产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
Ezh2(AC22)小鼠单克隆抗体
目录 :
3147
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
AC22
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀 , 免疫组化-石蜡切片, 其他, 免疫印迹基因敲除验证
文章摘录数: 57
出版应用/物种/样品/稀释参考文献
  • 免疫组化; 小鼠; 图 1h
  • 免疫印迹; 小鼠; 图 1a
Ferreira M, Verbinnen I, Fardilha M, Van Eynde A, Bollen M. The deletion of the protein phosphatase 1 regulator NIPP1 in testis causes hyperphosphorylation and degradation of the histone methyltransferase EZH2. J Biol Chem. 2018;293:18031-18039 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2c
  • 免疫印迹; 人类; 图 2a
Xia L, Huang W, Bellani M, Seidman M, Wu K, Fan D, et al. CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes. Cancer Cell. 2017;31:653-668.e7 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s10
He Y, Selvaraju S, Curtin M, Jakob C, Zhu H, Comess K, et al. The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol. 2017;13:389-395 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 1a
Göllner S, Oellerich T, Agrawal Singh S, Schenk T, Klein H, Rohde C, et al. Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia. Nat Med. 2017;23:69-78 pubmed 出版商
  • 免疫印迹; 人类; 图 4b
Katsushima K, Natsume A, Ohka F, Shinjo K, Hatanaka A, Ichimura N, et al. Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment. Nat Commun. 2016;7:13616 pubmed 出版商
  • 免疫沉淀; 人类; 图 5
  • 免疫细胞化学; 人类; 图 3
  • 免疫印迹; 人类; 图 5
Wang Y, Sun H, Wang J, Wang H, Meng L, Xu C, et al. DNA-PK-mediated phosphorylation of EZH2 regulates the DNA damage-induced apoptosis to maintain T-cell genomic integrity. Cell Death Dis. 2016;7:e2316 pubmed 出版商
  • 免疫印迹; 人类; 图 s6
Itahana Y, Zhang J, Göke J, Vardy L, Han R, Iwamoto K, et al. Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells. Sci Rep. 2016;6:28112 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
Chung H, Xu C, Fuchs A, Mund A, Lange M, Staege H, et al. PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3. elife. 2016;5: pubmed 出版商
  • 免疫印迹; 小鼠; 图 s12d
Lu C, Jain S, Hoelper D, Bechet D, Molden R, Ran L, et al. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science. 2016;352:844-9 pubmed 出版商
  • 免疫印迹; 人类; 图 3c
Kopparapu P, Bhoi S, Mansouri L, Arabanian L, Plevova K, Pospisilova S, et al. Epigenetic silencing of miR-26A1 in chronic lymphocytic leukemia and mantle cell lymphoma: Impact on EZH2 expression. Epigenetics. 2016;11:335-43 pubmed 出版商
  • 免疫印迹; 人类; 图 1c
Jo S, Lee Y, Kim S, Lee H, Chung H. PCGF2 negatively regulates arsenic trioxide-induced PML-RARA protein degradation via UBE2I inhibition in NB4 cells. Biochim Biophys Acta. 2016;1863:1499-509 pubmed 出版商
  • 免疫印迹; 人类; 图 4b
Grohar P, Kim S, Rangel Rivera G, Sen N, Haddock S, Harlow M, et al. Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma. Cell Rep. 2016;14:598-610 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Zhang Q, Wan M, Shi J, Horita D, Miller L, Kute T, et al. Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation. J Mol Cell Biol. 2016;8:232-43 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:75; 图 s1
Zemke M, Draganova K, Klug A, Schöler A, Zurkirchen L, Gay M, et al. Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation. BMC Biol. 2015;13:103 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 1
Grassian A, Scales T, Knutson S, Kuntz K, McCarthy N, Lowe C, et al. A Medium-Throughput Single Cell CRISPR-Cas9 Assay to Assess Gene Essentiality. Biol Proced Online. 2015;17:15 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7a
Oravecz A, Apostolov A, Polak K, Jost B, Le Gras S, Chan S, et al. Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2. Nat Commun. 2015;6:8823 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 4
  • 免疫印迹; 人类; 图 4
Pacini L, Savini C, Ghittoni R, Saidj D, Lamartine J, Hasan U, et al. Downregulation of Toll-Like Receptor 9 Expression by Beta Human Papillomavirus 38 and Implications for Cell Cycle Control. J Virol. 2015;89:11396-405 pubmed 出版商
  • 免疫沉淀; 小鼠; 图 5
  • 免疫印迹; 小鼠; 1:1000; 图 s11
Fei Q, Yang X, Jiang H, Wang Q, Yu Y, Yu Y, et al. SETDB1 modulates PRC2 activity at developmental genes independently of H3K9 trimethylation in mouse ES cells. Genome Res. 2015;25:1325-35 pubmed 出版商
  • 免疫印迹; 人类; 1:3000; 图 7
Heubach J, Monsior J, Deenen R, Niegisch G, Szarvas T, Niedworok C, et al. The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells. Mol Cancer. 2015;14:108 pubmed 出版商
  • 免疫印迹; 人类; 图 1d
Chen H, Gao S, Li J, Liu D, Sheng C, Yao C, et al. Wedelolactone disrupts the interaction of EZH2-EED complex and inhibits PRC2-dependent cancer. Oncotarget. 2015;6:13049-59 pubmed
  • 免疫印迹; 人类; 图 4
Matsuda Y, Kobayashi Ishihara M, Fujikawa D, Ishida T, Watanabe T, Yamagishi M. Epigenetic heterogeneity in HIV-1 latency establishment. Sci Rep. 2015;5:7701 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Wurm S, Zhang J, Guinea Viniegra J, García F, Muñoz J, Bakiri L, et al. Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2. Genes Dev. 2015;29:144-56 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 s4d
  • 免疫印迹; 人类; 图 s4d
Kim H, Park J, Won H, Lee J, Kong G. CBX7 inhibits breast tumorigenicity through DKK-1-mediated suppression of the Wnt/β-catenin pathway. FASEB J. 2015;29:300-13 pubmed 出版商
  • 其他; 大鼠; 图 5a
Atta H, El Rehany M, Hammam O, Abdel Ghany H, Ramzy M, Roderfeld M, et al. Mutant MMP-9 and HGF gene transfer enhance resolution of CCl4-induced liver fibrosis in rats: role of ASH1 and EZH2 methyltransferases repression. PLoS ONE. 2014;9:e112384 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Iannetti A, Ledoux A, Tudhope S, Sellier H, Zhao B, Mowla S, et al. Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence. PLoS Genet. 2014;10:e1004642 pubmed 出版商
  • 免疫沉淀; 人类
Negishi M, Wongpalee S, Sarkar S, Park J, Lee K, Shibata Y, et al. A new lncRNA, APTR, associates with and represses the CDKN1A/p21 promoter by recruiting polycomb proteins. PLoS ONE. 2014;9:e95216 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:50
Piper M, Barry G, Harvey T, McLeay R, Smith A, Harris L, et al. NFIB-mediated repression of the epigenetic factor Ezh2 regulates cortical development. J Neurosci. 2014;34:2921-30 pubmed 出版商
  • 免疫印迹; 小鼠
Lee S, Phipson B, Hyland C, Leong H, Allan R, Lun A, et al. Polycomb repressive complex 2 (PRC2) suppresses E?-myc lymphoma. Blood. 2013;122:2654-63 pubmed 出版商
  • 免疫组化; 小鼠
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Natsume A, Ito M, Katsushima K, Ohka F, Hatanaka A, Shinjo K, et al. Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma. Cancer Res. 2013;73:4559-70 pubmed 出版商
  • 免疫细胞化学; 人类
Martin N, Popov N, Aguilo F, O Loghlen A, Raguz S, Snijders A, et al. Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK?a regulation. EMBO J. 2013;32:982-95 pubmed 出版商
Barsotti A, Ryskin M, Zhong W, Zhang W, Giannakou A, Loreth C, et al. Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth. Oncotarget. 2015;6:2928-38 pubmed
Gaudichon J, Milano F, Cahu J, DaCosta L, Martens A, Renoir J, et al. Deazaneplanocin a is a promising drug to kill multiple myeloma cells in their niche. PLoS ONE. 2014;9:e107009 pubmed 出版商
Cho S, Park J, Kang Y. AGO2 and SETDB1 cooperate in promoter-targeted transcriptional silencing of the androgen receptor gene. Nucleic Acids Res. 2014;42:13545-56 pubmed 出版商
Riquelme E, Suraokar M, Behrens C, Lin H, Girard L, Nilsson M, et al. VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapy. Clin Cancer Res. 2014;20:3849-61 pubmed 出版商
Baas R, Lelieveld D, van Teeffelen H, Lijnzaad P, Castelijns B, van Schaik F, et al. A novel microscopy-based high-throughput screening method to identify proteins that regulate global histone modification levels. J Biomol Screen. 2014;19:287-96 pubmed 出版商
Ding X, Wang X, Sontag S, Qin J, Wanek P, Lin Q, et al. The polycomb protein Ezh2 impacts on induced pluripotent stem cell generation. Stem Cells Dev. 2014;23:931-40 pubmed 出版商
Nakashima Y, Haneji T. Stimulation of osteoclast formation by RANKL requires interferon regulatory factor-4 and is inhibited by simvastatin in a mouse model of bone loss. PLoS ONE. 2013;8:e72033 pubmed 出版商
Stovall D, Wan M, Miller L, Cao P, Maglic D, Zhang Q, et al. The regulation of SOX7 and its tumor suppressive role in breast cancer. Am J Pathol. 2013;183:1645-1653 pubmed 出版商
Coe B, Thu K, Aviel Ronen S, Vucic E, Gazdar A, Lam S, et al. Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer. PLoS ONE. 2013;8:e71670 pubmed 出版商
Saurat N, Andersson T, Vasistha N, Molnár Z, Livesey F. Dicer is required for neural stem cell multipotency and lineage progression during cerebral cortex development. Neural Dev. 2013;8:14 pubmed 出版商
Holdt L, Hoffmann S, Sass K, Langenberger D, Scholz M, Krohn K, et al. Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. PLoS Genet. 2013;9:e1003588 pubmed 出版商
Au S, Wong C, Lee J, Wong C, Ng I. EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers. PLoS ONE. 2013;8:e68226 pubmed 出版商
Pommier A, Dufour J, Alves G, Viennois E, de Boussac H, Trousson A, et al. Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice. PLoS Genet. 2013;9:e1003483 pubmed 出版商
Laursen K, Mongan N, Zhuang Y, Ng M, Benoit Y, Gudas L. Polycomb recruitment attenuates retinoic acid-induced transcription of the bivalent NR2F1 gene. Nucleic Acids Res. 2013;41:6430-43 pubmed 出版商
Accardi R, Fathallah I, Gruffat H, Mariggiò G, Le Calvez Kelm F, Voegele C, et al. Epstein - Barr virus transforming protein LMP-1 alters B cells gene expression by promoting accumulation of the oncoprotein ?Np73?. PLoS Pathog. 2013;9:e1003186 pubmed 出版商
Hagarman J, Motley M, Kristjansdottir K, Soloway P. Coordinate regulation of DNA methylation and H3K27me3 in mouse embryonic stem cells. PLoS ONE. 2013;8:e53880 pubmed 出版商
Niegisch G, Knievel J, Koch A, Hader C, Fischer U, Albers P, et al. Changes in histone deacetylase (HDAC) expression patterns and activity of HDAC inhibitors in urothelial cancers. Urol Oncol. 2013;31:1770-9 pubmed 出版商
Wan M, Huang W, Kute T, Miller L, Zhang Q, Hatcher H, et al. Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27. Am J Pathol. 2012;180:2120-33 pubmed 出版商
Esposito F, Tornincasa M, Pallante P, Federico A, Borbone E, Pierantoni G, et al. Down-regulation of the miR-25 and miR-30d contributes to the development of anaplastic thyroid carcinoma targeting the polycomb protein EZH2. J Clin Endocrinol Metab. 2012;97:E710-8 pubmed 出版商
Stojic L, Jasencakova Z, Prezioso C, Stützer A, Bodega B, Pasini D, et al. Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells. Epigenetics Chromatin. 2011;4:16 pubmed 出版商
Fussbroich B, Wagener N, Macher Goeppinger S, Benner A, Fälth M, Sultmann H, et al. EZH2 depletion blocks the proliferation of colon cancer cells. PLoS ONE. 2011;6:e21651 pubmed 出版商
Xie Z, Bi C, Cheong L, Liu S, Huang G, Zhou J, et al. Determinants of sensitivity to DZNep induced apoptosis in multiple myeloma cells. PLoS ONE. 2011;6:e21583 pubmed 出版商
Testoni B, Schinzari V, Guerrieri F, Gerbal Chaloin S, Blandino G, Levrero M. p53-paralog DNp73 oncogene is repressed by IFN?/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor. Oncogene. 2011;30:2670-8 pubmed 出版商
Angrisano T, Sacchetti S, Natale F, Cerrato A, Pero R, Keller S, et al. Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells. Nucleic Acids Res. 2011;39:1993-2006 pubmed 出版商
Hebbard L, Cecena G, Golas J, Sawada J, Ellies L, Charbono A, et al. Control of mammary tumor differentiation by SKI-606 (bosutinib). Oncogene. 2011;30:301-12 pubmed 出版商
Van Dessel N, Beke L, Görnemann J, Minnebo N, Beullens M, Tanuma N, et al. The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets. Nucleic Acids Res. 2010;38:7500-12 pubmed 出版商
Kalushkova A, Fryknäs M, Lemaire M, Fristedt C, Agarwal P, Eriksson M, et al. Polycomb target genes are silenced in multiple myeloma. PLoS ONE. 2010;5:e11483 pubmed 出版商
产品信息
SKU号 :
3147S
产品名称 :
Ezh2(AC22)小鼠单克隆抗体
规格 :
100微升
Price-(USD) :
235美元
物种x :
H, M, R, Mk
应用 :
免疫荧光(免疫细胞化学)
产品种类 :
Chromatin Regulation / Nuclear Function
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
98
宿主 :
小鼠
靶标 :
EZH2
最初蛋白 :
EZH2
别名 :
ENX-1,ENX1,EZH1,EZH2,Enhancer of zeste homolog 2,Histone-lysine N-methyltransferase EZH2,KMT6,KMT6A,Lysine N-methyltransferase 6,MGC9169,enhancer of zeste 2,enhancer of zeste homolog 2 (Drosophila)
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。