产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
Phospho-Akt (Ser473) (736E11) Rabbit mAb
目录 :
3787
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
736E11
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化-自由浮动切片
文章摘录数: 82
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 图 4d
Lee M, Jung K, Song J, Sung M, Ahn S, Lee B, et al. IRS2 Amplification as a Predictive Biomarker in Response to Ceritinib in Small Cell Lung Cancer. Mol Ther Oncolytics. 2020;16:188-196 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 4n, e9s
Tan S, Swathi Y, Tan S, Goh J, Seishima R, Murakami K, et al. AQP5 enriches for stem cells and cancer origins in the distal stomach. Nature. 2020;578:437-443 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s6a
Hsu H, Liu C, Lin J, Hsu T, Hsu J, Li A, et al. Involvement of collagen XVII in pluripotency gene expression and metabolic reprogramming of lung cancer stem cells. J Biomed Sci. 2020;27:5 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 s2b
Gao L, Hu Y, Tian Y, Fan Z, Wang K, Li H, et al. Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Nat Commun. 2019;10:1665 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3d
Yao W, Rose J, Wang W, Seth S, Jiang H, Taguchi A, et al. Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Nature. 2019;: pubmed 出版商
  • 免疫印迹; 人类; 图 2b
  • 免疫印迹; 小鼠; 图 7c
Wang W, Shen T, Dong B, Creighton C, Meng Y, Zhou W, et al. MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling. J Clin Invest. 2019;: pubmed 出版商
  • 免疫印迹; 人类; 图 7b1
  • 免疫印迹; 小鼠; 图 7b2
Zhu Y, Qu C, Hong X, Jia Y, Lin M, Luo Y, et al. Trabid inhibits hepatocellular carcinoma growth and metastasis by cleaving RNF8-induced K63 ubiquitination of Twist1. Cell Death Differ. 2019;26:306-320 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:50; 图 s6h, s14f, s15g
  • 免疫组化-石蜡切片; 人类; 1:50; 图 s17b
Ruess D, Heynen G, Ciecielski K, Ai J, Berninger A, Kabacaoglu D, et al. Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med. 2018;24:954-960 pubmed 出版商
  • 免疫组化; 人类; 1:50; 图 7
Xiao Z, Gaertner S, Morresi Hauf A, Genzel R, Duell T, Ullrich A, et al. Metformin Triggers Autophagy to Attenuate Drug-Induced Apoptosis in NSCLC Cells, with Minor Effects on Tumors of Diabetic Patients. Neoplasia. 2017;19:385-395 pubmed 出版商
  • 免疫印迹; 人类; 图 s2f
Zhao D, Lu X, Wang G, Lan Z, Liao W, Li J, et al. Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer. Nature. 2017;542:484-488 pubmed 出版商
  • 免疫组化; 人类; 图 5a
  • 免疫组化; 小鼠; 图 6a
Chen Y, Li C, Xie H, Fan Y, Yang Z, Ma J, et al. Infiltrating mast cells promote renal cell carcinoma angiogenesis by modulating PI3K→︀AKT→︀GSK3β→︀AM signaling. Oncogene. 2017;36:2879-2888 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:50; 图 4i
Barcus C, O Leary K, Brockman J, Rugowski D, Liu Y, Garcia N, et al. Elevated collagen-I augments tumor progressive signals, intravasation and metastasis of prolactin-induced estrogen receptor alpha positive mammary tumor cells. Breast Cancer Res. 2017;19:9 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 s3
Kidger A, Rushworth L, Stellzig J, Davidson J, Bryant C, Bayley C, et al. Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling. Proc Natl Acad Sci U S A. 2017;114:E317-E326 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Cao J, Tyburczy M, Moss J, Darling T, Widlund H, Kwiatkowski D. Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation. J Clin Invest. 2017;127:349-364 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5a
Hong J, Shin M, Douglas I, Chung K, Kim E, Jung J, et al. Inhibition of EphA2/EphrinA1 signal attenuates lipopolysaccharide-induced lung injury. Clin Sci (Lond). 2016;130:1993-2003 pubmed
  • 免疫印迹; 小鼠; 1:3000; 图 3
Balasooriya G, Johnson J, Basson M, Rawlins E. An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium. Dev Cell. 2016;37:85-97 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 4
  • 免疫组化-石蜡切片; 人类; 图 7
Du L, Chen X, Cao Y, Lu L, Zhang F, Bornstein S, et al. Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFβ signaling. Oncogene. 2016;35:4641-52 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Luo C, Liao W, Dadi S, Toure A, Li M. Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Nature. 2016;529:532-6 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2
  • 免疫印迹; 人类; 1:1000; 图 2
Xu D, Shan B, Lee B, Zhu K, Zhang T, Sun H, et al. Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system. elife. 2015;4:e10510 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3a
Singh S, Chand H, Gundavarapu S, Saeed A, Langley R, Tesfaigzi Y, et al. HIF-1α Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice. PLoS ONE. 2015;10:e0137757 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6
Conde Perez A, Gros G, Longvert C, Pedersen M, Petit V, Aktary Z, et al. A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity. Nat Commun. 2015;6:8093 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Artero Castro A, Perez Alea M, Feliciano A, Leal J, Genestar M, Castellvi J, et al. Disruption of the ribosomal P complex leads to stress-induced autophagy. Autophagy. 2015;11:1499-519 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
Castillo Lluva S, Hontecillas Prieto L, Blanco Gómez A, Del Mar Sáez Freire M, García Cenador B, García Criado J, et al. A new role of SNAI2 in postlactational involution of the mammary gland links it to luminal breast cancer development. Oncogene. 2015;34:4777-90 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:100; 图 1
Lokody I, Francis J, Gardiner J, Erler J, Swain A. Pten Regulates Epithelial Cytodifferentiation during Prostate Development. PLoS ONE. 2015;10:e0129470 pubmed 出版商
  • 免疫印迹; 人类
Barber A, Castillo Martin M, Bonal D, Jia A, Rybicki B, Christiano A, et al. PI3K/AKT pathway regulates E-cadherin and Desmoglein 2 in aggressive prostate cancer. Cancer Med. 2015;4:1258-71 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 5
Pan D, Jiang C, Ma Z, Blonska M, You M, Lin X. MALT1 is required for EGFR-induced NF-?B activation and contributes to EGFR-driven lung cancer progression. Oncogene. 2016;35:919-28 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Choi H, Zhang H, Park H, Choi K, Lee H, Agrawal V, et al. Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2. Nat Commun. 2015;6:6943 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4d
Pasiliao C, Chang C, Sutherland B, Valdez S, Schaeffer D, Yapp D, et al. The involvement of insulin-like growth factor 2 binding protein 3 (IMP3) in pancreatic cancer cell migration, invasion, and adhesion. BMC Cancer. 2015;15:266 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1 ug/ml; 表 1
Cookman C, Belcher S. Estrogen Receptor-β Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma. Endocrinology. 2015;156:2395-408 pubmed 出版商
  • 免疫印迹; 人类
Hatfield I, Harvey I, Yates E, Redd J, Reiter L, Bridges D. The role of TORC1 in muscle development in Drosophila. Sci Rep. 2015;5:9676 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2
Milan G, Romanello V, Pescatore F, Armani A, Paik J, Frasson L, et al. Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy. Nat Commun. 2015;6:6670 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 1:300
  • 免疫印迹; 小鼠; 1:300
Philippou A, Minozzo F, Spinazzola J, Smith L, Lei H, Rassier D, et al. Masticatory muscles of mouse do not undergo atrophy in space. FASEB J. 2015;29:2769-79 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Qu D, Chen Y, Xu X, Zhang M, Zhang Y, Li S. Cbl-b-regulated extracellular signal-regulated kinase signaling is involved in the shikonin-induced apoptosis of lung cancer cells in vitro. Exp Ther Med. 2015;9:1265-1270 pubmed
  • 免疫组化; 人类; 1:100; 图 7
Cheng Y, Chen P, Chiang H, Suen C, Hwang M, Lin T, et al. Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT. Cell Death Dis. 2015;6:e1584 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Gray A, Stephens C, Bigelow R, Coleman D, Cardelli J. The polyphenols (-)-epigallocatechin-3-gallate and luteolin synergistically inhibit TGF-β-induced myofibroblast phenotypes through RhoA and ERK inhibition. PLoS ONE. 2014;9:e109208 pubmed 出版商
  • 免疫印迹; 人类; 图 4c
Yang Y, Zhou W, Xia J, Gu Z, Wendlandt E, Zhan X, et al. NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma. Oncotarget. 2014;5:11986-97 pubmed
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 5
Stodden G, Lindberg M, King M, Paquet M, MacLean J, Mann J, et al. Loss of Cdh1 and Trp53 in the uterus induces chronic inflammation with modification of tumor microenvironment. Oncogene. 2015;34:2471-82 pubmed 出版商
  • 免疫组化; 人类; 1:100
  • 免疫印迹; 人类
Peng W, Hu X, Yao L, Jiang Y, Shao Z. Elevated expression of Girdin in the nucleus indicates worse prognosis for patients with estrogen receptor-positive breast cancer. Ann Surg Oncol. 2014;21 Suppl 4:S648-56 pubmed 出版商
  • 免疫印迹; 人类
  • 免疫印迹; 小鼠
Maurin H, Lechat B, Borghgraef P, Devijver H, Jaworski T, Van Leuven F. Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3?/?. Eur J Neurosci. 2014;40:2442-53 pubmed 出版商
  • 免疫组化; 小鼠; 1:50
Foth M, Ahmad I, van Rhijn B, van der Kwast T, Bergman A, King L, et al. Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice. J Pathol. 2014;233:148-58 pubmed 出版商
  • 免疫印迹; 小鼠
Trotter J, Lee G, Kazdoba T, Crowell B, Domogauer J, Mahoney H, et al. Dab1 is required for synaptic plasticity and associative learning. J Neurosci. 2013;33:15652-68 pubmed 出版商
Heijink A, Everts M, Honeywell M, Richards R, Kok Y, de Vries E, et al. Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity. Cell Rep. 2019;28:2345-2357.e5 pubmed 出版商
Wang G, Huang Y, Wu Z, Zhao C, Cong H, Ju S, et al. KRAS-mutant colon cancer cells respond to combined treatment of ABT263 and axitinib. Biosci Rep. 2019;39: pubmed 出版商
Barros Silva J, Linn D, Steiner I, Guo G, Ali A, Pakula H, et al. Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer. Cell Rep. 2018;25:3504-3518.e6 pubmed 出版商
Yu B, Li B, Zhou X, Shi D, Yang W. Cytoplasmic FOXP1 expression is correlated with ER and calpain II expression and predicts a poor outcome in breast cancer. Diagn Pathol. 2018;13:36 pubmed 出版商
Izycka Swieszewska E, Bien E, Stefanowicz J, Szurowska E, Szutowicz Zielińska E, Koczkowska M, et al. Malignant Gliomas as Second Neoplasms in Pediatric Cancer Survivors: Neuropathological Study. Biomed Res Int. 2018;2018:4596812 pubmed 出版商
Sreekumar A, Toneff M, Toh E, Roarty K, Creighton C, Belka G, et al. WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis. Dev Cell. 2017;43:436-448.e6 pubmed 出版商
Maridas D, DeMambro V, Le P, Mohan S, Rosen C. IGFBP4 Is Required for Adipogenesis and Influences the Distribution of Adipose Depots. Endocrinology. 2017;158:3488-3500 pubmed 出版商
Sommerova L, Ondrousková E, Vojtesek B, Hrstka R. Suppression of AGR2 in a TGF-β-induced Smad regulatory pathway mediates epithelial-mesenchymal transition. BMC Cancer. 2017;17:546 pubmed 出版商
Xin B, Yamamoto M, Fujii K, Ooshio T, Chen X, Okada Y, et al. Critical role of Myc activation in mouse hepatocarcinogenesis induced by the activation of AKT and RAS pathways. Oncogene. 2017;36:5087-5097 pubmed 出版商
Wong K, Liu A, Hong W, Xu Z, Luk J. Integrin α2β1 inhibits MST1 kinase phosphorylation and activates Yes-associated protein oncogenic signaling in hepatocellular carcinoma. Oncotarget. 2016;7:77683-77695 pubmed 出版商
Zopf D, Fichtner I, Bhargava A, Steinke W, Thierauch K, Diefenbach K, et al. Pharmacologic activity and pharmacokinetics of metabolites of regorafenib in preclinical models. Cancer Med. 2016;5:3176-3185 pubmed 出版商
Porreca I, Ulloa Severino L, D Angelo F, Cuomo D, Ceccarelli M, Altucci L, et al. "Stockpile" of Slight Transcriptomic Changes Determines the Indirect Genotoxicity of Low-Dose BPA in Thyroid Cells. PLoS ONE. 2016;11:e0151618 pubmed 出版商
Pallangyo C, Ziegler P, Greten F. IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis. J Exp Med. 2015;212:2253-66 pubmed 出版商
Kuboki Y, Shimizu K, Hatori T, Yamamoto M, Shibata N, Shiratori K, et al. Molecular biomarkers for progression of intraductal papillary mucinous neoplasm of the pancreas. Pancreas. 2015;44:227-35 pubmed 出版商
Carlino M, Fung C, Shahheydari H, Todd J, Boyd S, Irvine M, et al. Preexisting MEK1P124 mutations diminish response to BRAF inhibitors in metastatic melanoma patients. Clin Cancer Res. 2015;21:98-105 pubmed 出版商
Liu Z, Chen X, Song H, Wang H, Zhang G, Wang H, et al. Snail regulated by PKC/GSK-3? pathway is crucial for EGF-induced epithelial-mesenchymal transition (EMT) of cancer cells. Cell Tissue Res. 2014;358:491-502 pubmed 出版商
Beretti F, Manni P, Longo C, Argenziano G, Farnetani F, Cesinaro A, et al. CD271 is expressed in melanomas with more aggressive behaviour, with correlation of characteristic morphology by in vivo reflectance confocal microscopy. Br J Dermatol. 2015;172:662-8 pubmed 出版商
Ohtsubo K, Yamada T, Zhao L, Jin T, Takeuchi S, Mouri H, et al. Expression of Akt kinase-interacting protein 1, a scaffold protein of the PI3K/PDK1/Akt pathway, in pancreatic cancer. Pancreas. 2014;43:1093-100 pubmed 出版商
Bertaggia E, Scabia G, Dalise S, Lo Verso F, Santini F, Vitti P, et al. Haptoglobin is required to prevent oxidative stress and muscle atrophy. PLoS ONE. 2014;9:e100745 pubmed 出版商
Pickhard A, Gröber S, Haug A, Piontek G, Wirth M, Straßen U, et al. Survivin and pAkt as potential prognostic markers in squamous cell carcinoma of the head and neck. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117:733-42 pubmed 出版商
Yamaguchi H, Kuboki Y, Hatori T, Yamamoto M, Shimizu K, Shiratori K, et al. The discrete nature and distinguishing molecular features of pancreatic intraductal tubulopapillary neoplasms and intraductal papillary mucinous neoplasms of the gastric type, pyloric gland variant. J Pathol. 2013;231:335-41 pubmed 出版商
Wang K, Cao F, Fang W, Hu Y, Chen Y, Ding H, et al. Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression. BMC Cancer. 2013;13:343 pubmed 出版商
Ganly I, Ricarte Filho J, Eng S, Ghossein R, Morris L, Liang Y, et al. Genomic dissection of Hurthle cell carcinoma reveals a unique class of thyroid malignancy. J Clin Endocrinol Metab. 2013;98:E962-72 pubmed 出版商
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产品信息
SKU号 :
3787S
产品名称 :
Phospho-Akt (Ser473) (736E11) Rabbit mAb
规格 :
100微升
Price-(USD) :
274美元
物种x :
H, M,(R)
应用 :
免疫组化(冷冻)
产品种类 :
PI3K / Akt Signaling
运输温度 :
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
60
宿主 :
靶标 :
Akt1(Ser473)磷酸盐/Akt2(Ser474)磷酸盐/Akt3(Ser472)磷酸盐
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。