产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb
目录 :
4060
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
D9E
反应物种 :
仓鼠, African green monkey, 中国人仓鼠, 人类, 小鼠, 大鼠, , , 斑马鱼, fruit fly , 非洲爪蛙, 拟南芥, domestic rabbit, 猕猴
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化-自由浮动切片, 免疫印迹基因敲除验证
文章摘录数: 1323
出版应用/物种/样本/稀释参考文献
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Lin G, Li J, Cai J, Zhang H, Xin Q, Wang N, et al. RNA-binding Protein MBNL2 regulates Cancer Cell Metastasis through MiR-182-MBNL2-AKT Pathway. J Cancer. 2021;12:6715-6726 pubmed 出版商
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Eritja N, Navaridas R, Ruiz Mitjana A, Vidal Sabanés M, Egea J, Encinas M, et al. Endometrial PTEN Deficiency Leads to SMAD2/3 Nuclear Translocation. Cancers (Basel). 2021;13: pubmed 出版商
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Passman A, Strauss R, McSpadden S, Finch Edmondson M, Andrewartha N, Woo K, et al. Maraviroc Prevents HCC Development by Suppressing Macrophages and the Liver Progenitor Cell Response in a Murine Chronic Liver Disease Model. Cancers (Basel). 2021;13: pubmed 出版商
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Zhu X, Peng S, Wang L, Chen X, Feng C, Liu Y, et al. Identification of phosphoenolpyruvate carboxykinase 1 as a potential therapeutic target for pancreatic cancer. Cell Death Dis. 2021;12:918 pubmed 出版商
  • 免疫印迹; 拟南芥; 图 5c
Minton D, Elliehausen C, Javors M, Santangello K, Konopka A. Rapamycin-induced hyperglycemia is associated with exacerbated age-related osteoarthritis. Arthritis Res Ther. 2021;23:253 pubmed 出版商
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Li R, Hao Y, Wang Q, Meng Y, Wu K, Liu C, et al. ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation. Cell Death Dis. 2021;12:911 pubmed 出版商
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Jung S, Kim D, Choi Y, Kim S, Park H, Lee H, et al. Contribution of p53 in sensitivity to EGFR tyrosine kinase inhibitors in non-small cell lung cancer. Sci Rep. 2021;11:19667 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s7d
Nickl B, Qadri F, Bader M. Anti-inflammatory role of Gpnmb in adipose tissue of mice. Sci Rep. 2021;11:19614 pubmed 出版商
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Mesquita F, Abrami L, Sergeeva O, Turelli P, Qing E, Kunz B, et al. S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity. Dev Cell. 2021;56:2790-2807.e8 pubmed 出版商
  • 免疫印迹; 人类; 图 7b
Zhao Y, Sun J, Li Y, Zhou X, Zhai W, Wu Y, et al. Tryptophan 2,3-dioxygenase 2 controls M2 macrophages polarization to promote esophageal squamous cell carcinoma progression via AKT/GSK3β/IL-8 signaling pathway. Acta Pharm Sin B. 2021;11:2835-2849 pubmed 出版商
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Li K, Wu R, Zhou M, Tong H, Luo K. Desmosomal proteins of DSC2 and PKP1 promote cancer cells survival and metastasis by increasing cluster formation in circulatory system. Sci Adv. 2021;7:eabg7265 pubmed 出版商
  • 免疫印迹; 小鼠; 图 9b
Liu C, Chen G, Chen Y, Dang Y, Nie G, Wu D, et al. Danlou Tablets Inhibit Atherosclerosis in Apolipoprotein E-Deficient Mice by Inducing Macrophage Autophagy: The Role of the PI3K-Akt-mTOR Pathway. Front Pharmacol. 2021;12:724670 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3a
Rossetti G, Ermer J, Stentenbach M, Siira S, Richman T, Milenkovic D, et al. A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance. Sci Adv. 2021;7:eabi7514 pubmed 出版商
  • 免疫印迹; 大鼠; 图 6b
Hu S, Liu D, Li C, Xu Y, Hu K, Cui L, et al. Wuzi-Yanzong prescription alleviates spermatogenesis disorder induced by heat stress dependent on Akt, NF-κB signaling pathway. Sci Rep. 2021;11:18824 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3b
Langdon C, Gadek K, Garcia M, Evans M, Reed K, Bush M, et al. Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity. Nat Commun. 2021;12:5520 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5b
Liu Y, Li Y, Huang S, Li Y, Xia J, Jia J, et al. Liver-specific over-expression of Cripto-1 in transgenic mice promotes hepatocyte proliferation and deregulated expression of hepatocarcinogenesis-related genes and signaling pathways. Aging (Albany NY). 2021;13:21155-21190 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7a
Rajendran R, Rajendran V, Giraldo Velasquez M, Megalofonou F, Gurski F, Stadelmann C, et al. Oligodendrocyte-Specific Deletion of FGFR1 Reduces Cerebellar Inflammation and Neurodegeneration in MOG35-55-Induced EAE. Int J Mol Sci. 2021;22: pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 2g
Machida Y, Imai T. Different properties of mammary carcinogenesis induced by two chemical carcinogens, DMBA and PhIP, in heterozygous BALB/c Trp53 knockout mice. Oncol Lett. 2021;22:738 pubmed 出版商
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Wang C, Yang Z, Xu E, Shen X, Wang X, Li Z, et al. Apolipoprotein C-II induces EMT to promote gastric cancer peritoneal metastasis via PI3K/AKT/mTOR pathway. Clin Transl Med. 2021;11:e522 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6b
Chen Q, Fan K, Chen X, Xie X, Huang L, Song G, et al. Ezrin regulates synovial angiogenesis in rheumatoid arthritis through YAP and Akt signalling. J Cell Mol Med. 2021;25:9378-9389 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2b
De Velasco M, Kura Y, Ando N, Sako N, Banno E, Fujita K, et al. Context-Specific Efficacy of Apalutamide Therapy in Preclinical Models of Pten-Deficient Prostate Cancer. Cancers (Basel). 2021;13: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1d
Dong J, Viswanathan S, Adami E, Schafer S, Kuthubudeen F, Widjaja A, et al. The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling. elife. 2021;10: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1c
Tang X, Li G, Shi L, Su F, Qian M, Liu Z, et al. Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis. Nat Commun. 2021;12:5058 pubmed 出版商
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Luo J, Lu C, Feng M, Dai L, Wang M, Qiu Y, et al. Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish. J Exp Clin Cancer Res. 2021;40:262 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 6d
Reynoso S, Castillo V, Katkar G, López Sánchez I, Taheri S, Espinoza C, et al. GIV/Girdin, a non-receptor modulator for Gαi/s, regulates spatiotemporal signaling during sperm capacitation and is required for male fertility. elife. 2021;10: pubmed 出版商
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Kareddula A, Medina D, Petrosky W, Dolfi S, Tereshchenko I, Walton K, et al. The role of chromodomain helicase DNA binding protein 1 (CHD1) in promoting an invasive prostate cancer phenotype. Ther Adv Urol. 2021;13:17562872211022462 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 1:200; 图 4a
  • 免疫印迹; 小鼠; 1:2000; 图 3b
Ceccarelli M, D Andrea G, Micheli L, Gentile G, Cavallaro S, Merlino G, et al. Tumor Growth in the High Frequency Medulloblastoma Mouse Model Ptch1+/-/Tis21KO Has a Specific Activation Signature of the PI3K/AKT/mTOR Pathway and Is Counteracted by the PI3K Inhibitor MEN1611. Front Oncol. 2021;11:692053 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2e
Vinsland E, Baskaran P, Mihaylov S, Hobbs C, Wood H, Bouybayoune I, et al. The zinc finger/RING domain protein Unkempt regulates cognitive flexibility. Sci Rep. 2021;11:16299 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6d
Xu X, Lei Y, Chen L, Zhou H, Liu H, Jiang J, et al. Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target. J Exp Clin Cancer Res. 2021;40:253 pubmed 出版商
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Herranz C, Mateo F, Baiges A, Ruiz de Garibay G, Junza A, Johnson S, et al. Histamine signaling and metabolism identify potential biomarkers and therapies for lymphangioleiomyomatosis. EMBO Mol Med. 2021;13:e13929 pubmed 出版商
  • 免疫印迹; 人类; 1:500-1:1000; 图 s1a
  • 免疫印迹; 小鼠; 1:500-1:1000; 图 1a
Vichas A, Riley A, Nkinsi N, Kamlapurkar S, Parrish P, Lo A, et al. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Nat Commun. 2021;12:4789 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:100; 图 5d
  • 免疫印迹基因敲除验证; 人类; 1:2000; 图 2b
Feng W, Cao Z, Lim P, Zhao H, Luo H, Mao N, et al. Rapid interrogation of cancer cell of origin through CRISPR editing. Proc Natl Acad Sci U S A. 2021;118: pubmed 出版商
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  • 免疫印迹; 小鼠; 1:1000; 图 1g
Jiang Q, Zheng N, Bu L, Zhang X, Zhang X, Wu Y, et al. SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions. Mol Cancer. 2021;20:100 pubmed 出版商
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Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani D, et al. GRB2 enforces homology-directed repair initiation by MRE11. Sci Adv. 2021;7: pubmed 出版商
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Mygland L, Brinch S, Strand M, Olsen P, Aizenshtadt A, Lund K, et al. Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines. iScience. 2021;24:102807 pubmed 出版商
  • 免疫印迹; 大鼠; 1:500; 图 3a
Meng L, Zhang Y, Li D, Shang X, Hao X, Chen X, et al. TIMP3 attenuates cerebral ischemia/reperfusion-induced apoptosis and oxidative stress in neurocytes by regulating the AKT pathway. Exp Ther Med. 2021;22:973 pubmed 出版商
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Laliotis G, Chavdoula E, Paraskevopoulou M, Kaba A, La Ferlita A, Singh S, et al. AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing. Nat Commun. 2021;12:4624 pubmed 出版商
  • 免疫印迹; 人类; 图 10a
Jeong A, Cheng S, Zhong R, Bennett D, Bergo M, Li L. Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Acta Neuropathol Commun. 2021;9:129 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 2a
Matsuzawa T, Morita M, Shimane A, Otsuka R, Mei Y, Irie F, et al. Heparan sulfate promotes differentiation of white adipocytes to maintain insulin sensitivity and glucose homeostasis. J Biol Chem. 2021;:101006 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Jiao L, Eickhoff R, Egners A, Jumpertz S, Roth J, Erdem M, et al. Deletion of mTOR in liver epithelial cells enhances hepatic metastasis of colon cancer. J Pathol. 2021;255:270-284 pubmed 出版商
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Shen C, Hsieh C, Jiang K, Lin C, Chiang N, Li T, et al. AUY922 induces retinal toxicity through attenuating TRPM1. J Biomed Sci. 2021;28:55 pubmed 出版商
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Guo J, Cheng J, Zheng N, Zhang X, Dai X, Zhang L, et al. Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner. Adv Sci (Weinh). 2021;8:e2004303 pubmed 出版商
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Xu L, Zhang X, Xin Y, Ma J, Yang C, Zhang X, et al. Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway. Cell Death Dis. 2021;12:710 pubmed 出版商
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Liu H, Zang P, Lee I, Anderson B, Christiani A, Strait Bodey L, et al. Growth hormone secretagogue receptor-1a mediates ghrelin's effects on attenuating tumour-induced loss of muscle strength but not muscle mass. J Cachexia Sarcopenia Muscle. 2021;12:1280-1295 pubmed 出版商
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Wang W, Lu G, Liu H, Xiong Z, Leung H, Cao R, et al. Pten Regulates Cardiomyocyte Differentiation by Modulating Non-CG Methylation via Dnmt3. Adv Sci (Weinh). 2021;:e2100849 pubmed 出版商
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Saltykova I, Elahi A, Pitale P, Gorbatyuk O, Athar M, Gorbatyuk M. Tribbles homolog 3-mediated targeting the AKT/mTOR axis in mice with retinal degeneration. Cell Death Dis. 2021;12:664 pubmed 出版商
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Wang Q, Tao C, Hannan A, Yoon S, Min X, Peregrin J, et al. Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling. Sci Adv. 2021;7: pubmed 出版商
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Sakai H, Kawakami H, Teramura T, Onodera Y, Somers E, Furuuchi K, et al. Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer. Clin Transl Med. 2021;11:e454 pubmed 出版商
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Guix F, Capitán A, Casadomé Perales Á, Palomares Perez I, López Del Castillo I, Miguel V, et al. Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup. Life Sci Alliance. 2021;4: pubmed 出版商
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Zhang X, Zhao S, Yuan Q, Zhu L, Li F, Wang H, et al. TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression. Cell Death Dis. 2021;12:642 pubmed 出版商
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Zhang B, Lapenta K, Wang Q, Nam J, Chung D, Robert M, et al. Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis. J Biol Chem. 2021;297:100887 pubmed 出版商
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Wu Q, Tian A, Li B, Leduc M, Forveille S, Hamley P, et al. IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms. J Immunother Cancer. 2021;9: pubmed 出版商
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Tian L, Chen C, Guo Y, Zhang F, Mi J, Feng Q, et al. mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer. Neoplasia. 2021;23:643-652 pubmed 出版商
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Zhu J, Cai T, Zhou J, Du W, Zeng Y, Liu T, et al. CD151 drives cancer progression depending on integrin α3β1 through EGFR signaling in non-small cell lung cancer. J Exp Clin Cancer Res. 2021;40:192 pubmed 出版商
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Yin S, Liu L, Brobbey C, PALANISAMY V, Ball L, Olsen S, et al. PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis. Nat Commun. 2021;12:3444 pubmed 出版商
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Wang J, Zhang Y, Xiao Y, Yuan X, Li P, Wang X, et al. Boosting immune surveillance by low-dose PI3K inhibitor facilitates early intervention of breast cancer. Am J Cancer Res. 2021;11:2005-2024 pubmed
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Qin X, Li J, Wang S, Lv J, Luan F, Liu Y, et al. Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer. Theranostics. 2021;11:6950-6965 pubmed 出版商
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Li H, Zhao S, Shen L, Wang P, Liu S, Ma Y, et al. E2F2 inhibition induces autophagy via the PI3K/Akt/mTOR pathway in gastric cancer. Aging (Albany NY). 2021;13:13626-13643 pubmed 出版商
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Chen Y, Chen Y, Jiang X, Shi M, Yang Z, Chen Z, et al. Vascular Adventitial Fibroblasts-Derived FGF10 Promotes Vascular Smooth Muscle Cells Proliferation and Migration in vitro and the Neointima Formation in vivo. J Inflamm Res. 2021;14:2207-2223 pubmed 出版商
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Schwiebs A, Faqar Uz Zaman F, Herrero San Juan M, Radeke H. S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3. Int J Mol Sci. 2021;22: pubmed 出版商
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Su S, Chen J, Jiang Y, Wang Y, Vital T, Zhang J, et al. SPOP and OTUD7A Control EWS-FLI1 Protein Stability to Govern Ewing Sarcoma Growth. Adv Sci (Weinh). 2021;8:e2004846 pubmed 出版商
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Mou S, Zhou Z, Feng H, Zhang N, Lin Z, Aiyasiding X, et al. Liquiritin Attenuates Lipopolysaccharides-Induced Cardiomyocyte Injury via an AMP-Activated Protein Kinase-Dependent Signaling Pathway. Front Pharmacol. 2021;12:648688 pubmed 出版商
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Kulkarni N, O Neill A, Dokoshi T, Luo E, Wong G, Gallo R. Sequence determinants in the cathelicidin LL-37 that promote inflammation via presentation of RNA to scavenger receptors. J Biol Chem. 2021;297:100828 pubmed 出版商
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Lötsch D, Kirchhofer D, Englinger B, Jiang L, Okonechnikov K, Senfter D, et al. Targeting fibroblast growth factor receptors to combat aggressive ependymoma. Acta Neuropathol. 2021;142:339-360 pubmed 出版商
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Li L, Yang L, Yang F, Zhao X, Xue S, Gong F. Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice. J Inflamm Res. 2021;14:1959-1971 pubmed 出版商
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Tamura T, Kodama T, Sato K, Murai K, Yoshioka T, Shigekawa M, et al. Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation. J Clin Invest. 2021;131: pubmed 出版商
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Kamm D, Pyles K, Sharpe M, Healy L, Colca J, McCommis K. Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide. J Biol Chem. 2021;296:100807 pubmed 出版商
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Lei S, Zhang B, Huang L, Zheng Z, Xie S, Shen L, et al. SRSF1 promotes the inclusion of exon 3 of SRA1 and the invasion of hepatocellular carcinoma cells by interacting with exon 3 of SRA1pre-mRNA. Cell Death Discov. 2021;7:117 pubmed 出版商
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Bi Y, Chen X, Wei B, Wang L, Gong L, Li H, et al. DEPTOR stabilizes ErbB2 to promote the proliferation and survival of ErbB2-positive breast cancer cells. Theranostics. 2021;11:6355-6369 pubmed 出版商
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Cao C, Zhang Y, Cheng J, Wu F, Niu X, Hu X, et al. β-Arrestin2 Inhibits the Apoptosis and Facilitates the Proliferation of Fibroblast-like Synoviocytes in Diffuse-type Tenosynovial Giant Cell Tumor. Cancer Genomics Proteomics. 2021;18:461-470 pubmed 出版商
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Zheng H, Xu W, Zhou W, Yang R, Chen P, Liu T, et al. Beraprost ameliorates postmenopausal osteoporosis by regulating Nedd4-induced Runx2 ubiquitination. Cell Death Dis. 2021;12:497 pubmed 出版商
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Li Q, Liu M, Sun Y, Jin T, Zhu P, Wan X, et al. SLC6A8-mediated intracellular creatine accumulation enhances hypoxic breast cancer cell survival via ameliorating oxidative stress. J Exp Clin Cancer Res. 2021;40:168 pubmed 出版商
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Al Zahrani K, Abou Hamad J, Pascoal J, Labrèche C, Garland B, Sabourin L. AKT-mediated phosphorylation of Sox9 induces Sox10 transcription in a murine model of HER2-positive breast cancer. Breast Cancer Res. 2021;23:55 pubmed 出版商
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Luo L, Zhang Z, Qiu N, Ling L, Jia X, Song Y, et al. Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer. Nat Commun. 2021;12:2699 pubmed 出版商
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Kaneko K, Lin H, Fu Y, Saha P, De la Puente Gomez A, Xu Y, et al. Rap1 in the VMH regulates glucose homeostasis. JCI Insight. 2021;6: pubmed 出版商
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产品信息
SKU号 :
4060L
产品名称 :
Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb
规格 :
300微升
Price-(USD) :
723美元
物种x :
H, M, R, Hm, Mk, Dm, Z, B, (C, X, Dg, Pg)
应用 :
流式细胞仪
产品种类 :
PI3K / Akt Signaling
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
60
宿主 :
靶标 :
Akt1(Ser473)磷酸盐/Akt2(Ser474)磷酸盐/Akt3(Ser472)磷酸盐
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。