产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
磷酸化IRF(Ser396)(4D4G)兔单克隆抗体
目录 :
4947
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
4D4G
反应物种 :
中国人树鼩鼱科, African green monkey, 人类, 小鼠, pigs
应用 :
免疫印迹, 免疫细胞化学, 染色质免疫沉淀 , 免疫组化-冰冻切片, proximity ligation assay
文章摘录数: 124
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:200; 图 4i
Sun L, Li Y, Misumi I, Gonzalez Lopez O, Hensley L, Cullen J, et al. IRF3-mediated pathogenicity in a murine model of human hepatitis A. PLoS Pathog. 2021;17:e1009960 pubmed 出版商
  • 免疫印迹; pigs ; 图 1i
Wang Z, Chen J, Wu X, Ma D, Zhang X, Li R, et al. PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection. PLoS Pathog. 2021;17:e1009940 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 1i
Bruand M, Barras D, Mina M, Ghisoni E, Morotti M, Lanitis E, et al. Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING. Cell Rep. 2021;36:109412 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2g
Shen Y, Tang K, Chen D, Hong M, Sun F, Wang S, et al. Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation. Cell Rep. 2021;35:109272 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5h
Zhang G, Li R, Li W, Yang S, Sun Q, Yin H, et al. Toll-like receptor 3 ablation prevented high-fat diet-induced obesity and metabolic disorder. J Nutr Biochem. 2021;95:108761 pubmed 出版商
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Lopacinski A, Sweatt A, Smolko C, Gray Gaillard E, Borgman C, Shah M, et al. Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback. Cell Syst. 2021;12:304-323.e13 pubmed 出版商
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Guo G, Gao M, Gao X, Zhu B, Huang J, Luo K, et al. SARS-CoV-2 non-structural protein 13 (nsp13) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response. Signal Transduct Target Ther. 2021;6:119 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4a
Tao L, Lemoff A, Wang G, Zarek C, Lowe A, Yan N, et al. Reactive oxygen species oxidize STING and suppress interferon production. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 8b
Kang L, Yu H, Yang X, Zhu Y, Bai X, Wang R, et al. Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke. Nat Commun. 2020;11:2488 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2h
Weindel C, Bell S, Vail K, West K, Patrick K, Watson R. LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Cai H, Yan L, Liu N, Xu M, Cai H. IFI16 promotes cervical cancer progression by upregulating PD-L1 in immunomicroenvironment through STING-TBK1-NF-kB pathway. Biomed Pharmacother. 2020;123:109790 pubmed 出版商
  • proximity ligation assay; 人类; 1:1000; 图 3a
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  • 免疫印迹; 小鼠; 图 s4f
Liu Y, You Y, Lu Z, Yang J, Li P, Liu L, et al. N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication. Science. 2019;365:1171-1176 pubmed 出版商
  • 免疫印迹; 人类
Xu G, Xia Z, Deng F, Liu L, Wang Q, Yu Y, et al. Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex. PLoS Pathog. 2019;15:e1008002 pubmed 出版商
  • 免疫印迹; 人类; 图 2c
Zierhut C, Yamaguchi N, Paredes M, Luo J, Carroll T, Funabiki H. The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death. Cell. 2019;178:302-315.e23 pubmed 出版商
  • 免疫印迹; 人类; 图 2f
Xia Z, Xu G, Nie L, Liu L, Peng N, He Q, et al. NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1. J Immunol. 2019;: pubmed 出版商
  • 免疫印迹; 人类; 图 2c
Zhang W, Wang G, Xu Z, Tu H, Hu F, Dai J, et al. Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS. Cell. 2019;: pubmed 出版商
  • 免疫印迹; 人类; 图 5f
Liu C, Li X, Nan F, Jiang S, Gao X, Guo S, et al. Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity. Cell. 2019;177:865-880.e21 pubmed 出版商
  • 免疫印迹; 人类; 图 7a
Skjesol A, Yurchenko M, Bösl K, Gravastrand C, Nilsen K, Grøvdal L, et al. The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2. PLoS Pathog. 2019;15:e1007684 pubmed 出版商
  • 免疫印迹; 人类; 图 5b
Guan X, Zhang M, Fu M, Luo S, Hu Q. Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-β Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation. Front Immunol. 2019;10:290 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3d
Tan Y, Kagan J. Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility. Cell. 2019;: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3a, 3c, s3d
Liu Z, Wu C, Pan Y, Liu H, Wang X, Yang Y, et al. NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages. Sci Adv. 2019;5:eaav0163 pubmed 出版商
  • 免疫印迹; 人类; 图 3e
Majumdar T, Sharma S, Kumar M, Hussain M, Chauhan N, Kalia I, et al. Tryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection. Cell Death Dis. 2019;10:161 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6c
Arora H, Wilcox S, Johnson L, Munro L, Eyford B, Pfeifer C, et al. The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock. Immunity. 2019;50:418-431.e6 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1a
Liu D, Wu H, Wang C, Li Y, Tian H, Siraj S, et al. STING directly activates autophagy to tune the innate immune response. Cell Death Differ. 2018;: pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 2d, 2l
  • 免疫印迹; 小鼠; 1:500; 图 1p, 5g, 6f
Benmerzoug S, Rose S, Bounab B, Gosset D, Duneau L, Chenuet P, et al. STING-dependent sensing of self-DNA drives silica-induced lung inflammation. Nat Commun. 2018;9:5226 pubmed 出版商
  • 免疫印迹; 人类; 图 4b
Qi D, Hu L, Jiao T, Zhang T, Tong X, Ye X. Phosphatase Cdc25A Negatively Regulates the Antiviral Immune Response by Inhibiting TBK1 Activity. J Virol. 2018;92: pubmed 出版商
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Liu Z, Qin Q, Wu C, Li H, Shou J, Yang Y, et al. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. Nat Commun. 2018;9:2789 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4d
Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 4b
Yang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, et al. UBXN3B positively regulates STING-mediated antiviral immune responses. Nat Commun. 2018;9:2329 pubmed 出版商
  • 免疫印迹; 人类; 图 5f
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  • 免疫印迹; 人类; 图 9d
Yurchenko M, Skjesol A, Ryan L, Richard G, Kandasamy R, Wang N, et al. SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. J Cell Biol. 2018;217:1411-1429 pubmed 出版商
  • 免疫印迹; 人类; 图 5b
Gaidt M, Ebert T, Chauhan D, Ramshorn K, Pinci F, Zuber S, et al. The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3. Cell. 2017;171:1110-1124.e18 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6d
Nguyen T, Smith B, Tate M, Belz G, Barrios M, Elgass K, et al. SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition. Immunity. 2017;47:498-509.e6 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s17c
Ip W, Hoshi N, Shouval D, Snapper S, Medzhitov R. Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science. 2017;356:513-519 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 3a
Song Y, Lai L, Chong Z, He J, Zhang Y, Xue Y, et al. E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses. Nat Commun. 2017;8:14654 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3a
Shan M, Lin S, Li S, Du Y, Zhao H, Hong H, et al. TIR-Domain-Containing Adapter-Inducing Interferon-? (TRIF) Is Essential for MPTP-Induced Dopaminergic Neuroprotection via Microglial Cell M1/M2 Modulation. Front Cell Neurosci. 2017;11:35 pubmed 出版商
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Almine J, O Hare C, Dunphy G, Haga I, Naik R, Atrih A, et al. IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes. Nat Commun. 2017;8:14392 pubmed 出版商
  • 免疫印迹; 人类; 图 2b
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Hsia H, Hutti J, Baldwin A. Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity. J Biol Chem. 2017;292:5405-5417 pubmed 出版商
  • 免疫印迹; 人类; 图 2d
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  • 免疫印迹; 小鼠; 图 2A
  • 免疫印迹; 人类; 图 5A
Bakshi S, Taylor J, Strickson S, McCartney T, Cohen P. Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon ?. Biochem J. 2017;474:1163-1174 pubmed 出版商
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  • 免疫印迹; 人类; 图 4a
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Boro M, Singh V, Balaji K. Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses. Sci Rep. 2016;6:37695 pubmed 出版商
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Xu L, Yu D, Fan Y, Peng L, Wu Y, Yao Y. Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew. Proc Natl Acad Sci U S A. 2016;113:10950-5 pubmed 出版商
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  • 免疫印迹; 人类; 图 3
  • 免疫印迹; 小鼠; 图 3
Zhao K, Zhang M, Zhang L, Wang P, Song G, Liu B, et al. Intracellular osteopontin stabilizes TRAF3 to positively regulate innate antiviral response. Sci Rep. 2016;6:23771 pubmed 出版商
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Qin Y, Liu Q, Tian S, Xie W, Cui J, Wang R. TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3? to TBK1. Cell Res. 2016;26:613-28 pubmed 出版商
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Zhang G, Chan B, Samarina N, Abere B, Weidner Glunde M, Buch A, et al. Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS. Proc Natl Acad Sci U S A. 2016;113:E1034-43 pubmed 出版商
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产品信息
SKU号 :
4947S
产品名称 :
磷酸化IRF(Ser396)(4D4G)兔单克隆抗体
规格 :
100微升
Price-(USD) :
274美元
物种x :
H, M
应用 :
免疫印迹
产品种类 :
免疫学和炎症
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
45-55
宿主 :
靶标 :
IRF-3(Ser396)磷酸盐
最初蛋白 :
IRF3
别名 :
IRF-3, IRF3, 干扰素调节因子3
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。