产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
MEK1/2(L38C12)小鼠单克隆抗体
目录 :
4694
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
L38C12
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪
文章摘录数: 41
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 s3d
Huang J, Wang X, Li B, Shen S, Wang R, Tao H, et al. L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression. J Immunother Cancer. 2022;10: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4b
Grinat J, Kosel F, Goveas N, Kranz A, Alexopoulou D, Rajewsky K, et al. Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells. Life Sci Alliance. 2022;5: pubmed 出版商
  • 免疫印迹; 小鼠; 图 4c
Li S, Zhu Z, Xue M, Pan X, Tong G, Yi X, et al. The protective effects of fibroblast growth factor 10 against hepatic ischemia-reperfusion injury in mice. Redox Biol. 2021;40:101859 pubmed 出版商
  • 免疫印迹; 小鼠
Goswami D, Chen D, Yang Y, Gudla P, Columbus J, Worthy K, et al. Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 e6d
Amendola C, Mahaffey J, Parker S, Ahearn I, Chen W, Zhou M, et al. KRAS4A directly regulates hexokinase 1. Nature. 2019;576:482-486 pubmed 出版商
  • 免疫印迹; 人类; 图 3d
Rushing A, Rushing B, Hoang K, Sanders S, Peloponese J, Polakowski N, et al. HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I. PLoS Pathog. 2019;15:e1007922 pubmed 出版商
  • 免疫印迹; 人类; 图 4b
Neel D, Allegakoen D, Olivas V, Mayekar M, Hemmati G, Chatterjee N, et al. Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins. Cancer Res. 2019;79:546-556 pubmed 出版商
  • 免疫印迹; 人类; 图 s10b, s10d
  • 免疫印迹; 小鼠; 图 s10c
Gerber T, Murawala P, Knapp D, Masselink W, Schuez M, Hermann S, et al. Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration. Science. 2018;362: pubmed 出版商
  • 免疫印迹; 人类; 图 3d
Vanshylla K, Bartsch C, Hitzing C, Krümpelmann L, Wienands J, Engels N. Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells. Sci Rep. 2018;8:4244 pubmed 出版商
  • 免疫印迹; 人类; 图 s5o
Schafer S, Viswanathan S, Widjaja A, Lim W, Moreno Moral A, Delaughter D, et al. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017;552:110-115 pubmed 出版商
  • 免疫印迹; 人类; 图 6f
Jiang X, Bao Y, Liu H, Kou X, Zhang Z, Sun F, et al. VPS34 stimulation of p62 phosphorylation for cancer progression. Oncogene. 2017;36:6850-6862 pubmed 出版商
  • 免疫印迹; 人类; 图 4d
Umstead M, Xiong J, Qi Q, Du Y, Fu H. Aurora kinase A interacts with H-Ras and potentiates Ras-MAPK signaling. Oncotarget. 2017;8:28359-28372 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3b
Xiang J, Yang S, Xin N, Gaertig M, Reeves R, Li S, et al. DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome. Proc Natl Acad Sci U S A. 2017;114:E1224-E1233 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2a
Kidger A, Rushworth L, Stellzig J, Davidson J, Bryant C, Bayley C, et al. Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling. Proc Natl Acad Sci U S A. 2017;114:E317-E326 pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Lagares Tena L, García Monclús S, López Alemany R, Almacellas Rabaiget O, Huertas Martínez J, Sáinz Jaspeado M, et al. Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway. Oncotarget. 2016;7:56889-56903 pubmed 出版商
  • 免疫细胞化学; 人类; 1:25; 图 4a
Dai H, Chen H, Liu W, You Y, Tan J, Yang A, et al. Effects of Raf kinase inhibitor protein expression on pancreatic cancer cell growth and motility: an in vivo and in vitro study. J Cancer Res Clin Oncol. 2016;142:2107-17 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5e
Zhang Y, Velez Delgado A, Mathew E, Li D, Mendez F, Flannagan K, et al. Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer. Gut. 2017;66:124-136 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Kemper K, Krijgsman O, Kong X, Cornelissen Steijger P, Shahrabi A, Weeber F, et al. BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts. Cell Rep. 2016;16:263-277 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1
Simpson D, Lemonie N, Morgan D, Gaddameedhi S, Kaufmann W. Oncogenic BRAF(V600E) Induces Clastogenesis and UVB Hypersensitivity. Cancers (Basel). 2015;7:1072-90 pubmed 出版商
  • 免疫印迹; 人类; 图 s3
Vogel C, Smit M, Maddalo G, Possik P, Sparidans R, van der Burg S, et al. Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK. Pigment Cell Melanoma Res. 2015;28:307-17 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s2
Guillaumond F, Bidaut G, Ouaissi M, Servais S, Gouirand V, Olivares O, et al. Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2015;112:2473-8 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Papadakis A, Sun C, Knijnenburg T, Xue Y, Grernrum W, Hölzel M, et al. SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer. Cell Res. 2015;25:445-58 pubmed 出版商
  • 免疫印迹; 小鼠
Park E, Kim B, Lee E, Chang E, Kim D, Choi S, et al. Targeting of receptor for advanced glycation end products suppresses cyst growth in polycystic kidney disease. J Biol Chem. 2014;289:9254-62 pubmed 出版商
  • 免疫印迹; 人类
Choi J, Landrette S, Wang T, Evans P, Bacchiocchi A, Bjornson R, et al. Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors. Pigment Cell Melanoma Res. 2014;27:253-62 pubmed 出版商
Tan M, Sng M, Cheng H, Low Z, Leong B, Chua D, et al. Deficiency in fibroblast PPARβ/δ reduces nonmelanoma skin cancers in mice. Cell Death Differ. 2020;27:2668-2680 pubmed 出版商
Jiu Y, Peranen J, Schaible N, Cheng F, Eriksson J, Krishnan R, et al. Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA. J Cell Sci. 2017;130:892-902 pubmed 出版商
Zhou M, Wiener H, Su W, Zhou Y, Liot C, Ahearn I, et al. VPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras trafficking. J Cell Biol. 2016;214:445-58 pubmed 出版商
Billing A, Ben Hamidane H, Dib S, Cotton R, Bhagwat A, Kumar P, et al. Comprehensive transcriptomic and proteomic characterization of human mesenchymal stem cells reveals source specific cellular markers. Sci Rep. 2016;6:21507 pubmed 出版商
Jang J, Lee A, Li J, Liyanage H, Yang Y, Guo L, et al. Common Oncogene Mutations and Novel SND1-BRAF Transcript Fusion in Lung Adenocarcinoma from Never Smokers. Sci Rep. 2015;5:9755 pubmed 出版商
Blum D, Labarge S. Registered report: Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. elife. 2014;3: pubmed 出版商
Carlino M, Fung C, Shahheydari H, Todd J, Boyd S, Irvine M, et al. Preexisting MEK1P124 mutations diminish response to BRAF inhibitors in metastatic melanoma patients. Clin Cancer Res. 2015;21:98-105 pubmed 出版商
Brobeil A, Graf M, Eiber M, Wimmer M. Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression. Biomolecules. 2012;2:122-42 pubmed 出版商
Hughes A, Spelke D, Xu Z, Kang C, Schaffer D, Herr A. Single-cell western blotting. Nat Methods. 2014;11:749-55 pubmed 出版商
Rizos H, Menzies A, Pupo G, Carlino M, Fung C, Hyman J, et al. BRAF inhibitor resistance mechanisms in metastatic melanoma: spectrum and clinical impact. Clin Cancer Res. 2014;20:1965-77 pubmed 出版商
Mayes D, Rizvi T, Titus Mitchell H, Oberst R, Ciraolo G, Vorhees C, et al. Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature. Cell Rep. 2013;4:1197-212 pubmed 出版商
Carnevale J, Ross L, Puissant A, Banerji V, Stone R, DeAngelo D, et al. SYK regulates mTOR signaling in AML. Leukemia. 2013;27:2118-28 pubmed 出版商
Lin S, Hoffmann K, Xiao Z, Jin N, Galli U, Mohr E, et al. MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma. Cancer Cell Int. 2013;13:3 pubmed 出版商
Lee J, Huang S, Lee M, Lee S, Ryu M, Kim S, et al. Dual specificity phosphatase 6 as a predictor of invasiveness in papillary thyroid cancer. Eur J Endocrinol. 2012;167:93-101 pubmed 出版商
Satoh T, Smith A, Sarde A, Lu H, Mian S, Mian S, et al. B-RAF mutant alleles associated with Langerhans cell histiocytosis, a granulomatous pediatric disease. PLoS ONE. 2012;7:e33891 pubmed 出版商
Falco A, Festa M, Basile A, Rosati A, Pascale M, Florenzano F, et al. BAG3 controls angiogenesis through regulation of ERK phosphorylation. Oncogene. 2012;31:5153-61 pubmed 出版商
Ahmad I, Patel R, Liu Y, Singh L, Taketo M, Wu X, et al. Ras mutation cooperates with ?-catenin activation to drive bladder tumourigenesis. Cell Death Dis. 2011;2:e124 pubmed 出版商
产品信息
SKU号 :
4694S
产品名称 :
MEK1/2(L38C12)小鼠单克隆抗体
规格 :
100微升
Price-(USD) :
235美元
物种x :
H, M, R, Mk
应用 :
流式细胞仪
产品种类 :
MAP Kinase Signaling
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
45
宿主 :
小鼠
靶标 :
MEK1/MEK2
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。