产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
GLI1(L42B10)小鼠单克隆抗体
目录 :
2643
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
L42B10
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫沉淀, 免疫组化-石蜡切片, 免疫印迹基因敲除验证
文章摘录数: 23
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:500; 图 4s1a
Kinnebrew M, Iverson E, Patel B, Pusapati G, Kong J, Johnson K, et al. Cholesterol accessibility at the ciliary membrane controls hedgehog signaling. elife. 2019;8: pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:1000; 图 3c
  • 免疫组化-石蜡切片; 小鼠; 1:100; 图 4d
Coni S, Mancuso A, Di Magno L, Sdruscia G, Manni S, Serrao S, et al. Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. Sci Rep. 2017;7:44079 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 2a
Xu T, Zhang H, Park S, Venneti S, Kuick R, Ha K, et al. Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis. Neoplasia. 2017;19:216-225 pubmed 出版商
  • 免疫印迹; 人类; 图 3c
Das S, Jackson W, Prasain J, Hanna A, Bailey S, Tucker J, et al. Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling. Sci Rep. 2017;7:40773 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Zhao Z, Lee R, Pusapati G, Iyu A, Rohatgi R, Ingham P. An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. EMBO Rep. 2016;17:739-52 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
Vukićević T, Schulz M, Faust D, Klussmann E. The Trafficking of the Water Channel Aquaporin-2 in Renal Principal Cells-a Potential Target for Pharmacological Intervention in Cardiovascular Diseases. Front Pharmacol. 2016;7:23 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Bhattacharyya S, Rainey M, Arya P, Mohapatra B, Mushtaq I, Dutta S, et al. Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development. Sci Rep. 2016;6:20727 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Shi X, Zhan X, Wu J. A positive feedback loop between Gli1 and tyrosine kinase Hck amplifies shh signaling activities in medulloblastoma. Oncogenesis. 2015;4:e176 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5d
Singh J, Wen X, Scales S. The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels. J Biol Chem. 2015;290:29663-75 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Inaguma S, Ito H, Riku M, Ikeda H, Kasai K. Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2. Oncotarget. 2015;6:28257-68 pubmed 出版商
  • 免疫印迹; 人类; 图 4b
  • 免疫印迹; 小鼠; 图 1a
Bora Singhal N, Perumal D, Nguyen J, Chellappan S. Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non-Small Cell Lung Cancer. Neoplasia. 2015;17:538-51 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Lee S, Litan A, Li Z, Graves B, Lindsey S, Barwe S, et al. Na,K-ATPase β1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity. Mol Cancer. 2015;14:159 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Chong Y, Mann R, Zhao C, Kato M, Beachy P. Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5. Genes Dev. 2015;29:262-76 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Shi X, Zhang Z, Zhan X, Cao M, Satoh T, Akira S, et al. An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth. Nat Commun. 2014;5:5425 pubmed 出版商
  • 免疫印迹; 人类
Matsumoto T, Tabata K, Suzuki T. The GANT61, a GLI inhibitor, induces caspase-independent apoptosis of SK-N-LO cells. Biol Pharm Bull. 2014;37:633-41 pubmed
  • 免疫印迹; 小鼠; 图 3
Barakat M, Humke E, Scott M. Kif3a is necessary for initiation and maintenance of medulloblastoma. Carcinogenesis. 2013;34:1382-92 pubmed 出版商
Pusapati G, Kong J, Patel B, Krishnan A, Sagner A, Kinnebrew M, et al. CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Dev Cell. 2018;44:113-129.e8 pubmed 出版商
Zhao Z, Jia Q, Wu M, Xie X, Wang Y, Song G, et al. Degalactotigonin, a Natural Compound from Solanum nigrum L., Inhibits Growth and Metastasis of Osteosarcoma through GSK3β Inactivation-Mediated Repression of the Hedgehog/Gli1 Pathway. Clin Cancer Res. 2018;24:130-144 pubmed 出版商
Po A, Silvano M, Miele E, Capalbo C, Eramo A, Salvati V, et al. Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma. Oncogene. 2017;36:4641-4652 pubmed 出版商
Luchetti G, Sircar R, Kong J, Nachtergaele S, Sagner A, Byrne E, et al. Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling. elife. 2016;5: pubmed 出版商
Byrne E, Sircar R, Miller P, Hedger G, Luchetti G, Nachtergaele S, et al. Structural basis of Smoothened regulation by its extracellular domains. Nature. 2016;535:517-522 pubmed 出版商
Carbe C, Cheng L, Addya S, Gold J, Gao E, Koch W, et al. Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium. Am J Physiol Heart Circ Physiol. 2014;307:H66-72 pubmed 出版商
Beauchamp E, Ringer L, Bulut G, Sajwan K, Hall M, Lee Y, et al. Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway. J Clin Invest. 2011;121:148-60 pubmed 出版商
产品信息
SKU号 :
2643S
产品名称 :
GLI1(L42B10)小鼠单克隆抗体
规格 :
100微升
Price-(USD) :
235美元
物种x :
H
应用 :
免疫沉淀
产品种类 :
发育生物学
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
160
宿主 :
小鼠
靶标 :
GLI1
最初蛋白 :
GLI1
别名 :
GLI,GLI family zinc finger 1,GLI1,Glioma-associated oncogene,Oncogene GLI,Zinc finger protein GLI1,glioma-associated oncogene family zinc finger 1,glioma-associated oncogene homolog 1 (zinc finger protein)
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。