产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
PKM2(D78A4)XP®兔单克隆抗体
目录 :
4053
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
D78A4
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, proximity ligation assay, 其他, 免疫印迹基因敲除验证
文章摘录数: 41
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 3a
  • 免疫印迹; 人类; 图 2a, 2e, s2k
Xu X, Sun Y, Cen X, Shan B, Zhao Q, Xie T, et al. Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model. Protein Cell. 2021;: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4f
Chen W, Huang F, Huang J, Li Y, Peng J, Zhuang Y, et al. SLC45A4 promotes glycolysis and prevents AMPK/ULK1-induced autophagy in TP53 mutant pancreatic ductal adenocarcinoma. J Gene Med. 2021;23:e3364 pubmed 出版商
  • 免疫组化; 小鼠; 1:200; 图 s4h
  • 免疫印迹; 小鼠; 1:2000; 图 s4g
Zhang S, Kim B, Zhu X, Gui X, Wang Y, Lan Z, et al. Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways. Nat Commun. 2020;11:2027 pubmed 出版商
  • 免疫印迹; 人类; 图 4j
Aldonza M, Ku J, Hong J, Kim D, Yu S, Lee M, et al. Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms. Sci Adv. 2020;6:eaav7416 pubmed 出版商
  • proximity ligation assay; 小鼠; 图 3e
  • 免疫印迹; 小鼠; 1:1000; 图 3d
Wei Y, Lu M, Mei M, Wang H, Han Z, Chen M, et al. Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection. Nat Commun. 2020;11:941 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s8
Hsu H, Liu C, Lin J, Hsu T, Hsu J, Li A, et al. Involvement of collagen XVII in pluripotency gene expression and metabolic reprogramming of lung cancer stem cells. J Biomed Sci. 2020;27:5 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s10b
Lee Y, Chen M, Lee J, Zhang J, Lin S, Fu T, et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019;364: pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 4h
  • 免疫印迹; 小鼠; 图 ef6c
Zhou H, Zhang R, Anand P, Stomberski C, Qian Z, Hausladen A, et al. Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury. Nature. 2019;565:96-100 pubmed 出版商
  • 其他; 人类; 图 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed 出版商
  • 免疫印迹; 人类; 图 2g
Yu P, Wilhelm K, Dubrac A, Tung J, Alves T, Fang J, et al. FGF-dependent metabolic control of vascular development. Nature. 2017;545:224-228 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:1000; 图 3f
  • 免疫细胞化学; 人类; 1:400; 图 s2a
  • 免疫印迹; 人类; 1:1000; 图 s3
Qi W, Keenan H, Li Q, Ishikado A, Kannt A, Sadowski T, et al. Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Nat Med. 2017;23:753-762 pubmed 出版商
  • 免疫印迹; 人类; 图 5f
Zhao X, Sun K, Lan Z, Song W, Cheng L, Chi W, et al. Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity. Sci Rep. 2017;7:46344 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Ma T, Fan B, Zhang C, Zhao H, Han C, Gao C, et al. Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway. Sci Rep. 2016;6:29926 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Amara S, Zheng M, Tiriveedhi V. Oleanolic Acid Inhibits High Salt-Induced Exaggeration of Warburg-like Metabolism in Breast Cancer Cells. Cell Biochem Biophys. 2016;74:427-34 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100
Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, et al. HIF-1?-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity. Nat Commun. 2016;7:11635 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5
Gdynia G, Sauer S, Kopitz J, Fuchs D, Duglova K, Ruppert T, et al. The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration. Nat Commun. 2016;7:10764 pubmed 出版商
  • 免疫印迹; 小鼠; 图 st1
Wang C, Che L, Hu J, Zhang S, Jiang L, Latte G, et al. Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade. Liver Int. 2016;36:1176-86 pubmed 出版商
  • 免疫沉淀; 人类; 图 2
  • 免疫印迹; 人类; 图 3
Altuntas S, Rossin F, Marsella C, D Eletto M, Diaz Hidalgo L, Farrace M, et al. The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation. Oncotarget. 2015;6:44941-54 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
Gao X, Krokowski D, Guan B, Bederman I, Majumder M, Parisien M, et al. Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response. elife. 2015;4:e10067 pubmed 出版商
  • 免疫沉淀; 人类; 图 1c
  • 免疫印迹; 人类; 图 2d
Xie X, Wang M, Mei J, Hu F, Ding F, Lv L. Pyruvate kinase M2 interacts with DNA damage-binding protein 2 and reduces cell survival upon UV irradiation. Biochem Biophys Res Commun. 2015;467:427-33 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s9
Nemazanyy I, Montagnac G, Russell R, Morzyglod L, Burnol A, Guan K, et al. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun. 2015;6:8283 pubmed 出版商
  • 免疫印迹; 人类; 图 7
Santi A, Caselli A, Ranaldi F, Paoli P, Mugnaioni C, Michelucci E, et al. Cancer associated fibroblasts transfer lipids and proteins to cancer cells through cargo vesicles supporting tumor growth. Biochim Biophys Acta. 2015;1853:3211-23 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Ledee D, Smith L, Bruce M, Kajimoto M, Isern N, Portman M, et al. c-Myc Alters Substrate Utilization and O-GlcNAc Protein Posttranslational Modifications without Altering Cardiac Function during Early Aortic Constriction. PLoS ONE. 2015;10:e0135262 pubmed 出版商
  • 免疫沉淀; 人类
  • 酶联免疫吸附测定; 人类; 1:1000
  • 免疫印迹; 人类
Zhang J, Gao Q, Zhou Y, Dier U, Hempel N, Hochwald S. Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis. Oncogene. 2016;35:1926-42 pubmed 出版商
  • 免疫组化; 人类; 图 4
Kim D, Fiske B, Birsoy K, Freinkman E, Kami K, Possemato R, et al. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 2015;520:363-7 pubmed 出版商
  • 免疫组化; 小鼠; 1:300; 图 8
Venkatesh A, Ma S, Le Y, Hall M, Rüegg M, Punzo C. Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. J Clin Invest. 2015;125:1446-58 pubmed 出版商
Liu F, Gao Y, Kong Y, Guan Y, Zhang J, Li S, et al. The diagnostic value of lower glucose consumption for IDH1 mutated gliomas on FDG-PET. BMC Cancer. 2021;21:83 pubmed 出版商
Wang H, Wang X, Xu L, Lin Y, Zhang J, Cao H. Identification of genomic alterations and associated transcriptomic profiling reveal the prognostic significance of MMP14 and PKM2 in patients with pancreatic cancer. Aging (Albany NY). 2020;12:18676-18692 pubmed 出版商
Macpherson J, Theisen A, Masino L, Fets L, Driscoll P, Encheva V, et al. Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation. elife. 2019;8: pubmed 出版商
Kono M, Maeda K, Stocton Gavanescu I, Pan W, Umeda M, Katsuyama E, et al. Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation. JCI Insight. 2019;4: pubmed 出版商
Guo C, Zhu Q, Tou F, Wen X, Kuang Y, Hu H. The prognostic value of PKM2 and its correlation with tumour cell PD-L1 in lung adenocarcinoma. BMC Cancer. 2019;19:289 pubmed 出版商
Monzon Casanova E, Screen M, Díaz Muñoz M, Coulson R, Bell S, Lamers G, et al. The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers. Nat Immunol. 2018;19:267-278 pubmed 出版商
Wang H, Nicolay B, Chick J, Gao X, Geng Y, Ren H, et al. The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. Nature. 2017;546:426-430 pubmed 出版商
de Wit R, Mujić Delić A, van Senten J, Fraile Ramos A, Siderius M, Smit M. Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells. Oncotarget. 2016;7:67966-67985 pubmed 出版商
Son S, Kim S, Moon E, Kim D, Pyo S, Um S. Prognostic significance and function of the vacuolar H+-ATPase subunit V1E1 in esophageal squamous cell carcinoma. Oncotarget. 2016;7:49334-49348 pubmed 出版商
Matsuda S, Adachi J, Ihara M, Tanuma N, Shima H, Kakizuka A, et al. Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor. Nucleic Acids Res. 2016;44:636-47 pubmed 出版商
Li J, Liu T, Zhao L, Chen W, Hou H, Ye Z, et al. Ginsenoside 20(S)‑Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells. Int J Oncol. 2015;46:775-81 pubmed 出版商
Liu J, Wu N, Ma L, Liu M, Liu G, Zhang Y, et al. Oleanolic acid suppresses aerobic glycolysis in cancer cells by switching pyruvate kinase type M isoforms. PLoS ONE. 2014;9:e91606 pubmed 出版商
Chang H, Olson L, Schwartz K. Ketolytic and glycolytic enzymatic expression profiles in malignant gliomas: implication for ketogenic diet therapy. Nutr Metab (Lond). 2013;10:47 pubmed 出版商
Anastasiou D, Yu Y, Israelsen W, Jiang J, Boxer M, Hong B, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol. 2012;8:839-47 pubmed
Anastasiou D, Poulogiannis G, Asara J, Boxer M, Jiang J, Shen M, et al. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science. 2011;334:1278-83 pubmed 出版商
产品信息
SKU号 :
4053S
产品名称 :
PKM2(D78A4)XP®兔单克隆抗体
规格 :
100微升
Price-(USD) :
260美元
物种x :
H, M, R, Mk
应用 :
免疫荧光(免疫细胞化学)
产品种类 :
代谢
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
60
宿主 :
靶标 :
PKM2
最初蛋白 :
PKM2
别名 :
CTHBP,Cytosolic thyroid hormone-binding protein,KPYM,MGC3932,OIP-3,OIP3,Opa-interacting protein 3,PK, muscle type,PK2,PK3,PKM,PKM2,Pyruvate kinase 2/3,Pyruvate kinase isozymes M1/M2,Pyruvate kinase muscle isozyme,TCB,THBP1,Thyroid hormone-binding protein 1,Tumor M2-PK,p58,pyruvate kinase, muscle,thyroid hormone-binding protein, cytosolic
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。