1491 pubmed 出版商
|
| Martins T, Eusebio N, Correia A, Marinho J, Casares F, Pereira P. TGFβ/Activin signalling is required for ribosome biogenesis and cell growth in Drosophila salivary glands. Open Biol. 2017;7: pubmed 出版商
|
| Cervia D, Assi E, De Palma C, Giovarelli M, Bizzozero L, Pambianco S, et al. Essential role for acid sphingomyelinase-inhibited autophagy in melanoma response to cisplatin. Oncotarget. 2016;7:24995-5009 pubmed 出版商
|
| Kiessling M, Curioni Fontecedro A, Samaras P, Lang S, Scharl M, Aguzzi A, et al. Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma. PLoS ONE. 2016;11:e0147682 pubmed 出版商
|
| Young C, Arteaga C, Cook R. Dual inhibition of Type I and Type III PI3 kinases increases tumor cell apoptosis in HER2+ breast cancers. Breast Cancer Res. 2015;17:148 pubmed 出版商
|
| Mahankali M, Farkaly T, Bedi S, Hostetler H, Gomez Cambronero J. Phosphatidic Acid (PA) can Displace PPARα/LXRα Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells. Sci Rep. 2015;5:15379 pubmed 出版商
|
| Hatfield I, Harvey I, Yates E, Redd J, Reiter L, Bridges D. The role of TORC1 in muscle development in Drosophila. Sci Rep. 2015;5:9676 pubmed 出版商
|
| Ayuso M, Martínez Alonso E, Salvador N, Bonova P, Regidor I, Alcázar A. Dissociation of eIF4E-binding protein 2 (4E-BP2) from eIF4E independent of Thr37/Thr46 phosphorylation in the ischemic stress response. PLoS ONE. 2015;10:e0121958 pubmed 出版商
|
| Miettinen T, Björklund M. Modified ribosome profiling reveals high abundance of ribosome protected mRNA fragments derived from 3' untranslated regions. Nucleic Acids Res. 2015;43:1019-34 pubmed 出版商
|
| Akin D, Wang S, Habibzadegah Tari P, Law B, Ostrov D, Li M, et al. A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors. Autophagy. 2014;10:2021-35 pubmed 出版商
|
| Micel L, Tentler J, Tan A, Selby H, Brunkow K, Robertson K, et al. Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants. Mol Cancer Ther. 2015;14:317-25 pubmed 出版商
|
| Katayama R, Friboulet L, Koike S, Lockerman E, Khan T, Gainor J, et al. Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib. Clin Cancer Res. 2014;20:5686-96 pubmed 出版商
|
| Knight Z, Schmidt S, Birsoy K, Tan K, Friedman J. A critical role for mTORC1 in erythropoiesis and anemia. elife. 2014;3:e01913 pubmed 出版商
|
| Wei F, Leung K, Li G, Qin J, Chow S, Huang S, et al. Low intensity pulsed ultrasound enhanced mesenchymal stem cell recruitment through stromal derived factor-1 signaling in fracture healing. PLoS ONE. 2014;9:e106722 pubmed 出版商
|
| Asnaghi L, Lin M, Lim K, Lim K, Tripathy A, Wendeborn M, et al. Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation. PLoS ONE. 2014;9:e105372 pubmed 出版商
|
| Lehmann B, Bauer J, Schafer J, Pendleton C, Tang L, Johnson K, et al. PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors. Breast Cancer Res. 2014;16:406 pubmed 出版商
|
| Wolfe A, Singh K, Zhong Y, Drewe P, Rajasekhar V, Sanghvi V, et al. RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer. Nature. 2014;513:65-70 pubmed 出版商
|
| Romaker D, Kumar V, Cerqueira D, Cox R, Wessely O. MicroRNAs are critical regulators of tuberous sclerosis complex and mTORC1 activity in the size control of the Xenopus kidney. Proc Natl Acad Sci U S A. 2014;111:6335-40 pubmed 出版商
|
| Bitting R, Healy P, Creel P, Turnbull J, Morris K, Wood S, et al. A phase Ib study of combined VEGFR and mTOR inhibition with vatalanib and everolimus in patients with advanced renal cell carcinoma. Clin Genitourin Cancer. 2014;12:241-50 pubmed 出版商
|
| Zhao X, Lu S, Nie J, Hu X, Luo W, Wu X, et al. Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice. Mol Cell Biol. 2014;34:1966-75 pubmed 出版商
|
| Wang C, Bajikar S, Jamal L, Atkins K, Janes K. A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies. Nat Cell Biol. 2014;16:345-56 pubmed 出版商
|
| Manzoni C, Mamais A, Dihanich S, McGoldrick P, Devine M, Zerle J, et al. Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation. Biochem Biophys Res Commun. 2013;441:862-6 pubmed 出版商
|
| Yogev O, Williams V, Hinits Y, Hughes S. eIF4EBP3L acts as a gatekeeper of TORC1 in activity-dependent muscle growth by specifically regulating Mef2ca translational initiation. PLoS Biol. 2013;11:e1001679 pubmed 出版商
|
| Valvezan A, Huang J, Lengner C, Pack M, Klein P. Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish. Dis Model Mech. 2014;7:63-71 pubmed 出版商
|
| Li J, Davies B, Han S, Zhou M, Bai Y, Zhang J, et al. The AKT inhibitor AZD5363 is selectively active in PI3KCA mutant gastric cancer, and sensitizes a patient-derived gastric cancer xenograft model with PTEN loss to Taxotere. J Transl Med. 2013;11:241 pubmed 出版商
|
| Uddin S, Qin Y. Enhancement of osteogenic differentiation and proliferation in human mesenchymal stem cells by a modified low intensity ultrasound stimulation under simulated microgravity. PLoS ONE. 2013;8:e73914 pubmed 出版商
|
| Wong J, Li S, Lim E, Wang Y, Wang C, Zhang H, et al. A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning. PLoS Biol. 2013;11:e1001657 pubmed 出版商
|
| Siebel A, Cubillos Rojas M, Santos R, Schneider T, Bonan C, Bartrons R, et al. Contribution of S6K1/MAPK signaling pathways in the response to oxidative stress: activation of RSK and MSK by hydrogen peroxide. PLoS ONE. 2013;8:e75523 pubmed 出版商
|
| Manzoni C, Mamais A, Dihanich S, Abeti R, Soutar M, Plun Favreau H, et al. Inhibition of LRRK2 kinase activity stimulates macroautophagy. Biochim Biophys Acta. 2013;1833:2900-2910 pubmed 出版商
|
| Kwak S, Jeong M, Choi J, Kim D, Min H, Yoon Y, et al. Amelioration of behavioral abnormalities in BH(4)-deficient mice by dietary supplementation of tyrosine. PLoS ONE. 2013;8:e60803 pubmed 出版商
|
| Lorin S, Tol M, Bauvy C, Strijland A, Poüs C, Verhoeven A, et al. Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy. Autophagy. 2013;9:850-60 pubmed 出版商
|
| Bian S, Sun X, Bai A, Zhang C, Li L, Enjyoji K, et al. P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death. PLoS ONE. 2013;8:e60184 pubmed 出版商
|
| Fabre B, Lambour T, Delobel J, Amalric F, Monsarrat B, Burlet Schiltz O, et al. Subcellular distribution and dynamics of active proteasome complexes unraveled by a workflow combining in vivo complex cross-linking and quantitative proteomics. Mol Cell Proteomics. 2013;12:687-99 pubmed 出版商
|
| Kim S, Jang Y, Chau G, Pyo S, Um S. Prognostic significance and function of phosphorylated ribosomal protein S6 in esophageal squamous cell carcinoma. Mod Pathol. 2013;26:327-35 pubmed 出版商
|
| Syed F, Sherris D, Paus R, Varmeh S, Singh S, Pandolfi P, et al. Keloid disease can be inhibited by antagonizing excessive mTOR signaling with a novel dual TORC1/2 inhibitor. Am J Pathol. 2012;181:1642-58 pubmed 出版商
|
| Thomas A, Lee P, Dalton J, Nomie K, Stoica L, Costa Mattioli M, et al. A versatile method for cell-specific profiling of translated mRNAs in Drosophila. PLoS ONE. 2012;7:e40276 pubmed 出版商
|
| Bates J, Salzman J, May D, García P, Hogan G, McIntosh M, et al. Extensive gene-specific translational reprogramming in a model of B cell differentiation and Abl-dependent transformation. PLoS ONE. 2012;7:e37108 pubmed 出版商
|
| Orr S, Boutz D, Wang R, Chronis C, Lea N, Thayaparan T, et al. Proteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entry. Mol Syst Biol. 2012;8:573 pubmed 出版商
|
| Geissler R, Golbik R, Behrens S. The DEAD-box helicase DDX3 supports the assembly of functional 80S ribosomes. Nucleic Acids Res. 2012;40:4998-5011 pubmed 出版商
|
| Boamah E, Kotova E, Garabedian M, Jarnik M, Tulin A. Poly(ADP-Ribose) polymerase 1 (PARP-1) regulates ribosomal biogenesis in Drosophila nucleoli. PLoS Genet. 2012;8:e1002442 pubmed 出版商
|
| Papageorgiou A, Avruch J. A genome-wide RNAi screen for polypeptides that alter rpS6 phosphorylation. Methods Mol Biol. 2012;821:187-214 pubmed 出版商
|
| Iadevaia V, Zhang Z, Jan E, Proud C. mTOR signaling regulates the processing of pre-rRNA in human cells. Nucleic Acids Res. 2012;40:2527-39 pubmed 出版商
|
| Kye M, Neveu P, Lee Y, Zhou M, Steen J, Sahin M, et al. NMDA mediated contextual conditioning changes miRNA expression. PLoS ONE. 2011;6:e24682 pubmed 出版商
|
| De Raedt T, Walton Z, Yecies J, Li D, Chen Y, Malone C, et al. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell. 2011;20:400-13 pubmed 出版商
|
| Zeidan Q, Wang Z, De Maio A, Hart G. O-GlcNAc cycling enzymes associate with the translational machinery and modify core ribosomal proteins. Mol Biol Cell. 2010;21:1922-36 pubmed 出版商
|
| Liu J, Fong Y, Chang C, Huang C, Chen H, Yang W, et al. Cyclooxygenase-2 enhances alpha2beta1 integrin expression and cell migration via EP1 dependent signaling pathway in human chondrosarcoma cells. Mol Cancer. 2010;9:43 pubmed 出版商
|
| Bensaad K, Cheung E, Vousden K. Modulation of intracellular ROS levels by TIGAR controls autophagy. EMBO J. 2009;28:3015-26 pubmed 出版商
|
| Zhang J, Tomasini A, Mayer A. RBM19 is essential for preimplantation development in the mouse. BMC Dev Biol. 2008;8:115 pubmed 出版商
|
| Tyler W, Tufail Y, Finsterwald M, Tauchmann M, Olson E, Majestic C. Remote excitation of neuronal circuits using low-intensity, low-frequency ultrasound. PLoS ONE. 2008;3:e3511 pubmed 出版商
|