产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
磷酸化YAP(Ser127)抗体
目录 :
4911
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
人类, 小鼠, 大鼠, ,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, reverse phase protein lysate microarray, 其他, 免疫印迹基因敲除验证
文章摘录数: 70
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 11
Van Sciver N, Ohashi M, Pauly N, Bristol J, Nelson S, JOHANNSEN E, et al. Hippo signaling effectors YAP and TAZ induce Epstein-Barr Virus (EBV) lytic reactivation through TEADs in epithelial cells. PLoS Pathog. 2021;17:e1009783 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Xiao L, Shi X, Li Z, Li M, Zhang M, Yan S, et al. Downregulation of LINC01508 contributes to cisplatin resistance in ovarian cancer via the regulation of the Hippo-YAP pathway. J Gynecol Oncol. 2021;32:e77 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1a
Mia M, Cibi D, Abdul Ghani S, Song W, Tee N, Ghosh S, et al. YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction. PLoS Biol. 2020;18:e3000941 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5c
Seo G, Han H, Vargas R, Yang B, Li X, Wang W. MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation. Cell Rep. 2020;32:107860 pubmed 出版商
  • 免疫印迹; 人类; 图 4d, 5f
Rigiracciolo D, Nohata N, Lappano R, Cirillo F, Talia M, Scordamaglia D, et al. IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells. Cells. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 图 1s2b, 1s3a
Bae S, Ni L, Luo X. STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 7b
Zhou T, Gao B, Fan Y, Liu Y, Feng S, Cong Q, et al. Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 图 7b
Kim J, Berrios C, Kim M, SCHADE A, Adelmant G, Yeerna H, et al. STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 小鼠; 图 4d
Moya I, Castaldo S, Van den Mooter L, Soheily S, Sansores Garcia L, Jacobs J, et al. Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice. Science. 2019;366:1029-1034 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 1:1000; 图 4a
  • 免疫印迹; 人类; 1:1000; 图 4d
Zeng H, Castillo Cabrera J, Manser M, Lu B, Yang Z, Strande V, et al. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 人类; 图 3b
Zhou L, Wang Q, Zhang H, Li Y, Xie S, Xu M. YAP Inhibition by Nuciferine via AMPK-Mediated Downregulation of HMGCR Sensitizes Pancreatic Cancer Cells to Gemcitabine. Biomolecules. 2019;9: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3b, 3j
Park M, Kim A, Manandhar S, Oh S, Jang G, Kang L, et al. CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 1c
Menon V, Thomas R, Elgueta C, Horl M, Osborn T, Hallett P, et al. Comprehensive Cell Surface Antigen Analysis Identifies Transferrin Receptor Protein-1 (CD71) as a Negative Selection Marker for Human Neuronal Cells. Stem Cells. 2019;37:1293-1306 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3a
Rong X, Han Q, Lin X, Kremerskothen J, Wang E. FRMPD1 activates the Hippo pathway via interaction with WWC3 to suppress the proliferation and invasiveness of lung cancer cells. Cancer Manag Res. 2019;11:3395-3410 pubmed 出版商
  • 免疫印迹; 人类; 图 8a
Miller C, Lou H, Simpson C, van de Kooij B, Ha B, Fisher O, et al. Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output. PLoS Biol. 2019;17:e2006540 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3a
Li B, He J, Lv H, Liu Y, Lv X, Zhang C, et al. c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow. J Clin Invest. 2019;129:1167-1179 pubmed 出版商
  • 免疫印迹; 人类; 图 1f
Rausch V, Bostrom J, Park J, Bravo I, Feng Y, Hay D, et al. The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae. Curr Biol. 2019;29:242-255.e6 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 1b
Yao F, Zhou Z, Kim J, Hang Q, Xiao Z, Ton B, et al. SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity. Nat Commun. 2018;9:2269 pubmed 出版商
  • 其他; 人类; 图 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5c
Ibar C, Kirichenko E, Keepers B, Enners E, Fleisch K, Irvine K. Tension-dependent regulation of mammalian Hippo signaling through LIMD1. J Cell Sci. 2018;131: pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:500; 图 4d
Lu L, Finegold M, Johnson R. Hippo pathway coactivators Yap and Taz are required to coordinate mammalian liver regeneration. Exp Mol Med. 2018;50:e423 pubmed 出版商
  • 免疫印迹; 人类; 图 8c
Kim J, Kim Y, Kim J, Park D, Bae H, Lee D, et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. 2017;127:3441-3461 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Toloczko A, Guo F, Yuen H, Wen Q, Wood S, Ong Y, et al. Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway. Cancer Res. 2017;77:4921-4933 pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 1fs2
Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson Peer K, et al. YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis. elife. 2017;6: pubmed 出版商
  • reverse phase protein lysate microarray; 人类; 图 st6
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4e
Ragni C, Diguet N, Le Garrec J, Novotova M, Resende T, Pop S, et al. Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth. Nat Commun. 2017;8:14582 pubmed 出版商
  • 免疫印迹; 人类; 图 3c
Lee H, Diaz M, Price K, Ozuna J, Zhang S, Sevick Muraca E, et al. Fluid shear stress activates YAP1 to promote cancer cell motility. Nat Commun. 2017;8:14122 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 3b
Hirai M, Arita Y, McGlade C, Lee K, Chen J, Evans S. Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest. 2017;127:569-582 pubmed 出版商
  • 免疫印迹; 人类; 图 s4a
Nguyen H, Kugler J, Cohen S. DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins. PLoS ONE. 2017;12:e0169587 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3b
  • 免疫印迹; 小鼠; 1:500; 图 3a
Jerić I, Maurer G, Cavallo A, Raguz J, Desideri E, Tarkowski B, et al. A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis. Nat Commun. 2016;7:13781 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1b
  • 免疫组化-石蜡切片; 大鼠; 1:100; 图 1i
Wang L, Luo J, Li B, Tian X, Chen L, Huang Y, et al. Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature. 2016;540:579-582 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1a
Moroishi T, Hayashi T, Pan W, Fujita Y, Holt M, Qin J, et al. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016;167:1525-1539.e17 pubmed 出版商
  • 免疫印迹; 人类; 图 s2f
Kim W, Khan S, Gvozdenovic Jeremic J, Kim Y, Dahlman J, Kim H, et al. Hippo signaling interactions with Wnt/?-catenin and Notch signaling repress liver tumorigenesis. J Clin Invest. 2017;127:137-152 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1a
  • 免疫印迹; 小鼠; 1:1000; 图 1g
Kim H, Kim M, Park Y, Park I, Kim T, Yang S, et al. Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice. Gastroenterology. 2017;152:616-630 pubmed 出版商
  • 免疫印迹; 人类; 图 5h
Matsumoto Y, La Rose J, Kent O, Wagner M, Narimatsu M, Levy A, et al. Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. J Clin Invest. 2016;126:4482-4496 pubmed 出版商
  • 免疫印迹; 人类; 1:100; 图 st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed 出版商
  • 免疫印迹; 人类; 图 5A
Georgescu M, Gagea M, Cote G. NHERF1/EBP50 Suppresses Wnt-?-Catenin Pathway-Driven Intestinal Neoplasia. Neoplasia. 2016;18:512-23 pubmed 出版商
  • 免疫印迹; 人类; 图 2
  • 免疫印迹; 小鼠; 图 2
Vahid S, Thaper D, Gibson K, Bishop J, Zoubeidi A. Molecular chaperone Hsp27 regulates the Hippo tumor suppressor pathway in cancer. Sci Rep. 2016;6:31842 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 1:500; 图 4e
  • 免疫印迹; 大鼠; 图 4c
Ruess D, Probst M, Marjanovic G, Wittel U, Hopt U, Keck T, et al. HDACi Valproic Acid (VPA) and Suberoylanilide Hydroxamic Acid (SAHA) Delay but Fail to Protect against Warm Hepatic Ischemia-Reperfusion Injury. PLoS ONE. 2016;11:e0161233 pubmed 出版商
  • 免疫组化; 小鼠; 1:150; 图 6
  • 免疫印迹; 小鼠; 1:2000; 图 s3
Reginensi A, Enderle L, Gregorieff A, Johnson R, Wrana J, McNeill H. A critical role for NF2 and the Hippo pathway in branching morphogenesis. Nat Commun. 2016;7:12309 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4
Fernando R, Cotter L, Perrin Tricaud C, Berthelot J, Bartolami S, Pereira J, et al. Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway. Nat Commun. 2016;7:12186 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7g
Huang D, Li X, Sun L, Huang P, Ying H, Wang H, et al. Regulation of Hippo signalling by p38 signalling. J Mol Cell Biol. 2016;8:328-37 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Feng X, Liu P, Zhou X, Li M, Li F, Wang Z, et al. Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration. J Biol Chem. 2016;291:18947-58 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 7c
Huang Z, Hu J, Pan J, Wang Y, Hu G, Zhou J, et al. YAP stabilizes SMAD1 and promotes BMP2-induced neocortical astrocytic differentiation. Development. 2016;143:2398-409 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 3d
  • 免疫印迹; 人类; 1:1000; 图 3d
Simile M, Latte G, Demartis M, Brozzetti S, Calvisi D, Porcu A, et al. Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease. Oncotarget. 2016;7:49194-49216 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Chen X, Stauffer S, Chen Y, Dong J. Ajuba Phosphorylation by CDK1 Promotes Cell Proliferation and Tumorigenesis. J Biol Chem. 2016;291:14761-72 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Ni T, Kuperwasser C. Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer. elife. 2016;5: pubmed 出版商
  • 免疫印迹; 鸡; 1:1000; 图 7
McKey J, Martire D, de Santa Barbara P, Faure S. LIX1 regulates YAP1 activity and controls the proliferation and differentiation of stomach mesenchymal progenitors. BMC Biol. 2016;14:34 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:1000; 图 5
Lodge E, Russell J, Patist A, Francis West P, Andoniadou C. Expression Analysis of the Hippo Cascade Indicates a Role in Pituitary Stem Cell Development. Front Physiol. 2016;7:114 pubmed 出版商
  • 免疫印迹; 人类; 图 2d
Thongon N, Castiglioni I, Zucal C, Latorre E, D Agostino V, Bauer I, et al. The GSK3β inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level. Oncotarget. 2016;7:26551-66 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
Keyvani Chahi A, Martin C, Jones N. Nephrin Suppresses Hippo Signaling through the Adaptor Proteins Nck and WTIP. J Biol Chem. 2016;291:12799-808 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1
Ma B, Cheng H, Gao R, Mu C, Chen L, Wu S, et al. Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways. Nat Commun. 2016;7:11123 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:50; 图 6
  • 免疫细胞化学; 人类; 1:50; 图 6
Grampa V, Delous M, Zaidan M, Odye G, Thomas S, Elkhartoufi N, et al. Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation. PLoS Genet. 2016;12:e1005894 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
Lehmann W, Mossmann D, Kleemann J, Mock K, Meisinger C, Brummer T, et al. ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types. Nat Commun. 2016;7:10498 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Liu X, Li H, Rajurkar M, Li Q, Cotton J, Ou J, et al. Tead and AP1 Coordinate Transcription and Motility. Cell Rep. 2016;14:1169-1180 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Dai X, Zhuang L, Wang D, Zhou T, Chang L, Gai R, et al. Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells. Oncotarget. 2016;7:6933-47 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
  • 免疫印迹; 人类; 图 7
Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, et al. Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc Natl Acad Sci U S A. 2016;113:E71-80 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Kim M, Kim M, Park S, Lee C, Lim D. Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition. EMBO Rep. 2016;17:64-78 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Tanas M, Ma S, Jadaan F, Ng C, Weigelt B, Reis Filho J, et al. Mechanism of action of a WWTR1(TAZ)-CAMTA1 fusion oncoprotein. Oncogene. 2016;35:929-38 pubmed 出版商
Papaspyropoulos A, Bradley L, Thapa A, Leung C, Toskas K, Koennig D, et al. RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73. Nat Commun. 2018;9:424 pubmed 出版商
Elosegui Artola A, Andreu I, Beedle A, Lezamiz A, Uroz M, Kosmalska A, et al. Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. Cell. 2017;171:1397-1410.e14 pubmed 出版商
Mochizuki M, Lorenz V, Ivanek R, Della Verde G, Gaudiello E, Marsano A, et al. Polo-Like Kinase 2 is Dynamically Regulated to Coordinate Proliferation and Early Lineage Specification Downstream of Yes-Associated Protein 1 in Cardiac Progenitor Cells. J Am Heart Assoc. 2017;6: pubmed 出版商
Moleirinho S, Hoxha S, Mandati V, Curtale G, Troutman S, Ehmer U, et al. Regulation of localization and function of the transcriptional co-activator YAP by angiomotin. elife. 2017;6: pubmed 出版商
Kim Y, Choe S, Cho K, Cho D, Kang J, Park C, et al. Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis. Exp Mol Med. 2017;49:e296 pubmed 出版商
Seo E, Kim W, Hur J, Kim H, Nam S, Choi A, et al. The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis. Sci Rep. 2016;6:31931 pubmed 出版商
Maître J, Turlier H, Illukkumbura R, Eismann B, Niwayama R, Nedelec F, et al. Asymmetric division of contractile domains couples cell positioning and fate specification. Nature. 2016;536:344-348 pubmed 出版商
Zhou T, Zhuang L, Hu Y, Zhou Y, Lin W, Wang D, et al. Inactivation of hypoxia-induced YAP by statins overcomes hypoxic resistance tosorafenib in hepatocellular carcinoma cells. Sci Rep. 2016;6:30483 pubmed 出版商
Gruber R, Panayiotou R, Nye E, Spencer Dene B, Stamp G, Behrens A. YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling. Gastroenterology. 2016;151:526-39 pubmed 出版商
Nelson N, Clark G. Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling. Oncotarget. 2016;7:33821-31 pubmed 出版商
Liu C, Chan S, Guo F, Toloczko A, Cui L, Hong W. MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells. Oncotarget. 2016;7:13706-16 pubmed 出版商
产品信息
SKU号 :
4911S
产品名称 :
磷酸化YAP(Ser127)抗体
规格 :
100微升
Price-(USD) :
274美元
物种x :
H, M, R, (Mk, B)
应用 :
免疫组化(石蜡)
产品种类 :
发育生物学
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
多克隆抗体
分子量 :
65 to 75
宿主 :
靶标 :
YAP(Ser127)磷酸盐
最初蛋白 :
YAP1
别名 :
65 kDa Yes-associated protein,YAP,YAP1,YAP2,YAP65,YKI,Yes-associated protein 1,Yes-associated protein 1, 65kDa,Yorkie homolog,yes-associated protein 2
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。