产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
毛细血管扩张性共济失调症突变蛋白(D2E2)兔单克隆抗体
目录 :
2873
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
D2E2
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫沉淀, 其他
文章摘录数: 69
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:3500; 图 5j
Xia R, Liu T, Li W, Xu X. RNA-binding protein RBM24 represses colorectal tumourigenesis by stabilising PTEN mRNA. Clin Transl Med. 2021;11:e383 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5d
Maurizy C, Abeza C, Lemmers B, Gabola M, Longobardi C, Pinet V, et al. The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium. Nat Commun. 2021;12:4810 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s5d
Laine A, Nagelli S, Farrington C, Butt U, Cvrljevic A, Vainonen J, et al. CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis. Cancer Res. 2021;81:4319-4331 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 7h
Sato M, Kadomatsu T, Miyata K, Warren J, Tian Z, Zhu S, et al. The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis. Nat Commun. 2021;12:2529 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1b
Ho K, Luo H, Zhu W, Tang Y. Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress. Sci Rep. 2021;11:7502 pubmed 出版商
  • 免疫印迹; 人类; 图 4c
Clementi E, Inglin L, Beebe E, Gsell C, Garajova Z, Markkanen E. Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction. BMC Biol. 2020;18:36 pubmed 出版商
  • 免疫印迹; 人类; 图 2b, 2d
Lochab S, Singh Y, Sengupta S, Nandicoori V. Mycobacterium tuberculosis exploits host ATM kinase for survival advantage through SecA2 secretome. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5b
Li K, Zhao S, Long J, Su J, Wu L, Tao J, et al. A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products. Cancer Cell Int. 2020;20:36 pubmed 出版商
  • 免疫印迹; 人类; 图 1d
  • 免疫印迹; 小鼠; 图 6c
Song Y, Lu H, Wang Q, Xiang R. Targeting Angiogenesis by Blocking the ATM-SerRS-VEGFA Pathway for UV-Induced Skin Photodamage and Melanoma Growth. Cancers (Basel). 2019;11: pubmed 出版商
  • 免疫印迹; 人类; 图 3i
Lang X, Green M, Wang W, Yu J, Choi J, Jiang L, et al. Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11. Cancer Discov. 2019;9:1673-1685 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1a
Martínez J, Tarallo D, Martinez Palma L, Victoria S, Bresque M, Rodriguez Bottero S, et al. Mitofusins modulate the increase in mitochondrial length, bioenergetics and secretory phenotype in therapy-induced senescent melanoma cells. Biochem J. 2019;476:2463-2486 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5e
Gross K, Zhou W, Breindel J, Ouyang J, Jin D, Sokol E, et al. Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium. Cell Rep. 2019;28:394-407.e6 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5b
Ergun S, Fernandez D, Weiss T, Li L. STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition. Cell. 2019;: pubmed 出版商
  • 免疫印迹; 人类; 图 3b
Li K, Meng Z, Jiang L, Xia C, Xu K, Yuan D, et al. CDKL1 promotes the chemoresistance of human oral squamous cell carcinoma cells to hydroxycamptothecin. Mol Cell Probes. 2019;44:57-62 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s6a
Gronke K, Hernandez P, Zimmermann J, Klose C, Kofoed Branzk M, Guendel F, et al. Interleukin-22 protects intestinal stem cells against genotoxic stress. Nature. 2019;566:249-253 pubmed 出版商
  • 免疫印迹; 人类; 图 5g
Meisenberg C, Pinder S, Hopkins S, Wooller S, Benstead Hume G, Pearl F, et al. Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability. Mol Cell. 2019;73:212-223.e7 pubmed 出版商
  • 其他; 人类; 图 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Paul A, Wang B. RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage. Mol Cell. 2017;66:458-472.e5 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s3a
Kang H, Park J, Choi K, Kim Y, Choi H, Jung C, et al. Chemical screening identifies ATM as a target for alleviating senescence. Nat Chem Biol. 2017;13:616-623 pubmed 出版商
  • 免疫印迹; 人类; 图 3e
Smith E, Gole B, Willis N, Soria R, Starnes L, Krumpelbeck E, et al. DEK is required for homologous recombination repair of DNA breaks. Sci Rep. 2017;7:44662 pubmed 出版商
  • 免疫印迹; 人类; 图 3b
Xu P, Zhou Z, Xiong M, Zou W, Deng X, Ganaie S, et al. Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway. PLoS Pathog. 2017;13:e1006266 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Stav Noraas T, Edelmann R, Poulsen L, Sundnes O, Phung D, Küchler A, et al. Endothelial IL-33 Expression Is Augmented by Adenoviral Activation of the DNA Damage Machinery. J Immunol. 2017;198:3318-3325 pubmed 出版商
  • 免疫印迹; 人类; 图 2a, 2b
Karanika S, Karantanos T, Li L, Wang J, Park S, Yang G, et al. Targeting DNA Damage Response in Prostate Cancer by Inhibiting Androgen Receptor-CDC6-ATR-Chk1 Signaling. Cell Rep. 2017;18:1970-1981 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5B
Kemter E, Frohlich T, Arnold G, Wolf E, Wanke R. Mitochondrial Dysregulation Secondary to Endoplasmic Reticulum Stress in Autosomal Dominant Tubulointerstitial Kidney Disease - UMOD (ADTKD-UMOD). Sci Rep. 2017;7:42970 pubmed 出版商
  • 免疫印迹; 人类; 图 s8b
Meisenberg C, Ashour M, El Shafie L, Liao C, Hodgson A, Pilborough A, et al. Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Res. 2017;45:1159-1176 pubmed 出版商
  • 免疫印迹; 人类; 1:100; 图 st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed 出版商
  • 免疫印迹; 人类; 图 6b
Cassimere E, Mauvais C, Denicourt C. p27Kip1 Is Required to Mediate a G1 Cell Cycle Arrest Downstream of ATM following Genotoxic Stress. PLoS ONE. 2016;11:e0162806 pubmed 出版商
  • 免疫印迹; 人类; 图 s2
Hong X, Liu W, Song R, Shah J, Feng X, Tsang C, et al. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res. 2016;44:8855-8869 pubmed
  • 免疫印迹; 人类; 图 3d
Peng Y, Miao H, Wu S, Yang W, Zhang Y, Xie G, et al. ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2. Autophagy. 2016;12:2167-2182 pubmed
  • 免疫印迹; 人类; 图 4
Ah Koon L, Lesage D, Lemadre E, Souissi I, Fagard R, Varin Blank N, et al. Cellular response to alkylating agent MNNG is impaired in STAT1-deficients cells. J Cell Mol Med. 2016;20:1956-65 pubmed 出版商
  • 免疫印迹; 人类; 图 5d
Luo H, Cowen L, Yu G, Jiang W, Tang Y. SMG7 is a critical regulator of p53 stability and function in DNA damage stress response. Cell Discov. 2016;2:15042 pubmed 出版商
  • 免疫印迹; 人类; 图 5c
Chen C, Tsao N, Huang L, Yen Y, Liu X, Lehman C, et al. The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells. Cell Rep. 2016;16:1287-1299 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 8
Yang H, Wu L, Ke S, Wang W, Yang L, Gao X, et al. Downregulation of Ubiquitin-conjugating Enzyme UBE2D3 Promotes Telomere Maintenance and Radioresistance of Eca-109 Human Esophageal Carcinoma Cells. J Cancer. 2016;7:1152-62 pubmed 出版商
  • 免疫印迹; 人类; 图 S4
Sears C, Cooney S, Chin Sinex H, Mendonca M, Turchi J. DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer. DNA Repair (Amst). 2016;40:35-46 pubmed 出版商
  • 免疫印迹; 小鼠; 图 8f
Martin B, Chadwick W, Janssens J, Premont R, Schmalzigaug R, Becker K, et al. GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging. Front Endocrinol (Lausanne). 2015;6:191 pubmed 出版商
  • 免疫印迹; 人类; 图 4d
Chavoshi S, Egorova O, Lacdao I, Farhadi S, Sheng Y, Saridakis V. Identification of Kaposi Sarcoma Herpesvirus (KSHV) vIRF1 Protein as a Novel Interaction Partner of Human Deubiquitinase USP7. J Biol Chem. 2016;291:6281-91 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Kralovicova J, Knut M, Cross N, Vorechovsky I. Exon-centric regulation of ATM expression is population-dependent and amenable to antisense modification by pseudoexon targeting. Sci Rep. 2016;6:18741 pubmed 出版商
  • 免疫印迹; 人类; 图 5c
García V, Lara Chica M, Cantarero I, Sterner O, Calzado M, Muñoz E. Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells. Oncotarget. 2016;7:4490-506 pubmed 出版商
  • 免疫印迹; 人类; 图 6b
Hausmann C, Temme A, Cordes N, Eke I. ILKAP, ILK and PINCH1 control cell survival of p53-wildtype glioblastoma cells after irradiation. Oncotarget. 2015;6:34592-605 pubmed 出版商
  • 免疫印迹; 人类; 图 2g
Guo Y, Feng W, Sy S, Huen M. ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response. J Biol Chem. 2015;290:27545-56 pubmed 出版商
  • 免疫印迹; 人类; 图 3h
Torres M, Pandita R, Kulak O, Kumar R, Formstecher E, Horikoshi N, et al. Role of the Exocyst Complex Component Sec6/8 in Genomic Stability. Mol Cell Biol. 2015;35:3633-45 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s3
Hartlerode A, Morgan M, Wu Y, Buis J, Ferguson D. Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors. Nat Struct Mol Biol. 2015;22:736-43 pubmed 出版商
  • 免疫沉淀; 小鼠; 图 8
  • 免疫印迹; 小鼠; 图 5
Wang J, Chen S, Sun C, Chien T, Chern Y. A central role of TRAX in the ATM-mediated DNA repair. Oncogene. 2016;35:1657-70 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1g
Masuda Y, Takahashi H, Sato S, Tomomori Sato C, Saraf A, Washburn M, et al. TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. Nat Commun. 2015;6:7299 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Neumann J, Yang Y, Köhler R, Giaisi M, Witzens Harig M, Liu D, et al. Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest. Int J Cancer. 2015;137:2739-48 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Hollingworth R, Skalka G, Stewart G, Hislop A, Blackbourn D, Grand R. Activation of DNA Damage Response Pathways during Lytic Replication of KSHV. Viruses. 2015;7:2908-27 pubmed 出版商
  • 免疫印迹; 人类; 图 5e
Guendel I, Meltzer B, Baer A, Dever S, Valerie K, Guo J, et al. BRCA1 functions as a novel transcriptional cofactor in HIV-1 infection. Virol J. 2015;12:40 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1,2,3,4,5,6,7
Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, et al. Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy. EMBO J. 2015;34:1214-30 pubmed 出版商
  • 免疫印迹; 人类; 图 S11
Wang L, Liu R, Ye P, Wong C, Chen G, Zhou P, et al. Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun. 2015;6:5909 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6d
Cao J, Lu Y, Qi J, An G, Mao Z, Jia H, et al. MiR-630 inhibits proliferation by targeting CDC7 kinase, but maintains the apoptotic balance by targeting multiple modulators in human lung cancer A549 cells. Cell Death Dis. 2014;5:e1426 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Chen Z, Liu B, Tang N, Xu Y, Ye X, Li Z, et al. FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response. Nucleic Acids Res. 2014;42:11560-9 pubmed 出版商
  • 免疫印迹; 人类
Lin B, Gupta D, Heinen C. Human pluripotent stem cells have a novel mismatch repair-dependent damage response. J Biol Chem. 2014;289:24314-24 pubmed 出版商
  • 免疫印迹; 小鼠
Schweikl H, Petzel C, Bolay C, Hiller K, Buchalla W, Krifka S. 2-Hydroxyethyl methacrylate-induced apoptosis through the ATM- and p53-dependent intrinsic mitochondrial pathway. Biomaterials. 2014;35:2890-904 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Chen Y, Kamili A, Hardy J, Groblewski G, Khanna K, Byrne J. Tumor protein D52 represents a negative regulator of ATM protein levels. Cell Cycle. 2013;12:3083-97 pubmed 出版商
  • 免疫印迹; 人类
Hu R, Wang E, Peng G, Dai H, Lin S. Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage. Cell Cycle. 2013;12:2033-41 pubmed 出版商
Zhao J, Dang X, Zhang P, Nguyen L, Cao D, Wang L, et al. Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection. Cell Discov. 2018;4:16 pubmed 出版商
Gao X, Wang W, Yang H, Wu L, He Z, Zhou S, et al. UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo. Oncotarget. 2016;7:32543-53 pubmed 出版商
Mihailovich M, Bremang M, Spadotto V, Musiani D, Vitale E, Varano G, et al. miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth. Nat Commun. 2015;6:8725 pubmed 出版商
Schoors S, Bruning U, Missiaen R, Queiroz K, Borgers G, Elia I, et al. Fatty acid carbon is essential for dNTP synthesis in endothelial cells. Nature. 2015;520:192-197 pubmed 出版商
Huang C, Chuang C, Shu W, Chang C, Chen C, Fan T, et al. Distinct epidermal keratinocytes respond to extremely low-frequency electromagnetic fields differently. PLoS ONE. 2014;9:e113424 pubmed 出版商
Huang C, Chang C, Chen C, Chuang C, Chiang C, Shu W, et al. Extremely low-frequency electromagnetic fields cause G1 phase arrest through the activation of the ATM-Chk2-p21 pathway. PLoS ONE. 2014;9:e104732 pubmed 出版商
Krześniak M, Zajkowicz A, Matuszczyk I, Rusin M. Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D. Mech Ageing Dev. 2014;139:11-21 pubmed 出版商
Katyal S, Lee Y, Nitiss K, Downing S, Li Y, Shimada M, et al. Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014;17:813-21 pubmed 出版商
Jin Y, An G, Ni J, Li S, Jia H. ATM-dependent E2F1 accumulation in the nucleolus is an indicator of ribosomal stress in early response to DNA damage. Cell Cycle. 2014;13:1627-38 pubmed 出版商
Rizos H, Menzies A, Pupo G, Carlino M, Fung C, Hyman J, et al. BRAF inhibitor resistance mechanisms in metastatic melanoma: spectrum and clinical impact. Clin Cancer Res. 2014;20:1965-77 pubmed 出版商
Tang H, Sampath P, Yan X, Thorne S. Potential for enhanced therapeutic activity of biological cancer therapies with doxycycline combination. Gene Ther. 2013;20:770-8 pubmed 出版商
Hawkes W, Printsev I, Alkan Z. Selenoprotein W depletion induces a p53- and p21-dependent delay in cell cycle progression in RWPE-1 prostate epithelial cells. J Cell Biochem. 2012;113:61-9 pubmed 出版商
Zhu H, Yue J, Pan Z, Wu H, Cheng Y, Lu H, et al. Involvement of Caveolin-1 in repair of DNA damage through both homologous recombination and non-homologous end joining. PLoS ONE. 2010;5:e12055 pubmed 出版商
Fuchs F, Pau G, Kranz D, Sklyar O, Budjan C, Steinbrink S, et al. Clustering phenotype populations by genome-wide RNAi and multiparametric imaging. Mol Syst Biol. 2010;6:370 pubmed 出版商
产品信息
SKU号 :
2873S
产品名称 :
毛细血管扩张性共济失调症突变蛋白(D2E2)兔单克隆抗体
规格 :
100微升
Price-(USD) :
235美元
物种x :
H, M
应用 :
免疫印迹
产品种类 :
细胞周期/节律点控制
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
350
宿主 :
靶标 :
毛细血管扩张性共济失调症突变蛋白
最初蛋白 :
毛细血管扩张性共济失调症突变蛋白
别名 :
A-T mutated,AT mutated,AT1,ATA,ATC,ATD,ATDC,ATE,ATM,Ataxia telangiectasia mutated,DKFZp781A0353,MGC74674,Serine-protein kinase ATM,TEL1,TEL1, telomere maintenance 1, homolog,TELO1,ataxia telangiectasia mutated (includes complementation groups A, C and D),human phosphatidylinositol 3-kinase homolog
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。