出版应用/物种/样本/稀释 | 参考文献 |
---|
| Cibi D, Mia M, Guna Shekeran S, Yun L, Sandireddy R, Gupta P, et al. Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate. elife. 2019;8: pubmed 出版商
|
- 免疫组化-石蜡切片; 大鼠; 1:250; 图 8c, 9b
- 免疫印迹; 大鼠; 1:250; 图 s1f
| Mammone T, Chidlow G, Casson R, Wood J. Improved immunohistochemical detection of phosphorylated mitogen-activated protein kinases in the injured rat optic nerve head. Histochem Cell Biol. 2019;151:435-456 pubmed 出版商
|
| Richardson J, Armbruster N, Günter M, Henes J, Autenrieth S. Staphylococcus aureus PSM Peptides Modulate Human Monocyte-Derived Dendritic Cells to Prime Regulatory T Cells. Front Immunol. 2018;9:2603 pubmed 出版商
|
| Panda S, Gekara N. The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex. Nat Commun. 2018;9:4654 pubmed 出版商
|
| Mamo T, Wittern A, Kleppa M, Bohnenpoll T, Weiss A, Kispert A. BMP4 uses several different effector pathways to regulate proliferation and differentiation in the epithelial and mesenchymal tissue compartments of the developing mouse ureter. Hum Mol Genet. 2017;26:3553-3563 pubmed 出版商
|
| Mindos T, Dun X, North K, Doddrell R, Schulz A, Edwards P, et al. Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity. J Cell Biol. 2017;216:495-510 pubmed 出版商
|
| Wu M, Chen W, Lu Y, Zhu G, Hao L, Li Y. Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway. Nat Commun. 2017;8:13700 pubmed 出版商
|
| Milara J, Cervera A, de Diego A, Sanz C, Juan G, Gavaldá A, et al. Non-neuronal cholinergic system contributes to corticosteroid resistance in chronic obstructive pulmonary disease patients. Respir Res. 2016;17:145 pubmed
|
- 免疫组化-石蜡切片; 大鼠; 1:25; 图 4b
- 免疫印迹; 大鼠; 1:1000; 图 4c
| Yan S, Wang Y, Liu P, Chen A, Chen M, Yao D, et al. Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9. Evid Based Complement Alternat Med. 2016;2016:2546402 pubmed 出版商
|
| Zhang Y, Hu S, Chen Y, Guo M, Wang S. Hepatocyte growth factor inhibits hypoxia/reoxygenation-induced activation of xanthine oxidase in endothelial cells through the JAK2 signaling pathway. Int J Mol Med. 2016;38:1055-62 pubmed 出版商
|
| Cheng G, Gao F, Sun X, Bi H, Zhu Y. Paris saponin VII suppresses osteosarcoma cell migration and invasion by inhibiting MMP?2/9 production via the p38 MAPK signaling pathway. Mol Med Rep. 2016;14:3199-205 pubmed 出版商
|
| Kim J, Weeratunga P, Kim M, Nikapitiya C, Lee B, Uddin M, et al. Inhibitory effects of an aqueous extract from Cortex Phellodendri on the growth and replication of broad-spectrum of viruses in vitro and in vivo. BMC Complement Altern Med. 2016;16:265 pubmed 出版商
|
- 免疫组化-石蜡切片; 小鼠; 1:200; 图 5d
| Zhang J, Jing X, Niu W, Zhang M, Ge L, Miao C, et al. Peroxiredoxin 1 has an anti-apoptotic role via apoptosis signal-regulating kinase 1 and p38 activation in mouse models with oral precancerous lesions. Oncol Lett. 2016;12:413-420 pubmed
|
| Wang T, Pan D, Zhou Z, You Y, Jiang C, Zhao X, et al. Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut. PLoS Pathog. 2016;12:e1005662 pubmed 出版商
|
| Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, et al. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Nat Commun. 2016;7:11385 pubmed 出版商
|
| Hamanoue M, Morioka K, Ohsawa I, Ohsawa K, Kobayashi M, Tsuburaya K, et al. Cell-permeable p38?MAP kinase promotes migration of adult neural stem/progenitor cells. Sci Rep. 2016;6:24279 pubmed 出版商
|
| Yu Z, Chen T, Li X, Yang M, Tang S, Zhu X, et al. Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response. elife. 2016;5: pubmed 出版商
|
| Shi C, Iura A, Terajima M, Liu F, Lyons K, Pan H, et al. Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors. Sci Rep. 2016;6:24256 pubmed 出版商
|
| Acharya M, Sokolovska A, Tam J, Conway K, Stefani C, Raso F, et al. αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells. Nat Commun. 2016;7:10917 pubmed 出版商
|
| Cao L, Qin X, Peterson M, Haller S, Wilson K, Hu N, et al. CARD9 knockout ameliorates myocardial dysfunction associated with high fat diet-induced obesity. J Mol Cell Cardiol. 2016;92:185-95 pubmed 出版商
|
| van der Mijn J, Broxterman H, Knol J, Piersma S, de Haas R, Dekker H, et al. Sunitinib activates Axl signaling in renal cell cancer. Int J Cancer. 2016;138:3002-10 pubmed 出版商
|
| Roth Flach R, Skoura A, Matevossian A, Danai L, Zheng W, Cortes C, et al. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis. Nat Commun. 2015;6:8995 pubmed 出版商
|
| Ittig S, Schmutz C, Kasper C, Amstutz M, Schmidt A, Sauteur L, et al. A bacterial type III secretion-based protein delivery tool for broad applications in cell biology. J Cell Biol. 2015;211:913-31 pubmed 出版商
|
| Gong Y, Qiu W, Ning X, Yang X, Liu L, Wang Z, et al. CCDC34 is up-regulated in bladder cancer and regulates bladder cancer cell proliferation, apoptosis and migration. Oncotarget. 2015;6:25856-67 pubmed 出版商
|
| Simard E, Söllradl T, Maltais J, Boucher J, D Orléans Juste P, Grandbois M. Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function. PLoS ONE. 2015;10:e0128881 pubmed 出版商
|
| Wang S, Awad K, Elinoff J, Dougherty E, Ferreyra G, Wang J, et al. G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAY. J Biol Chem. 2015;290:19544-57 pubmed 出版商
|
| Meena J, Cerutti A, Beichler C, Morita Y, Bruhn C, Kumar M, et al. Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion. EMBO J. 2015;34:1371-84 pubmed 出版商
|
| Zhang Q, Kuang H, Chen C, Yan J, Do Umehara H, Liu X, et al. The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation. Nat Immunol. 2015;16:458-66 pubmed 出版商
|
| Kim S, Ka S, Lee Y, Park B, Fei X, Jung J, et al. The new 4-O-methylhonokiol analog GS12021 inhibits inflammation and macrophage chemotaxis: role of AMP-activated protein kinase α activation. PLoS ONE. 2015;10:e0117120 pubmed 出版商
|
| Jilg C, Ketscher A, Metzger E, Hummel B, Willmann D, Rüsseler V, et al. PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells. Oncotarget. 2014;5:12646-64 pubmed
|
| Wang Y, Xiao X, Li N, Yang D, Xing Y, Huo R, et al. Oestrogen inhibits BMP4-induced BMP4 expression in cardiomyocytes: a potential mechanism of oestrogen-mediated protection against cardiac hypertrophy. Br J Pharmacol. 2015;172:5586-95 pubmed 出版商
|
| Zhao X, Zhu L, Chang Q, Jiang C, You Y, Luo T, et al. C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation. J Biol Chem. 2014;289:30052-62 pubmed 出版商
|
| Maeda S, Wada H, Naito Y, Nagano H, Simmons S, Kagawa Y, et al. Interferon-? acts on the S/G2/M phases to induce apoptosis in the G1 phase of an IFNAR2-expressing hepatocellular carcinoma cell line. J Biol Chem. 2014;289:23786-95 pubmed 出版商
|
| Hu J, Cheng Y, Li Y, Jin Z, Pan Y, Liu G, et al. microRNA-128 plays a critical role in human non-small cell lung cancer tumourigenesis, angiogenesis and lymphangiogenesis by directly targeting vascular endothelial growth factor-C. Eur J Cancer. 2014;50:2336-50 pubmed 出版商
|
| Fischer A, Zelinka C, Gallina D, Scott M, Todd L. Reactive microglia and macrophage facilitate the formation of Müller glia-derived retinal progenitors. Glia. 2014;62:1608-28 pubmed 出版商
|
| Cazanave S, Wang X, Zhou H, Rahmani M, Grant S, Durrant D, et al. Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis. Cell Death Differ. 2014;21:1303-12 pubmed 出版商
|
| Krishna S, Luan C, Mishra R, Xu L, Scheidt K, Anderson W, et al. A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4. PLoS ONE. 2013;8:e81504 pubmed 出版商
|
| Lee J, Park J, Kwon O, Kim H, Fornace A, Cha H. Off-target response of a Wip1 chemical inhibitor in skin keratinocytes. J Dermatol Sci. 2014;73:125-34 pubmed 出版商
|
| Lu Q, Harris V, Sun X, Hou Y, Black S. Ca²?/calmodulin-dependent protein kinase II contributes to hypoxic ischemic cell death in neonatal hippocampal slice cultures. PLoS ONE. 2013;8:e70750 pubmed 出版商
|
| Hauerslev S, Sveen M, Vissing J, Krag T. Protein turnover and cellular stress in mildly and severely affected muscles from patients with limb girdle muscular dystrophy type 2I. PLoS ONE. 2013;8:e66929 pubmed 出版商
|
| Aoshiba K, Tsuji T, Kameyama S, Itoh M, Semba S, Yamaguchi K, et al. Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury. Exp Toxicol Pathol. 2013;65:1053-62 pubmed 出版商
|
| Maeda Y, Fukushima K, Omichi R, Kariya S, Nishizaki K. Time courses of changes in phospho- and total- MAP kinases in the cochlea after intense noise exposure. PLoS ONE. 2013;8:e58775 pubmed 出版商
|
| Xu L, Gordon R, FARMER R, Pattanayak A, Binkowski A, Huang X, et al. Precision therapeutic targeting of human cancer cell motility. Nat Commun. 2018;9:2454 pubmed 出版商
|
| Rao S, Sigl V, Wimmer R, Novatchkova M, Jais A, Wagner G, et al. RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer. Genes Dev. 2017;31:2099-2112 pubmed 出版商
|
| Moriwaki S, Into T, Suzuki K, Miyauchi M, Takata T, Shibayama K, et al. γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis. Sci Rep. 2016;6:35930 pubmed 出版商
|
| Ou B, Zhao J, Guan S, Feng H, Wangpu X, Zhu C, et al. CCR4 promotes metastasis via ERK/NF-κB/MMP13 pathway and acts downstream of TNF-α in colorectal cancer. Oncotarget. 2016;7:47637-47649 pubmed 出版商
|
| Lee H, Jang H, Kim H, Shin S, Choo G, Park Y, et al. Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.)in YD-15 tongue mucoepidermoid carcinoma cells. Int J Mol Med. 2016;37:939-48 pubmed 出版商
|
| Bueno Silva B, Kawamoto D, Ando Suguimoto E, Alencar S, Rosalen P, Mayer M. Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages. PLoS ONE. 2015;10:e0144954 pubmed 出版商
|
| Kim J, Lee Y, Kim J, Lee W, Park K, Lee J. Agmatine Attenuates Brain Edema and Apoptotic Cell Death after Traumatic Brain Injury. J Korean Med Sci. 2015;30:943-52 pubmed 出版商
|
| Schwartz A, Sarver D, Sugg K, Dzierzawski J, Gumucio J, Mendias C. p38 MAPK signaling in postnatal tendon growth and remodeling. PLoS ONE. 2015;10:e0120044 pubmed 出版商
|
| Lee J, Kim Y, Song I, Ha S, Kim Y, Baek N, et al. Cyanidin-3-glucoside isolated from mulberry fruit protects pancreatic β-cells against oxidative stress-induced apoptosis. Int J Mol Med. 2015;35:405-12 pubmed 出版商
|
| Pavese J, Ogden I, Voll E, Huang X, Xu L, Jovanovic B, et al. Mitogen-activated protein kinase kinase 4 (MAP2K4) promotes human prostate cancer metastasis. PLoS ONE. 2014;9:e102289 pubmed 出版商
|
| Zhou H, Guo W, Zhao Y, Wang Y, Zha R, Ding J, et al. MicroRNA-135a acts as a putative tumor suppressor by directly targeting very low density lipoprotein receptor in human gallbladder cancer. Cancer Sci. 2014;105:956-65 pubmed 出版商
|
| Rickard D, Sehon C, Kasparcova V, Kallal L, Haile P, Zeng X, et al. Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway. PLoS ONE. 2014;9:e96737 pubmed 出版商
|
| Khare S, Ratsimandresy R, de Almeida L, Cuda C, Rellick S, Misharin A, et al. The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Nat Immunol. 2014;15:343-53 pubmed 出版商
|
| Bukulmez H, Khan F, Bartels C, Murakami S, Ortiz Lopez A, Sattar A, et al. Protective effects of C-type natriuretic peptide on linear growth and articular cartilage integrity in a mouse model of inflammatory arthritis. Arthritis Rheumatol. 2014;66:78-89 pubmed 出版商
|
| Börgeling Y, Schmolke M, Viemann D, Nordhoff C, Roth J, Ludwig S. Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses and protects mice from lethal H5N1 infection. J Biol Chem. 2014;289:13-27 pubmed 出版商
|
| Zhuo B, Wang R, Zhang H, Qin H, Yin Y, Shi Y. Interleukin-24 inhibits cell migration and invasion in the neuroblastoma cell line SH-SY5Y. Oncol Rep. 2013;30:2749-54 pubmed 出版商
|
| Cao L, Cao Y, Xu C, Edvinsson L. Altered endothelin receptor expression and affinity in spontaneously hypertensive rat cerebral and coronary arteries. PLoS ONE. 2013;8:e73761 pubmed 出版商
|
| Dzieran J, Fabian J, Feng T, Coulouarn C, Ilkavets I, Kyselova A, et al. Comparative analysis of TGF-?/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines. PLoS ONE. 2013;8:e72252 pubmed 出版商
|
| Yentrapalli R, Azimzadeh O, Sriharshan A, Malinowsky K, Merl J, Wojcik A, et al. The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation. PLoS ONE. 2013;8:e70024 pubmed 出版商
|
| Rickard D, Sehon C, Kasparcova V, Kallal L, Zeng X, Montoute M, et al. Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. PLoS ONE. 2013;8:e69619 pubmed 出版商
|
| Amako Y, Iglói Z, Mankouri J, Kazlauskas A, Saksela K, Dallas M, et al. Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis. J Biol Chem. 2013;288:24753-63 pubmed 出版商
|
| Cao Y, Xia D, Qi S, Du J, Ma P, Wang S, et al. Epiregulin can promote proliferation of stem cells from the dental apical papilla via MEK/Erk and JNK signalling pathways. Cell Prolif. 2013;46:447-56 pubmed 出版商
|
| MartÃnez AbadÃas N, Holmes G, Pankratz T, Wang Y, Zhou X, Jabs E, et al. From shape to cells: mouse models reveal mechanisms altering palate development in Apert syndrome. Dis Model Mech. 2013;6:768-79 pubmed 出版商
|
| Lien E, Nagiec M, Dohlman H. Proper protein glycosylation promotes mitogen-activated protein kinase signal fidelity. Biochemistry. 2013;52:115-24 pubmed 出版商
|
| Cao L, Zhang Y, Cao Y, Edvinsson L, Xu C. Secondhand smoke exposure causes bronchial hyperreactivity via transcriptionally upregulated endothelin and 5-hydroxytryptamine 2A receptors. PLoS ONE. 2012;7:e44170 pubmed 出版商
|
| Magnussen G, Holm R, Emilsen E, Rosnes A, Slipicevic A, Flørenes V. High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: potential for targeted therapy. PLoS ONE. 2012;7:e38254 pubmed 出版商
|
| Sheng L, Zhou Y, Chen Z, Ren D, Cho K, Jiang L, et al. NF-?B–inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action. Nat Med. 2012;18:943-9 pubmed 出版商
|
| Cao L, Zhang Y, Cao Y, Edvinsson L, Xu C. Cigarette smoke upregulates rat coronary artery endothelin receptors in vivo. PLoS ONE. 2012;7:e33008 pubmed 出版商
|
| Handra Luca A, Lesty C, Hammel P, Sauvanet A, Rebours V, Martin A, et al. Biological and prognostic relevance of mitogen-activated protein kinases in pancreatic adenocarcinoma. Pancreas. 2012;41:416-21 pubmed 出版商
|
| Bohdanowicz M, Balkin D, De Camilli P, Grinstein S. Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling. Mol Biol Cell. 2012;23:176-87 pubmed 出版商
|
| Seisenbacher G, Hafen E, Stocker H. MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress. PLoS Genet. 2011;7:e1002168 pubmed 出版商
|
| Warr N, Bogani D, Siggers P, Brixey R, Tateossian H, Dopplapudi A, et al. Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1. PLoS ONE. 2011;6:e19572 pubmed 出版商
|
| Nakou M, Bertsias G, Stagakis I, Centola M, Tassiulas I, Hatziapostolou M, et al. Gene network analysis of bone marrow mononuclear cells reveals activation of multiple kinase pathways in human systemic lupus erythematosus. PLoS ONE. 2010;5:e13351 pubmed 出版商
|
| Nayak G, Prentice H, Milton S. Neuroprotective signaling pathways are modulated by adenosine in the anoxia tolerant turtle. J Cereb Blood Flow Metab. 2011;31:467-75 pubmed 出版商
|
| Bhandari D, Seo K, Roh K, Jung J, Kang S, Kang K. REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells. PLoS ONE. 2010;5:e10493 pubmed 出版商
|
| Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, et al. Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol. 2009;7:e1000196 pubmed 出版商
|
| Bromberg White J, Boguslawski E, Duesbery N. Perturbation of mouse retinal vascular morphogenesis by anthrax lethal toxin. PLoS ONE. 2009;4:e6956 pubmed 出版商
|
| Miyaji M, Kortum R, Surana R, Li W, Woolard K, Simpson R, et al. Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice. Proc Natl Acad Sci U S A. 2009;106:14502-7 pubmed 出版商
|