出版应用/物种/样本/稀释 | 参考文献 |
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- 免疫印迹基因敲除验证; 人类; 1:1000; 图 2e
| Wang Y, Liu I, Chen K, Wu H. NOTCH1 signaling promotes protein stability of HER3 through the AKT pathway in squamous cell carcinoma of head and neck. Oncogenesis. 2021;10:59 pubmed 出版商
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| Yamagishi M, Kubokawa M, Kuze Y, Suzuki A, Yokomizo A, Kobayashi S, et al. Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma. Nat Commun. 2021;12:4821 pubmed 出版商
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| Roper N, Velez M, Chiappori A, Kim Y, Wei J, Sindiri S, et al. Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer. Nat Commun. 2021;12:3880 pubmed 出版商
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| Ofek S, Wiszniak S, Kagan S, Tondl M, Schwarz Q, Kalcheim C. Notch signaling is a critical initiator of roof plate formation as revealed by the use of RNA profiling of the dorsal neural tube. BMC Biol. 2021;19:84 pubmed 出版商
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| Ni W, Chen Z, Zhou X, Yang R, Yu M, Lu J, et al. Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma. Signal Transduct Target Ther. 2021;6:27 pubmed 出版商
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- 免疫组化; 人类; 1:50; 图 1f
- 免疫印迹; 人类; 1:1000; 图 1c
| Pan L, Lemieux M, Thomas T, Rogers J, Lipper C, Lee W, et al. IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation. elife. 2020;9: pubmed 出版商
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| Eyler C, Matsunaga H, Hovestadt V, Vantine S, van Galen P, Bernstein B. Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance. Genome Biol. 2020;21:174 pubmed 出版商
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| Caolo V, Debant M, Endesh N, Futers T, Lichtenstein L, Bartoli F, et al. Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells. elife. 2020;9: pubmed 出版商
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| Liao T, Lin C, Jiang J, Yang S, Teng H, Yang M. Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3B in colorectal cancer. Theranostics. 2020;10:6095-6112 pubmed 出版商
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- 免疫印迹; 小鼠; 1:1000; 图 3f, 3h
| Kuang Y, Golan O, Preusse K, Cain B, Christensen C, Salomone J, et al. Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism. elife. 2020;9: pubmed 出版商
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| Park D, Cheng J, McGrath J, Lim M, Cushman C, Swanson S, et al. Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis. Nat Cell Biol. 2020;22:603-615 pubmed 出版商
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| Liu H, Mei F, Yang W, Wang H, Wong E, Cai J, et al. Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling. Sci Adv. 2020;6:eaay3566 pubmed 出版商
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- 免疫组化-石蜡切片; 小鼠; 1:100; 图 1a
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- 免疫印迹; 人类; 图 6c
- 免疫组化-石蜡切片; 小鼠; 图 5c
- 免疫印迹; 小鼠; 图 5d
| Li L, Guturi K, Gautreau B, Patel P, Saad A, Morii M, et al. Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. J Clin Invest. 2018;128:4525-4542 pubmed 出版商
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- 免疫组化-石蜡切片; 人类; 1:150; 图 5a
| Eley L, Alqahtani A, MacGrogan D, Richardson R, Murphy L, Salguero Jimenez A, et al. A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice. elife. 2018;7: pubmed 出版商
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| Das A, Huang G, Bonkowski M, Longchamp A, Li C, Schultz M, et al. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2018;173:74-89.e20 pubmed 出版商
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| Hu X, Das B, Hou H, He W, Yan R. BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions. J Exp Med. 2018;215:927-940 pubmed 出版商
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| Nandagopal N, Santat L, Lebon L, Sprinzak D, Bronner M, Elowitz M. Dynamic Ligand Discrimination in the Notch Signaling Pathway. Cell. 2018;172:869-880.e19 pubmed 出版商
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| Steinbuck M, Arakcheeva K, Winandy S. Novel TCR-Mediated Mechanisms of Notch Activation and Signaling. J Immunol. 2018;200:997-1007 pubmed 出版商
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| Fang J, Coon B, Gillis N, Chen Z, Qiu J, Chittenden T, et al. Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. Nat Commun. 2017;8:2149 pubmed 出版商
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| Polacheck W, Kutys M, Yang J, Eyckmans J, Wu Y, Vasavada H, et al. A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature. 2017;552:258-262 pubmed 出版商
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| Jin L, Vu T, Yuan G, Datta P. STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway. Cancer Res. 2017;77:5464-5478 pubmed 出版商
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| Sawaguchi S, Varshney S, Ogawa M, Sakaidani Y, Yagi H, Takeshita K, et al. O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals. elife. 2017;6: pubmed 出版商
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- 免疫组化; 大鼠; 1:100; 图 1e
- 免疫印迹; 大鼠; 1:300; 图 1a
| Zeng W, Han Y, Zhu G, Huang L, Deng Y, Wang Q, et al. Hypertonic saline attenuates expression of Notch signaling and proinflammatory mediators in activated microglia in experimentally induced cerebral ischemia and hypoxic BV-2 microglia. BMC Neurosci. 2017;18:32 pubmed 出版商
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| Mandl M, Zhang S, Ulrich M, Schmoeckel E, Mayr D, Vollmar A, et al. Inhibition of Cdk5 induces cell death of tumor-initiating cells. Br J Cancer. 2017;116:912-922 pubmed 出版商
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| Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, et al. The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor. Nat Commun. 2017;8:14002 pubmed 出版商
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| Hirai M, Arita Y, McGlade C, Lee K, Chen J, Evans S. Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest. 2017;127:569-582 pubmed 出版商
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| Li S, Hu H, He Z, Liang D, Sun R, Lan K. Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway. PLoS Pathog. 2016;12:e1005900 pubmed 出版商
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- 免疫组化-冰冻切片; 小鼠; 1:1000; 图 3c
| Kuzmanov U, Guo H, Buchsbaum D, Cosme J, Abbasi C, Isserlin R, et al. Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2016;113:12592-12597 pubmed
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| Greene L, Nathwani S, Zisterer D. Inhibition of ?-secretase activity synergistically enhances tumour necrosis factor-related apoptosis-inducing ligand induced apoptosis in T-cell acute lymphoblastic leukemia cells via upregulation of death receptor 5. Oncol Lett. 2016;12:2900-2905 pubmed
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| Stoyanova T, Riedinger M, Lin S, Faltermeier C, Smith B, Zhang K, et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016;113:E6457-E6466 pubmed
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| Asnaghi L, Tripathy A, Yang Q, Kaur H, Hanaford A, Yu W, et al. Targeting Notch signaling as a novel therapy for retinoblastoma. Oncotarget. 2016;7:70028-70044 pubmed 出版商
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| Hong X, Liu W, Song R, Shah J, Feng X, Tsang C, et al. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res. 2016;44:8855-8869 pubmed
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| Hoare M, Ito Y, Kang T, Weekes M, Matheson N, Patten D, et al. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol. 2016;18:979-92 pubmed 出版商
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| Ramo K, Sugamura K, Craige S, Keaney J, Davis R. Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development. elife. 2016;5: pubmed 出版商
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| Deskin B, Lasky J, Zhuang Y, Shan B. Requirement of HDAC6 for activation of Notch1 by TGF-?1. Sci Rep. 2016;6:31086 pubmed 出版商
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| Phillips E, Lang V, Bohlen J, Bethke F, Puccio L, Tichy D, et al. Targeting atypical protein kinase C iota reduces viability in glioblastoma stem-like cells via a notch signaling mechanism. Int J Cancer. 2016;139:1776-87 pubmed 出版商
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| Carofino B, Ayanga B, Tracey L, Brooke Bisschop T, Justice M. PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL. Biol Open. 2016;5:645-53 pubmed 出版商
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| Huang G, Yang X, Chen K, Xing J, Guo L, Zhu L, et al. Porf-2 Inhibits Neural Stem Cell Proliferation Through Wnt/?-Catenin Pathway by Its GAP Domain. Front Cell Neurosci. 2016;10:85 pubmed 出版商
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| Lynch J, McEwen R, Crafter C, McDermott U, Garnett M, Barry S, et al. Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen. Oncotarget. 2016;7:22128-39 pubmed 出版商
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- 免疫组化-冰冻切片; 小鼠; 1:100; 图 6
- 免疫印迹; 小鼠; 1:1000; 图 6
| Wang W, Jossin Y, Chai G, Lien W, Tissir F, Goffinet A. Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling. Nat Commun. 2016;7:10936 pubmed 出版商
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| Tominaga A, Cai T, Takagi Niidome S, Iwatsubo T, Tomita T. Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production. J Neurosci. 2016;36:1362-72 pubmed 出版商
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| Noh H, Hah Y, Ha J, Kang M, Zada S, Rha S, et al. Regulation of the epithelial to mesenchymal transition and metastasis by Raf kinase inhibitory protein-dependent Notch1 activity. Oncotarget. 2016;7:4632-46 pubmed 出版商
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| Bolduc D, Montagna D, Gu Y, Selkoe D, Wolfe M. Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain. Proc Natl Acad Sci U S A. 2016;113:E509-18 pubmed 出版商
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- 免疫细胞化学; 人类; 图 5d
- 免疫印迹; 人类; 图 5b
| Zhang S, Schneider L, Vick B, Grunert M, Jeremias I, Menche D, et al. Anti-leukemic effects of the V-ATPase inhibitor Archazolid A. Oncotarget. 2015;6:43508-28 pubmed 出版商
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| Herranz D, Ambesi Impiombato A, Sudderth J, Sánchez MartÃn M, Belver L, Tosello V, et al. Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia. Nat Med. 2015;21:1182-9 pubmed 出版商
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| Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, et al. The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. PLoS Genet. 2015;11:e1005503 pubmed 出版商
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| Ray A, Vasudevan S, Sengupta S. 6-Shogaol Inhibits Breast Cancer Cells and Stem Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of Autophagic Cell Death. PLoS ONE. 2015;10:e0137614 pubmed 出版商
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| Xie C, Wei D, Zhao L, Marchetto S, Mei L, Borg J, et al. Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis. J Cell Biol. 2015;209:721-37 pubmed 出版商
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| Sato M, Rodríguez Barrueco R, Yu J, Do C, Silva J, Gautier J. MYC is a critical target of FBXW7. Oncotarget. 2015;6:3292-305 pubmed
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| Nguyen D, Rubinstein L, Takebe N, Miele L, Tomaszewski J, Ivy P, et al. Notch1 phenotype and clinical stage progression in non-small cell lung cancer. J Hematol Oncol. 2015;8:9 pubmed 出版商
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- 免疫组化-冰冻切片; 人类; 1:100
- 免疫印迹; 人类; 1:800
| Lim K, Brandt W, Heth J, Muraszko K, Fan X, Bar E, et al. Lateral inhibition of Notch signaling in neoplastic cells. Oncotarget. 2015;6:1666-77 pubmed
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| So J, Lin J, Wahler J, Liby K, Sporn M, Suh N. A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer. PLoS ONE. 2014;9:e107616 pubmed 出版商
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| Aydin I, Melamed R, Adams S, Castillo Martin M, Demir A, Bryk D, et al. FBXW7 mutations in melanoma and a new therapeutic paradigm. J Natl Cancer Inst. 2014;106:dju107 pubmed 出版商
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| Kumar V, Palermo R, Talora C, Campese A, Checquolo S, Bellavia D, et al. Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia. Leukemia. 2014;28:2324-35 pubmed 出版商
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| Yoshida R, Nagata M, Nakayama H, Niimori Kita K, Hassan W, Tanaka T, et al. The pathological significance of Notch1 in oral squamous cell carcinoma. Lab Invest. 2013;93:1068-81 pubmed 出版商
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| Dabelsteen S, Pallesen E, Marinova I, Nielsen M, Adamopoulou M, Rømer T, et al. Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model. Dev Cell. 2020;54:669-684.e7 pubmed 出版商
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| Dai K, Huang L, Huang Y, Chen Z, Yang L, Jiang Y. 1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model. Front Immunol. 2017;8:320 pubmed 出版商
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| Machado A, Rodríguez Expósito E, Lopez M, Hernandez M. Phylogenetic analysis of the genus Laparocerus, with comments on colonisation and diversification in Macaronesia (Coleoptera, Curculionidae, Entiminae). Zookeys. 2017;:1-77 pubmed 出版商
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| Liao X, Zhang A, Zheng M, Li M, Chen C, Xu H, et al. Chemical or genetic Pin1 inhibition exerts potent anticancer activity against hepatocellular carcinoma by blocking multiple cancer-driving pathways. Sci Rep. 2017;7:43639 pubmed 出版商
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| Kim W, Khan S, Gvozdenovic Jeremic J, Kim Y, Dahlman J, Kim H, et al. Hippo signaling interactions with Wnt/?-catenin and Notch signaling repress liver tumorigenesis. J Clin Invest. 2017;127:137-152 pubmed 出版商
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| Ezratty E, Pasolli H, Fuchs E. A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation. J Cell Biol. 2016;214:89-101 pubmed 出版商
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| Gama Norton L, Ferrando E, Ruiz Herguido C, Liu Z, Liu Z, Guiu J, et al. Notch signal strength controls cell fate in the haemogenic endothelium. Nat Commun. 2015;6:8510 pubmed 出版商
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| Stasiulewicz M, Gray S, Mastromina I, Silva J, Björklund M, Seymour P, et al. A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo. Development. 2015;142:2291-303 pubmed 出版商
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| Lin M, Price E, Boatman S, Hagedorn E, Trompouki E, Satishchandran S, et al. Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. elife. 2015;4: pubmed 出版商
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| Rettig E, Chung C, Bishop J, Howard J, Sharma R, Li R, et al. Cleaved NOTCH1 Expression Pattern in Head and Neck Squamous Cell Carcinoma Is Associated with NOTCH1 Mutation, HPV Status, and High-Risk Features. Cancer Prev Res (Phila). 2015;8:287-95 pubmed 出版商
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| Jegalian A, Bodo J, Hsi E. NOTCH1 intracellular domain immunohistochemistry as a diagnostic tool to distinguish T-lymphoblastic lymphoma from thymoma. Am J Surg Pathol. 2015;39:565-72 pubmed 出版商
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| Rowe M, Raithatha S, Shannon Lowe C. Counteracting effects of cellular Notch and Epstein-Barr virus EBNA2: implications for stromal effects on virus-host interactions. J Virol. 2014;88:12065-76 pubmed 出版商
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| Zhang X, Yang B, Wang J, Mo X, Zhang J, Hua Z. FADD is essential for glucose uptake and survival of thymocytes. Biochem Biophys Res Commun. 2014;451:202-7 pubmed 出版商
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| Capaccione K, Hong X, Morgan K, Liu W, Bishop J, Liu L, et al. Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma. Oncotarget. 2014;5:3636-50 pubmed
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| Nickel N, Godau J, Willie B, Duda G, Schwarzer R, Cirovic B, et al. Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model. Blood Cancer J. 2014;4:e217 pubmed 出版商
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| South A, Purdie K, Watt S, Haldenby S, den Breems N, Dimon M, et al. NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis. J Invest Dermatol. 2014;134:2630-2638 pubmed 出版商
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| Hagenbeek T, Wu X, Choy L, Sanchez Irizarry C, Seshagiri S, Stinson J, et al. Murine Pten(-/-) T-ALL requires non-redundant PI3K/mTOR and DLL4/Notch1 signals for maintenance and ?c/TCR signals for thymic exit. Cancer Lett. 2014;346:237-48 pubmed 出版商
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| Simonetti G, Carette A, Silva K, Wang H, De Silva N, Heise N, et al. IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity. J Exp Med. 2013;210:2887-902 pubmed 出版商
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| Arruga F, Gizdić B, Serra S, Vaisitti T, Ciardullo C, Coscia M, et al. Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia. Leukemia. 2014;28:1060-70 pubmed 出版商
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| Carofino B, Ayanga B, Justice M. A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). Dis Model Mech. 2013;6:1494-506 pubmed 出版商
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| Caliceti C, Aquila G, Pannella M, Morelli M, Fortini C, Pinton P, et al. 17β-estradiol enhances signalling mediated by VEGF-A-delta-like ligand 4-notch1 axis in human endothelial cells. PLoS ONE. 2013;8:e71440 pubmed 出版商
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| Mezquita B, Mezquita J, Barrot C, Carvajal S, Pau M, Mezquita P, et al. A truncated-Flt1 isoform of breast cancer cells is upregulated by Notch and downregulated by retinoic acid. J Cell Biochem. 2014;115:52-61 pubmed 出版商
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| Kluk M, Ashworth T, Wang H, Knoechel B, Mason E, Morgan E, et al. Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry. PLoS ONE. 2013;8:e67306 pubmed 出版商
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| Wang X, Yu H, Linnoila R, Li L, Li D, Mo B, et al. Musashi1 as a potential therapeutic target and diagnostic marker for lung cancer. Oncotarget. 2013;4:739-50 pubmed
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| Zhao J, Ma M, Ren H, Liu Z, Edelman M, Pan H, et al. Anti-HDGF targets cancer and cancer stromal stem cells resistant to chemotherapy. Clin Cancer Res. 2013;19:3567-76 pubmed 出版商
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| Tezgel A, González Pérez G, Telfer J, Osborne B, Minter L, Tew G. Novel protein transduction domain mimics as nonviral delivery vectors for siRNA targeting NOTCH1 in primary human T cells. Mol Ther. 2013;21:201-9 pubmed 出版商
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| Sakamoto K, Fujii T, Kawachi H, Miki Y, Omura K, Morita K, et al. Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Lab Invest. 2012;92:688-702 pubmed 出版商
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| Zheng W, Tammela T, Yamamoto M, Anisimov A, Holopainen T, Kaijalainen S, et al. Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor. Blood. 2011;118:1154-62 pubmed 出版商
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| Treanor L, Volanakis E, Zhou S, Lu T, Sherr C, Sorrentino B. Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies. Blood. 2011;117:5453-62 pubmed 出版商
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