产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
Akt (pan) (C67E7) Rabbit mAb
目录 :
4691
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
C67E7
反应物种 :
仓鼠, 人类, 小鼠, 大鼠, , , 斑马鱼, 黑腹果蝇
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, reverse phase protein lysate microarray, 其他, mass cytometry
文章摘录数: 567
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 2b
  • 免疫印迹; 人类; 1:1000; 图 2a
VASAN N, Razavi P, Johnson J, Shao H, Shah H, Antoine A, et al. Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors. Science. 2019;366:714-723 pubmed 出版商
  • 免疫印迹; 人类; 1:1500; 图 3a
Petersen C, Mahmood B, Badsted C, Dahlby T, Rasmussen H, Hansen M, et al. Possible predisposition for colorectal carcinogenesis due to altered gene expressions in normal appearing mucosa from patients with colorectal neoplasia. BMC Cancer. 2019;19:643 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 2a
Wang H, Huang F, Zhang Z, Wang P, Luo Y, Li H, et al. Feedback Activation of SGK3 and AKT Contributes to Rapamycin Resistance by Reactivating mTORC1/4EBP1 Axis via TSC2 in Breast Cancer. Int J Biol Sci. 2019;15:929-941 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3c
Singh R, Peng S, Viswanath P, Sambandam V, Shen L, Rao X, et al. Non-canonical cMet regulation by vimentin mediates Plk1 inhibitor-induced apoptosis. EMBO Mol Med. 2019;: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6s1c
Sommars M, Ramachandran K, Senagolage M, Futtner C, Germain D, Allred A, et al. Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis. elife. 2019;8: pubmed 出版商
  • mass cytometry; 人类; 图 3a
Wagner J, Rapsomaniki M, Chevrier S, Anzeneder T, Langwieder C, Dykgers A, et al. A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer. Cell. 2019;177:1330-1345.e18 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 s1e
Castel P, Cheng A, Cuevas Navarro A, Everman D, Papageorge A, Simanshu D, et al. RIT1 oncoproteins escape LZTR1-mediated proteolysis. Science. 2019;363:1226-1230 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s18a
Shen T, Li H, Song Y, Li L, Lin J, Wei G, et al. Alternative polyadenylation dependent function of splicing factor SRSF3 contributes to cellular senescence. Aging (Albany NY). 2019;11:1356-1388 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6b
  • 免疫印迹; 人类; 图 6f
Mentrup T, Theodorou K, Cabrera Cabrera F, Helbig A, Happ K, Gijbels M, et al. Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis. J Exp Med. 2019;: pubmed 出版商
  • 免疫印迹; 人类; 图 2l
Cao J, Zhao M, Liu J, Zhang X, Pei Y, Wang J, et al. RACK1 Promotes Self-Renewal and Chemoresistance of Cancer Stem Cells in Human Hepatocellular Carcinoma through Stabilizing Nanog. Theranostics. 2019;9:811-828 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6i
Teissier T, Quersin V, Gnemmi V, Daroux M, Howsam M, Delguste F, et al. Knockout of receptor for advanced glycation end-products attenuates age-related renal lesions. Aging Cell. 2019;18:e12850 pubmed 出版商
  • 免疫印迹; 人类; 图 6b
Yambire K, Fernández Mosquera L, Steinfeld R, Mühle C, Ikonen E, Milosevic I, et al. Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5c
Su W, Wang Y, Wang F, Zhang B, Zhang H, Shen Y, et al. Circular RNA hsa_circ_0007059 indicates prognosis and influences malignant behavior via AKT/mTOR in oral squamous cell carcinoma. J Cell Physiol. 2019;: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4h
Ding Y, Li N, Dong B, Guo W, Wei H, Chen Q, et al. Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer. J Clin Invest. 2019;129:759-773 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 3b, 4f, 5f
Zhou X, Zhang R, Zou Z, Shen X, Xie T, Xu C, et al. Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat. Br J Pharmacol. 2019;176:478-490 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6c
Liang C, Ma Y, Yong L, Yang C, Wang P, Liu X, et al. Y-box binding protein-1 promotes tumorigenesis and progression via the epidermal growth factor receptor/AKT pathway in spinal chordoma. Cancer Sci. 2019;110:166-179 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5e
Zhang M, Suarez E, Vasquez J, Nathanson L, Peterson L, Rajapakshe K, et al. Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity. Oncogene. 2019;38:1121-1135 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Nnah I, Wang B, Saqcena C, Weber G, Bonder E, Bagley D, et al. TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy. Autophagy. 2019;15:151-164 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5a
Nie S, Tan Y, Zhang Z, Chen G, Xiong J, Hu D, et al. Bilateral Implantation of Shear Stress Modifier in ApoE Knockout Mouse Induces Cognitive Impairment and Tau Abnormalities. Front Aging Neurosci. 2018;10:303 pubmed 出版商
  • 免疫印迹; 人类; 图 6c
Lu D, Song J, Sun Y, Qi F, Liu L, Jin Y, et al. Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders. J Autoimmun. 2018;94:156-165 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s3a
Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt F, Liniany L, Knight D, et al. PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells. Immunity. 2018;49:247-263.e7 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7a
Tan B, Shi X, Zhang J, Qin J, Zhang N, Ren H, et al. Inhibition of Rspo-Lgr4 Facilitates Checkpoint Blockade Therapy by Switching Macrophage Polarization. Cancer Res. 2018;78:4929-4942 pubmed 出版商
  • 免疫印迹; 人类; 图 2d
Fan P, Narzisi G, Jayaprakash A, Venturini E, Robine N, Smibert P, et al. YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics. Proc Natl Acad Sci U S A. 2018;115:E6030-E6038 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5a
Wang X, Du C, He X, Deng X, He Y, Zhou X. MiR-4463 inhibits the migration of human aortic smooth muscle cells by AMOT. Biosci Rep. 2018;38: pubmed 出版商
  • 免疫印迹; 小鼠; 图 s11a
Ubil E, Caskey L, Holtzhausen A, Hunter D, Story C, Earp H. Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. J Clin Invest. 2018;128:2356-2369 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5a
Anker J, Naseem A, Mok H, Schaeffer A, Abdulkadir S, Thumbikat P. Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy. Nat Commun. 2018;9:1591 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5c
Chiang A, Fowler S, Savjani R, Hilsenbeck S, Wallace C, Cirrito J, et al. Combination anti-Aβ treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice. J Exp Med. 2018;215:1349-1364 pubmed 出版商
  • 其他; 人类; 图 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1c
Rizzi C, Tiberi A, Giustizieri M, Marrone M, Gobbo F, Carucci N, et al. NGF steers microglia toward a neuroprotective phenotype. Glia. 2018;66:1395-1416 pubmed 出版商
  • 免疫印迹; 人类; 图 s3b
Janes M, Zhang J, Li L, Hansen R, Peters U, Guo X, et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell. 2018;172:578-589.e17 pubmed 出版商
  • 免疫印迹; 人类; 图 s7d
Souma T, Thomson B, Heinen S, Carota I, Yamaguchi S, Onay T, et al. Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP. Proc Natl Acad Sci U S A. 2018;115:1298-1303 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3a
Kunimoto H, Meydan C, Nazir A, Whitfield J, Shank K, Rapaport F, et al. Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity. Cancer Cell. 2018;33:44-59.e8 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4a
Sun H, Krauss R, Chang J, Teng B. PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction. J Lipid Res. 2018;59:207-223 pubmed 出版商
  • 免疫印迹; 人类; 图 2c
Bostner J, Alayev A, Berman A, Fornander T, Nordenskjold B, Holz M, et al. Raptor localization predicts prognosis and tamoxifen response in estrogen receptor-positive breast cancer. Breast Cancer Res Treat. 2018;168:17-27 pubmed 出版商
  • 免疫印迹; 小鼠; 1:3000; 图 4g
Meng Z, Tao W, Sun J, Wang Q, Mi L, Lin J. Uncoupling Exercise Bioenergetics From Systemic Metabolic Homeostasis by Conditional Inactivation of Baf60 in Skeletal Muscle. Diabetes. 2018;67:85-97 pubmed 出版商
  • 免疫印迹; 人类; 图 7
Reuther C, Heinzle V, Nölting S, Herterich S, Hahner S, Halilovic E, et al. The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. Neuroendocrinology. 2018;106:1-19 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5a
Kishore M, Cheung K, Fu H, Bonacina F, Wang G, Coe D, et al. Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Immunity. 2017;47:875-889.e10 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Zhang R, Li J, Yan X, Jin K, Li W, Xu J, et al. SODD promotes glucose uptake of colorectal cancer cells via AKT pathway. Cell Biol Int. 2017;: pubmed 出版商
  • 免疫印迹; 人类; 图 3d
  • 免疫印迹; 小鼠; 图 2b
Hwangbo C, Wu J, Papangeli I, Adachi T, Sharma B, Park S, et al. Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. Sci Transl Med. 2017;9: pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 6a
Zaytouni T, Tsai P, Hitchcock D, DuBois C, Freinkman E, Lin L, et al. Critical role for arginase 2 in obesity-associated pancreatic cancer. Nat Commun. 2017;8:242 pubmed 出版商
  • 免疫印迹; 人类; 图 9c
Peterson J, Lin B, Shin J, Phelan P, Tsichlis P, Schwob J, et al. Replication of JC Virus DNA in the G144 Oligodendrocyte Cell Line Is Dependent Upon Akt. J Virol. 2017;91: pubmed 出版商
  • 免疫印迹; 小鼠; 图 s5g
Chang S, Kohlgruber A, Mizoguchi F, Michelet X, Wolf B, Wei K, et al. Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes. J Clin Invest. 2017;127:3300-3312 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s10a
Ogura H, Nagatake Kobayashi Y, Adachi J, Tomonaga T, Fujita N, Katayama R. TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity. Sci Rep. 2017;7:5519 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Guilford B, Parson J, Grote C, Vick S, Ryals J, Wright D. Increased FNDC5 is associated with insulin resistance in high fat-fed mice. Physiol Rep. 2017;5: pubmed 出版商
  • 免疫印迹; 人类; 图 4b
van Groningen T, Koster J, Valentijn L, Zwijnenburg D, Akogul N, Hasselt N, et al. Neuroblastoma is composed of two super-enhancer-associated differentiation states. Nat Genet. 2017;49:1261-1266 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5f
Lingel H, Wissing J, Arra A, Schanze D, Lienenklaus S, Klawonn F, et al. CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation. Cell Death Differ. 2017;24:1739-1749 pubmed 出版商
  • 免疫印迹; 犬; 图 s3a
Zhang K, Myllymäki S, Gao P, Devarajan R, Kytölä V, Nykter M, et al. Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT. Oncogene. 2017;36:5681-5694 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6
Wang B, Gu Q, Li J. DOC-2/DAB2 interactive protein regulates proliferation and mobility of nasopharyngeal carcinoma cells by targeting PI3K/Akt pathway. Oncol Rep. 2017;38:317-324 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1j
Wang B, Jie Z, Joo D, Ordureau A, Liu P, Gan W, et al. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling. Nature. 2017;545:365-369 pubmed 出版商
  • 免疫印迹; 人类; 图 7a
Kapil S, Sharma B, Patil M, Elattar S, Yuan J, Hou S, et al. The cell polarity protein Scrib functions as a tumor suppressor in liver cancer. Oncotarget. 2017;8:26515-26531 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4c
Yang X, Qi L, Lin F, Ou Z. The role of the chemokine receptor XCR1 in breast cancer cells. Breast Cancer (Dove Med Press). 2017;9:227-236 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4b
Zhang X, Spiegelman N, Nelson O, Jing H, Lin H. SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. elife. 2017;6: pubmed 出版商
  • 免疫印迹; 小鼠; 图 4a
Xiao Y, Yang Z, Wu Q, Jiang X, Yuan Y, Chang W, et al. Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy. J Cell Biochem. 2017;118:3899-3910 pubmed 出版商
  • 免疫印迹; 人类; 图 3c
Lei L, Chen C, Zhao J, Wang H, Guo M, Zhou Y, et al. Targeted Expression of miR-7 Operated by TTF-1 Promoter Inhibited the Growth of Human Lung Cancer through the NDUFA4 Pathway. Mol Ther Nucleic Acids. 2017;6:183-197 pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Merhi A, Delree P, Marini A. The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling. Sci Rep. 2017;7:44602 pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Sahu U, Choudhury A, Parvez S, Biswas S, Kar S. Induction of intestinal stemness and tumorigenicity by aberrant internalization of commensal non-pathogenic E. coli. Cell Death Dis. 2017;8:e2667 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3b
CAROMILE L, Dortche K, Rahman M, Grant C, Stoddard C, Ferrer F, et al. PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer. Sci Signal. 2017;10: pubmed 出版商
  • reverse phase protein lysate microarray; 人类; 图 st6
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7a
Samuel S, Ghosh S, Majeed Y, Arunachalam G, Emara M, Ding H, et al. Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death. Biochem Pharmacol. 2017;132:118-132 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Koenen A, Babendreyer A, Schumacher J, Pasqualon T, Schwarz N, Seifert A, et al. The DRF motif of CXCR6 as chemokine receptor adaptation to adhesion. PLoS ONE. 2017;12:e0173486 pubmed 出版商
  • 免疫印迹; 人类; 图 1f
Li K, Mo C, Gong D, Chen Y, Huang Z, Li Y, et al. DDX17 nucleocytoplasmic shuttling promotes acquired gefitinib resistance in non-small cell lung cancer cells via activation of β-catenin. Cancer Lett. 2017;400:194-202 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3c
Deying W, Feng G, Shumei L, Hui Z, Ming L, Hongqing W. CAF-derived HGF promotes cell proliferation and drug resistance by up-regulating the c-Met/PI3K/Akt and GRP78 signalling in ovarian cancer cells. Biosci Rep. 2017;37: pubmed 出版商
  • 免疫印迹; 人类; 图 6a
Lal S, Cheung E, Zarei M, Preet R, Chand S, Mambelli Lisboa N, et al. CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype. Mol Cancer Res. 2017;15:696-707 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7a
Dong Q, Li J, Wu Q, Zhao N, Qian C, Ding D, et al. Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia/reperfusion injury in mice. Sci Rep. 2017;7:42678 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 4A
Wang N, Yao F, Li K, Zhang L, Yin G, Du M, et al. Fisetin regulates astrocyte migration and proliferation in vitro. Int J Mol Med. 2017;39:783-790 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
  • 免疫印迹; 小鼠; 图 s9e
Peng M, Yin N, Li M. SZT2 dictates GATOR control of mTORC1 signalling. Nature. 2017;543:433-437 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s9a
Compagno M, Wang Q, Pighi C, Cheong T, Meng F, Poggio T, et al. Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells. Nature. 2017;542:489-493 pubmed 出版商
  • 免疫印迹; 人类; 图 s5h
Wolfson R, Chantranupong L, Wyant G, Gu X, Orozco J, Shen K, et al. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. 2017;543:438-442 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6g
Qian Q, Liu Q, Zhou D, Pan H, Liu Z, He F, et al. Brain-specific ablation of Efr3a promotes adult hippocampal neurogenesis via the brain-derived neurotrophic factor pathway. FASEB J. 2017;31:2104-2113 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3a
Ganesan R, Hos N, Gutierrez S, Fischer J, Stepek J, Daglidu E, et al. Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. PLoS Pathog. 2017;13:e1006227 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1h
Xu W, Li B, Guan X, Chung S, Wang Y, Yip Y, et al. Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression. Nat Commun. 2017;8:14399 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 7a
Zhu Y, Takayama T, Wang B, Kent A, Zhang M, Binder B, et al. Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol. Sci Rep. 2017;7:41916 pubmed 出版商
  • 免疫印迹; 小鼠; 图 12A
Shen C, Zhou J, Wang X, Yu X, Liang C, Liu B, et al. Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3? Signaling Pathway. EBioMedicine. 2017;16:238-250 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1b
Sugg K, Korn M, Sarver D, Markworth J, Mendias C. Inhibition of platelet-derived growth factor signaling prevents muscle fiber growth during skeletal muscle hypertrophy. FEBS Lett. 2017;591:801-809 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4a
Kissing S, Rudnik S, Damme M, Lüllmann Rauch R, Ichihara A, Kornak U, et al. Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes. Autophagy. 2017;13:670-685 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4b
Liu J, Wang H, Gu J, Deng T, Yuan Z, Hu B, et al. BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein. Autophagy. 2017;13:739-753 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1500; 图 2a
Sheng L, Mao X, Yu Q, Yu D. Effect of the PI3K/AKT signaling pathway on hypoxia-induced proliferation and differentiation of bone marrow-derived mesenchymal stem cells. Exp Ther Med. 2017;13:55-62 pubmed 出版商
  • reverse phase protein lysate microarray; 人类; 图 3a
. Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384 pubmed 出版商
  • 免疫印迹; 大鼠; 图 4b
Zhang Y, Stefanovic B. mTORC1 phosphorylates LARP6 to stimulate type I collagen expression. Sci Rep. 2017;7:41173 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3d
Villar V, Nguyen T, Delcroix V, Terés S, Bouchecareilh M, Salin B, et al. mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation. Nat Commun. 2017;8:14124 pubmed 出版商
  • 免疫印迹; 人类; 图 3c,3d
Cao H, Yu S, Chen D, Jing C, Wang Z, Ma R, et al. Liver X receptor agonist T0901317 reverses resistance of A549 human lung cancer cells to EGFR-TKI treatment. FEBS Open Bio. 2017;7:35-43 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s7a
Kechele D, Blue R, Zwarycz B, Espenschied S, Mah A, Siegel M, et al. Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation. J Clin Invest. 2017;127:593-607 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 2b
  • 免疫印迹; 小鼠; 1:2000; 图 2b
Kang Y, Balter B, Csizmadia E, Haas B, Sharma H, Bronson R, et al. Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival. Nat Commun. 2017;8:14013 pubmed 出版商
  • 免疫印迹; 小鼠; 1:3000; 图 7e
Yue F, Bi P, Wang C, Shan T, Nie Y, Ratliff T, et al. Pten is necessary for the quiescence and maintenance of adult muscle stem cells. Nat Commun. 2017;8:14328 pubmed 出版商
  • 免疫印迹; 小鼠; 1:10,000; 图 5d
Dror E, Dalmas E, Meier D, Wueest S, Thévenet J, Thienel C, et al. Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation. Nat Immunol. 2017;18:283-292 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4a
Jung Y, Lee J, Sohn K, Lee Y, Seo Y, Kim C, et al. Adiponectin Signaling Regulates Lipid Production in Human Sebocytes. PLoS ONE. 2017;12:e0169824 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5c
Huang S, Mao J, Ding K, Zhou Y, Zeng X, Yang W, et al. Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease. Stem Cell Reports. 2017;8:84-94 pubmed 出版商
  • 免疫印迹; 人类; 图 4d
Zhao B, Hu W, Kumar S, Gonyo P, Rana U, Liu Z, et al. The Nogo-B receptor promotes Ras plasma membrane localization and activation. Oncogene. 2017;36:3406-3416 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 3c
Hirai M, Arita Y, McGlade C, Lee K, Chen J, Evans S. Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest. 2017;127:569-582 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3a
Hichino A, Okamoto M, Taga S, Akizuki R, Endo S, Matsunaga T, et al. Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. J Biol Chem. 2017;292:2411-2421 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 7a
Hu N, Chang H, Du B, Zhang Q, Arfat Y, Dang K, et al. Tetramethylpyrazine ameliorated disuse-induced gastrocnemius muscle atrophy in hindlimb unloading rats through suppression of Ca2+/ROS-mediated apoptosis. Appl Physiol Nutr Metab. 2017;42:117-127 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4b
Kocsis T, Trencsenyi G, Szabó K, Baán J, Müller G, Mendler L, et al. Myostatin propeptide mutation of the hypermuscular Compact mice decreases the formation of myostatin and improves insulin sensitivity. Am J Physiol Endocrinol Metab. 2017;312:E150-E160 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s3b
Li J, Casteels T, Frogne T, Ingvorsen C, Honore C, Courtney M, et al. Artemisinins Target GABAA Receptor Signaling and Impair ? Cell Identity. Cell. 2017;168:86-100.e15 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4d
Kariolis M, Miao Y, Diep A, Nash S, Olcina M, Jiang D, et al. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest. 2017;127:183-198 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Yang S, Ji Q, Chang B, Wang Y, Zhu Y, Li D, et al. STC2 promotes head and neck squamous cell carcinoma metastasis through modulating the PI3K/AKT/Snail signaling. Oncotarget. 2017;8:5976-5991 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2d
Park J, Kim S, Yoo J, Jang J, Lee A, Oh J, et al. Novel Neuroprotective Effects of Melanin-Concentrating Hormone in Parkinson's Disease. Mol Neurobiol. 2017;54:7706-7721 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 2
Chruvattil R, Banerjee S, Nath S, Machhi J, Kharkwal G, Yadav M, et al. Dexamethasone Alters the Appetite Regulation via Induction of Hypothalamic Insulin Resistance in Rat Brain. Mol Neurobiol. 2017;54:7483-7496 pubmed 出版商
  • 免疫印迹; 人类; 图 6a
Cieniewicz A, Kirchner T, Hinke S, Nanjunda R, D AQUINO K, Boayke K, et al. Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance. Diabetes. 2017;66:206-217 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Fan Y, Wang N, Rocchi A, Zhang W, Vassar R, Zhou Y, et al. Identification of natural products with neuronal and metabolic benefits through autophagy induction. Autophagy. 2017;13:41-56 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3b
Hau A, Leivo M, Gilder A, Hu J, Gonias S, Hansel D. mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer. Cell Signal. 2017;29:96-106 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:1000; 图 1c
Goebbels S, Wieser G, Pieper A, Spitzer S, Weege B, Yan K, et al. A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nat Neurosci. 2017;20:10-15 pubmed 出版商
  • 免疫印迹; 人类; 图 3b
Dandanell S, Skovborg C, Præst C, Kristensen K, Nielsen M, Lionett S, et al. Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health. Obes Res Clin Pract. 2017;11:489-498 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7h
Ratsimandresy R, Indramohan M, Dorfleutner A, Stehlik C. The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. Cell Mol Immunol. 2017;14:127-142 pubmed 出版商
  • 免疫印迹; 黑腹果蝇; 1:5000; 图 s3e
Monyak R, Emerson D, Schoenfeld B, Zheng X, Chambers D, Rosenfelt C, et al. Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model. Mol Psychiatry. 2017;22:1140-1148 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s6a
Karki R, Man S, Malireddi R, Kesavardhana S, Zhu Q, Burton A, et al. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 2016;540:583-587 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1a
Abshire C, Dragoi A, Roy C, Ivanov S. MTOR-Driven Metabolic Reprogramming Regulates Legionella pneumophila Intracellular Niche Homeostasis. PLoS Pathog. 2016;12:e1006088 pubmed 出版商
  • 免疫印迹; 人类; 图 6a
Tanouchi A, Taniuchi K, Furihata M, Naganuma S, Dabanaka K, Kimura M, et al. CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells. J Exp Clin Cancer Res. 2016;35:190 pubmed
  • 免疫印迹; 黑腹果蝇; 1:1000; 图 s5
Bangi E, Murgia C, Teague A, Sansom O, Cagan R. Functional exploration of colorectal cancer genomes using Drosophila. Nat Commun. 2016;7:13615 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Torgersen M, Klokk T, Kavaliauskiene S, Klose C, Simons K, Skotland T, et al. The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport. Oncotarget. 2016;7:86871-86888 pubmed 出版商
  • 免疫印迹; 大鼠; 图 6d
Pearson Leary J, McNay E. Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory. J Neurosci. 2016;36:11851-11864 pubmed
  • 免疫印迹; 人类; 图 2a
Vidimar V, Gius D, Chakravarti D, Bulun S, Wei J, Kim J. Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas. Sci Adv. 2016;2:e1601132 pubmed
  • 免疫印迹; 小鼠; 图 7a
Kong Q, Zhang H, Zhao T, Zhang W, Yan M, Dong X, et al. Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice. Int J Mol Med. 2016;38:1715-1726 pubmed 出版商
  • 免疫印迹; 仓鼠; 图 1b
Han C, Juncadella I, Kinchen J, Buckley M, Klibanov A, Dryden K, et al. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation. Nature. 2016;539:570-574 pubmed 出版商
  • 免疫印迹; 人类; 图 4c
Chu Q, Huang H, Huang T, Cao L, Peng L, Shi S, et al. Extracellular serglycin upregulates the CD44 receptor in an autocrine manner to maintain self-renewal in nasopharyngeal carcinoma cells by reciprocally activating the MAPK/β-catenin axis. Cell Death Dis. 2016;7:e2456 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1c
Sheen M, Marotti J, Allegrezza M, Rutkowski M, Conejo Garcia J, Fiering S. Constitutively activated PI3K accelerates tumor initiation and modifies histopathology of breast cancer. Oncogenesis. 2016;5:e267 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 表 1
Cardoso R, Burns A, Moeller J, Skinner D, Padmanabhan V. Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS. Endocrinology. 2016;157:4641-4653 pubmed
  • 免疫印迹; 小鼠; 图 5a
Zhao J, Chen C, Guo M, Tao Y, Cui P, Zhou Y, et al. MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4. Front Immunol. 2016;7:389 pubmed
  • 免疫印迹; 小鼠; 图 3a
Gómez Salinero J, López Olañeta M, Ortiz Sánchez P, Larrasa Alonso J, Gatto A, Felkin L, et al. The Calcineurin Variant CnA?1 Controls Mouse Embryonic Stem Cell Differentiation by Directing mTORC2 Membrane Localization and Activation. Cell Chem Biol. 2016;23:1372-1382 pubmed 出版商
  • 免疫印迹; 大鼠; 1:10,000; 图 3b
Takeuchi S, Iwama S, Takagi H, Kiyota A, Nakashima K, Izumida H, et al. Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons. PLoS ONE. 2016;11:e0164544 pubmed 出版商
  • 免疫印迹; 小鼠; 1:3000; 图 3d
Kimura T, Nada S, Takegahara N, Okuno T, Nojima S, Kang S, et al. Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals. Nat Commun. 2016;7:13130 pubmed 出版商
  • 免疫印迹; 人类; 图 9c
Rodina A, Wang T, Yan P, Gomes E, Dunphy M, Pillarsetty N, et al. The epichaperome is an integrated chaperome network that facilitates tumour survival. Nature. 2016;538:397-401 pubmed 出版商
  • 免疫印迹; 人类; 图 7
  • 免疫印迹; 小鼠; 图 1
Cizmecioglu O, Ni J, Xie S, Zhao J, Roberts T. Rac1-mediated membrane raft localization of PI3K/p110? is required for its activation by GPCRs or PTEN loss. elife. 2016;5: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5b
Broix L, Jagline H, Ivanova E, Schmucker S, Drouot N, Clayton Smith J, et al. Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia. Nat Genet. 2016;48:1349-1358 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4a
Wei R, Lin S, Wu W, Chen L, Li C, Chen H, et al. A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol Appl Pharmacol. 2016;311:88-98 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 4f
Cao R, Meng Z, Liu T, Wang G, Qian G, Cao T, et al. Decreased TRPM7 inhibits activities and induces apoptosis of bladder cancer cells via ERK1/2 pathway. Oncotarget. 2016;7:72941-72960 pubmed 出版商
  • 免疫印迹; 人类; 1:200; 图 st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Christensen B, Nellemann B, Jørgensen J, Pedersen S, Jessen N. Erythropoietin does not activate erythropoietin receptor signaling or lipolytic pathways in human subcutaneous white adipose tissue in vivo. Lipids Health Dis. 2016;15:160 pubmed 出版商
  • 免疫印迹; 人类; 图 6c
Rittig N, Bach E, Thomsen H, Pedersen S, Nielsen T, Jørgensen J, et al. Regulation of Lipolysis and Adipose Tissue Signaling during Acute Endotoxin-Induced Inflammation: A Human Randomized Crossover Trial. PLoS ONE. 2016;11:e0162167 pubmed 出版商
  • 免疫印迹; 斑马鱼; 1:5000; 图 1f
Shin M, Male I, Beane T, Villefranc J, Kok F, Zhu L, et al. Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors. Development. 2016;143:3785-3795 pubmed
  • 免疫印迹; 大鼠; 图 5
Hesler R, Huang J, Starr M, Treboschi V, Bernanke A, Nixon A, et al. TGF-?-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3. Carcinogenesis. 2016;37:1041-1051 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 5a
  • 免疫印迹; 人类; 1:1000; 图 s2b
Wang S, Jiang L, Han Y, Chew S, Ohara Y, Akatsuka S, et al. Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma. Oncotarget. 2016;7:69565-69578 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 s5b
Josowitz R, Mulero Navarro S, Rodriguez N, Falce C, Cohen N, Ullian E, et al. Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes. Stem Cell Reports. 2016;7:355-369 pubmed 出版商
  • 免疫印迹; 人类; 图 3, s3
Beale G, Haagensen E, Thomas H, Wang L, Revill C, Payne S, et al. Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer. Br J Cancer. 2016;115:682-90 pubmed 出版商
  • 免疫印迹; 人类; 图 6d
Buta C, Benabou E, Lequoy M, Régnault H, Wendum D, Meratbene F, et al. Heregulin-1ß and HER3 in hepatocellular carcinoma: status and regulation by insulin. J Exp Clin Cancer Res. 2016;35:126 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3f
Tsai S, Rodriguez A, Dastidar S, Del Greco E, Carr K, Sitzmann J, et al. Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice. Cell Rep. 2016;16:1903-14 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Oh B, Kim S, Lee Y, Hong H, Kim T, Kim S, et al. Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells. Oncotarget. 2016;7:57066-57076 pubmed 出版商
  • 免疫印迹; 人类; 图 5c
Ladd B, Mazzola A, Bihani T, Lai Z, BRADFORD J, Collins M, et al. Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations. Oncotarget. 2016;7:54120-54136 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 5
Coppo M, Chinenov Y, Sacta M, Rogatsky I. The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis. Nat Commun. 2016;7:12254 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 6
Jiao K, Zeng G, Niu L, Yang H, Ren G, Xu X, et al. Activation of ?2A-adrenergic signal transduction in chondrocytes promotes degenerative remodelling of temporomandibular joint. Sci Rep. 2016;6:30085 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2000; 图 1
Pan B, Huang X, Deng C. Chronic administration of aripiprazole activates GSK3β-dependent signalling pathways, and up-regulates GABAA receptor expression and CREB1 activity in rats. Sci Rep. 2016;6:30040 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Ma T, Fan B, Zhang C, Zhao H, Han C, Gao C, et al. Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway. Sci Rep. 2016;6:29926 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
McClelland Descalzo D, Satoorian T, Walker L, Sparks N, Pulyanina P, zur Nieden N. Glucose-Induced Oxidative Stress Reduces Proliferation in Embryonic Stem Cells via FOXO3A/?-Catenin-Dependent Transcription of p21(cip1). Stem Cell Reports. 2016;7:55-68 pubmed 出版商
  • 免疫印迹; 人类; 图 4b
Warner M, Bridge K, Hewitson J, Hodgkinson M, Heyam A, Massa B, et al. S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells. Nucleic Acids Res. 2016;44:9942-9955 pubmed
  • 免疫印迹; 人类; 图 6a
Shen P, Chen M, He M, Chen L, Song Y, Xiao P, et al. Inhibition of ER?/ERK/P62 cascades induces "autophagic switch" in the estrogen receptor-positive breast cancer cells exposed to gemcitabine. Oncotarget. 2016;7:48501-48516 pubmed 出版商
  • 免疫印迹; 大鼠; 1:500; 图 3
Li X, Chen Y, Wang L, Shang G, Zhang C, Zhao Z, et al. Quercetin alleviates pulmonary angiogenesis in a rat model of hepatopulmonary syndrome. Braz J Med Biol Res. 2016;49: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3c
Rozo M, Li L, Fan C. Targeting ?1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice. Nat Med. 2016;22:889-96 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7
Petrova L, Gran C, Bjoras M, Doetsch P. Efficient and Reliable Production of Vectors for the Study of the Repair, Mutagenesis, and Phenotypic Consequences of Defined DNA Damage Lesions in Mammalian Cells. PLoS ONE. 2016;11:e0158581 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Shriver M, Marimuthu S, Paul C, Geist J, Seale T, Konstantopoulos K, et al. Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit. Oncotarget. 2016;7:45414-45428 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6A
Maugeri G, D Amico A, Reitano R, Magro G, Cavallaro S, Salomone S, et al. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Front Pharmacol. 2016;7:139 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol. 2016;197:504-16 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Tejada T, Tan L, Torres R, Calvert J, Lambert J, Zaidi M, et al. IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction. Proc Natl Acad Sci U S A. 2016;113:6949-54 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Foltz S, Luan J, Call J, Patel A, Peissig K, Fortunato M, et al. Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy. Skelet Muscle. 2016;6:20 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5c
Stein S, Mack E, Rome K, Pajcini K, Ohtani T, Xu L, et al. Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL. PLoS ONE. 2016;11:e0155408 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Chan E, Shetty M, Sajikumar S, Chen C, Soong T, Wong B. ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model. Sci Rep. 2016;6:26119 pubmed 出版商
  • 免疫印迹; 人类; 图 7
Huang D, Zhao C, Ju R, Kumar A, Tian G, Huang L, et al. VEGF-B inhibits hyperglycemia- and Macugen-induced retinal apoptosis. Sci Rep. 2016;6:26059 pubmed 出版商
  • 免疫印迹; 黑腹果蝇; 图 6
Barry W, Thummel C. The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults. elife. 2016;5: pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Pastore N, Brady O, Diab H, Martina J, Sun L, Huynh T, et al. TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages. Autophagy. 2016;12:1240-58 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
Wang N, Dong B, Quan Y, Chen Q, Chu M, Xu J, et al. Regulation of Prostate Development and Benign Prostatic Hyperplasia by Autocrine Cholinergic Signaling via Maintaining the Epithelial Progenitor Cells in Proliferating Status. Stem Cell Reports. 2016;6:668-678 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Cieniewicz A, Cooper P, MCGEHEE J, Lingham R, Kihm A. Novel method demonstrates differential ligand activation and phosphatase-mediated deactivation of insulin receptor tyrosine-specific phosphorylation. Cell Signal. 2016;28:1037-47 pubmed 出版商
  • 免疫印迹; 人类; 图 6e
Vorvis C, Hatziapostolou M, Mahurkar Joshi S, Koutsioumpa M, Williams J, Donahue T, et al. Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer. Am J Physiol Gastrointest Liver Physiol. 2016;310:G1124-37 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Bie Q, Sun C, Gong A, Li C, Su Z, Zheng D, et al. Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/β-catenin pathway to enhance the stemness of gastric cancer. Sci Rep. 2016;6:25447 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 7a
Xu Z, Mei F, Liu H, Sun C, Zheng Z. C-C Motif Chemokine Receptor 9 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction. J Am Heart Assoc. 2016;5: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
Du R, Liu Z, Hou X, Fu G, An N, Wang L. Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells. Mol Med Rep. 2016;13:5045-52 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s1
Seo J, Singh N, Ottesen E, Sivanesan S, Shishimorova M, Singh R. Oxidative Stress Triggers Body-Wide Skipping of Multiple Exons of the Spinal Muscular Atrophy Gene. PLoS ONE. 2016;11:e0154390 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3d
Yard B, Adams D, Chie E, Tamayo P, Battaglia J, Gopal P, et al. A genetic basis for the variation in the vulnerability of cancer to DNA damage. Nat Commun. 2016;7:11428 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6
  • 免疫印迹; 大鼠; 1:1000; 图 6
Yu Z, Zhao G, Li P, Li Y, Zhou G, Chen Y, et al. Temozolomide in combination with metformin act synergistically to inhibit proliferation and expansion of glioma stem-like cells. Oncol Lett. 2016;11:2792-2800 pubmed
  • 免疫印迹; 人类; 图 1a
Xu K, Wang L, Feng W, Feng Y, Shu H. Phosphatidylinositol-3 kinase-dependent translational regulation of Id1 involves the PPM1G phosphatase. Oncogene. 2016;35:5807-5816 pubmed 出版商
  • 免疫印迹; 黑腹果蝇; 1:1000; 图 2a
Palu R, Thummel C. Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. PLoS Genet. 2016;12:e1005978 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Phelps Polirer K, Abt M, Smith D, Yeh E. Co-Targeting of JNK and HUNK in Resistant HER2-Positive Breast Cancer. PLoS ONE. 2016;11:e0153025 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2000; 图 2
Pan B, Huang X, Deng C. Aripiprazole and Haloperidol Activate GSK3?-Dependent Signalling Pathway Differentially in Various Brain Regions of Rats. Int J Mol Sci. 2016;17:459 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nat Commun. 2016;7:11127 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, et al. mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Nat Commun. 2016;7:11151 pubmed 出版商
  • 免疫印迹; 人类; 图 6a
Li X, Dai X, Wan L, Inuzuka H, Sun L, North B. Smurf1 regulation of DAB2IP controls cell proliferation and migration. Oncotarget. 2016;7:26057-69 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5
Cui J, Zhang F, Wang Y, Liu J, Ming X, Hou J, et al. Macrophage migration inhibitory factor promotes cardiac stem cell proliferation and endothelial differentiation through the activation of the PI3K/Akt/mTOR and AMPK pathways. Int J Mol Med. 2016;37:1299-309 pubmed 出版商
  • 免疫印迹; 人类; 图 7
Braley A, Kwak T, Jules J, Harja E, Landgraf R, Hudson B. Regulation of Receptor for Advanced Glycation End Products (RAGE) Ectodomain Shedding and Its Role in Cell Function. J Biol Chem. 2016;291:12057-73 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5
Maugeri G, D Amico A, Rasà D, Reitano R, Saccone S, Federico C, et al. Expression profile of Wilms Tumor 1 (WT1) isoforms in undifferentiated and all-trans retinoic acid differentiated neuroblastoma cells. Genes Cancer. 2016;7:47-58 pubmed
  • 免疫印迹; 仓鼠; 图 3a
Gao Z, Zhang H, Hu F, Yang L, Yang X, Zhu Y, et al. Glycan-deficient PrP stimulates VEGFR2 signaling via glycosaminoglycan. Cell Signal. 2016;28:652-62 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Lee I, Maniar K, Lydon J, Kim J. Akt regulates progesterone receptor B-dependent transcription and angiogenesis in endometrial cancer cells. Oncogene. 2016;35:5191-201 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Hayashi K, Michiue H, Yamada H, Takata K, Nakayama H, Wei F, et al. Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization. Sci Rep. 2016;6:23372 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
Winnay J, Solheim M, Dirice E, Sakaguchi M, Noh H, Kang H, et al. PI3-kinase mutation linked to insulin and growth factor resistance in vivo. J Clin Invest. 2016;126:1401-12 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2
  • 免疫印迹; 小鼠; 1:1000; 图 6
Dhar S, Kumar A, Zhang L, Rimando A, Lage J, Lewin J, et al. Dietary pterostilbene is a novel MTA1-targeted chemopreventive and therapeutic agent in prostate cancer. Oncotarget. 2016;7:18469-84 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
Hu W, Xiao L, Cao C, Hua S, Wu D. UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3β/β-catenin pathway. Oncotarget. 2016;7:15161-72 pubmed 出版商
  • 免疫沉淀; 人类; 图 3
  • 免疫印迹; 人类; 图 3
Zhang Y, Stefanovic B. Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen. Sci Rep. 2016;6:22597 pubmed 出版商
  • 免疫印迹; 人类; 图 3g
Lee D, Wang Y, Kalaitzidis D, Ramachandran J, Eda H, Sykes D, et al. Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy. J Clin Invest. 2016;126:1300-10 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6g
  • 免疫印迹; 人类; 图 7f
Ro S, Xue X, Ramakrishnan S, Cho C, Namkoong S, Jang I, et al. Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis. elife. 2016;5:e12204 pubmed 出版商
  • 免疫印迹; 小鼠
Schwarzer M, Makki K, Storelli G, Machuca Gayet I, Srůtková D, Hermanova P, et al. Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition. Science. 2016;351:854-7 pubmed 出版商
  • 免疫印迹; 人类; 图 7a
Oswald F, Rodriguez P, Giaimo B, Antonello Z, Mira L, Mittler G, et al. A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes. Nucleic Acids Res. 2016;44:4703-20 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Wu G, Zeng G. METCAM/MUC18 is a novel tumor and metastasis suppressor for the human ovarian cancer SKOV3 cells. BMC Cancer. 2016;16:136 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6
Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016;7:10592 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7
Senol Cosar O, Flach R, DiStefano M, Chawla A, Nicoloro S, Straubhaar J, et al. Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion. Nat Commun. 2016;7:10686 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
  • 免疫印迹; 小鼠; 1:1000; 图 1
Ding M, Bruick R, Yu Y. Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling. Nat Cell Biol. 2016;18:319-27 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
Egawa H, Jingushi K, Hirono T, Ueda Y, Kitae K, Nakata W, et al. The miR-130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN. Sci Rep. 2016;6:20574 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1
Button R, Vincent J, Strang C, Luo S. Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis. Oncotarget. 2016;7:5157-75 pubmed 出版商
  • 免疫印迹; 小鼠; 图 8a
Ito T, Itakura J, Takahashi S, Sato M, Mino M, Fushimi S, et al. Sprouty-Related Ena/Vasodilator-Stimulated Phosphoprotein Homology 1-Domain-Containing Protein-2 Critically Regulates Influenza A Virus-Induced Pneumonia. Crit Care Med. 2016;44:e530-43 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4b
Ho N, Morrison J, Silva A, Coomber B. The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression. Biosci Rep. 2016;36:e00299 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Jeong J, VanHouten J, Dann P, Kim W, Sullivan C, Yu H, et al. PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer. Proc Natl Acad Sci U S A. 2016;113:E282-90 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 1b
Yamaguchi T, Lu C, Ida L, Yanagisawa K, Usukura J, Cheng J, et al. ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1. Nat Commun. 2016;7:10060 pubmed 出版商
  • 免疫印迹; 小鼠; 图 st1
Wang C, Che L, Hu J, Zhang S, Jiang L, Latte G, et al. Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade. Liver Int. 2016;36:1176-86 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000-1:5000; 图 5c
Lai Y, Yu X, Lin X, He S. Inhibition of mTOR sensitizes breast cancer stem cells to radiation-induced repression of self-renewal through the regulation of MnSOD and Akt. Int J Mol Med. 2016;37:369-77 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6
Zhang Y, Fan J, Ho J, Hu T, Kneeland S, Fan X, et al. Crim1 regulates integrin signaling in murine lens development. Development. 2016;143:356-66 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s2
Kiermaier E, Moussion C, Veldkamp C, Gerardy Schahn R, de Vries I, Williams L, et al. Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. Science. 2016;351:186-90 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Debruyne D, Bhatnagar N, Sharma B, Luther W, Moore N, Cheung N, et al. ALK inhibitor resistance in ALK(F1174L)-driven neuroblastoma is associated with AXL activation and induction of EMT. Oncogene. 2016;35:3681-91 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Yasuda K, Takahashi M, Mori N. Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor Expression. PLoS ONE. 2015;10:e0142943 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Ye Z, Al Aidaroos A, Park J, Yuen H, Zhang S, Gupta A, et al. PRL-3 activates mTORC1 in Cancer Progression. Sci Rep. 2015;5:17046 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Diersch S, Wirth M, Schneeweis C, Jörs S, Geisler F, Siveke J, et al. Kras(G12D) induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells. Oncogene. 2016;35:3880-6 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3h
Skeldon A, Morizot A, Douglas T, Santoro N, Kursawe R, Kozlitina J, et al. Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance. J Immunol. 2016;196:437-47 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7e
Askoxylakis V, Ferraro G, Kodack D, Badeaux M, Shankaraiah R, Seano G, et al. Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment. J Natl Cancer Inst. 2016;108: pubmed 出版商
  • 免疫印迹; 小鼠; 图 2j
Lee D, Goldberg A. Muscle Wasting in Fasting Requires Activation of NF-κB and Inhibition of AKT/Mechanistic Target of Rapamycin (mTOR) by the Protein Acetylase, GCN5. J Biol Chem. 2015;290:30269-79 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
Pasini L, Re A, Tebaldi T, Ricci G, Boi S, Adami V, et al. TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines. BMC Cancer. 2015;15:777 pubmed 出版商
  • 免疫印迹; 小鼠
Zhang L, Zhang S, Yao J, Lowery F, Zhang Q, Huang W, et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015;527:100-104 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5
Vajravelu B, Hong K, Al Maqtari T, Cao P, Keith M, Wysoczynski M, et al. C-Kit Promotes Growth and Migration of Human Cardiac Progenitor Cells via the PI3K-AKT and MEK-ERK Pathways. PLoS ONE. 2015;10:e0140798 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
Lu R, Herrera B, Eshleman H, Fu Y, Bloom A, Li Z, et al. Shigella Effector OspB Activates mTORC1 in a Manner That Depends on IQGAP1 and Promotes Cell Proliferation. PLoS Pathog. 2015;11:e1005200 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Arriola Apelo S, Neuman J, Baar E, Syed F, Cummings N, Brar H, et al. Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system. Aging Cell. 2016;15:28-38 pubmed 出版商
  • 免疫印迹; 人类
Luehders K, Sasai N, Davaapil H, Kurosawa Yoshida M, Hiura H, Brah T, et al. The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway. Development. 2015;142:3351-61 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2b
Payne S, Maher M, Tran N, Van De Hey D, Foley T, Yueh A, et al. PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors. Oncogenesis. 2015;4:e169 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Sasaki N, Itakura Y, Toyoda M. Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells. J Biol Chem. 2015;290:25475-86 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 4
Ebert S, Dyle M, Bullard S, Dierdorff J, Murry D, Fox D, et al. Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. J Biol Chem. 2015;290:25497-511 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Chiang K, Chen H, Hsu S, Pang J, Wang S, Hsu J, et al. PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo. Drug Des Devel Ther. 2015;9:4631-8 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6g
Lee Y, Yun M, Kim H, Jeon B, Park B, Lee B, et al. Exogenous administration of DLK1 ameliorates hepatic steatosis and regulates gluconeogenesis via activation of AMPK. Int J Obes (Lond). 2016;40:356-65 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3f
Chang C, Lin W, Pai L, Lee H, Wu S, Ding S, et al. Cytoophidium assembly reflects upregulation of IMPDH activity. J Cell Sci. 2015;128:3550-5 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 2
Nishimoto S, Tanaka H, Okamoto M, Okada K, Murase T, Yoshikawa H. Methylcobalamin promotes the differentiation of Schwann cells and remyelination in lysophosphatidylcholine-induced demyelination of the rat sciatic nerve. Front Cell Neurosci. 2015;9:298 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Lee I, Jung K, Kim I, Lee H, Kim M, Yun S, et al. Human neural stem cells alleviate Alzheimer-like pathology in a mouse model. Mol Neurodegener. 2015;10:38 pubmed 出版商
  • 免疫印迹; 人类; 图 e7d
Saeed M, Andreo U, Chung H, Espiritu C, Branch A, Silva J, et al. SEC14L2 enables pan-genotype HCV replication in cell culture. Nature. 2015;524:471-5 pubmed 出版商
  • 免疫细胞化学; 人类; 1:400
  • 免疫印迹; 人类; 1:1000
Zeng Z, Jing D, Zhang X, Duan Y, Xue F. Cyclic mechanical stretch promotes energy metabolism in osteoblast-like cells through an mTOR signaling-associated mechanism. Int J Mol Med. 2015;36:947-56 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1c
Krishnan N, Krishnan K, Connors C, Choy M, Page R, Peti W, et al. PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J Clin Invest. 2015;125:3163-77 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Sarma P, Bag I, Ramaiah M, Kamal A, Bhadra U, Pal Bhadra M. Bisindole-PBD regulates breast cancer cell proliferation via SIRT-p53 axis. Cancer Biol Ther. 2015;16:1486-501 pubmed 出版商
  • 免疫印迹; 人类
Zhou J, Joshi B, Duan X, Pant A, Qiu Z, Kuick R, et al. EGFR Overexpressed in Colonic Neoplasia Can be Detected on Wide-Field Endoscopic Imaging. Clin Transl Gastroenterol. 2015;6:e101 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Jiang S, Zou Z, Nie P, Wen R, Xiao Y, Tang J. Synergistic Effects between mTOR Complex 1/2 and Glycolysis Inhibitors in Non-Small-Cell Lung Carcinoma Cells. PLoS ONE. 2015;10:e0132880 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2.e
Laberge R, Sun Y, Orjalo A, Patil C, Freund A, Zhou L, et al. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat Cell Biol. 2015;17:1049-61 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Jing L, Li S, Li Q. Akt/hypoxia-inducible factor-1α signaling deficiency compromises skin wound healing in a type 1 diabetes mouse model. Exp Ther Med. 2015;9:2141-2146 pubmed
  • 免疫印迹; 小鼠; 1:1000; 图 s4
Chang C, Lin C, Lu C, Martel J, Ko Y, Ojcius D, et al. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat Commun. 2015;6:7489 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Yang L, Li Y, Bhattacharya A, Zhang Y. Inhibition of ERBB2-overexpressing Tumors by Recombinant Human Prolidase and Its Enzymatically Inactive Mutant. EBioMedicine. 2015;2:396-405 pubmed
  • 免疫印迹; 人类; 图 4
Li X, Cui P, Jiang H, Guo Y, Pishdari B, Hu M, et al. Reversing the reduced level of endometrial GLUT4 expression in polycystic ovary syndrome: a mechanistic study of metformin action. Am J Transl Res. 2015;7:574-86 pubmed
  • 免疫印迹; 小鼠; 图 5
Subathra M, Korrapati M, Howell L, Arthur J, Shayman J, Schnellmann R, et al. Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells. Am J Physiol Renal Physiol. 2015;309:F204-15 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2b
Gross S, Rotwein P. Akt signaling dynamics in individual cells. J Cell Sci. 2015;128:2509-19 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Tréhoux S, Lahdaoui F, Delpu Y, Renaud F, Leteurtre E, Torrisani J, et al. Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells. Biochim Biophys Acta. 2015;1853:2392-403 pubmed 出版商
  • 免疫印迹; 大鼠; 图 3
Zhang F, Cui J, Lv B, Yu B. Nicorandil protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis. Int J Mol Med. 2015;36:415-23 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1b
DiPilato L, Ahmad F, Harms M, Seale P, Manganiello V, Birnbaum M. The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin. Mol Cell Biol. 2015;35:2752-60 pubmed 出版商
  • 免疫印迹; 人类
Tang X, Chen X, Xu Y, Qiao Y, Zhang X, Wang Y, et al. CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and βTrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells. Cell Signal. 2015;27:1694-702 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
  • 免疫印迹; 大鼠; 图 1
Li J, Ren J, Liu X, Jiang L, He W, Yuan W, et al. Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis. Kidney Int. 2015;88:515-27 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2000
Heinen A, Beyer F, Tzekova N, Hartung H, Küry P. Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype. Exp Neurol. 2015;271:25-35 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7d
Raimondi L, De Luca A, Amodio N, Manno M, Raccosta S, Taverna S, et al. Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation. Oncotarget. 2015;6:13772-89 pubmed
  • 免疫印迹; 人类; 图 4a
Fonseca B, Zakaria C, Jia J, Graber T, Svitkin Y, Tahmasebi S, et al. La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1). J Biol Chem. 2015;290:15996-6020 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Lee E, Park E, Mun H, Chang E, Ko J, Kim D, et al. Soluble receptor for advanced glycation end products inhibits disease progression in autosomal dominant polycystic kidney disease by down-regulating cell proliferation. FASEB J. 2015;29:3506-14 pubmed 出版商
  • 免疫印迹; 人类
Pasqualon T, Pruessmeyer J, Weidenfeld S, Babendreyer A, Groth E, Schumacher J, et al. A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation. Cell Mol Life Sci. 2015;72:3783-801 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Kim H, Kim I, Dong Y, Lee I, Kim J, Kim J, et al. Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression. Int J Mol Sci. 2015;16:8772-88 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1
Sharon C, Baranwal S, Patel N, Rodriguez Agudo D, Pandak W, Majumdar A, et al. Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. Oncotarget. 2015;6:15332-47 pubmed
  • 免疫印迹; 小鼠
Tancioni I, Miller N, Uryu S, Lawson C, Jean C, Chen X, et al. FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth. Breast Cancer Res. 2015;17:47 pubmed 出版商
  • 免疫印迹; 人类; 图 1f, 2e, 4h
Ferreira R, Law M, Jahn S, Davis B, Heldermon C, Reinhard M, et al. Novel agents that downregulate EGFR, HER2, and HER3 in parallel. Oncotarget. 2015;6:10445-59 pubmed
  • 免疫印迹; 人类; 图 s8
Ohashi M, Holthaus A, Calderwood M, Lai C, Krastins B, Sarracino D, et al. The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth. PLoS Pathog. 2015;11:e1004822 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Gassen N, Hartmann J, Zannas A, Kretzschmar A, Zschocke J, Maccarrone G, et al. FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications. Mol Psychiatry. 2016;21:277-89 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Yamakoshi K, Katano S, Iida M, Kimura H, Okuma A, Ikemoto Uezumi M, et al. Dysregulation of the Bmi-1/p16(Ink⁴a) pathway provokes an aging-associated decline of submandibular gland function. Aging Cell. 2015;14:616-24 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Cerqueira O, Truesdell P, Baldassarre T, Vilella Arias S, Watt K, Meens J, et al. CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis. Oncotarget. 2015;6:9397-408 pubmed
  • 免疫印迹; 小鼠; 图 S4b
Jia D, Duan F, Peng P, Sun L, Ruan Y, Gu J. Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice. PLoS ONE. 2015;10:e0121939 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 8
Kann M, Bae E, Lenz M, Li L, Trannguyen B, Schumacher V, et al. WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 2015;142:1254-66 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Graziani G, Artuso S, De Luca A, Muzi A, Rotili D, Scimeca M, et al. A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib. Biochem Pharmacol. 2015;95:16-27 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000
Tapia O, Fong L, Huber M, Young S, Gerace L. Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. PLoS ONE. 2015;10:e0116196 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Cuesto G, Jordán Álvarez S, Enriquez Barreto L, Ferrús A, Morales M, Acebes A. GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons. PLoS ONE. 2015;10:e0118475 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6a
Chen W, Xu B, Xiao A, Liu L, Fang X, Liu R, et al. TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury. Mol Brain. 2015;8:11 pubmed 出版商
  • 免疫印迹; 人类
Münzberg C, Höhn K, Krndija D, Maaß U, Bartsch D, Slater E, et al. IGF-1 drives chromogranin A secretion via activation of Arf1 in human neuroendocrine tumour cells. J Cell Mol Med. 2015;19:948-59 pubmed 出版商
  • 免疫印迹; 人类
Lee J, Chung L, Chen Y, Feng T, Chen W, Juang H. Upregulation of B-cell translocation gene 2 by epigallocatechin-3-gallate via p38 and ERK signaling blocks cell proliferation in human oral squamous cell carcinoma cells. Cancer Lett. 2015;360:310-8 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Sanjurjo L, Amézaga N, Aran G, Naranjo Gómez M, Arias L, Armengol C, et al. The human CD5L/AIM-CD36 axis: A novel autophagy inducer in macrophages that modulates inflammatory responses. Autophagy. 2015;11:487-502 pubmed 出版商
  • 免疫印迹; 人类; 图 4a,b
Fumagalli I, Dugue D, Bibault J, Clémenson C, Vozenin M, Mondini M, et al. Cytotoxic effect of lapatinib is restricted to human papillomavirus-positive head and neck squamous cell carcinoma cell lines. Onco Targets Ther. 2015;8:335-45 pubmed 出版商
  • 免疫印迹; 斑马鱼; 图 4a
Jeffery J, Neyt C, Moore W, Paterson S, Bower N, Chenevix Trench G, et al. Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish. FASEB J. 2015;29:1999-2009 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Castorina A, Waschek J, Marzagalli R, Cardile V, Drago F. PACAP interacts with PAC1 receptors to induce tissue plasminogen activator (tPA) expression and activity in schwann cell-like cultures. PLoS ONE. 2015;10:e0117799 pubmed 出版商
  • 免疫印迹; 人类
  • 免疫印迹; 小鼠
Schreiber K, Ortiz D, Academia E, Anies A, Liao C, Kennedy B. Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins. Aging Cell. 2015;14:265-73 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4a
Chen Z, Shen H, Sun C, Yin L, Tang F, Zheng P, et al. Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity. Am J Physiol Endocrinol Metab. 2015;308:E460-9 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Chandler R, Damrauer J, Raab J, Schisler J, Wilkerson M, Didion J, et al. Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling. Nat Commun. 2015;6:6118 pubmed 出版商
  • 免疫印迹; 人类
Yoo J, Kim T, Kong S, Lee J, Choi W, Kim K, et al. Role of Mig-6 in hepatic glucose metabolism. J Diabetes. 2016;8:86-97 pubmed 出版商
  • 免疫印迹; 小鼠
Nakazawa H, Yamada M, Tanaka T, Kramer J, Yu Y, Fischman A, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS ONE. 2015;10:e0116633 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2000; 图 12
Pino M, Verstraeten S. Tl(I) and Tl(III) alter the expression of EGF-dependent signals and cyclins required for pheochromocytoma (PC12) cell-cycle resumption and progression. J Appl Toxicol. 2015;35:952-69 pubmed 出版商
  • 免疫印迹; 人类
Inaba J, McConnell E, Davis K. Lunasin sensitivity in non-small cell lung cancer cells is linked to suppression of integrin signaling and changes in histone acetylation. Int J Mol Sci. 2014;15:23705-24 pubmed 出版商
  • 免疫印迹; 人类
Pastor Clerigues A, Martí Bonmatí E, Milara J, Almudever P, Cortijo J. Anti-inflammatory and anti-fibrotic profile of fish oil emulsions used in parenteral nutrition-associated liver disease. PLoS ONE. 2014;9:e115404 pubmed 出版商
  • 免疫印迹; 人类; 图 2g
  • 免疫印迹; 小鼠; 图 3d
Yoda A, Adelmant G, Tamburini J, Chapuy B, Shindoh N, Yoda Y, et al. Mutations in G protein β subunits promote transformation and kinase inhibitor resistance. Nat Med. 2015;21:71-5 pubmed 出版商
  • 免疫印迹; 小鼠
Bisson J, Mills B, Paul Helt J, Zwaka T, Cohen E. Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT. Dev Biol. 2015;398:80-96 pubmed 出版商
  • 免疫印迹; 人类
Yang R, Chen Y, Tang C, Li H, Wang B, Yan Q, et al. MicroRNA-144 suppresses cholangiocarcinoma cell proliferation and invasion through targeting platelet activating factor acetylhydrolase isoform 1b. BMC Cancer. 2014;14:917 pubmed 出版商
  • 免疫印迹; 大鼠; 1:500
Galinato M, Orio L, Mandyam C. Methamphetamine differentially affects BDNF and cell death factors in anatomically defined regions of the hippocampus. Neuroscience. 2015;286:97-108 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s7
Kim T, Jo S, Choi H, Park J, Kim M, Nojima H, et al. Identification of Creb3l4 as an essential negative regulator of adipogenesis. Cell Death Dis. 2014;5:e1527 pubmed 出版商
  • 免疫印迹; 大鼠
Soga M, Ohashi A, Taniguchi M, Matsui T, Tsuda T. The di-peptide Trp-His activates AMP-activated protein kinase and enhances glucose uptake independently of insulin in L6 myotubes. FEBS Open Bio. 2014;4:898-904 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Alayev A, Berger S, Kramer M, Schwartz N, Holz M. The combination of rapamycin and resveratrol blocks autophagy and induces apoptosis in breast cancer cells. J Cell Biochem. 2015;116:450-7 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Cai X, Dai Z, Reeves R, Caballero Benítez A, Duran K, Delrow J, et al. Autonomous stimulation of cancer cell plasticity by the human NKG2D lymphocyte receptor coexpressed with its ligands on cancer cells. PLoS ONE. 2014;9:e108942 pubmed 出版商
  • 免疫印迹; 小鼠
Rai S, Tanaka H, Suzuki M, Ogoh H, Taniguchi Y, Morita Y, et al. Clathrin assembly protein CALM plays a critical role in KIT signaling by regulating its cellular transport from early to late endosomes in hematopoietic cells. PLoS ONE. 2014;9:e109441 pubmed 出版商
  • 免疫印迹; 小鼠
Morioka T, Sakabe M, Ioka T, Iguchi T, Mizuta K, Hattammaru M, et al. An important role of endothelial hairy-related transcription factors in mouse vascular development. Genesis. 2014;52:897-906 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Peng M, Yin N, Li M. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell. 2014;159:122-133 pubmed 出版商
  • 免疫印迹; 猪; 1:500
Zhang S, Ren M, Zeng X, He P, Ma X, Qiao S. Leucine stimulates ASCT2 amino acid transporter expression in porcine jejunal epithelial cell line (IPEC-J2) through PI3K/Akt/mTOR and ERK signaling pathways. Amino Acids. 2014;46:2633-42 pubmed 出版商
  • 免疫印迹; 大鼠
  • 免疫印迹; 小鼠
Zeldich E, Chen C, Colvin T, Bove Fenderson E, Liang J, Tucker Zhou T, et al. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem. 2014;289:24700-15 pubmed 出版商
  • 免疫印迹; 人类; 图 2c
Dai X, North B, Inuzuka H. Negative regulation of DAB2IP by Akt and SCFFbw7 pathways. Oncotarget. 2014;5:3307-15 pubmed
  • 免疫印迹; 小鼠; 1:1000
Johnston Cox H, Eisenstein A, Koupenova M, Carroll S, Ravid K. The macrophage A2B adenosine receptor regulates tissue insulin sensitivity. PLoS ONE. 2014;9:e98775 pubmed 出版商
  • 免疫印迹; 人类; 图 7d
Raimondi L, Amodio N, Di Martino M, Altomare E, Leotta M, Caracciolo D, et al. Targeting of multiple myeloma-related angiogenesis by miR-199a-5p mimics: in vitro and in vivo anti-tumor activity. Oncotarget. 2014;5:3039-54 pubmed
  • 免疫印迹; 人类; 图 4
Chin R, Fu X, Pai M, Vergnes L, Hwang H, Deng G, et al. The metabolite ?-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014;510:397-401 pubmed 出版商
  • 免疫印迹; 人类
Cen B, Xiong Y, Song J, Mahajan S, DuPont R, McEachern K, et al. The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling. Mol Cell Biol. 2014;34:2517-32 pubmed 出版商
  • 免疫印迹; 人类
Kim K, Lee S, Ryu S, Han D. Efficient isolation and elution of cellular proteins using aptamer-mediated protein precipitation assay. Biochem Biophys Res Commun. 2014;448:114-9 pubmed 出版商
  • 免疫印迹; 小鼠
Bian Z, Liao H, Zhang Y, Wu Q, Zhou H, Yang Z, et al. Never in mitosis gene A related kinase-6 attenuates pressure overload-induced activation of the protein kinase B pathway and cardiac hypertrophy. PLoS ONE. 2014;9:e96095 pubmed 出版商
  • 免疫印迹; 人类
Bao Y, Cao X, Luo D, Sun R, Peng L, Wang L, et al. Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis. Cell Cycle. 2014;13:1958-69 pubmed 出版商
  • 免疫印迹; 人类
Liu B, Cao Y, Huizinga T, Hafler D, Toes R. TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells. Eur J Immunol. 2014;44:2121-9 pubmed 出版商
  • 免疫印迹; 大鼠
Tobin G, Zhang J, Goodwin D, Stewart S, Xu L, Knapton A, et al. The role of eNOS phosphorylation in causing drug-induced vascular injury. Toxicol Pathol. 2014;42:709-24 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Wahl S, McLane L, Bercury K, Macklin W, Wood T. Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination. J Neurosci. 2014;34:4453-65 pubmed 出版商
  • 免疫印迹; 人类
Yoon H, Choi Y, Song J, Do I, Kang S, Ko Y, et al. Targeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis in ovarian clear cell carcinoma cell lines. PLoS ONE. 2014;9:e88587 pubmed 出版商
  • 免疫印迹; 小鼠
Park E, Kim B, Lee E, Chang E, Kim D, Choi S, et al. Targeting of receptor for advanced glycation end products suppresses cyst growth in polycystic kidney disease. J Biol Chem. 2014;289:9254-62 pubmed 出版商
  • 免疫印迹; 小鼠; 1:400
Xiao W, Feng Y, Holst J, Hartmann B, Yang H, Teitelbaum D. Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition. FASEB J. 2014;28:2073-87 pubmed 出版商
  • 免疫印迹; 大鼠
Li J, Xu Z, Jiang L, Mao J, Zeng Z, Fang L, et al. Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury. Kidney Int. 2014;86:86-102 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Morgan K, Black L. Mimicking isovolumic contraction with combined electromechanical stimulation improves the development of engineered cardiac constructs. Tissue Eng Part A. 2014;20:1654-67 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Yue X, Hariri D, Caballero B, Zhang S, Bartlett M, Kaut O, et al. Comparative study of the neurotrophic effects elicited by VEGF-B and GDNF in preclinical in vivo models of Parkinson's disease. Neuroscience. 2014;258:385-400 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Zhang Y, Zhang X, Gao L, Liu Y, Jiang D, Chen K, et al. Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction. Biochim Biophys Acta. 2014;1842:232-44 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Castorina A, Scuderi S, D Amico A, Drago F, D Agata V. PACAP and VIP increase the expression of myelin-related proteins in rat schwannoma cells: involvement of PAC1/VPAC2 receptor-mediated activation of PI3K/Akt signaling pathways. Exp Cell Res. 2014;322:108-21 pubmed 出版商
  • 免疫印迹; 小鼠; 1:10000
Chen Z, Morris D, Jiang L, Liu Y, Rui L. SH2B1 in ?-cells regulates glucose metabolism by promoting ?-cell survival and islet expansion. Diabetes. 2014;63:585-95 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, et al. Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy. FASEB J. 2014;28:131-42 pubmed 出版商
  • 免疫印迹; 人类
Paugh B, Zhu X, Qu C, Endersby R, Diaz A, Zhang J, et al. Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas. Cancer Res. 2013;73:6219-29 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:250
  • 免疫印迹; 人类
Kucherlapati M, Esfahani S, Habibollahi P, Wang J, Still E, Bronson R, et al. Genotype directed therapy in murine mismatch repair deficient tumors. PLoS ONE. 2013;8:e68817 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Iacovides D, Johnson A, Wang N, Boddapati S, Korkola J, Gray J. Identification and quantification of AKT isoforms and phosphoforms in breast cancer using a novel nanofluidic immunoassay. Mol Cell Proteomics. 2013;12:3210-20 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Garcia Murillas I, Sharpe R, Pearson A, Campbell J, Natrajan R, Ashworth A, et al. An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer. Oncogene. 2014;33:2478-86 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Griffeth R, Carretero J, Burks D. Insulin receptor substrate 2 is required for testicular development. PLoS ONE. 2013;8:e62103 pubmed 出版商
  • 免疫印迹; 人类
  • 免疫印迹; 小鼠
Beckham T, Cheng J, Lu P, Shao Y, Troyer D, Lance R, et al. Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Oncogenesis. 2013;2:e49 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Tokami H, Ago T, Sugimori H, Kuroda J, Awano H, Suzuki K, et al. RANTES has a potential to play a neuroprotective role in an autocrine/paracrine manner after ischemic stroke. Brain Res. 2013;1517:122-32 pubmed 出版商
  • 免疫印迹; 大鼠
Luo L, Lu A, Wang Y, Hong A, Chen Y, Hu J, et al. Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats. Exp Gerontol. 2013;48:427-36 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Kim H, Woo H, Ryu J, Bok J, Kim J, Choi S, et al. Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development. PLoS ONE. 2013;8:e55609 pubmed 出版商
  • 免疫印迹; 小鼠
Dai J, Shen D, Bian Z, Zhou H, Gan H, Zong J, et al. IKKi deficiency promotes pressure overload-induced cardiac hypertrophy and fibrosis. PLoS ONE. 2013;8:e53412 pubmed 出版商
Shahi Thakuri P, Gupta M, Singh S, Joshi R, Glasgow E, Lekan A, et al. Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling. BMC Cancer. 2020;20:4 pubmed 出版商
Balaji Ragunathrao V, Anwar M, Akhter M, Chavez A, Mao D, Natarajan V, et al. Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling. Cell Rep. 2019;29:3472-3487.e4 pubmed 出版商
Martinez M, Martínez N, Miranda J, Maldonado H, Silva Ortiz W. Caveolin-1 Regulates P2Y2 Receptor Signaling during Mechanical Injury in Human 1321N1 Astrocytoma. Biomolecules. 2019;9: pubmed 出版商
Takeda A, Maher T, Zhang Y, Lanahan S, Bucklin M, Compton S, et al. Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology. Nat Commun. 2019;10:4364 pubmed 出版商
Chowdhury D, Alrefai H, Landero Figueroa J, Candor K, Porollo A, Fecher R, et al. Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages. Cell Rep. 2019;27:3873-3886.e7 pubmed 出版商
Walia V, Cuenca A, Vetter M, Insinna C, Perera S, Lu Q, et al. Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis. Dev Cell. 2019;: pubmed 出版商
Boichuck M, Zorea J, Elkabets M, Wolfson M, Fraifeld V. c-Met as a new marker of cellular senescence. Aging (Albany NY). 2019;11:2889-2897 pubmed 出版商
White S, Avantaggiati M, Nemazanyy I, Di Poto C, Yang Y, Pende M, et al. YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells. Dev Cell. 2019;49:425-443.e9 pubmed 出版商
Yankaskas C, Thompson K, Paul C, Vitolo M, Mistriotis P, Mahendra A, et al. A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens. Nat Biomed Eng. 2019;3:452-465 pubmed 出版商
Götzel K, Chemnitzer O, Maurer L, Dietrich A, Eichfeld U, Lyros O, et al. In-depth characterization of the Wnt-signaling/β-catenin pathway in an in vitro model of Barrett's sequence. BMC Gastroenterol. 2019;19:38 pubmed 出版商
Zhang L, Chen J, Ning D, Liu Q, Wang C, Zhang Z, et al. FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21. J Exp Clin Cancer Res. 2019;38:101 pubmed 出版商
Senturk M, Lin G, Zuo Z, Mao D, Watson E, Mikos A, et al. Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification. Nat Cell Biol. 2019;21:384-396 pubmed 出版商
Deng W, Fernandez A, McLaughlin S, Klinke D. WNT1-inducible signaling pathway protein 1 (WISP1/CCN4) stimulates melanoma invasion and metastasis by promoting the epithelial-mesenchymal transition. J Biol Chem. 2019;294:5261-5280 pubmed 出版商
Coa L, Abreu T, Tashima A, Green J, Pascon R, Vallim M, et al. AKT/protein kinase B associates with β-actin in the nucleus of melanoma cells. Biosci Rep. 2019;39: pubmed 出版商
Zhang Z, Chen J, Huang W, Ning D, Liu Q, Wang C, et al. FAM134B induces tumorigenesis and epithelial-to-mesenchymal transition via Akt signaling in hepatocellular carcinoma. Mol Oncol. 2019;13:792-810 pubmed 出版商
Schaal C, Bora Singhal N, Kumar D, Chellappan S. Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer. Mol Cancer. 2018;17:149 pubmed 出版商
Angelini G, Salinari S, Bertuzzi A, Iaconelli A, Mingrone G. Metabolic surgery improves insulin resistance through the reduction of gut-secreted heat shock proteins. Commun Biol. 2018;1:69 pubmed 出版商
Okazaki T, Tamai K, Shibuya R, Nakamura M, Mochizuki M, Yamaguchi K, et al. Periostin is a negative prognostic factor and promotes cancer cell proliferation in non-small cell lung cancer. Oncotarget. 2018;9:31187-31199 pubmed 出版商
Tan H, Wu C, Jin L. A Possible Role for Long Interspersed Nuclear Elements-1 (LINE-1) in Huntington's Disease Progression. Med Sci Monit. 2018;24:3644-3652 pubmed 出版商
Sun H, Zhao X, Zhang C, Zhang Z, Lun J, Liao W, et al. MiR-455-3p inhibits the degenerate process of chondrogenic differentiation through modification of DNA methylation. Cell Death Dis. 2018;9:537 pubmed 出版商
Du W, Ni L, Liu B, Wei Y, Lv Y, Qiang S, et al. Upregulation of SALL4 by EGFR activation regulates the stemness of CD44-positive lung cancer. Oncogenesis. 2018;7:36 pubmed 出版商
Olona A, Terra X, Ko J, Grau Bové C, Pinent M, Ardevol A, et al. Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis. Mol Metab. 2018;11:18-32 pubmed 出版商
Meakin P, Mezzapesa A, Benabou E, Haas M, Bonardo B, Grino M, et al. The beta secretase BACE1 regulates the expression of insulin receptor in the liver. Nat Commun. 2018;9:1306 pubmed 出版商
Romano G, Chen P, Song P, McQuade J, Liang R, Liu M, et al. A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling. Cancer Discov. 2018;8:556-567 pubmed 出版商
Gan T, Li B, Mishra B, Jones K, Ernst P. MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation. J Immunol. 2018;200:1682-1691 pubmed 出版商
Ran L, Chen Y, Sher J, Wong E, Murphy D, Zhang J, et al. FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor. Cancer Discov. 2018;8:234-251 pubmed 出版商
Grey W, Ivey A, Milne T, Haferlach T, Grimwade D, Uhlmann F, et al. The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability. Biochim Biophys Acta Mol Cell Res. 2018;1865:105-116 pubmed 出版商
Jing H, Zhang X, Wisner S, Chen X, Spiegelman N, Linder M, et al. SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a. elife. 2017;6: pubmed 出版商
Schafer S, Viswanathan S, Widjaja A, Lim W, Moreno Moral A, Delaughter D, et al. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017;552:110-115 pubmed 出版商
Clift D, McEwan W, Labzin L, Konieczny V, Mogessie B, James L, et al. A Method for the Acute and Rapid Degradation of Endogenous Proteins. Cell. 2017;171:1692-1706.e18 pubmed 出版商
Guo L, Zhang P, Chen Z, Xia H, Li S, Zhang Y, et al. Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression. J Clin Invest. 2017;127:4449-4461 pubmed 出版商
Hagar J, Edin M, Lih F, Thurlow L, Koller B, Cairns B, et al. Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock. J Immunol. 2017;199:3634-3643 pubmed 出版商
Lina T, Luo T, Velayutham T, Das S, McBride J. Ehrlichia Activation of Wnt-PI3K-mTOR Signaling Inhibits Autolysosome Generation and Autophagic Destruction by the Mononuclear Phagocyte. Infect Immun. 2017;85: pubmed 出版商
Baldassarre T, Truesdell P, Craig A. Endophilin A2 promotes HER2 internalization and sensitivity to trastuzumab-based therapy in HER2-positive breast cancers. Breast Cancer Res. 2017;19:110 pubmed 出版商
Younan P, Iampietro M, Nishida A, Ramanathan P, Santos R, Dutta M, et al. Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm. MBio. 2017;8: pubmed 出版商
Williams M, Vaught D, Joly M, Hicks D, Sanchez V, Owens P, et al. ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation. Breast Cancer Res. 2017;19:105 pubmed 出版商
Joung J, Engreitz J, Konermann S, Abudayyeh O, Verdine V, Aguet F, et al. Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood. Nature. 2017;548:343-346 pubmed 出版商
Kabraji S, Solé X, Huang Y, Bango C, Bowden M, Bardia A, et al. AKT1low quiescent cancer cells persist after neoadjuvant chemotherapy in triple negative breast cancer. Breast Cancer Res. 2017;19:88 pubmed 出版商
Kulas J, Puig K, Combs C. Amyloid precursor protein in pancreatic islets. J Endocrinol. 2017;235:49-67 pubmed 出版商
Joeng K, Lee Y, Lim J, Chen Y, Jiang M, Munivez E, et al. Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis. J Clin Invest. 2017;127:2678-2688 pubmed 出版商
Vieira N, Spinazzola J, Alexander M, Moreira Y, Kawahara G, Gibbs D, et al. Repression of phosphatidylinositol transfer protein ? ameliorates the pathology of Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2017;114:6080-6085 pubmed 出版商
Hattori A, Tsunoda M, Konuma T, Kobayashi M, Nagy T, Glushka J, et al. Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia. Nature. 2017;545:500-504 pubmed 出版商
Tellios N, Belrose J, Tokarewicz A, Hutnik C, Liu H, Leask A, et al. TGF-? induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma. Sci Rep. 2017;7:812 pubmed 出版商
Jia X, Xu J, Gu Y, Gu X, Li W, Wang Y. Vitamin D suppresses oxidative stress-induced microparticle release by human umbilical vein endothelial cells. Biol Reprod. 2017;96:199-210 pubmed 出版商
Ohshima K, Nojima S, Tahara S, Kurashige M, Hori Y, Hagiwara K, et al. Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer. Sci Rep. 2017;7:45504 pubmed 出版商
Lin C, Chen H, Lin C, Wu H, Sheu J, Chen H. Apigenin-induced lysosomal degradation of ?-catenin in Wnt/?-catenin signaling. Sci Rep. 2017;7:372 pubmed 出版商
Li X, Zhang Z, Li Y, Zhao Y, Zhai W, Yang L, et al. miR-18a counteracts AKT and ERK activation to inhibit the proliferation of pancreatic progenitor cells. Sci Rep. 2017;7:45002 pubmed 出版商
LeBlanc M, Wang W, Chen X, Caberoy N, Guo F, Shen C, et al. Secretogranin III as a disease-associated ligand for antiangiogenic therapy of diabetic retinopathy. J Exp Med. 2017;214:1029-1047 pubmed 出版商
Nakama T, Yoshida S, Ishikawa K, Kubo Y, Kobayashi Y, Zhou Y, et al. Therapeutic Effect of Novel Single-Stranded RNAi Agent Targeting Periostin in Eyes with Retinal Neovascularization. Mol Ther Nucleic Acids. 2017;6:279-289 pubmed 出版商
Fujiki K, Inamura H, Miyayama T, Matsuoka M. Involvement of Notch1 signaling in malignant progression of A549 cells subjected to prolonged cadmium exposure. J Biol Chem. 2017;292:7942-7953 pubmed 出版商
Vaden R, Oswald N, Potts M, Macmillan J, White M. FUSION-Guided Hypothesis Development Leads to the Identification of N?,N?-Dimethyladenosine, a Marine-Derived AKT Pathway Inhibitor. Mar Drugs. 2017;15: pubmed 出版商
Uchibori K, Inase N, Araki M, Kamada M, Sato S, Okuno Y, et al. Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer. Nat Commun. 2017;8:14768 pubmed 出版商
Liang X, Shi H, Yang L, Qiu C, Lin S, Qi Y, et al. Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells. Br J Cancer. 2017;116:903-911 pubmed 出版商
Huang H, Lin H, Huang M. The lactoferricin B-derived peptide, LfB17-34, induces melanogenesis in B16F10 cells. Int J Mol Med. 2017;39:595-602 pubmed 出版商
Ruiz M, Okada H, Dahlback B. HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium. Lipids Health Dis. 2017;16:36 pubmed 出版商
Luk C, Shi S, Cai E, Sivasubramaniyam T, Krishnamurthy M, Brunt J, et al. FAK signalling controls insulin sensitivity through regulation of adipocyte survival. Nat Commun. 2017;8:14360 pubmed 出版商
Engel N, Adamus A, Schauer N, Kuhn J, Nebe B, Seitz G, et al. Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation. PLoS ONE. 2017;12:e0169742 pubmed 出版商
Sato K, Idelevich A, Nagano K, Rowe G, Gori F, Baron R. Hypothalamic ΔFosB prevents age-related metabolic decline and functions via SNS. Aging (Albany NY). 2017;9:353-369 pubmed 出版商
Guo J, Dou L, Meng X, Chen Z, Yang W, Fang W, et al. Hepatic MiR-291b-3p Mediated Glucose Metabolism by Directly Targeting p65 to Upregulate PTEN Expression. Sci Rep. 2017;7:39899 pubmed 出版商
Zhu H, Zhang Y, Chen J, Qiu J, Huang K, Wu M, et al. IDH1 R132H Mutation Enhances Cell Migration by Activating AKT-mTOR Signaling Pathway, but Sensitizes Cells to 5-FU Treatment as NADPH and GSH Are Reduced. PLoS ONE. 2017;12:e0169038 pubmed 出版商
Noguchi K, Hongama K, Hariki S, Nonomiya Y, Katayama K, Sugimoto Y. Functional Effects of AKT3 on Aurora Kinase Inhibitor-induced Aneuploidy. J Biol Chem. 2017;292:1910-1924 pubmed 出版商
Laker R, Taddeo E, Akhtar Y, Zhang M, Hoehn K, Yan Z. The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue-Specific Control of Metabolic Homeostasis. PLoS ONE. 2016;11:e0167910 pubmed 出版商
Wei C, Louis H, Schmitt M, Albuisson E, Orlowski S, Levy B, et al. Effects of low doses of esmolol on cardiac and vascular function in experimental septic shock. Crit Care. 2016;20:407 pubmed 出版商
Chen B, Liu J, Ho T, Ding X, Mo Y. ERK-mediated NF-?B activation through ASIC1 in response to acidosis. Oncogenesis. 2016;5:e279 pubmed 出版商
Chen H, Wu G, Sun Q, Dong Y, Zhao H. Hyperbaric oxygen protects mandibular condylar chondrocytes from interleukin-1?-induced apoptosis via the PI3K/AKT signaling pathway. Am J Transl Res. 2016;8:5108-5117 pubmed
Wang S, Li C, Wang W, Xing C. PBX3 promotes gastric cancer invasion and metastasis by inducing epithelial-mesenchymal transition. Oncol Lett. 2016;12:3485-3491 pubmed
Li J, Lin X, Zhang Y, Liu W, Mi X, Zhang J, et al. Preparative Purification of Bioactive Compounds from Flos Chrysanthemi Indici and Evaluation of Its Antiosteoporosis Effect. Evid Based Complement Alternat Med. 2016;2016:2587201 pubmed
Haagensen E, Thomas H, Schmalix W, Payne A, Kevorkian L, Allen R, et al. Enhanced anti-tumour activity of the combination of the novel MEK inhibitor WX-554 and the novel PI3K inhibitor WX-037. Cancer Chemother Pharmacol. 2016;78:1269-1281 pubmed 出版商
Nelson V, Ali A, Dutta N, Ghosh S, Jana M, Ganguli A, et al. Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1. Oncotarget. 2016;7:78281-78296 pubmed 出版商
Bolino A, Piguet F, Alberizzi V, Pellegatta M, Rivellini C, Guerrero Valero M, et al. Niacin-mediated Tace activation ameliorates CMT neuropathies with focal hypermyelination. EMBO Mol Med. 2016;8:1438-1454 pubmed 出版商
Søgaard D, Østergård T, Blachnio Zabielska A, Baranowski M, Vigelsø A, Andersen J, et al. Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity. J Diabetes Res. 2016;2016:2372741 pubmed
Zopf D, Fichtner I, Bhargava A, Steinke W, Thierauch K, Diefenbach K, et al. Pharmacologic activity and pharmacokinetics of metabolites of regorafenib in preclinical models. Cancer Med. 2016;5:3176-3185 pubmed 出版商
Liao Y, Lee T, Twu Y, Hsu S, Yang C, Wang C, et al. Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver. J Biomed Sci. 2016;23:69 pubmed
Xu D, Zhang B, Liao C, Zhang W, Wang W, Chang Y, et al. Human beta-defensin 3 contributes to the carcinogenesis of cervical cancer via activation of NF-κB signaling. Oncotarget. 2016;7:75902-75913 pubmed 出版商
Gordon R, Neal M, Luo J, Langley M, Harischandra D, Panicker N, et al. Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration. Nat Commun. 2016;7:12932 pubmed 出版商
McCommis K, Hodges W, Bricker D, Wisidagama D, Compan V, Remedi M, et al. An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion. Mol Metab. 2016;5:602-614 pubmed 出版商
Zhou J, Yao K, Zhang Y, Chen G, Lai K, Yin H, et al. Thioredoxin Binding Protein-2 Regulates Autophagy of Human Lens Epithelial Cells under Oxidative Stress via Inhibition of Akt Phosphorylation. Oxid Med Cell Longev. 2016;2016:4856431 pubmed
Gastebois C, Chanon S, Rome S, Durand C, Pelascini E, Jalabert A, et al. Transition from physical activity to inactivity increases skeletal muscle miR-148b content and triggers insulin resistance. Physiol Rep. 2016;4: pubmed 出版商
Yi H, Wang Z, Li X, Yin M, Wang L, Aldalbahi A, et al. Silica Nanoparticles Target a Wnt Signal Transducer for Degradation and Impair Embryonic Development in Zebrafish. Theranostics. 2016;6:1810-20 pubmed 出版商
Zou Z, Ma C, Medoro L, Chen L, Wang B, Gupta R, et al. LncRNA ANRIL is up-regulated in nasopharyngeal carcinoma and promotes the cancer progression via increasing proliferation, reprograming cell glucose metabolism and inducing side-population stem-like cancer cells. Oncotarget. 2016;7:61741-61754 pubmed 出版商
Moxley K, Wang L, Welm A, Bieniasz M. Short-form Ron is a novel determinant of ovarian cancer initiation and progression. Genes Cancer. 2016;7:169-81 pubmed 出版商
Li Y, Cui S, Sun S, Shi W, Song Z, Wang S, et al. Chemoprevention of intestinal tumorigenesis by the natural dietary flavonoid myricetin in APCMin/+ mice. Oncotarget. 2016;7:60446-60460 pubmed 出版商
Kabir T, Leigh R, Tasena H, Mellone M, Coletta R, Parkinson E, et al. A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts. Aging (Albany NY). 2016;8:1608-35 pubmed 出版商
Pal J, Patil V, Mondal B, Shukla S, Hegde A, Arivazhagan A, et al. Epigenetically silenced GNG4 inhibits SDF1?/CXCR4 signaling in mesenchymal glioblastoma. Genes Cancer. 2016;7:136-47 pubmed 出版商
Ou B, Zhao J, Guan S, Feng H, Wangpu X, Zhu C, et al. CCR4 promotes metastasis via ERK/NF-κB/MMP13 pathway and acts downstream of TNF-α in colorectal cancer. Oncotarget. 2016;7:47637-47649 pubmed 出版商
Liang T, Zhang Y, Yin S, Gan T, An T, Zhang R, et al. Cardio-protecteffect of qiliqiangxin capsule on left ventricular remodeling, dysfunction and apoptosis in heart failure rats after chronic myocardial infarction. Am J Transl Res. 2016;8:2047-58 pubmed
Cai Y, Zhang J, Lao X, Jiang H, Yu Y, Deng Y, et al. Construction of a disulfide-stabilized diabody against fibroblast growth factor-2 and the inhibition activity in targeting breast cancer. Cancer Sci. 2016;107:1141-50 pubmed 出版商
Huang Y, Chang C, Lee S, Jou Y, Shih H. Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression. Oncotarget. 2016;7:43256-43266 pubmed 出版商
Sharma P, Arias E, Cartee G. Protein Phosphatase 1-? Regulates AS160 Ser588 and Thr642 Dephosphorylation in Skeletal Muscle. Diabetes. 2016;65:2606-17 pubmed 出版商
Arimochi H, Sasaki Y, Kitamura A, Yasutomo K. Differentiation of preadipocytes and mature adipocytes requires PSMB8. Sci Rep. 2016;6:26791 pubmed 出版商
Mitsui Y, Chang I, Kato T, Hashimoto Y, Yamamura S, Fukuhara S, et al. Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer. Oncotarget. 2016;7:49107-49121 pubmed 出版商
Muter J, Brighton P, Lucas E, Lacey L, Shmygol A, Quenby S, et al. Progesterone-Dependent Induction of Phospholipase C-Related Catalytically Inactive Protein 1 (PRIP-1) in Decidualizing Human Endometrial Stromal Cells. Endocrinology. 2016;157:2883-93 pubmed 出版商
Gao L, Wang X, Niu Y, Duan D, Yang X, Hao J, et al. Molecular targets of Chinese herbs: a clinical study of hepatoma based on network pharmacology. Sci Rep. 2016;6:24944 pubmed 出版商
de la Cruz Morcillo M, Berger J, Sanchez Prieto R, Saada S, Naves T, Guillaudeau A, et al. p75 neurotrophin receptor and pro-BDNF promote cell survival and migration in clear cell renal cell carcinoma. Oncotarget. 2016;7:34480-97 pubmed 出版商
Lien E, Lyssiotis C, Juvekar A, Hu H, Asara J, Cantley L, et al. Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer. Nat Cell Biol. 2016;18:572-8 pubmed 出版商
Sun P, Wei S, Wei X, Wang J, Zhang Y, Qiao M, et al. Anger Emotional Stress Influences VEGF/VEGFR2 and Its Induced PI3K/AKT/mTOR Signaling Pathway. Neural Plast. 2016;2016:4129015 pubmed 出版商
Balasooriya G, Johnson J, Basson M, Rawlins E. An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium. Dev Cell. 2016;37:85-97 pubmed 出版商
Coppock J, Vermeer P, Vermeer D, Lee K, Miskimins W, Spanos W, et al. mTOR inhibition as an adjuvant therapy in a metastatic model of HPV+ HNSCC. Oncotarget. 2016;7:24228-41 pubmed 出版商
Qin Wei Z, Yong Guang L. Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling. Exp Ther Med. 2016;11:978-984 pubmed
Tsokanos F, Albert M, Demetriades C, Spirohn K, Boutros M, Teleman A. eIF4A inactivates TORC1 in response to amino acid starvation. EMBO J. 2016;35:1058-76 pubmed 出版商
Caron A, Labbé S, Lanfray D, Blanchard P, Villot R, Roy C, et al. Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity. Mol Metab. 2016;5:102-112 pubmed 出版商
Tobita T, Guzman Lepe J, Takeishi K, Nakao T, Wang Y, Meng F, et al. SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids. PLoS ONE. 2016;11:e0149344 pubmed 出版商
Chen L, Huang J, Ji Y, Zhang X, Wang P, Deng K, et al. Tripartite motif 32 prevents pathological cardiac hypertrophy. Clin Sci (Lond). 2016;130:813-28 pubmed 出版商
Yueh A, Payne S, Leystra A, Van De Hey D, Foley T, Pasch C, et al. Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K. PLoS ONE. 2016;11:e0148730 pubmed 出版商
Yang L, Wang Y, Xing R, Bai L, Li C, Li Z, et al. Mimotope mimicking epidermal growth factor receptor alleviates mononuclear cell infiltration in exocrine glands induced by muscarinic acetylcholine 3 receptor. Clin Immunol. 2016;163:111-9 pubmed 出版商
Vujic I, Sanlorenzo M, Esteve Puig R, Vujic M, Kwong A, Tsumura A, et al. Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget. 2016;7:7297-306 pubmed 出版商
Sunkel B, Wu D, Chen Z, Wang C, Liu X, Ye Z, et al. Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence. Nucleic Acids Res. 2016;44:4105-22 pubmed 出版商
Kierulf Lassen C, Kristensen M, Birn H, Jespersen B, Nørregaard R. No Effect of Remote Ischemic Conditioning Strategies on Recovery from Renal Ischemia-Reperfusion Injury and Protective Molecular Mediators. PLoS ONE. 2015;10:e0146109 pubmed 出版商
Xu M, Palmer A, Ding H, Weivoda M, Pirtskhalava T, White T, et al. Targeting senescent cells enhances adipogenesis and metabolic function in old age. elife. 2015;4:e12997 pubmed 出版商
Ye Y, Xiao L, Wang S, Yue W, Yin Q, Sun M, et al. Up-regulation of REG3A in colorectal cancer cells confers proliferation and correlates with colorectal cancer risk. Oncotarget. 2016;7:3921-33 pubmed 出版商
Zhang L, Wang J, Liang R, Huang S, Xu J, Yuan L, et al. RASSF8 downregulation promotes lymphangiogenesis and metastasis in esophageal squamous cell carcinoma. Oncotarget. 2015;6:34510-24 pubmed 出版商
Yamaguchi H, Kawazu M, Yasuda T, Soda M, Ueno T, Kojima S, et al. Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer. Cancer Sci. 2015;106:1687-92 pubmed 出版商
Katsura Y, Kubota H, Kunida K, Kanno A, Kuroda S, Ozawa T. An optogenetic system for interrogating the temporal dynamics of Akt. Sci Rep. 2015;5:14589 pubmed 出版商
Liu X, Liao W, Yuan Q, Ou Y, Huang J. TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells. Oncotarget. 2015;6:34309-20 pubmed 出版商
Lamming D, Cummings N, Rastelli A, Gao F, Cava E, Bertozzi B, et al. Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model. Oncotarget. 2015;6:31233-40 pubmed 出版商
Guo A, He D, Xu H, Geng C, Zhao J. Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents. Sci Rep. 2015;5:14046 pubmed 出版商
Chan E, Chen C, Cole G, Wong B. Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice. Sci Rep. 2015;5:13842 pubmed 出版商
Myers A, Lin L, Nancarrow D, Wang Z, Ferrer Torres D, Thomas D, et al. IGFBP2 modulates the chemoresistant phenotype in esophageal adenocarcinoma. Oncotarget. 2015;6:25897-916 pubmed 出版商
Kawano M, Tanaka K, Itonaga I, Ikeda S, Iwasaki T, Tsumura H. microRNA-93 promotes cell proliferation via targeting of PTEN in Osteosarcoma cells. J Exp Clin Cancer Res. 2015;34:76 pubmed 出版商
Pan B, Chen J, Lian J, Huang X, Deng C. Unique Effects of Acute Aripiprazole Treatment on the Dopamine D2 Receptor Downstream cAMP-PKA and Akt-GSK3β Signalling Pathways in Rats. PLoS ONE. 2015;10:e0132722 pubmed 出版商
Sasaki Y, Ohta M, Desai D, Figueiredo J, Whelan M, Sugano T, et al. Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance. PLoS ONE. 2015;10:e0131176 pubmed 出版商
Black J, Harrell J, Leisner T, Fellmeth M, George S, Reinhold D, et al. CIB1 depletion impairs cell survival and tumor growth in triple-negative breast cancer. Breast Cancer Res Treat. 2015;152:337-46 pubmed 出版商
Man S, Zhu Q, Zhu L, Liu Z, Karki R, Malik A, et al. Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer. Cell. 2015;162:45-58 pubmed 出版商
Murgatroyd C, Pena C, Podda G, Nestler E, Nephew B. Early life social stress induced changes in depression and anxiety associated neural pathways which are correlated with impaired maternal care. Neuropeptides. 2015;52:103-11 pubmed 出版商
Saucedo L, Buffa G, Rosso M, Guillardoy T, Góngora A, Munuce M, et al. Fibroblast Growth Factor Receptors (FGFRs) in Human Sperm: Expression, Functionality and Involvement in Motility Regulation. PLoS ONE. 2015;10:e0127297 pubmed 出版商
Guan Y, Cheng Y, Yin Y, Duan J, Wei G, Weng Y, et al. A novel animal model of impaired glucose tolerance induced by the interaction of vitamin E deficiency and (60)Co radiation. Biomed Res Int. 2015;2015:457246 pubmed 出版商
Nakakido M, Deng Z, Suzuki T, Dohmae N, Nakamura Y, Hamamoto R. Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN. Neoplasia. 2015;17:367-73 pubmed 出版商
Silveira A, Laranjeira A, Rodrigues G, Leal P, Cardoso B, Barata J, et al. PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia. Oncotarget. 2015;6:13105-18 pubmed
Moriya J, Ferrara N. Inhibition of protein kinase C enhances angiogenesis induced by platelet-derived growth factor C in hyperglycemic endothelial cells. Cardiovasc Diabetol. 2015;14:19 pubmed 出版商
Han Z, Jiang Y, Yang Y, Li X, Yang Z, Cao K, et al. Deletion of PDK1 causes cardiac sodium current reduction in mice. PLoS ONE. 2015;10:e0122436 pubmed 出版商
Kawashiri M, Nakanishi C, Tsubokawa T, Shimojima M, Yoshida S, Yoshimuta T, et al. Impact of Enhanced Production of Endogenous Heme Oxygenase-1 by Pitavastatin on Survival and Functional Activities of Bone Marrow-derived Mesenchymal Stem Cells. J Cardiovasc Pharmacol. 2015;65:601-6 pubmed 出版商
Woodcock K, Kierdorf K, Pouchelon C, Vivancos V, Dionne M, Geissmann F. Macrophage-derived upd3 cytokine causes impaired glucose homeostasis and reduced lifespan in Drosophila fed a lipid-rich diet. Immunity. 2015;42:133-44 pubmed
Wang Z, Xu D, Ding H, Kim J, Zhang J, Hai T, et al. Loss of ATF3 promotes Akt activation and prostate cancer development in a Pten knockout mouse model. Oncogene. 2015;34:4975-84 pubmed 出版商
Rohrbach T, Jarboe J, Anderson J, Trummell H, Hicks P, Weaver A, et al. Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity. Int J Oncol. 2015;46:1079-88 pubmed 出版商
Duan H, Qu L, Shou C. Activation of EGFR-PI3K-AKT signaling is required for Mycoplasma hyorhinis-promoted gastric cancer cell migration. Cancer Cell Int. 2014;14:135 pubmed 出版商
Moisan A, Lee Y, Zhang J, Hudak C, Meyer C, Prummer M, et al. White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015;17:57-67 pubmed 出版商
Qiu Y, Li W, Zhang H, Liu Y, Tian X, Fang W. P2X7 mediates ATP-driven invasiveness in prostate cancer cells. PLoS ONE. 2014;9:e114371 pubmed 出版商
Mooij H, Cabrales P, Bernelot Moens S, Xu D, Udayappan S, Tsai A, et al. Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function. J Am Heart Assoc. 2014;3:e001274 pubmed 出版商
Kuboki Y, Shimizu K, Hatori T, Yamamoto M, Shibata N, Shiratori K, et al. Molecular biomarkers for progression of intraductal papillary mucinous neoplasm of the pancreas. Pancreas. 2015;44:227-35 pubmed 出版商
Xu L, Wang S, Li B, Sun A, Zou Y, Ge J. A protective role of ciglitazone in ox-LDL-induced rat microvascular endothelial cells via modulating PPARγ-dependent AMPK/eNOS pathway. J Cell Mol Med. 2015;19:92-102 pubmed 出版商
Elsherif L, Ozler M, Zayed M, Shen J, Chernoff J, Faber J, et al. Potential compensation among group I PAK members in hindlimb ischemia and wound healing. PLoS ONE. 2014;9:e112239 pubmed 出版商
Lu T, Yang W, Wang Z, Hu Z, Zeng X, Yang C, et al. Knockdown of glucose-regulated protein 78/binding immunoglobulin heavy chain protein expression by asymmetric small interfering RNA induces apoptosis in prostate cancer cells and attenuates migratory capability. Mol Med Rep. 2015;11:249-56 pubmed 出版商
Aoyama A, Katayama R, Oh hara T, Sato S, Okuno Y, Fujita N. Tivantinib (ARQ 197) exhibits antitumor activity by directly interacting with tubulin and overcomes ABC transporter-mediated drug resistance. Mol Cancer Ther. 2014;13:2978-90 pubmed 出版商
Schulz E, Klampfl P, Holzapfel S, Janecke A, Ulz P, Renner W, et al. Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X. Nat Commun. 2014;5:5191 pubmed 出版商
Lew E, Oh J, Burrola P, Lax I, Zagórska A, Través P, et al. Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities. elife. 2014;3: pubmed 出版商
Bao M, Zhang Y, Lou X, Cheng Y, Zhou H. Protective effects of let-7a and let-7b on oxidized low-density lipoprotein induced endothelial cell injuries. PLoS ONE. 2014;9:e106540 pubmed 出版商
Katayama R, Friboulet L, Koike S, Lockerman E, Khan T, Gainor J, et al. Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib. Clin Cancer Res. 2014;20:5686-96 pubmed 出版商
Moak S, Dougan G, MarElia C, Danse W, Fernandez A, Kuehl M, et al. Enhanced glucose tolerance in pancreatic-derived factor (PANDER) knockout C57BL/6 mice. Dis Model Mech. 2014;7:1307-15 pubmed 出版商
Trucco L, Andreoli V, Núñez N, Maccioni M, Bocco J. Krüppel-like factor 6 interferes with cellular transformation induced by the H-ras oncogene. FASEB J. 2014;28:5262-76 pubmed 出版商
Engel N, Falodun A, Kühn J, Kragl U, Langer P, Nebe B. Pro-apoptotic and anti-adhesive effects of four African plant extracts on the breast cancer cell line MCF-7. BMC Complement Altern Med. 2014;14:334 pubmed 出版商
Wang Q, Wang H, Zhang Y, Zhang Y, Xiao W. Activation of uPAR is required for cigarette smoke extract-induced epithelial-mesenchymal transition in lung epithelial cells. Oncol Res. 2013;21:295-305 pubmed 出版商
Zagórska A, Través P, Lew E, Dransfield I, Lemke G. Diversification of TAM receptor tyrosine kinase function. Nat Immunol. 2014;15:920-8 pubmed 出版商
Asnaghi L, Lin M, Lim K, Lim K, Tripathy A, Wendeborn M, et al. Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation. PLoS ONE. 2014;9:e105372 pubmed 出版商
Zhang X, Yang B, Wang J, Mo X, Zhang J, Hua Z. FADD is essential for glucose uptake and survival of thymocytes. Biochem Biophys Res Commun. 2014;451:202-7 pubmed 出版商
Shimabukuro J, Yamaoka A, Murata K, Kotani E, Hirano T, Nakajima Y, et al. 3D co-cultures of keratinocytes and melanocytes and cytoprotective effects on keratinocytes against reactive oxygen species by insect virus-derived protein microcrystals. Mater Sci Eng C Mater Biol Appl. 2014;42:64-9 pubmed 出版商
Hauser J, Lindner R. Coalescence of B cell receptor and invariant chain MHC II in a raft-like membrane domain. J Leukoc Biol. 2014;96:843-55 pubmed 出版商
Gronnier C, Bruyère E, Lahdaoui F, Jonckheere N, Perrais M, Leteurtre E, et al. The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells. Biochim Biophys Acta. 2014;1843:2432-7 pubmed 出版商
Fappi A, Godoy T, Maximino J, Rizzato V, Neves J, Chadi G, et al. The effects of omega-3 fatty acid supplementation on dexamethasone-induced muscle atrophy. Biomed Res Int. 2014;2014:961438 pubmed 出版商
Liu J, Ke F, Xu Z, Liu Z, Zhang L, Yan S, et al. CCR6 is a prognostic marker for overall survival in patients with colorectal cancer, and its overexpression enhances metastasis in vivo. PLoS ONE. 2014;9:e101137 pubmed 出版商
Mehta V, Abi Nader K, Shangaris P, Shaw S, Filippi E, Benjamin E, et al. Local over-expression of VEGF-D?N?C in the uterine arteries of pregnant sheep results in long-term changes in uterine artery contractility and angiogenesis. PLoS ONE. 2014;9:e100021 pubmed 出版商
Takagi S, Takemoto A, Takami M, Oh hara T, Fujita N. Platelets promote osteosarcoma cell growth through activation of the platelet-derived growth factor receptor-Akt signaling axis. Cancer Sci. 2014;105:983-8 pubmed 出版商
Outani H, Tanaka T, Wakamatsu T, Imura Y, Hamada K, Araki N, et al. Establishment of a novel clear cell sarcoma cell line (Hewga-CCS), and investigation of the antitumor effects of pazopanib on Hewga-CCS. BMC Cancer. 2014;14:455 pubmed 出版商
Chow J, Lawrence R, Healy M, Dominy J, Liao J, Breen D, et al. Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation. Mol Metab. 2014;3:419-31 pubmed 出版商
KOCALIS H, Hagan S, George L, Turney M, Siuta M, Laryea G, et al. Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis. Mol Metab. 2014;3:394-407 pubmed 出版商
Algars A, Avoranta T, Osterlund P, Lintunen M, Sundström J, Jokilehto T, et al. Heterogeneous EGFR gene copy number increase is common in colorectal cancer and defines response to anti-EGFR therapy. PLoS ONE. 2014;9:e99590 pubmed 出版商
Wang H, Duan L, Zou Z, Li H, Yuan S, Chen X, et al. Activation of the PI3K/Akt/mTOR/p70S6K pathway is involved in S100A4-induced viability and migration in colorectal cancer cells. Int J Med Sci. 2014;11:841-9 pubmed 出版商
Weekes M, Tomasec P, Huttlin E, Fielding C, Nusinow D, Stanton R, et al. Quantitative temporal viromics: an approach to investigate host-pathogen interaction. Cell. 2014;157:1460-72 pubmed 出版商
Fuke Y, Hishinuma M, Namikawa M, Oishi Y, Matsuzaki T. Wasabi-derived 6-(methylsulfinyl)hexyl isothiocyanate induces apoptosis in human breast cancer by possible involvement of the NF-?B pathways. Nutr Cancer. 2014;66:879-87 pubmed 出版商
Wang B, Yang G, Liang X, Zhu M, Du M. Grape seed extract prevents skeletal muscle wasting in interleukin 10 knockout mice. BMC Complement Altern Med. 2014;14:162 pubmed 出版商
Kim H, Abd Elmageed Z, Davis C, El Bahrawy A, Naura A, Ekaidi I, et al. Correlation between PDZK1, Cdc37, Akt and breast cancer malignancy: the role of PDZK1 in cell growth through Akt stabilization by increasing and interacting with Cdc37. Mol Med. 2014;20:270-9 pubmed 出版商
Williams J, Kim I, Ito E, Shi W, Yue S, Siu L, et al. Pre-clinical characterization of Dacomitinib (PF-00299804), an irreversible pan-ErbB inhibitor, combined with ionizing radiation for head and neck squamous cell carcinoma. PLoS ONE. 2014;9:e98557 pubmed 出版商
Tang H, Zhang Q, Yang L, Dong Y, Khan M, Yang F, et al. Reprint of "GPR30 mediates estrogen rapid signaling and neuroprotection". Mol Cell Endocrinol. 2014;389:92-8 pubmed 出版商
Gao L, Wang X, Wang X, Zhang L, Qiang C, Chang S, et al. IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma. Oncotarget. 2014;5:2562-74 pubmed
O Neal W, Griffin W, Kent S, Faiz F, HODGES J, Vuncannon J, et al. Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy. Front Physiol. 2014;5:132 pubmed 出版商
Luo J, Weaver M, Cao B, Dennis J, Van Biber B, Laflamme M, et al. Cobalt protoporphyrin pretreatment protects human embryonic stem cell-derived cardiomyocytes from hypoxia/reoxygenation injury in vitro and increases graft size and vascularization in vivo. Stem Cells Transl Med. 2014;3:734-44 pubmed 出版商
Bao M, Zhang Y, Lou X, Xiao Y, Cheng Y, Zhou H. Puerarin protects endothelial cells from oxidized low density lipoprotein induced injuries via the suppression of LOX-1 and induction of eNOS. Can J Physiol Pharmacol. 2014;92:299-306 pubmed 出版商
Borsting E, Patel S, Declèves A, Lee S, Rahman Q, Akira S, et al. Tribbles homolog 3 attenuates mammalian target of rapamycin complex-2 signaling and inflammation in the diabetic kidney. J Am Soc Nephrol. 2014;25:2067-78 pubmed 出版商
Cheng X, Li Y, Tan J, Sun B, Xiao Y, Fang X, et al. CCL20 and CXCL8 synergize to promote progression and poor survival outcome in patients with colorectal cancer by collaborative induction of the epithelial-mesenchymal transition. Cancer Lett. 2014;348:77-87 pubmed 出版商
Krook M, Nicholls L, Scannell C, Chugh R, Thomas D, Lawlor E. Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma. Mol Cancer Res. 2014;12:953-64 pubmed 出版商
Ong Q, Chan E, Lim M, Wong B. Expression of human apolipoprotein E4 reduces insulin-receptor substrate 1 expression and Akt phosphorylation in the ageing liver. FEBS Open Bio. 2014;4:260-5 pubmed 出版商
Medina E, Oberheu K, Polusani S, Ortega V, Velagaleti G, Oyajobi B. PKA/AMPK signaling in relation to adiponectin's antiproliferative effect on multiple myeloma cells. Leukemia. 2014;28:2080-9 pubmed 出版商
Schmid C, Streicher J, Meltzer H, Bohn L. Clozapine acts as an agonist at serotonin 2A receptors to counter MK-801-induced behaviors through a ?arrestin2-independent activation of Akt. Neuropsychopharmacology. 2014;39:1902-13 pubmed 出版商
Carpenter R, Paw I, Dewhirst M, Lo H. Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells. Oncogene. 2015;34:546-57 pubmed 出版商
Westphalen K, Gusarova G, Islam M, Subramanian M, Cohen T, Prince A, et al. Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity. Nature. 2014;506:503-6 pubmed 出版商
Ong Q, Chan E, Lim M, Cole G, Wong B. Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice. Sci Rep. 2014;4:3754 pubmed 出版商
Wills M, Tong J, Tremblay S, Moran M, Jones N. The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor. Mol Biol Cell. 2014;25:739-52 pubmed 出版商
Reddy M, Akula B, Cosenza S, Athuluridivakar S, Mallireddigari M, Pallela V, et al. Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5). J Med Chem. 2014;57:578-99 pubmed 出版商
Ghosh A, Lu G, Su G, McEvoy B, Sadiq O, DiMusto P, et al. Phosphorylation of AKT and abdominal aortic aneurysm formation. Am J Pathol. 2014;184:148-58 pubmed 出版商
Wan G, Xie W, Liu Z, Xu W, Lao Y, Huang N, et al. Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway. Autophagy. 2014;10:70-9 pubmed 出版商
Zhang S, Li J, Lea R, Amaya E, Dorey K. A functional genome-wide in vivo screen identifies new regulators of signalling pathways during early Xenopus embryogenesis. PLoS ONE. 2013;8:e79469 pubmed 出版商
Miura H, Matsuda M, Aoki K. Development of a FRET biosensor with high specificity for Akt. Cell Struct Funct. 2014;39:9-20 pubmed
Han K, Holder J, Schaaf C, Lu H, Chen H, Kang H, et al. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature. 2013;503:72-7 pubmed 出版商
El Gazzar A, Cai X, Reeves R, Dai Z, Caballero Benítez A, McDonald D, et al. Effects on tumor development and metastatic dissemination by the NKG2D lymphocyte receptor expressed on cancer cells. Oncogene. 2014;33:4932-40 pubmed 出版商
Mukhopadhyay C, Zhao X, Maroni D, Band V, Naramura M. Distinct effects of EGFR ligands on human mammary epithelial cell differentiation. PLoS ONE. 2013;8:e75907 pubmed 出版商
Su Y, Cui L, Piao C, Li B, Zhao L. The effects of hematopoietic growth factors on neurite outgrowth. PLoS ONE. 2013;8:e75562 pubmed 出版商
Pucer A, Brglez V, Payre C, Pungercar J, Lambeau G, Petan T. Group X secreted phospholipase A(2) induces lipid droplet formation and prolongs breast cancer cell survival. Mol Cancer. 2013;12:111 pubmed 出版商
Wong J, Li S, Lim E, Wang Y, Wang C, Zhang H, et al. A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning. PLoS Biol. 2013;11:e1001657 pubmed 出版商
Kota V, Dhople V, Fullbright G, Smythe N, Szulc Z, Bielawska A, et al. 2'-hydroxy C16-ceramide induces apoptosis-associated proteomic changes in C6 glioma cells. J Proteome Res. 2013;12:4366-75 pubmed 出版商
Lorenzato A, Biolatti M, Delogu G, Capobianco G, Farace C, Dessole S, et al. AKT activation drives the nuclear localization of CSE1L and a pro-oncogenic transcriptional activation in ovarian cancer cells. Exp Cell Res. 2013;319:2627-36 pubmed 出版商
Subramani A, Alsidawi S, Jagannathan S, Sumita K, Sasaki A, Aronow B, et al. The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis. Sci Rep. 2013;3:2392 pubmed 出版商
Straus D. TNF? and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells. Mol Cancer. 2013;12:78 pubmed 出版商
Chen Y, Chi P, Rockowitz S, Iaquinta P, Shamu T, Shukla S, et al. ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. Nat Med. 2013;19:1023-9 pubmed 出版商
Wang Q, Wang Y, Zhang Y, Zhang Y, Xiao W. The role of uPAR in epithelial-mesenchymal transition in small airway epithelium of patients with chronic obstructive pulmonary disease. Respir Res. 2013;14:67 pubmed 出版商
Liao R, Jung J, Tchaicha J, Wilkerson M, Sivachenko A, Beauchamp E, et al. Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma. Cancer Res. 2013;73:5195-205 pubmed 出版商
Guo F, Ma Y, Kadegowda A, Betters J, Xie P, Liu G, et al. Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice. J Lipid Res. 2013;54:2109-20 pubmed 出版商
Fujiki K, Inamura H, Matsuoka M. Phosphorylation of FOXO3a by PI3K/Akt pathway in HK-2 renal proximal tubular epithelial cells exposed to cadmium. Arch Toxicol. 2013;87:2119-27 pubmed 出版商
Sadighi Akha A, Theriot C, Erb Downward J, McDermott A, Falkowski N, Tyra H, et al. Acute infection of mice with Clostridium difficile leads to eIF2? phosphorylation and pro-survival signalling as part of the mucosal inflammatory response. Immunology. 2013;140:111-22 pubmed 出版商
Nakles R, Kallakury B, Furth P. The PPAR? agonist efatutazone increases the spectrum of well-differentiated mammary cancer subtypes initiated by loss of full-length BRCA1 in association with TP53 haploinsufficiency. Am J Pathol. 2013;182:1976-85 pubmed 出版商
de Jong A, Maass A, Oberdorf Maass S, de Boer R, van Gilst W, Van Gelder I. Cyclical stretch induces structural changes in atrial myocytes. J Cell Mol Med. 2013;17:743-53 pubmed 出版商
Goyal P, Brünnert D, Ehrhardt J, Bredow M, Piccenini S, Zygmunt M. Cytokine IL-6 secretion by trophoblasts regulated via sphingosine-1-phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways. Mol Hum Reprod. 2013;19:528-38 pubmed 出版商
Kharbanda A, Rajabi H, Jin C, Raina D, Kufe D. Oncogenic MUC1-C promotes tamoxifen resistance in human breast cancer. Mol Cancer Res. 2013;11:714-23 pubmed 出版商
Urao N, Sudhahar V, Kim S, Chen G, McKinney R, Kojda G, et al. Critical role of endothelial hydrogen peroxide in post-ischemic neovascularization. PLoS ONE. 2013;8:e57618 pubmed 出版商
Benhenda S, Ducroux A, Rivi re L, Sobhian B, Ward M, Dion S, et al. Methyltransferase PRMT1 is a binding partner of HBx and a negative regulator of hepatitis B virus transcription. J Virol. 2013;87:4360-71 pubmed 出版商
Cervelli V, Scioli M, Gentile P, Doldo E, Bonanno E, Spagnoli L, et al. Platelet-rich plasma greatly potentiates insulin-induced adipogenic differentiation of human adipose-derived stem cells through a serine/threonine kinase Akt-dependent mechanism and promotes clinical fat graft maintenance. Stem Cells Transl Med. 2012;1:206-20 pubmed 出版商
Hsueh Y, Yen C, Shih N, Chiang N, Li C, Chen L. Autophagy is involved in endogenous and NVP-AUY922-induced KIT degradation in gastrointestinal stromal tumors. Autophagy. 2013;9:220-33 pubmed 出版商
Zaman M, Thamminana S, Shahryari V, Chiyomaru T, Deng G, Saini S, et al. Inhibition of PTEN gene expression by oncogenic miR-23b-3p in renal cancer. PLoS ONE. 2012;7:e50203 pubmed 出版商
Wu A, Dalvi P, Lu X, Yang M, Riddick D, Matthews J, et al. Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells. Mol Pharmacol. 2013;83:377-88 pubmed 出版商
Asai J, Takenaka H, Hirakawa S, Sakabe J, Hagura A, Kishimoto S, et al. Topical simvastatin accelerates wound healing in diabetes by enhancing angiogenesis and lymphangiogenesis. Am J Pathol. 2012;181:2217-24 pubmed 出版商
Tsujimoto I, Yoshida A, Yoneda Kato N, Kato J. Depletion of CSN5 inhibits Ras-mediated tumorigenesis by inducing premature senescence in p53-null cells. FEBS Lett. 2012;586:4326-31 pubmed 出版商
Zhao Q, Niu Y, Matsumoto K, Tsuneyama K, Tanaka K, Miyata T, et al. Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain. BMC Complement Altern Med. 2012;12:188 pubmed 出版商
Choi J, Wu W, Muchir A, Iwata S, Homma S, Worman H. Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation. J Biol Chem. 2012;287:40513-24 pubmed 出版商
Fujita M, Tohji C, Honda Y, Yamamoto Y, Nakamura T, Yagami T, et al. Cytotoxicity of 15-deoxy-?(12,14)-prostaglandin J(2) through PPAR?-independent pathway and the involvement of the JNK and Akt pathway in renal cell carcinoma. Int J Med Sci. 2012;9:555-66 pubmed
Litvak V, Ratushny A, Lampano A, Schmitz F, Huang A, Raman A, et al. A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses. Nature. 2012;490:421-5 pubmed 出版商
Yang M, Yuan F, Li P, Chen Z, Chen A, Li S, et al. Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells. Mol Cancer. 2012;11:54 pubmed
Moriyama M, Moriyama H, Ueda A, Nishibata Y, Okura H, Ichinose A, et al. Human adipose tissue-derived multilineage progenitor cells exposed to oxidative stress induce neurite outgrowth in PC12 cells through p38 MAPK signaling. BMC Cell Biol. 2012;13:21 pubmed 出版商
Cheng L, Lin Z, Shu R, Liu D, Zhang X, Liu B, et al. Analogous effects of recombinant human full-length amelogenin expressed by Pichia pastoris yeast and enamel matrix derivative in vitro. Cell Prolif. 2012;45:456-65 pubmed 出版商
Tsunoda T, Ota T, Fujimoto T, Doi K, Tanaka Y, Yoshida Y, et al. Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model. Mol Cancer. 2012;11:46 pubmed 出版商
Almansour N, Pirogova E, Coloe P, Cosic I, Istivan T. A bioactive peptide analogue for myxoma virus protein with a targeted cytotoxicity for human skin cancer in vitro. J Biomed Sci. 2012;19:65 pubmed 出版商
Sharma N, Kumar V, Everingham S, Mali R, Kapur R, Zeng L, et al. SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice. Mol Cell Biol. 2012;32:2653-63 pubmed 出版商
He Z, Gao Y, Deng Y, Li W, Chen Y, Xing S, et al. Lipopolysaccharide induces lung fibroblast proliferation through Toll-like receptor 4 signaling and the phosphoinositide3-kinase-Akt pathway. PLoS ONE. 2012;7:e35926 pubmed 出版商
Mundra J, Terskiy A, Howells R. Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. J Pharmacol Exp Ther. 2012;342:273-87 pubmed 出版商
Zhang S, Zhou X, Lang R, Guo F. RhoA of the Rho family small GTPases is essential for B lymphocyte development. PLoS ONE. 2012;7:e33773 pubmed 出版商
Jonckheere N, Skrypek N, Merlin J, Dessein A, Dumont P, Leteurtre E, et al. The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways. PLoS ONE. 2012;7:e32232 pubmed 出版商
Jothi M, Nishijo K, Keller C, Mal A. AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cell. Cell Cycle. 2012;11:895-908 pubmed 出版商
Krishnapuram R, Kirk Ballard H, Dhurandhar E, Dubuisson O, Messier V, Rabasa Lhoret R, et al. Insulin receptor-independent upregulation of cellular glucose uptake. Int J Obes (Lond). 2013;37:146-53 pubmed 出版商
Lan R, Geng H, Polichnowski A, Singha P, Saikumar P, McEwen D, et al. PTEN loss defines a TGF-?-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis. Am J Physiol Renal Physiol. 2012;302:F1210-23 pubmed 出版商
Weigert O, Lane A, Bird L, Kopp N, Chapuy B, Van Bodegom D, et al. Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. J Exp Med. 2012;209:259-73 pubmed 出版商
Zhou H, Shen D, Bian Z, Zong J, Deng W, Zhang Y, et al. Activating transcription factor 3 deficiency promotes cardiac hypertrophy, dysfunction, and fibrosis induced by pressure overload. PLoS ONE. 2011;6:e26744 pubmed 出版商
Yang S, Xiao X, Meng X, Leslie K. A mechanism for synergy with combined mTOR and PI3 kinase inhibitors. PLoS ONE. 2011;6:e26343 pubmed 出版商
Peeters A, Fraisl P, van den Berg S, Ver Loren van Themaat E, van Kampen A, Rider M, et al. Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor ? coactivator 1? (PGC-1?) suppression. J Biol Chem. 2011;286:42162-79 pubmed 出版商
Jeong H, Lee S, Yun H, Baek K, Kwon N, Park K, et al. Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects. J Biomed Sci. 2011;18:55 pubmed 出版商
Wen Q, Zhou L, Zhou C, Zhou M, Luo W, Ma L. Change in hepatocyte growth factor concentration promote mesenchymal stem cell-mediated osteogenic regeneration. J Cell Mol Med. 2012;16:1260-73 pubmed 出版商
Fonseca B, Alain T, Finestone L, Huang B, Rolfe M, Jiang T, et al. Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by p. J Biol Chem. 2011;286:27111-22 pubmed 出版商
Peng S, Lai Y, Huang H, Huang H, Huang Y. A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons. Nucleic Acids Res. 2010;38:7446-57 pubmed 出版商
Sánchez Blázquez P, Rodríguez Muñoz M, Garzón J. Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling. PLoS ONE. 2010;5:e11278 pubmed 出版商
Benedettini E, Sholl L, Peyton M, Reilly J, Ware C, Davis L, et al. Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis. Am J Pathol. 2010;177:415-23 pubmed 出版商
Mahajan K, Coppola D, Challa S, Fang B, Chen Y, Zhu W, et al. Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. PLoS ONE. 2010;5:e9646 pubmed 出版商
Rosner M, Fuchs C, Siegel N, Valli A, Hengstschlager M. Functional interaction of mammalian target of rapamycin complexes in regulating mammalian cell size and cell cycle. Hum Mol Genet. 2009;18:3298-310 pubmed 出版商
Allard D, Figg N, Bennett M, Littlewood T. Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3. J Biol Chem. 2008;283:19739-47 pubmed 出版商
Gray M, van Buren G, Dallas N, Xia L, Wang X, Yang A, et al. Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver. J Natl Cancer Inst. 2008;100:109-20 pubmed 出版商
产品信息
SKU号 :
4691L
产品名称 :
Akt (pan) (C67E7) Rabbit mAb
规格 :
300微升
Price-(USD) :
574美元
物种x :
H, M, R, Mk, Dm, (Pg)
应用 :
流式细胞仪
产品种类 :
PI3K / Akt Signaling
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
60
宿主 :
靶标 :
Akt1/Akt2/Akt3
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。