产品简要
公司名称 :
赛信通(上海)生物试剂有限公司
产品类型 :
抗体
产品名称 :
eIF2α(D7D3)XP®兔单克隆抗体
目录 :
5324
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
D7D3
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片
文章摘录数: 58
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 1b
Kitakaze K, Oyadomari M, Zhang J, Hamada Y, Takenouchi Y, Tsuboi K, et al. ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model. Mol Metab. 2021;54:101338 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2b
Yan M, Wang Z, Xia T, Jin S, Liu Y, Hu H, et al. Enhancement of TEX264-Mediated ER-Phagy Contributes to the Therapeutic Effect of Glycycoumarin against APA Hepatotoxicity in Mice. Biomedicines. 2021;9: pubmed 出版商
  • 免疫印迹; 小鼠; 图 4b
Swarnkar S, Avchalumov Y, Espadas I, Grinman E, Liu X, Raveendra B, et al. Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation. Cell Rep. 2021;36:109369 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1b
Cho J, Lee J, Kim H, Lee H, Fang Z, Kwon H, et al. Ethyl Acetate Fraction of Amomum villosum var. xanthioides Attenuates Hepatic Endoplasmic Reticulum Stress-Induced Non-Alcoholic Steatohepatitis via Improvement of Antioxidant Capacities. Antioxidants (Basel). 2021;10: pubmed 出版商
  • 免疫印迹; 人类; 图 1a
  • 免疫印迹; 小鼠; 图 1a, 5a
Misra J, Holmes M, T Mirek E, Langevin M, Kim H, Carlson K, et al. Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress. Nucleic Acids Res. 2021;49:5726-5742 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 3a
Wang Y, Lee Y, Hsu Y, Chiu I, Huang C, Huang C, et al. The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice. Environ Health Perspect. 2021;129:57003 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2a
Yin S, Li L, Tao Y, Yu J, Wei S, Liu M, et al. The Inhibitory Effect of Artesunate on Excessive Endoplasmic Reticulum Stress Alleviates Experimental Colitis in Mice. Front Pharmacol. 2021;12:629798 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2a
Lu Y, Kavianpour S, Zhang T, Zhang X, Nguyen D, Thombre R, et al. MARK2 phosphorylates eIF2α in response to proteotoxic stress. PLoS Biol. 2021;19:e3001096 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2f
  • 免疫印迹; 人类; 1:1000; 图 s6
von Roemeling C, Wang Y, Qie Y, Yuan H, Zhao H, Liu X, et al. Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity. Nat Commun. 2020;11:1508 pubmed 出版商
  • 免疫印迹; 人类
Xu Y, Fulciniti M, Samur M, Ho M, Deng S, Liu L, et al. YWHAE/14-3-3ε expression impacts the protein load, contributing to proteasome inhibitor sensitivity in multiple myeloma. Blood. 2020;136:468-479 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2b
Inda M, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J, et al. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nat Commun. 2020;11:319 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Johnston B, Pringle E, McCormick C. KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication. PLoS Pathog. 2019;15:e1008185 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 5f
Zhu H, Bhatt B, Sivaprakasam S, Cai Y, Liu S, Kodeboyina S, et al. Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR. Nat Commun. 2019;10:1084 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6d
Cai Y, Zhu G, Liu S, Pan Z, Quintero M, Poole C, et al. Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation. Cell Discov. 2019;5:7 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Wang D, Xu Q, Yuan Q, Jia M, Niu H, Liu X, et al. Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab. Oncogene. 2019;38:3458-3474 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2i
Aggarwal S, Gabrovsek L, Langeberg L, Golkowski M, Ong S, Smith F, et al. Depletion of dAKAP1-protein kinase A signaling islands from the outer mitochondrial membrane alters breast cancer cell metabolism and motility. J Biol Chem. 2019;294:3152-3168 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:150; 图 4c
Maziuk B, Apicco D, Cruz A, Jiang L, Ash P, da Rocha E, et al. RNA binding proteins co-localize with small tau inclusions in tauopathy. Acta Neuropathol Commun. 2018;6:71 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4b
Sonobe Y, Ghadge G, Masaki K, Sendoel A, Fuchs E, Roos R. Translation of dipeptide repeat proteins from the C9ORF72 expanded repeat is associated with cellular stress. Neurobiol Dis. 2018;116:155-165 pubmed 出版商
  • 免疫印迹; 人类; 图 s3c
Ivanov I, Shin B, Loughran G, Tzani I, Young Baird S, Cao C, et al. Polyamine Control of Translation Elongation Regulates Start Site Selection on Antizyme Inhibitor mRNA via Ribosome Queuing. Mol Cell. 2018;70:254-264.e6 pubmed 出版商
  • 免疫印迹; 人类; 图 3b
Liu R, Moss B. Vaccinia Virus C9 Ankyrin Repeat/F-Box Protein Is a Newly Identified Antagonist of the Type I Interferon-Induced Antiviral State. J Virol. 2018;92: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s5c
Nguyen A, Prado M, Schmidt P, Sendamarai A, Wilson Grady J, Min M, et al. UBE2O remodels the proteome during terminal erythroid differentiation. Science. 2017;357: pubmed 出版商
  • 免疫印迹; 小鼠; 图 5b
Hsu J, Hubbell Engler B, Adelmant G, Huang J, Joyce C, Vazquez F, et al. PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer. Cancer Res. 2017;77:4613-4625 pubmed 出版商
  • 免疫印迹; 人类; 图 3d
Potes Y, de Luxán Delgado B, Rodríguez González S, Guimarães M, Solano J, Fernández Fernández M, et al. Overweight in elderly people induces impaired autophagy in skeletal muscle. Free Radic Biol Med. 2017;110:31-41 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 6a
Xiong G, Hindi S, Mann A, Gallot Y, Bohnert K, Cavener D, et al. The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration. elife. 2017;6: pubmed 出版商
  • 免疫印迹; 小鼠; 图 9d
Ohgaki R, Ohmori T, Hara S, Nakagomi S, Kanai Azuma M, Kaneda Nakashima K, et al. Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc. Mol Cell Biol. 2017;37: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4b
Dimasi P, Quintiero A, Shelkovnikova T, Buchman V. Modulation of p-eIF2α cellular levels and stress granule assembly/disassembly by trehalose. Sci Rep. 2017;7:44088 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1c
Biever A, Boubaker Vitre J, Cutando L, Gracia Rubio I, Costa Mattioli M, Puighermanal E, et al. Repeated Exposure to D-Amphetamine Decreases Global Protein Synthesis and Regulates the Translation of a Subset of mRNAs in the Striatum. Front Mol Neurosci. 2016;9:165 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4h
Sendoel A, Dunn J, Rodriguez E, Naik S, Gomez N, Hurwitz B, et al. Translation from unconventional 5' start sites drives tumour initiation. Nature. 2017;541:494-499 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4d
Newberry E, Xie Y, Kennedy S, Graham M, Crooke R, Jiang H, et al. Prevention of hepatic fibrosis with liver microsomal triglyceride transfer protein deletion in liver fatty acid binding protein null mice. Hepatology. 2017;65:836-852 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:2000; 图 s1a
Khoutorsky A, Sorge R, Prager Khoutorsky M, Pawlowski S, Longo G, Jafarnejad S, et al. eIF2? phosphorylation controls thermal nociception. Proc Natl Acad Sci U S A. 2016;113:11949-11954 pubmed
  • 免疫印迹; 人类; 图 4b
Wang C, Zhang F, Cao Y, Zhang M, Wang A, Xu M, et al. Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER Stress. Sci Rep. 2016;6:34330 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3a
Yang Z, Tsuchiya H, Zhang Y, Lee S, Liu C, Huang Y, et al. REV-ERB? Activates C/EBP Homologous Protein to Control Small Heterodimer Partner-Mediated Oscillation of Alcoholic Fatty Liver. Am J Pathol. 2016;186:2909-2920 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
Taniuchi S, Miyake M, Tsugawa K, Oyadomari M, Oyadomari S. Integrated stress response of vertebrates is regulated by four eIF2? kinases. Sci Rep. 2016;6:32886 pubmed 出版商
  • 免疫印迹; 人类; 图 4A
Zhang M, Qi Y, Li H, Cui J, Dai L, Frank J, et al. AIM2 inflammasome mediates Arsenic-induced secretion of IL-1 ? and IL-18. Oncoimmunology. 2016;5:e1160182 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6
Bai Y, Dong Z, Shang Q, Zhao H, Wang L, Guo C, et al. Pdcd4 Is Involved in the Formation of Stress Granule in Response to Oxidized Low-Density Lipoprotein or High-Fat Diet. PLoS ONE. 2016;11:e0159568 pubmed 出版商
  • 免疫印迹; 人类; 图 8
Liu R, Moss B. Opposing Roles of Double-Stranded RNA Effector Pathways and Viral Defense Proteins Revealed with CRISPR-Cas9 Knockout Cell Lines and Vaccinia Virus Mutants. J Virol. 2016;90:7864-79 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Berthoud V, Minogue P, Lambert P, Snabb J, Beyer E. The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses. J Biol Chem. 2016;291:17569-78 pubmed 出版商
  • 免疫细胞化学; 人类; 1:400; 图 8C
Zhou X, Wei Y, Qiu S, Xu Y, Zhang T, Zhang S. Propofol Decreases Endoplasmic Reticulum Stress-Mediated Apoptosis in Retinal Pigment Epithelial Cells. PLoS ONE. 2016;11:e0157590 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s3
Wang J, Farris A, Xu K, Wang P, Zhang X, Duong D, et al. GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis. Nat Commun. 2016;7:11795 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5
PluciÅ„ska K, Dekeryte R, Koss D, Shearer K, Mody N, Whitfield P, et al. Neuronal human BACE1 knockin induces systemic diabetes in mice. Diabetologia. 2016;59:1513-1523 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Yadav P, Selvaraj B, Bender F, Behringer M, Moradi M, Sivadasan R, et al. Neurofilament depletion improves microtubule dynamics via modulation of Stat3/stathmin signaling. Acta Neuropathol. 2016;132:93-110 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s2
Liao K, Guo M, Niu F, Yang L, Callen S, Buch S. Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis. J Neuroinflammation. 2016;13:33 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 5
Srinivasan R, Henley B, Henderson B, Indersmitten T, Cohen B, Kim C, et al. Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons. J Neurosci. 2016;36:65-79 pubmed 出版商
  • 免疫印迹; 小鼠
McIlroy G, Tammireddy S, Maskrey B, Grant L, Doherty M, Watson D, et al. Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue. Biochem Pharmacol. 2016;100:86-97 pubmed 出版商
  • 免疫印迹; 人类
Willy J, Young S, Stevens J, Masuoka H, Wek R. CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis. Mol Biol Cell. 2015;26:2190-204 pubmed 出版商
  • 免疫印迹; 小鼠; 图 f6
Chung J, Bauer D, Ghamari A, Nizzi C, Deck K, Kingsley P, et al. The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Sci Signal. 2015;8:ra34 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 8
Shimizu N, Maruyama T, Yoshikawa N, Matsumiya R, Ma Y, Ito N, et al. A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling. Nat Commun. 2015;6:6693 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Burgess H, Mohr I. Cellular 5'-3' mRNA exonuclease Xrn1 controls double-stranded RNA accumulation and anti-viral responses. Cell Host Microbe. 2015;17:332-344 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Lin Y, Zhang H, Liang J, Li K, Zhu W, Fu L, et al. Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers. Proc Natl Acad Sci U S A. 2014;111:E4504-12 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Ma Q, Ying M, Sui X, Zhang H, Huang H, Yang L, et al. Chronic copper exposure causes spatial memory impairment, selective loss of hippocampal synaptic proteins, and activation of PKR/eIF2α pathway in mice. J Alzheimers Dis. 2015;43:1413-27 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6a
Feng X, Krogh K, Wu C, Lin Y, Tsai H, Thayer S, et al. Receptor-interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell death. Nat Commun. 2014;5:4487 pubmed 出版商
  • 免疫印迹; 小鼠
Ost M, Werner F, Dokas J, Klaus S, Voigt A. Activation of AMPK?2 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity. PLoS ONE. 2014;9:e94689 pubmed 出版商
Wang Z, Xiong F, Xie X, Chen D, Pan J, Cheng L. Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress. BMC Nephrol. 2015;16:44 pubmed 出版商
Gao X, Wan J, Liu B, Ma M, Shen B, Qian S. Quantitative profiling of initiating ribosomes in vivo. Nat Methods. 2015;12:147-53 pubmed 出版商
Andruska N, Zheng X, Yang X, Helferich W, Shapiro D. Anticipatory estrogen activation of the unfolded protein response is linked to cell proliferation and poor survival in estrogen receptor α-positive breast cancer. Oncogene. 2015;34:3760-9 pubmed 出版商
Dixon S, Patel D, Welsch M, Skouta R, Lee E, Hayano M, et al. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. elife. 2014;3:e02523 pubmed 出版商
Zhao M, Zang B, Cheng M, Ma Y, Yang Y, Yang N. Differential responses of hepatic endoplasmic reticulum stress and inflammation in diet-induced obese rats with high-fat diet rich in lard oil or soybean oil. PLoS ONE. 2013;8:e78620 pubmed 出版商
Fujiki K, Inamura H, Matsuoka M. PI3K signaling mediates diverse regulation of ATF4 expression for the survival of HK-2 cells exposed to cadmium. Arch Toxicol. 2014;88:403-14 pubmed 出版商
产品信息
SKU号 :
5324P
产品名称 :
eIF2α(D7D3)XP®兔单克隆抗体
规格 :
40微升
Price-(USD) :
135美元
物种x :
H, M, R, Mk
应用 :
免疫组化(石蜡)
产品种类 :
Translational Control
运输温度 :
AMBIENT
储存温度 :
-20°C
产品类型 :
单克隆抗体
分子量 :
38
宿主 :
靶标 :
eIF2A
最初蛋白 :
eIF2A
别名 :
EIF-2,EIF2,EIF2A,EIF2S1,Eukaryotic translation initiation factor 2 subunit 1,Eukaryotic translation initiation factor 2 subunit alpha,IF2A,eIF-2-alpha,eIF-2A,eIF-2alpha,eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
公司信息
赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120
info@cst-c.com.cn
http://www.cst-c.com.cn
2158356288
公司总部: 美国
赛信通生物试剂有限公司1999年成立于美国麻省,是一家私人拥有的公司,在全世界拥有超过400名员工。我们致力于提供用于帮助确定的细胞功能和抗病机制的创新型的研究工具。公司自成立以来,赛信通已成为全球领先的生产用于扩大细胞信号通路知识的最高质量的激活状态蛋白和总蛋白的抗体。我们的使命是为客户提供世界上最高质量的研究工具,以加快生物研究和个性化药物的进展。