产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
Ezh2(D2C9)XP®兔单克隆抗体
目录 :
5246
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
D2C9
反应物种 :
人类, 小鼠, 大鼠, 斑马鱼
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片, ChIP-Seq, 核糖核酸免疫沉淀, mass cytometry, 免疫印迹基因敲除验证, 免疫组化基因敲除验证
文章摘录数: 97
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 2a
Gonzalez M, Naimo G, Anwar T, Paol xec A, Tekula S, Kim S, et al. EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression. iScience. 2022;25:104827 pubmed 出版商
  • 免疫印迹; 人类; 图 2b, 4e
Xing H, Gao M, Wang Y, Zhang X, Shi J, Wang X, et al. Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3Kα inhibitors in oesophageal squamous cell carcinoma. Clin Transl Med. 2022;12:e835 pubmed 出版商
  • 免疫组化; 小鼠; 1:200; 图 5k
  • 免疫印迹; 小鼠; 1:2000; 图 5o
Guo T, Han X, He J, Feng J, Jing J, Jane x10d kov xe1 E, et al. KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis. elife. 2022;11: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s10b
Wu Q, Shichino Y, Abe T, Suetsugu T, Omori A, Kiyonari H, et al. Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells. Nat Commun. 2022;13:470 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s1a
Wei Y, Chen J, Xu X, Li F, Wu K, Jiang Y, et al. Restoration of H3k27me3 Modification Epigenetically Silences Cry1 Expression and Sensitizes Leptin Signaling to Reduce Obesity-Related Properties. Adv Sci (Weinh). 2021;8:2004319 pubmed 出版商
  • 免疫组化; 小鼠; 1:200
Morel K, Sheahan A, Burkhart D, Baca S, Boufaied N, Liu Y, et al. EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer. Nat Cancer. 2021;2:444-456 pubmed 出版商
  • 免疫印迹; 人类; 图 1h, 4f
Tang B, Sun R, Wang D, Sheng H, Wei T, Wang L, et al. ZMYND8 preferentially binds phosphorylated EZH2 to promote a PRC2-dependent to -independent function switch in hypoxia-inducible factor-activated cancer. Proc Natl Acad Sci U S A. 2021;118: pubmed 出版商
  • 免疫组化; 人类; 图 6a
  • 免疫印迹; 人类; 图 5a
Wen Y, Hou Y, Yi X, Sun S, Guo J, He X, et al. EZH2 activates CHK1 signaling to promote ovarian cancer chemoresistance by maintaining the properties of cancer stem cells. Theranostics. 2021;11:1795-1813 pubmed 出版商
  • 免疫印迹; 人类; 图 6d
Su S, Li Q, Zhang M, Zhang P, Shen H, Zhang C. An E2F1/DDX11/EZH2 Positive Feedback Loop Promotes Cell Proliferation in Hepatocellular Carcinoma. Front Oncol. 2020;10:593293 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 4e
  • 免疫印迹; 人类; 图 4e
Bao Y, Oguz G, Lee W, Lee P, Ghosh K, Li J, et al. EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy. Nat Commun. 2020;11:5878 pubmed 出版商
  • 免疫组化; 小鼠; 图 5f
  • 免疫印迹; 人类; 图 3d
Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, et al. The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. J Clin Invest. 2020;: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s5c
Perkail S, Andricovich J, Kai Y, Tzatsos A. BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice. Nat Commun. 2020;11:3018 pubmed 出版商
  • ChIP-Seq; 人类; 1:50; 图 3a
  • 免疫沉淀; 人类; 1:500; 图 1d, 1e
  • 免疫印迹; 人类; 1:1000; 图 1b
Jain P, Ballaré C, Blanco E, Vizan P, Di Croce L. PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells. elife. 2020;9: pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 1a, 1b, 1c, 1d
Hoffmann F, Niebel D, Aymans P, Ferring Schmitt S, Dietrich D, Landsberg J. H3K27me3 and EZH2 expression in melanoma: relevance for melanoma progression and response to immune checkpoint blockade. Clin Epigenetics. 2020;12:24 pubmed 出版商
  • 免疫组化基因敲除验证; 小鼠; 图 2a
Du X, Chen Y, Zhang Q, Lin J, Yu Y, Pan Z, et al. Ezh2 Ameliorates Osteoarthritis by Activating TNFSF13B. J Bone Miner Res. 2020;35:956-965 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 1f
Enomoto T, Aoki M, Hamasaki M, Abe H, Nonaka M, Inoue T, et al. Midline Glioma in Adults: Clinicopathological, Genetic, and Epigenetic Analysis. Neurol Med Chir (Tokyo). 2020;60:136-146 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 1:100; 图 4h
  • 免疫沉淀; 人类; 1:300; 图 6e
  • 免疫印迹; 人类; 1:1000; 图 4c
Zhang L, Tian S, Pei M, Zhao M, Wang L, Jiang Y, et al. Crosstalk between histone modification and DNA methylation orchestrates the epigenetic regulation of the costimulatory factors, Tim‑3 and galectin‑9, in cervical cancer. Oncol Rep. 2019;42:2655-2669 pubmed 出版商
  • 免疫沉淀; 人类; 图 s1c
  • 免疫印迹; 人类; 1:1000; 图 s1b
Piunti A, Smith E, Morgan M, Ugarenko M, Khaltyan N, Helmin K, et al. CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism. Sci Adv. 2019;5:eaax2887 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 4c
  • 免疫细胞化学; 人类; 1:200; 图 3s3a, 3s3b, 3s3c
  • 免疫印迹; 人类; 1:1000; 图 3d
Azkanaz M, Rodríguez López A, de Boer B, Huiting W, Angrand P, Vellenga E, et al. Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 人类; 图 4i
Fan M, Zou Y, He P, Zhang S, Sun X, Li C. Long non-coding RNA SPRY4-IT1 promotes epithelial-mesenchymal transition of cervical cancer by regulating the miR-101-3p/ZEB1 axis. Biosci Rep. 2019;: pubmed 出版商
  • mass cytometry; 人类; 图 3a
Wagner J, Rapsomaniki M, Chevrier S, Anzeneder T, Langwieder C, Dykgers A, et al. A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer. Cell. 2019;177:1330-1345.e18 pubmed 出版商
  • 免疫组化; 人类; 1:100; 图 2a
  • 免疫印迹; 人类; 1:1000; 图 1f
Lima Fernandes E, Murison A, da Silva Medina T, Wang Y, Ma A, Leung C, et al. Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells. Nat Commun. 2019;10:1436 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Wang Z, Feng X, Molinolo A, Martin D, Vitale Cross L, Nohata N, et al. 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer. Cancer Res. 2019;: pubmed 出版商
  • 免疫细胞化学; 人类; 图 5a
  • 免疫印迹; 人类; 图 5b
Wei X, Guo J, Li Q, Jia Q, Jing Q, Li Y, et al. Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cells. Sci Adv. 2019;5:eaau7887 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s2
Chakraborty A, Laukka T, Myllykoski M, Ringel A, Booker M, Tolstorukov M, et al. Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate. Science. 2019;363:1217-1222 pubmed 出版商
  • 免疫印迹; 人类; 图 s1c
Meisenberg C, Pinder S, Hopkins S, Wooller S, Benstead Hume G, Pearl F, et al. Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability. Mol Cell. 2019;73:212-223.e7 pubmed 出版商
  • 免疫组化; 小鼠; 图 1h
  • 免疫印迹; 小鼠; 图 1a
Ferreira M, Verbinnen I, Fardilha M, Van Eynde A, Bollen M. The deletion of the protein phosphatase 1 regulator NIPP1 in testis causes hyperphosphorylation and degradation of the histone methyltransferase EZH2. J Biol Chem. 2018;293:18031-18039 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 5b
  • 流式细胞仪; 小鼠; 图 5a
Casey A, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, et al. Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. J Cell Biol. 2018;217:2951-2974 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s3b
Rothberg J, Maganti H, Jrade H, Porter C, Palidwor G, Cafariello C, et al. Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis. Cell Discov. 2018;4:21 pubmed 出版商
  • 免疫细胞化学; 人类; 图 3f
  • 免疫印迹; 人类; 1:1000; 图 3a
Le Duff M, Gouju J, Jonchère B, Guillon J, Toutain B, Boissard A, et al. Regulation of senescence escape by the cdk4-EZH2-AP2M1 pathway in response to chemotherapy. Cell Death Dis. 2018;9:199 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s15a
Wang P, Xu J, Wang Y, Cao X. An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism. Science. 2017;358:1051-1055 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4a
Patel N, Garikapati K, Pandita R, Singh D, Pandita T, Bhadra U, et al. miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin. Sci Rep. 2017;7:4263 pubmed 出版商
  • 免疫沉淀; 人类; 图 1b
  • 免疫细胞化学; 人类; 5 ug/ml; 图 1c
  • 免疫印迹; 人类; 图 2b
Jin Y, Huo B, Fu X, Hao T, Zhang Y, Guo Y, et al. LSD1 collaborates with EZH2 to regulate expression of interferon-stimulated genes. Biomed Pharmacother. 2017;88:728-737 pubmed 出版商
  • 免疫印迹; 人类; 图 3d
Gonzalez M, Martin E, Anwar T, Arellano Garcia C, Medhora N, Lama A, et al. Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth. Cell Rep. 2017;18:1215-1228 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4e
Lyroni K, Patsalos A, Daskalaki M, Doxaki C, Soennichsen B, Helms M, et al. Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages. J Immunol. 2017;198:1297-1307 pubmed 出版商
  • 免疫沉淀; 人类; 图 3a
  • 免疫印迹; 人类; 1:1000; 图 1e
Göllner S, Oellerich T, Agrawal Singh S, Schenk T, Klein H, Rohde C, et al. Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia. Nat Med. 2017;23:69-78 pubmed 出版商
  • 免疫沉淀; 小鼠; 图 s6
  • 免疫印迹; 小鼠; 1:1000; 图 s3
Cooper S, Grijzenhout A, Underwood E, Ancelin K, Zhang T, Nesterova T, et al. Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. Nat Commun. 2016;7:13661 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50
  • 免疫印迹; 人类; 1:1000; 图 3a
  • 免疫组化-石蜡切片; 小鼠; 1:50
  • 免疫印迹; 小鼠; 1:1000; 图 1a
Lu W, Liu S, Li B, Xie Y, Izban M, Ballard B, et al. SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer. Oncogene. 2017;36:1364-1373 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 2a
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 1c
  • 免疫印迹; 小鼠; 1:500; 图 1d
Xiao X, Senavirathna L, Gou X, Huang C, Liang Y, Liu L. EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis. Physiol Rep. 2016;4: pubmed 出版商
  • 免疫印迹; 人类; 图 6
Nelson D, Jaber Hijazi F, Cole J, Robertson N, Pawlikowski J, Norris K, et al. Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability. Genome Biol. 2016;17:158 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2b,4b,7b
Grinshtein N, Rioseco C, Marcellus R, UEHLING D, Aman A, Lun X, et al. Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells. Oncotarget. 2016;7:59360-59376 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 1c
Sashida G, Wang C, Tomioka T, Oshima M, Aoyama K, Kanai A, et al. The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition. J Exp Med. 2016;213:1459-77 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
Li J, Zhang S, Hu Q, Zhang K, Jin J, Zheng X, et al. The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells. Sci Rep. 2016;6:26971 pubmed 出版商
  • 免疫印迹; 人类; 图 1e
Fang D, Gan H, Lee J, Han J, Wang Z, Riester S, et al. The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science. 2016;352:1344-8 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Chen Y, Pan K, Wang P, Cao Z, Wang W, Wang S, et al. HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis. J Biol Chem. 2016;291:12688-705 pubmed 出版商
  • 免疫印迹; 小鼠; 图 8a
Minnich M, Tagoh H, Bönelt P, Axelsson E, Fischer M, Cebolla B, et al. Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation. Nat Immunol. 2016;17:331-43 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:2000; 图 7
  • 免疫印迹; 人类; 1:2000; 图 3e
Sengupta D, Byrum S, Avaritt N, Davis L, Shields B, Mahmoud F, et al. Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma. Mol Cell Proteomics. 2016;15:765-75 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Hernando H, Gelato K, Lesche R, Beckmann G, Koehr S, Otto S, et al. EZH2 Inhibition Blocks Multiple Myeloma Cell Growth through Upregulation of Epithelial Tumor Suppressor Genes. Mol Cancer Ther. 2016;15:287-98 pubmed 出版商
  • 免疫组化; 大鼠; 图 2
  • 免疫印迹; 大鼠; 图 1
Laumet G, Garriga J, Chen S, Zhang Y, Li D, Smith T, et al. G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition. Nat Neurosci. 2015;18:1746-55 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1a
Maleszewska M, Vanchin B, Harmsen M, Krenning G. The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence. Angiogenesis. 2016;19:9-24 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 6a
Zha L, Li F, Wu R, Artinian L, Rehder V, Yu L, et al. The Histone Demethylase UTX Promotes Brown Adipocyte Thermogenic Program Via Coordinated Regulation of H3K27 Demethylation and Acetylation. J Biol Chem. 2015;290:25151-63 pubmed 出版商
  • 免疫印迹; 人类; 图 st2
Tiffen J, Gunatilake D, Gallagher S, Gowrishankar K, Heinemann A, Cullinane C, et al. Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes. Oncotarget. 2015;6:27023-36 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1a
  • 免疫细胞化学; 人类; 1:200
Khan M, Walters L, Li Q, Thomas D, Miller J, Zhang Q, et al. Characterization and pharmacologic targeting of EZH2, a fetal retinal protein and epigenetic regulator, in human retinoblastoma. Lab Invest. 2015;95:1278-90 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 4
McCleland M, Soukup T, Liu S, Esensten J, De Sousa E Melo F, Yaylaoglu M, et al. Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis. J Pathol. 2015;237:508-19 pubmed 出版商
  • 免疫印迹; 人类; 图 7a
Kotomura N, Harada N, Ishihara S. The Proportion of Chromatin Graded between Closed and Open States Determines the Level of Transcripts Derived from Distinct Promoters in the CYP19 Gene. PLoS ONE. 2015;10:e0128282 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 3
  • 免疫沉淀; 人类; 图 3
  • 免疫印迹; 人类; 图 s3
Nishioka C, Ikezoe T, Yang J, Yokoyama A. Tetraspanin Family Member, CD82, Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling in Leukemia Cells. PLoS ONE. 2015;10:e0125017 pubmed 出版商
  • 免疫印迹; 人类
Fan H, Zhang H, Pascuzzi P, Andrisani O. Hepatitis B virus X protein induces EpCAM expression via active DNA demethylation directed by RelA in complex with EZH2 and TET2. Oncogene. 2016;35:715-26 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6g
Zhang P, Yang X, Ma X, Ingram D, Lazar A, Torres K, et al. Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway. Mol Cancer. 2015;14:55 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Wan J, Zhan J, Li S, Ma J, Xu W, Liu C, et al. PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression. Nucleic Acids Res. 2015;43:3591-604 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s3
  • 免疫印迹; 人类; 图 2
Zhou Q, Derti A, Ruddy D, Rakiec D, Kao I, Lira M, et al. A chemical genetics approach for the functional assessment of novel cancer genes. Cancer Res. 2015;75:1949-58 pubmed 出版商
  • 免疫印迹; 人类
Poirier J, Gardner E, Connis N, Moreira A, de Stanchina E, Hann C, et al. DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2. Oncogene. 2015;34:5869-78 pubmed 出版商
  • 免疫组化; 大鼠; 1:1000; 图 3
  • 免疫印迹; 大鼠; 1:1000; 图 s4
Koo J, Mazei Robison M, LaPlant Q, Egervári G, Braunscheidel K, Adank D, et al. Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area. Nat Neurosci. 2015;18:415-22 pubmed 出版商
  • 免疫组化; 小鼠; 图 s4
  • 免疫印迹; 人类; 1:200; 图 1
Fillmore C, Xu C, Desai P, Berry J, Rowbotham S, Lin Y, et al. EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors. Nature. 2015;520:239-42 pubmed 出版商
  • 染色质免疫沉淀 ; 斑马鱼; 1:100
Tien C, Jones A, Wang H, Gerigk M, Nozell S, Chang C. Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development. Development. 2015;142:722-31 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 3
Matsuda Y, Kobayashi Ishihara M, Fujikawa D, Ishida T, Watanabe T, Yamagishi M. Epigenetic heterogeneity in HIV-1 latency establishment. Sci Rep. 2015;5:7701 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 3
  • 免疫沉淀; 小鼠; 图 3
Wurm S, Zhang J, Guinea Viniegra J, García F, Muñoz J, Bakiri L, et al. Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2. Genes Dev. 2015;29:144-56 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Naganuma K, Hatta M, Ikebe T, Yamazaki J. Epigenetic alterations of the keratin 13 gene in oral squamous cell carcinoma. BMC Cancer. 2014;14:988 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Bhatnagar S, Gazin C, Chamberlain L, Ou J, Zhu X, Tushir J, et al. TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. Nature. 2014;516:116-20 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s7b
Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, et al. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014;20:1394-6 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:300
Karoopongse E, Yeung C, Byon J, Ramakrishnan A, Holman Z, Jiang P, et al. The KDM2B- let-7b -EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy. PLoS ONE. 2014;9:e107817 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Lu F, Liu Y, Jiang L, Yamaguchi S, Zhang Y. Role of Tet proteins in enhancer activity and telomere elongation. Genes Dev. 2014;28:2103-19 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Shpargel K, Starmer J, Yee D, Pohlers M, Magnuson T. KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development. PLoS Genet. 2014;10:e1004507 pubmed 出版商
  • 核糖核酸免疫沉淀; 人类; 图 4a
Sun N, Ye C, Zhao Q, Zhang Q, Xu C, Wang S, et al. Long noncoding RNA-EBIC promotes tumor cell invasion by binding to EZH2 and repressing E-cadherin in cervical cancer. PLoS ONE. 2014;9:e100340 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 1:100
  • 免疫沉淀; 人类; 1:1000
  • 免疫印迹; 人类; 1:1000
Cao Q, Wang X, Zhao M, Yang R, Malik R, Qiao Y, et al. The central role of EED in the orchestration of polycomb group complexes. Nat Commun. 2014;5:3127 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 1
Hayashi A, Morikawa T, Kawai T, Kume H, Ishikawa S, Homma Y, et al. Clinicopathological and prognostic significance of EZH2 expression in upper urinary tract carcinoma. Virchows Arch. 2014;464:463-71 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Corvetta D, Chayka O, Gherardi S, D Acunto C, Cantilena S, Valli E, et al. Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. J Biol Chem. 2013;288:8332-41 pubmed 出版商
Park S, Fong K, Kim J, Wang F, Lu X, Lee Y, et al. Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer. Sci Adv. 2021;7: pubmed 出版商
Huang S, Fantini D, Merrill B, Bagchi S, Guzman G, Raychaudhuri P. DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer. Cancer Res. 2017;77:6562-6575 pubmed 出版商
Vaz M, Hwang S, Kagiampakis I, Phallen J, Patil A, O Hagan H, et al. Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations. Cancer Cell. 2017;32:360-376.e6 pubmed 出版商
Hanssen L, Kassouf M, Oudelaar A, Biggs D, Preece C, Downes D, et al. Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo. Nat Cell Biol. 2017;19:952-961 pubmed 出版商
Jung H, Byun H, Jee B, Min S, Jeoun U, Lee Y, et al. The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence. J Biol Chem. 2017;292:3729-3739 pubmed 出版商
Ihira K, Dong P, Xiong Y, Watari H, Konno Y, Hanley S, et al. EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis. Oncotarget. 2017;8:13509-13520 pubmed 出版商
Wang X, Sehgal L, Jain N, Khashab T, Mathur R, Samaniego F. LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2. J Transl Med. 2016;14:346 pubmed 出版商
Liu H, Li W, Yu X, Gao F, Duan Z, Ma X, et al. EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Oncotarget. 2016;7:56338-56354 pubmed 出版商
Deaton A, Gómez Rodríguez M, Mieczkowski J, Tolstorukov M, Kundu S, Sadreyev R, et al. Enhancer regions show high histone H3.3 turnover that changes during differentiation. elife. 2016;5: pubmed 出版商
Bitler B, Aird K, Garipov A, Li H, Amatangelo M, Kossenkov A, et al. Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. Nat Med. 2015;21:231-8 pubmed 出版商
Bae W, Kang K, Yu J, Yoo K, Factor V, Kaji K, et al. The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration. FASEB J. 2015;29:1653-62 pubmed 出版商
Jia N, Li Q, Tao X, Wang J, Hua K, Feng W. Enhancer of zeste homolog 2 is involved in the proliferation of endometrial carcinoma. Oncol Lett. 2014;8:2049-2054 pubmed
Lee W, Teckie S, Wiesner T, Ran L, Prieto Granada C, Lin M, et al. PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. Nat Genet. 2014;46:1227-32 pubmed 出版商
Popovic R, Martinez Garcia E, Giannopoulou E, Zhang Q, Zhang Q, Ezponda T, et al. Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation. PLoS Genet. 2014;10:e1004566 pubmed 出版商
Wolfe A, Singh K, Zhong Y, Drewe P, Rajasekhar V, Sanghvi V, et al. RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer. Nature. 2014;513:65-70 pubmed 出版商
Blackledge N, Farcas A, Kondo T, King H, McGouran J, Hanssen L, et al. Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation. Cell. 2014;157:1445-59 pubmed 出版商
Girard N, Bazille C, Lhuissier E, Benateau H, Llombart Bosch A, Boumediene K, et al. 3-Deazaneplanocin A (DZNep), an inhibitor of the histone methyltransferase EZH2, induces apoptosis and reduces cell migration in chondrosarcoma cells. PLoS ONE. 2014;9:e98176 pubmed 出版商
Chattergoon M, Latanich R, Quinn J, Winter M, Buckheit R, Blankson J, et al. HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferon. PLoS Pathog. 2014;10:e1004082 pubmed 出版商
Svedlund J, Barazeghi E, Stalberg P, Hellman P, Akerstrom G, Björklund P, et al. The histone methyltransferase EZH2, an oncogene common to benign and malignant parathyroid tumors. Endocr Relat Cancer. 2014;21:231-9 pubmed 出版商
Li G, Warden C, Zou Z, Neman J, Krueger J, Jain A, et al. Altered expression of polycomb group genes in glioblastoma multiforme. PLoS ONE. 2013;8:e80970 pubmed 出版商
Forthun R, SenGupta T, Skjeldam H, Lindvall J, McCormack E, Gjertsen B, et al. Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid. PLoS ONE. 2012;7:e48992 pubmed 出版商
产品信息
SKU号 :
5246P
产品名称 :
Ezh2(D2C9)XP®兔单克隆抗体
规格 :
40微升
Price-(USD) :
135美元
物种x :
H, M, R, Mk
应用 :
染色质免疫沉淀
产品种类 :
Chromatin Regulation / Nuclear Function
运输温度 :
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
98
宿主 :
靶标 :
EZH2
最初蛋白 :
EZH2
别名 :
ENX-1,ENX1,EZH1,EZH2,Enhancer of zeste homolog 2,Histone-lysine N-methyltransferase EZH2,KMT6,KMT6A,Lysine N-methyltransferase 6,MGC9169,enhancer of zeste 2,enhancer of zeste homolog 2 (Drosophila)
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。