产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
Tuberin/TSC2 (D93F12) XP® Rabbit mAb
目录 :
4308
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
D93F12
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 免疫印迹基因敲除验证
文章摘录数: 48
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 2a, 3b
Han H, Kim S, Kim Y, Jang S, Kwon Y, Choi D, et al. A novel role of CRTC2 in promoting nonalcoholic fatty liver disease. Mol Metab. 2022;55:101402 pubmed 出版商
  • 免疫印迹; 人类
Yuan T, Annamalai K, Naik S, Lupse B, Geravandi S, Pal A, et al. The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis. Nat Commun. 2021;12:4928 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 3g
Chen X, Miao M, Zhou M, Chen J, Li D, Zhang L, et al. Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway. Cell Death Dis. 2021;12:761 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 3e
Alesi N, Akl E, Khabibullin D, Liu H, Nidhiry A, Garner E, et al. TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism. Nat Commun. 2021;12:4245 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s12
Zhang T, He M, Zhao L, Qin S, Zhu Z, Du X, et al. HDAC6 regulates primordial follicle activation through mTOR signaling pathway. Cell Death Dis. 2021;12:559 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Feng Y, Mischler W, Gurung A, Kavanagh T, Androsov G, Sadow P, et al. Therapeutic Targeting of the Secreted Lysophospholipase D Autotaxin Suppresses Tuberous Sclerosis Complex-Associated Tumorigenesis. Cancer Res. 2020;80:2751-2763 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:1000; 图 4j
Chen G, Xie W, Nah J, Sauvat A, Liu P, Pietrocola F, et al. 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB. EMBO Mol Med. 2019;11:e10469 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Nnah I, Wang B, Saqcena C, Weber G, Bonder E, Bagley D, et al. TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy. Autophagy. 2019;15:151-164 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3c
Dai S, Dulcey A, Hu X, Wassif C, Porter F, Austin C, et al. Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK. Autophagy. 2017;13:1435-1451 pubmed 出版商
  • 免疫细胞化学; 人类; 1:800; 图 5g
  • 免疫印迹; 人类; 1:1000; 图 5i
Bakula D, Müller A, Zuleger T, Takacs Z, Franz Wachtel M, Thost A, et al. WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy. Nat Commun. 2017;8:15637 pubmed 出版商
  • 免疫印迹; 人类; 图 5c
Merhi A, Delree P, Marini A. The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling. Sci Rep. 2017;7:44602 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 1a
Jacobs B, McNally R, Kim K, Blanco R, Privett R, You J, et al. Identification of mechanically regulated phosphorylation sites on tuberin (TSC2) that control mechanistic target of rapamycin (mTOR) signaling. J Biol Chem. 2017;292:6987-6997 pubmed 出版商
  • 免疫印迹; 大鼠; 图 4c
Ercan E, Han J, Di Nardo A, Winden K, Han M, Hoyo L, et al. Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex. J Exp Med. 2017;214:681-697 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 1:1000; 图 s3h
Villar V, Nguyen T, Delcroix V, Terés S, Bouchecareilh M, Salin B, et al. mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation. Nat Commun. 2017;8:14124 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1b
Rahman A, Haugh J. Kinetic Modeling and Analysis of the Akt/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Axis Reveals Cooperative, Feedforward Regulation. J Biol Chem. 2017;292:2866-2872 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6b
Yamauchi T, Nishiyama M, Moroishi T, Kawamura A, Nakayama K. FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells. Mol Cell Biol. 2017;37: pubmed 出版商
  • 免疫沉淀; 大鼠; 图 4c
  • 免疫印迹; 大鼠; 图 4c
  • 免疫印迹基因敲除验证; 人类; 图 1a
  • 免疫沉淀; 人类; 图 2c
Fettweis G, Di Valentin E, L homme L, Lassence C, Dequiedt F, Fillet M, et al. RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death. Biochim Biophys Acta Mol Cell Res. 2017;1864:113-124 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
  • 免疫印迹; 小鼠; 1:1000; 图 4
Bento C, Ashkenazi A, Jimenez Sanchez M, Rubinsztein D. The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway. Nat Commun. 2016;7:11803 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Hakim S, Dyson J, Feeney S, Davies E, Sriratana A, Koenig M, et al. Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling. Hum Mol Genet. 2016;25:2295-2313 pubmed
  • 免疫印迹基因敲除验证; 小鼠; 1:2000; 图 s10a
  • 免疫细胞化学; 小鼠; 1:200; 图 s6b
  • 免疫细胞化学; 人类; 1:200; 图 s4a
  • 免疫印迹; 人类; 1:2000; 图 s9a
Demetriades C, Plescher M, Teleman A. Lysosomal recruitment of TSC2 is a universal response to cellular stress. Nat Commun. 2016;7:10662 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 2a
  • 免疫印迹; 人类; 1:1000; 图 2e
  • 免疫细胞化学; 小鼠; 1:1000; 图 2c
  • 免疫印迹; 小鼠; 1:1000; 图 1s3i
Carroll B, Maetzel D, Maddocks O, Otten G, Ratcliff M, Smith G, et al. Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity. elife. 2016;5: pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
  • 免疫印迹; 人类; 图 5
Vural A, Al Khodor S, Cheung G, Shi C, Srinivasan L, McQuiston T, et al. Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection. J Immunol. 2016;196:846-56 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2b
Yan Y, Ollila S, Wong I, Vallenius T, Palvimo J, Vaahtomeri K, et al. SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling. Nat Commun. 2015;6:8979 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Ye Z, Al Aidaroos A, Park J, Yuen H, Zhang S, Gupta A, et al. PRL-3 activates mTORC1 in Cancer Progression. Sci Rep. 2015;5:17046 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2500; 图 5
Das R, Xu S, Nguyen T, Quan X, Choi S, Kim S, et al. Transforming Growth Factor β1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 Axis. J Biol Chem. 2015;290:30830-42 pubmed 出版商
  • 免疫细胞化学; 人类; 图 5d
Zhang S, Schneider L, Vick B, Grunert M, Jeremias I, Menche D, et al. Anti-leukemic effects of the V-ATPase inhibitor Archazolid A. Oncotarget. 2015;6:43508-28 pubmed 出版商
  • 免疫细胞化学; 人类; 1:800; 图 5
Agarwal S, Bell C, Taylor S, Moran R. p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res. 2016;14:66-77 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 s1
  • 免疫印迹基因敲除验证; 小鼠; 1:2000; 图 3
  • 免疫细胞化学; 小鼠; 图 5
Plescher M, Teleman A, Demetriades C. TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1. Sci Rep. 2015;5:13828 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Su X, Yu Y, Zhong Y, Giannopoulou E, Hu X, Liu H, et al. Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation. Nat Immunol. 2015;16:838-849 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Espana Agusti J, Tuveson D, Adams D, Matakidou A. A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules. Sci Rep. 2015;5:11061 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Harris White M, Ferbas K, Johnson M, Eslami P, Poteshkina A, Venkova K, et al. A cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies. Neurobiol Dis. 2015;84:60-8 pubmed 出版商
  • 免疫印迹; 人类
Verma R, Marchese A. The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR. J Biol Chem. 2015;290:6810-24 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
Liang N, Zhang C, Dill P, Panasyuk G, Pion D, Koka V, et al. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med. 2014;211:2249-63 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 s1
  • 免疫印迹; 人类; 图 s1
Peng M, Yin N, Li M. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell. 2014;159:122-133 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 2
Bartley C, O Keefe R, Bordey A. FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity. PLoS ONE. 2014;9:e96956 pubmed 出版商
Amemiya Y, Nakamura N, Ikeda N, Sugiyama R, Ishii C, Maki M, et al. Amino Acid-Mediated Intracellular Ca2+ Rise Modulates mTORC1 by Regulating the TSC2-Rheb Axis through Ca2+/Calmodulin. Int J Mol Sci. 2021;22: pubmed 出版商
Marques P, Kamitz A, Bartolomé A, Burillo J, Martínez H, Jimenez B, et al. Essential role of glucokinase in the protection of pancreatic β cells to the glucose energetic status. Cell Death Discov. 2019;5:138 pubmed 出版商
Peruchetti D, Silva Aguiar R, Siqueira G, Dias W, Caruso Neves C. High glucose reduces megalin-mediated albumin endocytosis in renal proximal tubule cells through protein kinase B O-GlcNAcylation. J Biol Chem. 2018;293:11388-11400 pubmed 出版商
Jia J, Abudu Y, Claude Taupin A, Gu Y, Kumar S, Choi S, et al. Galectins Control mTOR in Response to Endomembrane Damage. Mol Cell. 2018;70:120-135.e8 pubmed 出版商
Rubio A, Luoni M, Giannelli S, Radice I, Iannielli A, Cancellieri C, et al. Rapid and efficient CRISPR/Cas9 gene inactivation in human neurons during human pluripotent stem cell differentiation and direct reprogramming. Sci Rep. 2016;6:37540 pubmed 出版商
Zhang J, Wang J, Xu J, Lu Y, Jiang J, Wang L, et al. Curcumin targets the TFEB-lysosome pathway for induction of autophagy. Oncotarget. 2016;7:75659-75671 pubmed 出版商
Ito S, Tanaka Y, Oshino R, Aiba K, Thanasegaran S, Nishio N, et al. GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy. Sci Rep. 2015;5:8327 pubmed 出版商
Guan B, Krokowski D, Majumder M, Schmotzer C, Kimball S, Merrick W, et al. Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2?. J Biol Chem. 2014;289:12593-611 pubmed 出版商
Wu J, Shin J, Xie D, Wang H, Gao J, Zhong X. Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity. J Immunol. 2014;192:2643-50 pubmed 出版商
Munkley J, Rajan P, Lafferty N, Dalgliesh C, Jackson R, Robson C, et al. A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation. Oncotarget. 2014;5:131-9 pubmed
Dibble C, Elis W, Menon S, Qin W, Klekota J, Asara J, et al. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell. 2012;47:535-46 pubmed 出版商
Goto J, Talos D, Klein P, Qin W, Chekaluk Y, Anderl S, et al. Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci U S A. 2011;108:E1070-9 pubmed 出版商
Park J, Arakawa Takeuchi S, Jinno S, Okayama H. Rho-associated kinase connects a cell cycle-controlling anchorage signal to the mammalian target of rapamycin pathway. J Biol Chem. 2011;286:23132-41 pubmed 出版商
产品信息
SKU号 :
4308S
产品名称 :
Tuberin/TSC2 (D93F12) XP® Rabbit mAb
规格 :
100微升
Price-(USD) :
260美元
物种x :
H, M, R, Hm, Mk
应用 :
免疫荧光(免疫细胞化学)
产品种类 :
PI3K / Akt Signaling
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
200
宿主 :
靶标 :
Tuberin/TSC2
最初蛋白 :
TSC2
别名 :
FLJ43106,LAM,TSC2,TSC4,Tuberin,Tuberous sclerosis 2 protein,tuberous sclerosis 2
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。